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A New Yard Template Design for the Construction of Transshipment Container Terminals in China
Zhang Yu-Ting,Huang You-Fang,YAN Wei,He Jun-Liang 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.1
In order to accelerate the construction of transshipment container terminal in Chinese mainland, and to strength our global competitiveness about container terminals, a design plan of container yard for transshipment hubs is explored, which is suitable to China’s conditions and aims at Shanghai Port mainly. Considering the actual operation of transshipment in Chinese container terminals and overseas, a new yard template planning with mixed handling technology is proposed, which is appropriate for the container terminals located in Chinese mainland. An inbound unloading process model of proposed plan is built by eM-Plant, and the simulation result is analyzed to verify the feasibility and superiority of the new design plan. The exploration and design for transshipment hubs provide new thoughts and ideas for the container terminals development in China.
Possible Epithelial Ovarian Cancer Association with HPV18 or HPV33 Infection
Zhang, Pei-Pei,Zhou, Lei,Cao, Jia-Shi,Li, Yi-Ping,Zeng, Zhi,Sun, Ni,Shen, Li,Zhu, Hao-Yue,Ruan, Yang,Zha, Wen-Ting,Wang, Xin-Yu,Zhang, Ke-Qiang,Zhang, Ran Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6
The present study was conducted to investigate the prevalence of HPV infection in epithelial ovarian cancer (EOC) in Hunan province. DNA samples were collected from paraffin embedded ovarian tissue from 322 patients with EOC, 99 with ovarian benign tumors and 199 normal persons. The polymerase chain reaction and direct sequencing were used to identify the HPV types in the samples. The relationship between the infection of human papillomavirus (HPV) and the epithelial ovarian carcinoma (EOC) was investigated combined with clinical data. The prevalence of HPV18 and HPV33 in EOC group and benign group was higher than in the normal group. HPV18 and HPV33 may play a role in the development of both EOC and ovarian benign tumor and may participate in the development of EOC with traditional risk factors, family history and abortion, possibly exerting synergistic effects.
Yu, Ting-Ting,Han, Zhi-Gang,Shan, Li,Tao, Jie,Zhang, Tao,Yuan, Shuai-Fei,Shen, Hong-Li Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Background and Objective: Lung cancer is one of the malignant diseases which most seriously threat humansurvival and development. This study aimed to assess osteopontin (OPN) expression in non-small cell lung cancer (NSCLC) and any relationship with clinicopathological features. Methods: Immunohistochemistry was used to determine OPN expression and microvascular density (MVD) in 120 cases of NSCLC also undergoing clinical assessment. Results: Moderately positive expression of OPN was found in 34.6% (41/120) and strong expression in 47.5% (57/120) of the NSCLCs; OPN expression in carcinomas was higher than in pericarcinoma tissues (P<0.05). While no obvious association was observed with NSCLC patient age, gender, maximum diameter of the tumor and pathological type, OPN expression was more commonly detected in poorly differentiated carcinoma tissue and lymph node metastasis as well as at advanced clinical stage (P<0.05); OPN expression in cancer tissue was positively correlated with MVD (r = 0.839, P = 0.000). Conclusion: OPN plays an important role in promoting tumor angiogenesis and progress of NSCLCs and has the possibility to become the new target for therapy.
Evaluation of porcine urine-derived cells as nuclei donor for somatic cell nuclear transfer
Yu-Ting Zhang,Wang Yao,Meng-Jia Chai,Wen-Jing Liu,Yan Liu,Zhong-Hua Liu,Xiao-Gang Weng 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.2
Background: Somatic cell nuclear transfer (SCNT) is used widely in cloning, stem cell research, and regenerative medicine. The type of donor cells is a key factor affecting the SCNT efficiency. Objectives: This study examined whether urine-derived somatic cells could be used as donors for SCNT in pigs. Methods: The viability of cells isolated from urine was assessed using trypan blue and propidium iodide staining. The H3K9me3/H3K27me3 level of the cells was analyzed by immunofluorescence. The in vitro developmental ability of SCNT embryos was evaluated by the blastocyst rate and the expression levels of the core pluripotency factor. Blastocyst cell apoptosis was examined using a terminal deoxynucleotidyl transferase dUTP nick end-labeling assay. The in vivo developmental ability of SCNT embryos was evaluated after embryo transfer. Results: Most sow urine-derived cells were viable and could be cultured and propagated easily. On the other hand, most of the somatic cells isolated from the boar urine exhibited poor cellular activity. The in vitro development efficiency between the embryos produced by SCNT using porcine embryonic fibroblasts (PEFs) and urine-derived cells were similar. Moreover, The H3K9me3 in SCNT embryos produced from sow urine-derived cells and PEFs at the four-cell stage showed similar intensity. The levels of Oct4, Nanog, and Sox2 expression in blastocysts were similar in the two groups. Furthermore, there is a similar apoptotic level of cloned embryos produced by the two types of cells. Finally, the full-term development ability of the cloned embryos was evaluated, and the cloned fetuses from the urine-derived cells showed absorption. Conclusions: Sow urine-derived cells could be used to produce SCNT embryos.
