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Choi, Wook-chul,Reid, Storm N.S.,Ryu, Je-kwang,Kim, Yunsook,Jo, Young-Hong,Jeon, Byeong Hwan The Korean Society of Phycology 2016 ALGAE Vol.31 No.2
This study evaluated the effects of γ-aminobutyric acid (GABA)-enriched fermented sea tangle (GFST), as a functional food, on brain derived neurotrophic factor (BDNF)-related muscle growth and lipolysis, in a sarcopenic obesity high-risk group. Twenty-one middle-aged women (53-63 y) participated in this randomized, double-blind, placebo controlled study. Participants ingested either 1,000 mg of GFST (n = 10) or a sucrose placebo (CON) (n = 11) everyday, for 8 weeks. Subjects were asked to abstain from any regular exercise. Fasting venous blood samples, body composition and muscular strength were measured before and after supplementation period. Collectively, we demonstrated that GFST significantly decreased total fat mass and triglyceride in body composition, as well as significantly increasing serum BDNF (p < 0.001), angiotensin converting enzyme (p < 0.001), human growth hormone and insulin-like growth factor-1 levels (p < 0.05 and p < 0.05, respectively) accompanied by increased total lean mass (p < 0.01). Furthermore, the reported improvements in total work, knee extension and flexion at 60° s<sup>−1</sup> (p < 0.05), and peak torque normalized to body weight of knee flexion at 60° s<sup>−1</sup> (p < 0.05), support an ergogenic effect of GABA associated with increased growth factor levels. The use of GFST, as a functional food ingredient, to elicit anti-obesity effects and stimulate the release of muscle-related growth factors with increasing serum BDNF levels may provide a protective intervention for age-related degeneration such as sarcopenic obesity.
Min, Yunsook,Frost, Jennifer M.,Choi, Yeonhee Korean Society for Molecular and Cellular Biology 2020 Molecules and cells Vol.43 No.5
T-DNA insertional mutations in Arabidopsis genes have conferred huge benefits to the research community, greatly facilitating gene function analyses. However, the insertion process can cause chromosomal rearrangements. Here, we show an example of a likely rearrangement following T-DNA insertion in the Anti-Silencing Function 1B (ASF1B) gene locus on Arabidopsis chromosome 5, so that the phenotype was not relevant to the gene of interest, ASF1B. ASF1 is a histone H3/H4 chaperone involved in chromatin remodeling in the sporophyte and during reproduction. Plants that were homozygous for mutant alleles asf1a or asf1b were developmentally normal. However, following self-fertilization of double heterozygotes (ASF1A/asf1a ASF1B/asf1b, hereafter AaBb), defects were visible in both male and female gametes. Half of the AaBb and aaBb ovules displayed arrested embryo sacs with functional megaspore identity. Similarly, half of the AaBb and aaBb pollen grains showed centromere defects, resulting in pollen abortion at the bi-cellular stage of the male gametophyte. However, inheritance of the mutant allele in a given gamete did not solely determine the abortion phenotype. Introducing functional ASF1B failed to rescue the AaBb- and aaBb-mediated abortion, suggesting that heterozygosity in the ASF1B gene causes gametophytic defects, rather than the loss of ASF1. The presence of reproductive defects in heterozygous mutants but not in homozygotes, and the characteristic all-or-nothing pollen viability within tetrads, were both indicative of commonly-observed T-DNA-mediated translocation activity for this allele. Our observations reinforce the importance of complementation tests in assigning gene function using reverse genetics.
