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A Pore Size Distribution-Based Microscopic Model for Evaluatingthe Permeability of Clay
Qian-Feng Gao,Dan Zhao,Ling Zeng,Hui Dong 대한토목학회 2019 KSCE Journal of Civil Engineering Vol.23 No.12
This work aimed to propose a semi-empirical model that predicts the permeability of saturated clay using the data of mercury intrusion porosimetry (MIP). First, the pore size distribution (PSD) curve obtained from an MIP test was regarded as a discrete probability function of pore diameters; thus, its shape could be characterized by probability parameters (e.g., the expected value and the standard deviation). Subsequently, these probability parameters, combined with the microporosity calculated from the volume of intruded mercury, were correlated with the permeability of clay based on Hagen-Poiseuille's equation. Next, the performance of the proposed permeability model was verified using data reported in the literature. Thereafter, the model was applied to estimate the permeability of normally consolidated (NC) and overconsolidated (OC) kaolin subjected to various triaxial loading. The results highlighted that the proposed model is capable of characterizing the sensitive variation of kaolin permeability under different overconsolidation ratios (OCRs), stress paths, and stress levels.
A Mixed-Prediction based Method for Allocating Cloud Computing Resources
Qian Zhao,Guangsheng Feng,Rui Gao,Ke Han 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.2
Due to lacking valid prediction for resource requirement, the existing application approaches for cloud computing resource could hardly achieve a high efficiency. According to this point, we propose a mixed-prediction based resource allocation approach in this paper, which is abbreviated as MPRA. This proposed MPRA employs FFT (Fast Fourier Transform) theory to determine the cyclical attribution. If there is no such attribution existed, the Markov chain is alternatively used to predict the tendency of resource requirement. The experimental results show that the proposed MPRA could predict the future resource requirement more precisely. Moreover, based on the prediction result, it could also allocate the virtual machine resource adaptively, decrease the number of occupied physical machines, and reduce the probability of violating the SLA (Service-level Agreement).
Soil and ribbed concrete slab interface modeling using large shear box and 3D FEM
Qian, Jian-Gu,Gao, Qian,Xue, Jian-feng,Chen, Hong-Wei,Huang, Mao-Song Techno-Press 2017 Geomechanics & engineering Vol.12 No.2
Cast in situ and grouted concrete helical piles with 150-200 mm diameter half cylindrical ribs have become an economical and effective choice in Shanghai, China for uplift piles in deep soft soils. Though this type of pile has been successful used in practice, the reinforcing mechanism and the contribution of the ribs to the total resistance is not clear, and there is no clear guideline for the design of such piles. To study the inclusion of ribs to the contribution of shear resistance, the shear behaviour between silty sand and concrete slabs with parallel ribs at different spacing and angles were tested in a large direct shear box ($600mm{\times}400mm{\times}200mm$). The front panels of the shear box are detachable to observe the soil deformation after the test. The tests were modelled with three-dimensional finite element method in ABAQUS. It was found that, passive zones can be developed ahead of the ribs to form undulated failure surfaces. The shear resistance and failure mode are affected by the ratio of rib spacing to rib diameter. Based on the shape and continuity of the failure zones at the interface, the failure modes at the interface can be classified as "punching", "local" or "general" shear failure respectively. With the inclusion of the ribs, the pull out resistance can increase up to 17%. The optimum rib spacing to rib diameter ratio was found to be around 7 based on the observed experimental results and the numerical modelling.
Development and characterization of a fully functional small anti-HER2 antibody
( Jie Gao ),( Bo Hua Le ),( Hui Mei Li ),( Xun Min Zhang ),( Da Peng Zhang ),( Lei Zhao ),( Chong Wang ),( Chen Fang ),( Wei Zhu Qian ),( Sheng Hou ),( Geng Kou ),( Hua Feng Wei ),( Shu Shi ),( Hao Wa 생화학분자생물학회 2009 BMB Reports Vol.42 No.10
Zhang, Qian,Gao, Yang,Zhang, Hai-xia,Xu, Fei,Li, Feng Techno-Press 2018 Structural monitoring and maintenance Vol.5 No.1
The stability of cutting slope influences the safety of railway operation, and how to identify the stability of the slope quickly and determine the rational monitoring plan is a pressing problem at present. In this study, the attribute recognition model of risk assessment for high cutting slope stability in the heavy haul railway is established based on attribute mathematics theory, followed by the consequent monitoring scheme design. Firstly, based on comprehensive analysis on the risk factors of heavy haul railway loess slope, collapsibility, tectonic feature, slope shape, rainfall, vegetation conditions, train speed are selected as the indexes of the risk assessment, and the grading criteria of each index is established. Meanwhile, the weights of the assessment indexes are determined by AHP judgment matrix. Secondly, The attribute measurement functions are given to compute attribute measurement of single index and synthetic attribute, and the attribute recognition model was used to assess the risk of a typical heavy haul railway loess slope, Finally, according to the risk assessment results, the monitoring content and method of this loess slope were determined to avoid geological disasters and ensure the security of the railway infrastructure. This attribute identification- risk assessment- monitoring design mode could provide an effective way for the risk assessment and control of heavy haul railway in the loess plateau.
