Does H3K27M Mutation Impact Survival Outcome of High-Grade Spinal Cord Astrocytoma?

Fan Zhang,Lei Cheng,Ze Ding,Shengxi Wang,Xingang Zhao,Zijun Zhao,Cong Liang,Kun Wu,Dongao Zhang,Yinqian Wang,Tao Fan 대한척추신경외과학회 2023 Neurospine Vol.20 No.4

Objective: To evaluate the impact of H3K27M mutation in the prognosis of histological high-grade intramedullary astrocytoma. Methods: A total of 78 patients who were diagnosed with high-grade spinal cord astrocytoma were included. Clinical data consisting demographic, radiological, molecular features and treatment data were recorded. Univariate and multivariate Cox analysis were performed to investigate variables associated with survival outcome of histological high-grade spinal cord astrocytoma. Results: Median survival time was 21 months. Overall survival (OS) at 1 and 3 years was 65.7% and 40.7%, respectively. Sex, location, and tumor span did not present significant association with OS. Patients with H3K27M mutation showed significant shorter duration of symptom than patients with H3K27 wild-type. As respect to adjuvant treatment, adjuvant radiotherapy and chemotherapy were associated with favorable OS (both p = 0.01). Younger patients (age ≤ 18 years) had shorter OS (p = 0.008) than adult patients (age > 18 years). Of note, H3K27M mutation did not show significant impact on the survival outcome, regardless of histology grade 3 or grade 4 (p = 0.3). Conclusion: Histological high-grade spinal cord astrocytoma has dismal prognosis. Our study demonstrated that H3K27M mutation did not show significant impact on survival outcome of histological high-grade spinal cord astrocytoma.

Research of Acoustic Emission Testing Method with Application to Monitored for Wind Turbines

Qin Hongwu,Zhang Chao,Zhang Xian,Fan Qinyin 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.1

Acoustic Emission method of nondestructive check is based on exertion wave radiation and their registration during fast local material structure reorganization. It is used as a means of analysis of materials, constructions, productions control and diagnosis during operating time. In the article, it is applied to structural health monitoring of Wind Turbines. Acoustic emission testing is based condition monitoring system uses data already collected at the wind turbine controller. It is an effective way to monitor wind turbines for early warning of failures and performance issues. We used a number of measurements to develop anomaly detection algorithms and investigated classification techniques using clustering algorithms and principal components analysis for capturing fault signatures. When registering signal amplitude it is required to consider its frequency distribution connecting each amplitude rate with the corresponding vibration rate. The correlation and signal to noise ratio were evaluated by the algorithm based on frequency spectrum. Classical method of frequency distortion influence exclusion consists of FRF calculation with subsequent adjustment of received signals spectral characteristics.

A Joint Control Strategy for Automobile Active Grille Shutter and Cooling Fan

Liu Chuanbo,Wang Zhengju,Fan Chaojie,Zhang Ruonan,Man Xingjia 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.6

As an emerging technology improving fuel consumption, active grille shutter (AGS) has been applied in engine cooling system. For the reason of unreasonable matching method of grille opening and cooling fan, the problem of engine overcooling is widespread. As components with similar function of adjusting cooling air flow, the AGS and the cooling fan are separated from each other in parameter matching and operation which reduce cooling efficiency and fuel economy. To achieve precise cooling and improve fuel economy, a joint control strategy for AGS and cooling fan was proposed by using computational fluid dynamics. In order to verify the feasibility of the strategy, the fuel economy tests were carried out at 0 km/h, 90 km/h and 120 km/h, respectively. The results showed that the fuel consumption under the three working conditions was reduced by 0.01 L/ 100 km, 0.07 L/ 100 km and 0.13 L/ 100 km, respectively, indicating that the proposed strategy can significantly reduce fuel consumption.

Pore Structure Identification Method for Pervious Concrete based on Improved UNet and Fusion Algorithm

Fan Yu,Kailang Li,Hua Zhang,Rui Zhang,Zhang Gao,Yubin Huang 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.11

This paper aims to establish an automatic and accurate pore identification method for pervious concrete. The residual module and mixed loss functions were introduced to the original UNet network to obtain the improved UNet. CT scanning was conducted on the six groups of pervious concrete samples with different aggregate sizes to obtain the initial dataset. The initial dataset was marked and enhanced, and then the pore recognition model was trained. The influence of image brightness and contrast on pore identification was analyzed. The fusion algorithm was used to improve the robustness of the model. The results show that during model training, R-UNet began to converge 20 epochs earlier than UNet and the loss value was smaller. Moreover, the maximum increase of mIoU and mDice was 10.3% and 11.7% respectively, and the maximum decrease of mHD was 14.1%. The fusion algorithm could improve the segmentation accuracy of pores in brightness anomaly images. Compared with threshold segmentation method, the method proposed in this paper could improve the accuracy of pore edge segmentation and the “fine pores” identification, and reduced the pore identification defects. The value of mHD was decreased by 48.7% − 72.4%, and the efficiency of pore identification was greatly improved.

