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Synthesis and biological evaluation of the mimics of cis ligand for CD22
Yuki Sugamuna,Naoko Matsubara,Yuki Iwayama,Akiharu Ueki,Akihiro Imamura,Hiromune Ando,Takeshi Tsubata,Hideharu Ishida,Makoto Kiso 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
CD22 (siglec-2) is an accessory molecule of the B-cell receptor complex (BCR) that exertsnegative effects on receptor signaling. It is also well-documented that CD22 is a regulatoryprotein that sets a threshold for immune responses. The carbohydrate ligand recognized byCD22 is the sequence Neuα(2,6)Galβ(1,4)GlcNAc found on both neighboringglycoconjugate of the same cell (cis ligand) and on other cells that interact with B cells (transligands). Recently, we have reported that the C-9 amido derivative of sialic acid (GSC718;9-(4’-hydroxy-4-biphenyl)acetamido-9-deoxy-Neu5Gc-OBn) show a potent affinity andselectivity for CD22 than other siglecs such as MAG [1]. Moreover, the compoundpromoted the proliferation of B cells in vitro. As next step of our investigation, we intend toreinforce the promoting activity of GSC718 for B cell growth by chemical modification.Herein, we report the efficient synthesis of GSC718 analogs which have varied aglyconmoieties. To achieve the comprehensive synthesis of GSC718 analogs having varied aglycons, wereexamined every synthetic process to obtain a fine target compound. In case of thesialoside synthesis, the most time-consuming and troublesome process is thechromatographic separation of α-sialoside from other byproducts such as β−isomer, 2,3-enederivative etc. after glycosylation reaction with aglycon part. To improve this process, weemployed 1,5-lactam formation as the key step for separation because the lactam formation isknown to proceed only in α-sialoside [2]. At the beginning of the synthesis of targetmolecules, we synthesized a suitably modified sialic acid donor in good yields. Then, thesialyl donor was reacted with various 2-substituted-ethanols to give the mixtures of α- and β-glycosides and 2,3-ene derivative, which were subsequently advanced to 1,5-lactamformation. As we anticipated, 1,5-lactamized α-sialosides became isolable from themixtures due to its different polarity from the other byproducts. Finally, the obtained 1,5-lactamized silaosides were successfully converted into target structures via reaction sequenceincluding C9-midification with biphenyl amide group, lactam opening and globaldeprotection. The synthesized analogs were advanced to biological assay using B cells. In this poster presentation, we will also discuss the structure-activity relationships of thesynthesized analogs. [1] H. H. M. Abdu-Allah et al, Bioorg. Med. Chem. Lett. 2011, 19, 1966-1971. [2] H. Tanaka et al, Tetrahedron Lett. 2009, 50, 4478-4481.
Yukie Tateno,Kahoru Kumagai,Ryunosuke Monden,Kotaro Nanba,Ayumi Yano,Eri Shiraishi,Alan R. Teo,Masaru Tateno 대한소아청소년정신의학회 2021 소아청소년정신의학 Vol.32 No.1
Objectives: Among the many intervention programs for children with autism spectrum disorder (ASD), the Early Start Denver Model (ESDM) is one of the few approaches that has succeeded in demonstrating clinical efficacy in randomized control trials. Here, we investigate the clinical efficacy of ESDM intervention in young children with ASD in a community setting within Japan. Methods: All subjects were children with ASD who received ESDM intervention during the study period. Each ESDM session lasted 75 min and occurred once per week for at least 12 weeks. The outcome measures consisted of the Kyoto Scale of Psychological Development (K-test), Aberrant Behavior Checklist-Japanese version (ABC-J), and the Clinical Global Impression-Severity scale (CGI-S). Results: Twenty-seven subjects (29.4±6.4 months old) received ESDM intervention that lasted for 8.0±2.6 months on average. The score on Language and Social developmental quotient on the K-test increased significantly after the intervention. The total scores on the ABC-J and CGI-S significantly decreased after completion of the ESDM intervention. Conclusion: Our results suggest that ESDM intervention could reduce the severity of distinct clinical features of ASD, such as impairments in social interaction and communication assessed by the K-test, and maladaptive behavior rated by the ABC-J and CGI-S. We believe that the ESDM adapted to each institution might become one of the standard options for children with ASD in Japan.
