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Hai Lin Zhao,Yeong Shik Kim 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.9
A 1, 2-diglyceride-based multi-step colorimetric assay to measure the pancreatic lipase activity was applied for the determination of the kinetic profiles of the lipase inhibition with a slight modification and the validity verification. With this assay method, our study revealed that platycodin D, one of major constituents of Platycodi Radix, inhibits the pancreatic lipase activity in a competitive type, with the value of KI being 0.18±0.02 mM. In addition, PD has affected the values of Km, app and Kcat/Km in a dose- dependent manner. The results shed a meaningful light on how PD mediates lipid metabolism in the intestinal tracts. On the other hand, since the revised assay is sensitive, rapid, and does not affect the accuracy to the kinetic properties, it is applicable not only to evaluation of the kinetic properties of the pancreatic lipase, but also to highthroughput screening of pancreatic lipase activity.
Hai-zhen Zhao,Juan Wang,Fengxia Lv,Xiaomei Bie,Zhaoxin Lu 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.2
A water-soluble exopolysaccharide (PESP-1) was extracted and purified using DEAE Sephadex A-50 and Sephadex G-100 columns from a submerged culture broth of Pholiota squarrosa Quel. AS 5.245. PEPS-1 was investigated for antitumor activity against Heps tumors implanted in mice. An inhibition rate of 78.46% at a dosage of 100 mg/kg was observed. PEPS-1 significantly (p<0.05) increased the relative spleen/thymus indices of Heps tumor-bearing mice at a dosage of 100 mg/kg, compared with controls. Antitumor properties were probably related to stimulation of the immune response. Preliminary physicochemical analysis identified PEPS-1 as a heteropolysaccharide mainly containing D-mannose, D-glucose and D-galactose at molar ratios of 50:33:18. Small amounts of D-rhamnose and D-xylose were also detected. The average Mw of PEPS-1 was 3.26×104 Da. Structural features probably played an important role in the antitumor activity of PEPS-1.
( Hai Yan Zhao ),( Hui Ying Li ),( Jian Jin ),( Ji Zhe Jin ),( Long Ye Zhang ),( Mei Ying Xuan ),( Xue Mei Jin ),( Yu Ji Jiang ),( Hai Lan Zheng ),( Ying Shun Jin ),( Yong Jie Jin ),( Bum Soon Choi ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.0
Background/Aims: Accumulating evidence indicates that L-carnitine (LC) protects against multiorgan damage through its antioxidant properties and preservation of the mitochondria. Little information is available about the effects of LC on renal fibrosis. This study examined whether LC treatment would provide renoprotection in a rat model of unilateral ureteral obstruction (UUO) and in vitro. Methods: Sprague-Dawley rats that underwent UUO were treated daily with LC for 7 or 14 days. The influence of LC on renal injury caused by UUO was evaluated by histopathology, and analysis of gene expression, oxidative stress, mitochondrial function, programmed cell death, and phosphatidylinositol 3-kinase (PI3K)/ AKT/forkhead box protein O 1a (FoxO1a) signaling. In addition, H<sub>2</sub>O<sub>2</sub>-exposed human kidney cells (HK-2) were treated with LC. Results: LC treatment inhibited expression of proinflammatory and profibrotic cytokines, and was followed by a significant attenuation of tubulointerstitial inflammation and fibrosis. The increased oxidative stress caused by UUO was associated with mitochondrial dysfunction and excessive apoptosis and autophagy via PI3K/AKT/FoxO1a-dependent signaling, and this was abrogated by administration of LC. In H<sub>2</sub>O<sub>2</sub>-exposed HK-2 cells, LC decreased intracellular production of reactive oxygen species, and suppressed expression of profibrotic cytokines and reduced the number of apoptotic cells. Conclusions: LC protects against the progression of tubulointerstitial fibrosis in an obstructed kidney.
Effect of noise barrier on aerodynamic performance of high-speed train in crosswind
Zhao, Hai,Zhai, Wanming,Chen, Zaigang Techno-Press 2015 Wind and Structures, An International Journal (WAS Vol.20 No.4
A three-dimensional aerodynamic model and a vehicle dynamics model are established to investigate the effect of noise barrier on the dynamic performance of a high-speed train running on an embankment in crosswind in this paper. Based on the developed model, flow structures around the train with and without noise barrier are compared. Effect of the noise barrier height on the train dynamic performance is studied. Then, comparisons between the dynamic performance indexes of the train running on the windward track and on the leeward track are made. The calculated results show that the noise barrier has significant effects on the structure of the flow field around the train in crosswind and thus on the dynamic performance of the high-speed train. The dynamic performance of the train on the windward track is better than that on the leeward track. In addition, various heights of the noise barrier will have different effects on the train dynamic performance. The dynamic performance indexes keep decreasing with the increase of the noise barrier height before the height reaches a certain value, while these indexes have an inverse trend when the height is above this value. These results suggest that optimization on the noise barrier height is possible and demonstrate that the designed noise barrier height of the existing China Railway High-speed line analysed in this article is reasonable from the view point of the flow field structure and train dynamic performance although the noise barrier is always designed based on the noise-related standard.