이효민,윤은경,최윤호,이근영,조연숙,임철주,김종욱,양지선,양기화 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-
Aflatoxins은 fspergijfus fovur,4.forofj'cus,4.uonlius의 B차 대사산물로써, 유전독성을 지닌 강력한 발암물질로 알려지고 있으며, 간장, 신장, 신경계, 내분비계, 면역계 독성을 지니고있다. Aflatoxin은 열에 대한 저항성o'S 매우 커서 일반적인 열처리에 의해서 쉽게 파괴되지 않고, 식품섭친패턴이나 기후언1 따라 인체노출량이 상이하여 나라별 1일인체노출량이 3.5-Tln토Ag/day 정도인 것으로 보곤되고 있다. 본 연구에서는 aflatoxin중 가장 대표적인 Bl을 대상으로 한 위해성평가방땁론 연구를 통해 국내 곡류중 aflatoxin Bl 오염도자료와 식품섭취 패턴을 고려한 위해성평가를 수행하고 우리나라 국민들의 식품섭취와 관.된 aflatoxin 위해정도를 고려핫으로 그 관리대안을 제시코자 하였다. Aflatoxin의 인체노출평가를 위하여 우리나라 일반성인들을 대상으로 국민건강영양조사결과보고서에 제시된 식품소비량자료와 국내에써 조사된 바 있는 곡류, 두류, 견과류의 식붐오염도자료(1989-2000)를 활총하였다. 식품오염도자료는 결과의 대표성을 부여하기 위하여 bootstrap방법을 활용하여 정확도 검정을 실시함으로 얻어진 평근값을 활용하였다. 위해도결정에 쓰여진 a(latoxin 31의 발암력은 Yeh 등 t1989)이 제안한 자료로 B형간염비보균자의 경우 9(mg/kg/day)-'. B형간염보균자의 경우 230(mgAg/daH)-'을 사응하였다. 계산죈=ftatoxin Bl의 총인체노출량은 6.05×10-img/kg/'day였고, 인체노출량에 발암력을 고려하므로 계산된추골나라 일반성인에게 aflatoxin Bl식이노출로 나타날 수 있는 간암발생확률은 B형간암fT보균자의 경우차 보균f·『의 경우 각각 5.45×10-"와 1.39r10-'로 산출되었다. 머린이나 노약자, 그궈고 B형간염보균자 등을 포함한 민감그룹과 aflatorin B2, Cl, G2 등의 동시노출을 고려한다딴 식픔섭취를 통한 a긴atoxiri의 인체위해수준은 더 커질것으로 예측된다. 실제로 B형간염보균자의 경우, 식이섭취를 통한 만성 a친atoxin Bl 노출로 인해 간암이 발생할 확률이 비보균자에 비해 26배 정도 높은 것으로 나타나 철저한 씩이 관리가 필요하다. 일반성인(B형간염비보군자)의 경우, aflatoxin 31곡 대글 관리목표치를 십만명당 1명으로 할 경우 인체노출수준은 1.Ix10-srng/kg/day 이하로 조절되어야하고, 우리나라 일반성인의 1일 곡류, 두류, 견과류 섭취량 393.46g./da!·(보건복지부, 1999)과 체중(60kg)을 고려하고, 조리시 감소콘는 오염수준, aflatoxin에 오염된 식픔을 동시에 섭취할 가능성의 배제, 현실적 인 분석기술 수준의 미흡, 그리고 현기준과 비교된 비용-편익적인 면엔서의 문제점을 고려한다만, 곡류, 두류, 견과류 등을 포함한 식품들의 aflatorin Bl 최대오염수준은 0.2ppb이하로 조정되어야 할 것을 제아할 수 있다 Aflatoxins are unaviodable contaminats of corn, peanuts, rice, barley, soybean and other agricultural products that are stored under warm and humid conditions for sometime. The prominent aflatoxins found on food is aflatoxin B1, Which has most potent toxicological and carcinogenic properties of the aflatoxins. The range of human daily intake has been reported as 3.5-77ng/kg/day from various countries and human daily intake was mainly affected by food consumption pattern and climate of each other country. This study was conducted to identify excess cancer risk on aflatoxin B1 induced by domestic cereals ingestion and to suggest regulatory option on aflatoxin B1 for management based on acceptable risk value. For the quantification of human exposure dose to general adult, aflatoxin pollution data in foods were collected(1989-2000)and more accurate mean±data were obtained by bootstrapping, using the S-plus^()(Mathsoft) and also, daily food consumption data from National Health and Nutrition Survey Report(Minstry of Health and Welfare, 1999) and body weight(60kg, Korea Reserch institute of Standard and Science, 1997) were regarede. The used cancer potency of aflatoxin B1 was 9(mg/kg/day)^(-1) for individuals negative for hepatitis B and 230(mg/kg/day)^(-1) for individuals positive for hepatitis B suggested from epidemiological study by Yeh et al(1989). Estimated human exposure dose of aflatoxin B1 by cereals ingestion were 5.89×10^(-7)mg/kg/day and excess cancer risk value to liver cancer incidence were 5.30×10^(-6) for individuals negative for hepatitis B and 1.4×10^(-4) for individuals positive for hepatitis B. Individuals positive for hepatitis B revealed 26 fold higher excess liver cancer risk than individuals negative and therefore, they should be managed having special consideration. And, if the excess cancer risk for aflatoxins B1 is 10^(-5) as managing goal, human exposure level should be controlled as below 1.1×10^(-6)mg/kg/day. Thus, this study has suggested regulatory option as below 0.2ppb for aflatoxin B1 in cereals, legumes. and nuts.