Core prescription pattern of Chinese herbal medicine for depressive disorders in Taiwan: a nationwide population-based study

Diem Ngoc Hong Tran,I-Hsuan Hwang,Fun-Jou Chen,Yuan-Pu Tseng,Ching-Mao Chang,Shih-Jen Tsai,Jen-Lin Yang,Ta-Peng Wu,Chung-Hua Hsu,Fang-Pey Chen,Yen-Ying Kung 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.3

Background: Depressive disorders (DD) affect not only mood and behavior but also various physical functions. Traditional Chinese medicine (TCM) has been shown to have some benefits in treating DD. However, one formula or one single herb might be not show high efficacy when used to treat depression. Thus, this study aimed to examine the core prescription pattern of Chinese herbal medicine (CHM) among patients with DD in Taiwan as a reference for related research and clinical applications. Methods: All patients, who had been diagnosed with major depressive disorder or minor depression or dysthymia without any other baseline diseases and had at least one CHM outpatient clinical visit from 2002 to 2011, were extracted from three randomly sampled cohorts, namely the 2000, 2005 and 2010 cohorts of the National Health Insurance Research Database (NHIRD) of Taiwan. The collected data was analyzed to explore the patterns of herbal products. Results: There were 197,146 patients with a diagnosis of DD and of these 1806 subjects had only a diagnosis of DD and utilized CHM. The most common formula was Gan-Mai-Da-Zao-Tang (12.19%), while Suan-Zao-Ren (3.99%) was the most commonly prescribed single herb. The core pattern of prescriptions consisted of a combination of Gan-Mai-Da-Zao-Tang, Jia-Wei-Xiao-Yao-San, Chai-Hu-Jia-Long-Gu-Mu-Li-Tang, He-Huan-Pi, Yuan-Zhi and Shi-Chang-Pu. Conclusions: This study describes the CHM core prescription pattern used to treat patients in Taiwan with DD and it is a potential candidate for study in future pharmacological or clinical trials targeting DD.

Emulsion-directed liquid/liquid interfacial fabrication of lanthanide ion-doped block copolymer composite thin films

Hong, Ming,Geng, Yuanyuan,Liu, Mei,Xu, Yuan,Lee, Yong-Ill,Hao, Jingcheng,Liu, Hong-Guo Elsevier 2015 JOURNAL OF COLLOID AND INTERFACE SCIENCE - Vol.438 No.-

<P><B>Abstract</B></P> <P>An emulsion-directed assembly and adsorption approach has been used to fabricate composite films of polystyrene-b-poly(acryl acid)-b-polystyrene (PS-b-PAA-b-PS) and Eu<SUP>3+</SUP> and La<SUP>3+</SUP> ions at the planar liquid/liquid interface of the polymer DMF/chloroform (1:1, v/v) mixed solution (lower phase) and aqueous solutions of the corresponding salts (upper phase). The lower phase gradually transformed to a water-in-oil (W/O) emulsion via spontaneous emulsification due to the “ouzo effect”. Polymer molecules and the metal ions assembled around emulsion droplets that adsorbed at the planar liquid/liquid interface at last, resulting in formation of composite films. The film morphologies and structures depend on Ln<SUP>3+</SUP> ions: polymer/Eu<SUP>3+</SUP> composite films were foam films composed of microcapsules ranging in size from several hundreds of nanometers to micrometers, while polymer/La<SUP>3+</SUP> composite films were composed of hollow spheres several tens of nanometers in size. Fourier transform infrared (FTIR) spectra revealed that the coordination modes of carboxyl groups to Eu<SUP>3+</SUP> and La<SUP>3+</SUP> were bridging bidentate and ionic, respectively, in the two types of composites. These results indicate that stable microcapsules can be fabricated around droplets for polymer/Eu<SUP>3+</SUP> systems, while microcapsules of polymer/La<SUP>3+</SUP> are unstable. This leads to different film morphologies and structures. Compositions of these films were characterized using energy-dispersive spectroscopy (EDS) and X-ray photoelectron spectroscopy (XPS). In addition, foam films of polymer/Eu<SUP>3+</SUP>/2,2′-bipyridine (bpy) were fabricated using this approach, and their photoluminescence properties were investigated.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Composite films of block copolymer/Ln<SUP>3+</SUP> were fabricated at liquid/liquid interfaces. </LI> <LI> Eu<SUP>3+</SUP> and La<SUP>3+</SUP> have great effects on morphologies and microstructures of the films. </LI> <LI> Polymer/Eu<SUP>3+</SUP> and polymer/Eu<SUP>3+</SUP>/bpy films exhibit good luminescent properties. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Study on the Spatial Narrative of Immersion in VR Films