Effect of noise barrier on aerodynamic performance of high-speed train in crosswind
Hai Zhao,Wanming Zhai,Zaigang Chen 한국풍공학회 2015 Wind and Structures, An International Journal (WAS Vol.20 No.4
A three-dimensional aerodynamic model and a vehicle dynamics model are established toinvestigate the effect of noise barrier on the dynamic performance of a high-speed train running on anembankment in crosswind in this paper. Based on the developed model, flow structures around the train withand without noise barrier are compared. Effect of the noise barrier height on the train dynamic performanceis studied. Then, comparisons between the dynamic performance indexes of the train running on thewindward track and on the leeward track are made. The calculated results show that the noise barrier hassignificant effects on the structure of the flow field around the train in crosswind and thus on the dynamicperformance of the high-speed train. The dynamic performance of the train on the windward track is betterthan that on the leeward track. In addition, various heights of the noise barrier will have different effects onthe train dynamic performance. The dynamic performance indexes keep decreasing with the increase of thenoise barrier height before the height reaches a certain value, while these indexes have an inverse trend whenthe height is above this value. These results suggest that optimization on the noise barrier height is possibleand demonstrate that the designed noise barrier height of the existing China Railway High-speed lineanalysed in this article is reasonable from the view point of the flow field structure and train dynamicperformance although the noise barrier is always designed based on the noise-related standard.
Adsorption of Bovine Serum Albumin onto Tannic Acid-Immobilized Chitosan Resin
Hai-yan Li,Hai-mei Liu,Qin Zhao 한국섬유공학회 2020 Fibers and polymers Vol.21 No.11
A novel tannic acid-immobilized chitosan resin (TICR) was prepared by Mannich reaction for the adsorption ofproteins. The physical properties of TICR were characterized and the effects of contact time, pH, and initial concentration of(bovine serum albumin) BSA on its adsorption by TICR were investigated. The Langmuir isotherm model was applied todescribe the adsorption isotherm. The equilibrium data are fitted to the Langmuir isotherm model. The maximum monolayerBSA adsorption capacities of TICR were found to be 1.094, 1.487, and 1.694 mg/g at 298, 308, and 318 K, respectively. Furthermore, the data were analyzed on the basis of pseudo-first order, pseudo-second order, and intraparticle diffusionmodels. The correlation results suggested that the pseudo-second order model fitted the experimental data very well. Thethermodynamic study indicated that the adsorption process of BSA onto TICR was endothermic, and the Gibbs free energy(ΔGo), enthalpy (ΔHo), and entropy (ΔSo) of the adsorption process were calculated according adsorption isotherm data. TICRcould be reused for 10 times with only 19 % loss of adsorption capacity for BSA.
Cementing failure of the casing-cement-rock interfaces during hydraulic fracturing
Hai Y. Zhu,Jin G. Deng,Jun Zhao,Hu Zhao,Hai L. Liu,Teng Wang 사단법인 한국계산역학회 2014 Computers and Concrete, An International Journal Vol.14 No.1
Using the principle of damage mechanics, zero-thickness pore pressure cohesive elements(PPCE) are used to simulate the casing-cement interface (CCI) and cement-rock interface (CRI). The traction-separation law describes the emergence and propagation of the PPCE. Mohr-coulomb criteria determines the elastic and plastic condition of cement sheath and rock. The finite element model (FEM) of delamination fractures emergence and propagation along the casing-cement-rock (CCR) interfaces during hydraulic fracturing is established, and the emergence and propagation of fractures along the wellbore axial and circumferential direction are simulated. Regadless of the perforation angle (the angle between the perforation and the max. horizontal principle stress), mirco-annulus will be produced alonge the wellbore circumferential direction when the cementation strength of the CCI and the CRI is less than the rock tensile strength; the delamination fractures are hard to propagate along the horizontal wellbore axial direction; emergence and propagation of delamination fractures are most likely produced on the shallow formationwhen the in-situ stresses are lower; the failure mode of cement sheath in the deep well is mainly interfaces seperation and body damange caused by cement expansion and contraction, or pressure testing and well shut-in operations.