Active Fault Tolerant Control Scheme for Satellite Attitude Systems: Multiple Actuator Faults Case
Zhi-Feng Gao,Zepeng Zhou,Guoping Jiang,Mo-Shu Qian,Jin-Xing Lin 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.4
In this paper, an active fault tolerant control (FTC) design approach is proposed for the satellite attitude systems with exogenous disturbance and multiple actuator faults. Firstly, the nonlinear attitude system model of rigid satellite with multiple actuator faults is given. Next, an actuator fault diagnosis scheme, including a fault detection module and a fault estimation module, is given so as to detect the time of unknown actuator faults occurred and obtain their estimation values. Then, a terminal sliding mode-based fault tolerant attitude controller is designed using backstepping control technique, which guarantees that the closed-loop attitude systems of rigid satellite are asymptotically stable in the presence of multiple actuator faults. Numerical simulations illustrate the good performance of active FTC proposed in this study.
Wei, Guangfei,Yang, Feng,Wei, Fugang,Zhang, Lianjuan,Gao, Ying,Qian, Jun,Chen, Zhongjian,Jia, Zhengwei,Wang, Yong,Su, He,Dong, Linlin,Xu, Jiang,Chen, Shilin The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.6
Background: Panax quinquefolius and Panax notoginseng are widely used and well known for their pharmacological effects. As main pharmacological components, saponins have different distribution patterns in the root tissues of Panax plants. Methods: In this study, the representative ginsenosides were detected and quantified by desorption electrospray ionization mass spectrometry and high-performance liquid chromatography analysis to demonstrate saponin distribution in the root tissues of P. quinquefolius and P. notoginseng, and saponin metabolite profiles were analyzed by metabolomes to obtain the biomarkers of different root tissues. Finally, the transcriptome analysis was performed to demonstrate the molecular mechanisms of saponin distribution by gene profiles. Results: There was saponin distribution in the root tissues differed between P. quinquefolius and P. notoginseng. Eight-eight and 24 potential biomarkers were detected by metabolome analysis, and a total of 340 and 122 transcripts involved in saponin synthesis that were positively correlated with the saponin contents (R > 0.6, P < 0.05) in the root tissues of P. quinquefolius and P. notoginseng, respectively. Among them, GDPS1, CYP51, CYP64, and UGT11 were significantly correlated with the contents of Rg1, Re, Rc, Rb2, and Rd in P. quinquefolius. UGT255 was markedly related to the content of R1; CYP74, CYP89, CYP100, CYP103, CYP109, and UGT190 were markedly correlated with the Rd content in P. notoginseng.
Jing Liu,Yanhang Gao,Xianbo Wang,Zhiping Qian,Jinjun Chen,Yan Huang,Zhongji Meng,Xiaobo Lu,Guohong Deng,Feng Liu,Zhiguo Zhang,Hai Li,Xin Zheng 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.2
Purpose: This study investigated multidrug-resistant (MDR) pathogens and antibiotic strategies of culture-positive spontaneousascitic infection (SAI) in patients with acute decompensated cirrhosis. Materials and Methods: We retrospectively analyzed 432 acute decompensated cirrhotic patients with culture-positive SAI from11 teaching hospitals in China (January 2012 to May 2018). A Cox proportional hazards model analysis was conducted to identifyindependent predictors of 28-day mortality. Results: A total of 455 strains were isolated from 432 ascitic culture samples. Gram-negative bacteria (GNB), gram-positive bacteria(GPB), and fungi caused 52.3, 45.5, and 2.2% of all SAI episodes, respectively. Episodes were classified as nosocomial (41.2%), healthcare-related (34.7%), and community-acquired (24.1%). Escherichia coli (13.4%) and Klebsiella pneumoniae (2.4%) were extendedspectrumβ-lactamase producing isolates. The prevalence of methicillin-resistant Staphylococcus aureus was 1.1%. Ceftazidime,cefepime, aztreonam, and amikacin were recommended as first-line antibiotics agents for non-MDR GNB infections; piperacillin/tazobactam and carbapenems for MDR GNB in community-acquired and healthcare-related or nosocomial infections, respectively;and vancomycin or linezolid for GPB infections, regardless of drug-resistance status. Multivariate analysis revealed days ofhospital stay before SAI, upper gastrointestinal bleeding, white blood cell count, alanine aminotransferase, serum creatinine concentration,total bilirubin, and international normalized ratio as key independent predictors of 28-day mortality. Conclusion: MDR pathogens and antibiotic strategies were identified in patients with acute decompensated cirrhosis with culture-positive SAI, which may help optimize therapy and improve clinical outcomes.
( Shi Kun Zhang ),( Qian Ma ),( Su Bo Li ),( Hong Wei Gao ),( Ying Xia Tan ),( Feng Gong ),( Shou Ping Ji ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.6
RV-23 is a melittin-related antibacterial peptide (MRP) with lower cytotoxicity than either melittin or AR-23, another MRP. The aim of this study was to explore the mechanism of RV- 23`s antibacterial selectivity and its hemocompatibility. The results showed that all the peptides exhibited lytic activity against Staphylococcus aureus and Escherichia coli, with RV-23 showing the highest potency. Moreover, RV-23 had lower cytotoxicity than melittin or AR-23 at their minimal inhibitory concentration. In addition, CD experiments showed that melittin, RV-23, and AR-23 all had a typical α-helical structure, and RV-23 had the lowest α-helix content. The structural information showed that RV-23 has the lowest hydrophobicity and highest hydrophobic moment. Because hydrophobicity and α-helix content are believed to correlate with hemolysis, the results indicate that the selective lytic activity against bacteria of RV-23 may be due to its low hydrophobicity and α-helicity, which lead to low cytotoxicity without affecting antibacterial activity. Furthermore, RV-23 did not affect the structure and function of blood components such as red blood cells, platelets, albumin, and the blood coagulation system. In conclusion, RV-23 is a cell-selective antibacterial peptide with high hemocompatibility due to its unique structure.