SYNTHESIS AND SPECTROSCOPIC CHARACTERIZATION OF SALMON DNA-WRAPPED SINGLE-WALL CARBON NANOTUBES
YUKI ASADA,HIROFUMI DOHI,SHOTA KUWAHARA,TOSHIKI SUGAI,RYO KITAURA,HISANORI SHINOHARA 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2007 NANO Vol.2 No.5
Single-wall carbon nanotubes (SWNTs) can be well-dispersed in water by wrapping with short segments of natural DNA from salmon sperm. We report here the isolated DNA-wrapped SWNT hybrids. Measurements were carried out using UV-vis-NIR, near-infrared photoluminescence (PL) spectrum and atomic force microscopy (AFM). A possible charge transport between SWNTs and salmon-DNA is discussed in terms of observed spectral shifts in the photoluminescence spectra.
Design of Model Following Control Systems with Discrete-valued Signal Constraints
Yuki Minami 제어·로봇·시스템학회 2016 International Journal of Control, Automation, and Vol.14 No.1
This paper focuses on a design problem of model following control systems with discrete-valued inputconstraints. In the problem, we design a discrete-valued output controller such that the output behavior of thediscrete-valued input system is similar to that of a given reference model. In this paper, we first formulate thecontroller design problem, and then we analyze the performance of a class of controllers. Based on the result ofthe performance analysis, we analytically derive a controller characterized by the parameters of the plant and thereference model. Finally, we discuss a practical controller design problem considering the fixed-order, the stability,and the input-output gain constraints of controllers. The problem is solved by using a particle swarm optimizationalgorithm.
Yuki Kato,Joverienne Chavez,Shin Yamada,Soichi Hattori,Shuzo Takazawa,Hiroshi Ohuchi 대한슬관절학회 2019 대한슬관절학회지 Vol.31 No.2
Purpose: This study aimed to investigate anterior knee symptoms in patients who underwent anterior cruciate ligament (ACL) reconstruction using bonepatellar tendonbone (BPTB) graft followed by implantation of a betatricalcium phosphate (βTCP) block as a bone void filler.Materials and Methods: We retrospectively reviewed 84 cases of synthetic bone grafting using a βTCP block for the patellar bone defect in ACL reconstruction with a BPTB autograft. Computed tomography of the operated knee was performed immediately after the surgery to evaluate whether the grafted βTCP block protruded forward from the anterior surface of the patella. On the basis of the results, the cases were divided into a protrusion group (n=31) and a nonprotrusion group (n=53). Anterior knee symptoms at 12 months postoperatively and absorption of the grafted βTCP block were compared between the two groups.Results: Except for patellofemoral crepitus, there was no significant difference in anterior knee symptoms between the two groups (p>0.05). The incidence of patellofemoral crepitus was significantly lower in the protrusion group than in the nonprotrusion group (p=0.027). The groups showed no significant difference in βTCP absorption.Conclusions: The present study demonstrated that the protrusion of βTCP that was used as a bone void filler had no adverse effects.
Teacher’s Class Design in the First Year Experience
Yuki Enkai 한양대학교 교육공학연구소 2009 학습과학연구 Vol.3 No.1
In recent years, the number of colleges that have class of the First Year Experience has increased in Japan. The First Year Experience is a kind of class which is held for university freshman. However, this class contents and way of practice ate still seeking, therefore we need to study and improve problems. In this paper, I studied about the points which teachers think important when they teach class of the First Year Experience. There were difference points that teacher think important, because they have each ideas for curriculum.
Examination on Fatigue Limit and Crack Growth Characteristic of SBHS700 Base Metal
Yuki Ono,Koji Kinoshita 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.4
The object of this study is to clarify fatigue limit and fatigue crack growth characteristic of SBHS700 base metal which is 780 MPa class steel. This study carried out the fatigue tests of SBHS700 base metal containing diff erent defect size, and the fatigue limit was compared with that of the conventional steel. Test results indicate that the fatigue limit increased with decrease initial defect size, and can be precisely evaluated by using √area parameter model. This paper also presents that crack growth characteristic was almost the same as that of the conventional steel from the observation of striations by using Scanning electron microscope and length of beach marks.