Pilot Study of a Brief WeChat Intervention in China to Increase Students' Willingness to Assist a Flushing Student to Reduce Alcohol Use

Zhang, Fan,Yuen, Lok-Wa,Ding, Lanyan,Newman, Ian M.,Shell, Duane F. The Korean Society for Preventive Medicine 2018 예방의학회지 Vol.51 No.6

Objectives: This pilot study tested the effectiveness of a brief alcohol-related intervention delivered by the social media app WeChat to teach about ethanol-induced facial flushing and increase the willingness of students who see another student flushing to suggest that he or she should reduce or stop drinking. In the context of Chinese drinking culture, it is sometimes socially difficult to refuse a drink, even when experiencing physical discomfort, such as flushing. Methods: Classrooms of students in a medical university in China were randomly assigned to the intervention or control group. Students in the intervention group were invited to view 3 alcohol education lessons on WeChat during a 2-week period. A pretest and posttest before and after the 2-week period assessed changes in students' willingness to intervene if they saw someone flush while drinking. Data were collected about students' alcohol use and their ratings of the lessons. Results: Mixed-design analysis of variance yielded a significant time-by-treatment interaction effect on the variable of willingness to suggest that a flushing person stop or slow down their drinking, and the change was significant between the intervention and control groups. One-way analysis of covariance yielded a significant treatment effect at the posttest, after controlling for the pretest score. Students rated the lessons above the midpoint of the scale for being informative, interesting, and useful. Conclusions: The pilot study showed that a brief alcohol-related intervention delivered by WeChat could produce a measurable positive change in the willingness of university students to suggest that a student who flushes should stop drinking. This pilot study also suggested improvements for future lessons and evaluation design.

Identification of Authors and ethics of Research based on KODISA Case

ZHANG, Fan,SU, Shuai,YOUN, Myoung-KIl Korea Distribution Science Association 2020 연구윤리 Vol.1 No.2

Purpose: The author wants to specify scope of research, identify without giving burden, prevent unfair identification of the author, admit of production of the outcome, enact rules of identification, and build up foundation of development. Also, this study defines scope of publication of outcome of research to prevent unfair identification of authors and admit of them. Research design, data and methodology: The study described literary research, standard research, phenomenon research, and empirical result without methodologies, statistical analysis and scientific test and investigated operation system of KODISA cases. Results: At publication of findings of the research, researchers shall identify the ones of production of the finding to allocate help of the research. Conclusions: Scientific journals shall be controlled to develop ability and to grow up and have a system. Researchers shall give direction of other scientific journals. The study made efforts to be a model. KODISA Edition Team shall make an effort to keep and develop. So far, no regulation of identification of authors has produced disturbance so terminologies should be uniformed. Researchers shall keep rules of identification of authors to uniform and regulate identification of authors, conditions of authors, and order and correspondent authors. KODISA enacted rules of identification of authors for the first time in Korea to develop science.

Research on Participation and Position Evaluation of Korean Manufacturing Global Value Chain: Based on the Comparative Analysis with China and the United States