Yuan-Zi Sang,Kim-Hong Hong,David Junesok Lee 한국콘텐츠학회 2022 한국콘텐츠학회 ICCC 논문집 Vol.2022 No.12

Radiological gastrostomy: A comparative analysis of different image-guided methods

Hong-Tao Hu,Hang Yuan,Chen-Yang Guo,Quan-Jun Yao,Xiang Geng,Hong-Tao Cheng,Jun-Li Ma,Yan Zhao,Li Jiang,Yu-Qing Zhao,Hai-Liang Li 소화기인터벤션의학회 2021 International journal of gastrointestinal interven Vol.10 No.2

Background: Radiographic guided percutaneous gastrostomy has become a safe and effective enteral nutrition method for patients who can not eat by mouth. Fluoroscopy, computed tomography (CT) and cone-beam CT have been routinely used clinically. The aim of this study was to compare the advantages and disadvantages of percutaneous gastrostomy using different radiographic guided methods. Methods: We retrospectively analyzed the clinical data of 538 patients undergoing percutaneous gastrostomy in our department. According to the image guidance method used in gastrostomy, the patients were divided into groups A by fluoroscopy guidance, group B by fluoroscopy combined with C-arm CT guidance, and group C with the whole process CT guidance. The gastrostomy success rate, complication rate, procedure time, and patient radiation dose were analyzed in the three groups. Results: Among 538 patients, 534 were successful and the success rates are 94.3%, 99.3%, and 100% in group A, B, and C, respectively (P > 0.05). There were 3 cases occurred postoperative bleeding as serious adverse events and transferred to surgical gastrostomy. The minor complications include local infection, hyperplasia of granulation tissue, tube obstruction or prolapse, and local pain of the ostomy. The minor complication rates were 10.5%, 10.4%, and 7.7% in group A, B, and C, respectively (P > 0.05). The average procedure time was 25.57 ± 5.99 minutes, 29.01 ± 6.63 minutes, and 45.47 ± 8.98 minutes, respectively (χ2 = 87.98, P < 0.001). The average radiation dosage was 27.30 ± 19.27 mGy, 145.07 ± 106.08 mGy, and 2,590.26 ± 1,088.22 mGy, respectively (χ2 = 204.44, P < 0.001). Conclusion: There were no significant differences in the success rates and complication rates of gastrostomy under the three guiding methods. For difficult cases, CT-guided gastrostomy may be a very useful supplemental method.

Statistical Optimization of Culture Media and Conditions for Production of Mannan by Saccharomyces cerevisiae

Hong-Zhi Liu,Qiang Wang,Yuan-Yuan Liu,Fang Fang 한국생물공학회 2009 Biotechnology and Bioprocess Engineering Vol.14 No.5