Fan Zhang,Shuai Su 한국무역학회 2021 Journal of Korea trade Vol.25 No.2

Purpose – This article will take the Korean manufacturing industry as an example to estimate Korea’s global value chain status from the perspective of overall and sub-industry, hoping to provide a theoretical reference for Korean manufacturing to climb the global value chain. Design/methodology – Based on the WIOD data. The data is calculated by using MATLAB (2014a) coding. The data for 6 sectors are classified according to the International Standard Industrial Classification revision 3 (ISIC Rev. 3), the WIOD data are used to calculate and compare the position, participation and dynamics of the Korea, China and USA` manufacturing industry in the 1995-2016. Findings – The empirical results supported conclusions of the theoretical model. In the Korean GVC of electrical and optical sector, while stronger forward linkages than backward linkages to GVC are advantageous for an average advanced country, the benefits of downstream tasks are pronounced for non-advanced countries. And proved the correlation for an index to capture a country’s upstream position or downstream position, it makes sense to compare that Korea’s exports of intermediates in the same sector that are used by China and USA. Originality/value – The first is to re-examine the characteristics of South Korea’s participation in global value chains under a more systematic and accurate theoretical framework, which provides a new empirical reference for related research; the second is to content covers of the manufacturing 6 sectors, so as to more completely describe the characteristics of Korean manufacturing’s participation in global value chains; The value of this paper is providing empirical evidence of the effect of Korea’s the GVC of manufacturing sectors. In the GVC of 6 sectors, first three have a higher position in the value chain and are in the upper middle and upper reaches of the GVC. The latter two have a low GVC position index, which has become the main sector that pulls down the overall position of Korea’s manufacturing industry.

Crystal Structure, Fluorescence Property and Theoretical Calculation of the Zn(II) Complex with o-Aminobenzoic Acid and 1,10-Phenanthroline

Zhang, Zhongyu,Bi, Caifeng,Fan, Yuhua,Zhang, Xia,Zhang, Nan,Yan, Xingchen,Zuo, Jian Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.6

A novel complex [$Zn(phen)(o-AB)_2$] [phen: 1,10-phenanthroline o-AB: o-aminobenzoic acid] was synthesized and characterized by elemental analysis and X-ray diffraction single-crystal analysis. The crystal crystallizes in monoclinic, space group P2(1)/c with $a=7.6397(6){\AA}$, $b=16.8761(18){\AA}$, $c=17.7713(19){\AA}$, ${\alpha}=90^{\circ}$, ${\beta}=98.9570(10)^{\circ}$, ${\gamma}=90^{\circ}$, $V=2.2633(4)nm^3$, Z = 4, F(000) = 1064, S = 1.058, $Dc=1.520g{\cdot}cm^{-3}$, $R_1=0.0412$, $wR_2=0.0948$, ${\mu}=1.128mm^{-1}$. The Zn(II) is six coordinated by two nitrogen and four oxygen atoms from the 1,10-phenanthroline and o-aminobenzoic acid to furnish a distorted octahedron geometry. The complex exhibits intense fluorescence at room temperature. Theoretical studies of the title complex were carried out by density functional theory (DFT) B3LYP method. CCDC: 898291.

Carpooling Service for Large-Scale Taxicab Networks

Zhang, Desheng,He, Tian,Zhang, Fan,Lu, Mingming,Liu, Yunhuai,Lee, Haengju,Son, Sang H. Association for Computing Machinery 2016 ACM transactions on sensor networks Vol.12 No.3

<P>Carpooling has long held the promise of reducing gas consumption by decreasing mileage to deliver coriders. Although ad hoc carpools already exist in the real world through private arrangements, little research on the topic has been done. In this article, we present the first systematic work to design, implement, and evaluate a carpool service, called coRide, in a large-scale taxicab network intended to reduce total mileage for less gas consumption. Our coRide system consists of three components, a dispatching cloud server, passenger clients, and an onboard customized device, called TaxiBox. In the coRide design, in response to the delivery requests of passengers, dispatching cloud servers calculate cost-efficient carpool routes for taxicab drivers and thus lower fares for the individual passengers. To improve coRide's efficiency in mileage reduction, we formulate an NP-hard route calculation problem under different practical constraints. We then provide (1) an optimal algorithm using Linear Programming, (2) a 2-approximation algorithm with a polynomial complexity, and (3) its corresponding online version with a linear complexity. To encourage coRide's adoption, we present a win-win fare model as the incentive mechanism for passengers and drivers to participate. We test the performance of coRide by a comprehensive evaluation with a real-world trial implementation and a data-driven simulation with 14,000 taxi data from the Chinese city Shenzhen. The results show that compared with the ground truth, our service can reduce 33% of total mileage; with our win-win fare model, we can lower passenger fares by 49% and simultaneously increase driver profit by 76%.</P>

Bionic architectural design technique of traditional ancient ship concept --Conceptual Design of Architectural Landscape of Xiamen Haisi Memorial Park

Zhang Fan(장판),Kim, Yong Suk(김용석),Geon Seok Yang(양건석),RenHongFei,Ma Kang(마캉) 한국콘텐츠학회 2023 한국콘텐츠학회 종합학술대회 논문집 Vol.2023 No.5