In view of the increase in Saccharomyces cerevisiae mannan content, the culture medium and condition for S.cerevisiae were optimized in this study. The influence of culture medium ingredients such as carbon and nitrogen sources, inorganic ion, and enzyme activator on mannan production were evaluated using factional design. The mathematical model was established by the quadratic rotary combination design through response surface analysis. The optimized concentrations of culture medium were determined as follows: 4.98 g/100 mL, sucrose; 4.39 g/100 mL, soybean peptone; 3.10 g/100 mL, yeast extract; and 2.21 g/100 mL, glycerol. The optimized culture medium increased mannan production from 82.7 ± 3.4 mg/100 mL to 162.53 ± 3.47 mg/100 mL. The influence of original pH, inoculum size, temperature, and media volume on mannan production was evaluated and confirmed by orthogonale experimental design, with the order of effect as follows: media volume > temperature > initial pH > inoculation size. The optimized culture condition was pH, 5; inoculum size, 5 ml; temperature, 32oC; and media volume, 40 mL. The maximum mannan production increased to 258.5 ± 9.1 mg/100 mL at the optimum culture condition.=It was evident that the mannan production was affected significantly by culture medium and condition optimization (é < 0.01). In view of the increase in Saccharomyces cerevisiae mannan content, the culture medium and condition for S.cerevisiae were optimized in this study. The influence of culture medium ingredients such as carbon and nitrogen sources, inorganic ion, and enzyme activator on mannan production were evaluated using factional design. The mathematical model was established by the quadratic rotary combination design through response surface analysis. The optimized concentrations of culture medium were determined as follows: 4.98 g/100 mL, sucrose; 4.39 g/100 mL, soybean peptone; 3.10 g/100 mL, yeast extract; and 2.21 g/100 mL, glycerol. The optimized culture medium increased mannan production from 82.7 ± 3.4 mg/100 mL to 162.53 ± 3.47 mg/100 mL. The influence of original pH, inoculum size, temperature, and media volume on mannan production was evaluated and confirmed by orthogonale experimental design, with the order of effect as follows: media volume > temperature > initial pH > inoculation size. The optimized culture condition was pH, 5; inoculum size, 5 ml; temperature, 32oC; and media volume, 40 mL. The maximum mannan production increased to 258.5 ± 9.1 mg/100 mL at the optimum culture condition.=It was evident that the mannan production was affected significantly by culture medium and condition optimization (é < 0.01).

The Influence of Environmental Changes on the Generation and Development of Organizations

Yuan, Qing-Hong,Ding, Gang 계명대학교 산학연구소 2013 經營經濟 Vol.46 No.2

Purpose - This study attempts to examine the influence of external environments on the generation and development of organizations and the complex diversity of organizational form. Desing/Methodology - A theory analysis framework was set up first. Then, the case study method and secondary data were used to attest the framework, through a comparative analysis of a group of classical Chinese firms in the context of 30 years of China’s economic reform and opening-up. Findings - The generation and change of organizational structure is closely related to a wider range of organization ecology and institutional environments, rather than being the result of initiatives of organization itself. In China, enterprise external institutional factors are particularly important. Implications - The study facilitates to understand the generation and development of Chinese enterprises, and the universality and particularity of Chinese situation.

Palladium nanoparticles decorated MXene for plasmon-enhanced photocatalysis

Hong Yuan,Subin Yu,Dohyub Jang,Minju Kim,홍혜지,Filipe Marques Mota,김동하 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-

Two-dimensional MXene nanomaterials have found a wide application range in recent years. Here, Ti3C2MXene nanosheets exhibiting inherent photothermal activity reveal synergistic plasmon-enhanced photocatalyticproperties upon rational surface decoration with palladium nanoparticles (NPs). Pd incorporationinduces a 1.7-fold increase in the number of defect sites on the MXene surface. Mostimportantly, the introduced Pd nanoparticles favour an effective separation and collection of localizedsurface plasmon resonance (LSPR)-induced hot charge carriers generated at the surface of semimetallicTi3C2 NS, further facilitating the generation of hydrogen peroxide (H2O2). The generated H2O2is sequentially decomposed to hydroxyl radicals via the peroxidase (POD)-like activity of Pd NPs. ThePd@MXene shows approximately 2-fold enhancement of photocatalytic activity and excellent photostabilityunder laser irradiation. Taken together, this study highlights the promise of constructing active andstable MXene-based nanohybrids for highly effective photo-responsive nanomedicine.

454 Pyrosequencing Analysis of Bacterial Diversity Revealed by a Comparative Study of Soils from Mining Subsidence and Reclamation Areas

( Yuan Yuan Li ),( Long Qian Chen ),( Hong Yu Wen ),( Tian Jian Zhou ),( Ting Zhang ),( Xia Li Gao ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.3

Significant alteration in the microbial community can occur across reclamation areas suffering subsidence from mining. A reclamation site undergoing fertilization practices and an adjacent coal-excavated subsidence site (sites A and B, respectively) were examined to characterize the bacterial diversity using 454 high-throughput 16S rDNA sequencing. The dominant taxonomic groups in both the sites were Proteobacteria, Acidobacteria, Bacteroidetes, Betaproteobacteria, Actinobacteria, Gammaproteobacteria, Alphaproteobacteria, Deltaproteobacteria, Chloroflexi, and Firmicutes. However, the bacterial communities` abundance, diversity, and composition differed significantly between the sites. Site A presented higher bacterial diversity and more complex community structures than site B. The majority of sequences related to Proteobacteria, Gemmatimonadetes, Chloroflexi, Nitrospirae, Firmicutes, Betaproteobacteria, Deltaproteobacteria, and Anaerolineae were from site A; whereas those related to Actinobacteria, Planctomycetes, Bacteroidetes, Verrucomicrobia, Gammaproteobacteria, Nitriliruptoria, Alphaproteobacteria, and Phycisphaerae originated from site B. The distribution of some bacterial groups and subgroups in the two sites correlated with soil properties and vegetation due to reclamation practice. Site A exhibited enriched bacterial community, soil organic matter (SOM), and total nitrogen (TN), suggesting the presence of relatively diverse microorganisms. SOM and TN were important factors shaping the underlying microbial communities. Furthermore, the specific plant functional group (legumes) was also an important factor influencing soil microbial community composition. Thus, the effectiveness of 454 pyrosequencing in analyzing soil bacterial diversity was validated and an association between land ecological system restoration, mostly mediated by microbial communities, and an improvement in soil properties in coalmining reclamation areas was suggested.

Separation Technology, Thermodynamics : Characteristics and recognition mechanism of monolithic poly(methacrylic acid-ethylene glycol dimethacrylate) column

( Hong Yuan Yan ),( Long Mei Jin ),( Kyung Ho Row ) 한국화학공학회 2006 Korean Journal of Chemical Engineering Vol.23 No.4

Crack Resistance and Strength Properties of Red Clay Modified with Lignocellulose and Guar gum

Hong-Yuan Fu,Guang-Tao Yu,Qian-Feng Gao,Ling Zeng,Shuo-Peng Cao 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.10

Desiccation cracking is a common problem of red clay under wet and dry conditions. The presence of cracks could reduce soil strength properties, which is the major reason for shallow failure of red clay slopes. This study aims to propose some additives to improve the crack resistance as well as the strength of red clay. To this end, three natural fibers and three natural gels were primarily selected to modify red clay. Desiccation crack tests were conducted to identify the best fiber and gel in terms of crack resistance. Then, direct shear tests and uniaxial tensile tests were performed on the soil specimens modified by the best fiber and gel to determine the optimal dosages regarding strength improvements. The results demonstrated that natural gels reduced the crack resistance of red clay, while natural fibers could enhance the crack resistance. Lignocellulose was the best additive in improving the crack resistance of red clay, and the modified effect was positively correlated with the fiber dosage. Adding 1.5% lignocellulose into red clay could reduce the crack rate from 2.19% to 0.30%, with a reduction of 0.86 times. The tensile strength, shear strength and its parameters of lignocellulose-modified red clay showed a trend of increasing first and then decreasing with increasing lignocellulose dosage. At the optimal lignocellulose dosage of 0.75%, the shear strength and tensile strength were increased by 44.63% and 18.21%, respectively. The strength of red clay modified by both lignocellulose and guar gum was positively correlated with the dosage of guar gum, and the desirable dosage of guar gum was 1.0%. In engineering practice, the wet red clay mixed with 0.75% lignocellulose and grass seeds can be employed as planting soil and is sprayed uniformly onto the slope surface after excavation using a spraying planting machine. To further improve the strength of the planting soil, 1.0% guar gum solution can be sprayed on the soil surface. The findings could provide useful guidance for the protection of red clay slopes.