Zhou, Yu,Yang, Yun-Ling,Fan, Yu-Ting,Yang, Woochul,Zhang, Wei-Bin,Hu, Jian-Feng,Zhang, Zhi-Jun,Zhao, Jing-Tai The Royal Society of Chemistry 2019 Journal of Materials Chemistry C Vol.7 No.26
<P>A series of novel red emitting Mn<SUP>2+</SUP>-activated SrZnSO phosphors were successfully synthesized by solid-state reaction at high temperature. The photoluminescence (PL) and mechanoluminescence (ML) properties of these Mn<SUP>2+</SUP>-activated SrZnSO phosphors with different Mn<SUP>2+</SUP> concentrations were investigated. With increasing the concentration of Mn<SUP>2+</SUP> from <I>x</I> = 0 to 0.04, the unit cell volume increased from 153.82 to 154.19 Å<SUP>3</SUP> while the optical band gap decreased from 3.74 to 3.43 eV. The site occupation of Mn<SUP>2+</SUP> in the host lattice was demonstrated by Rietveld refinement, the electron paramagnetic resonance (EPR) spectrum, and the spectroscopic properties. A broad band emission peak at 603 nm of SrZn1−xMnxSO (0.001 ≤ <I>x</I> ≤ 0.04) with an excitation wavelength of 318 nm was attributed to electronic transitions of Mn<SUP>2+</SUP> from the <SUP>4</SUP>T1(<SUP>4</SUP>G) level to the <SUP>6</SUP>A1(<SUP>6</SUP>S) level. The lifetime of SrZn1−xMnxSO (0.001 ≤ <I>x</I> ≤ 0.04) decreased monotonously from 2.97 to 0.82 ms with increasing Mn<SUP>2+</SUP> concentration. In particular, intense emission of red light from SrZn1−xMnxSO (0.001 ≤ <I>x</I> ≤ 0.04) under compressive load could be observed even with the naked eye, indicating that SrZn1−xMnxSO could be used for stress sensors or stress imaging. There was a linear correlation between the ML intensity and external load in SrZn1−xMnxSO, and the ML intensity could be recovered under UV light irradiation. Considering its advantages of non-destruction, reproducibility, and high ML intensity, SrZn1−xMnxSO might be useful for non-destructive detection of stress.</P>
Is Folate Status a Risk Factor for Asthma or Other Allergic Diseases?
Ting Wang,Zong-An Liang,Yu-Lin Ji,Hong-Ping Zhang,Xin Zhang,Gang Wang 대한천식알레르기학회 2015 Allergy, Asthma & Immunology Research Vol.7 No.6
Purpose: It is controversial whether folate status is a risk factor for the development of asthma or other allergic diseases. This study was conducted to investigate whether indirect or direct exposure to folate and impaired folate metabolism, reflected as methylene-tetrahydrofolate reductase (MTHFR) C677T polymorphism, would contribute to the development of asthma and other allergic diseases. Methods: Electronic databases were searched to identify all studies assessing the association between folate status and asthma or other allergic diseases. Two reviewers independently assessed the eligibility of studies and extracted data. The relative risk (RR) or odds ratio (OR) with 95% confidence intervals (CI) was calculated and pooled. Results: Twenty-six studies (16 cohort, 7 case-control, and 3 cross-sectional studies) were identified. Maternal folic acid supplementation was not associated with the development of asthma, atopic dermatitis (AD), eczema, and sensitization in the offspring, whereas exposure during early pregnancy was related to wheeze occurrence in the offspring (RR=1.06, 95% CI=[1.02-1.09]). The TT genotype of MTHFR C677T polymorphism was at high risk of asthma (OR=1.41, 95% CI=[1.07-1.86]). Conclusions: It is indicated that maternal folic acid supplementation during early pregnancy may increase the risk of wheeze in early childhood and that the TT genotype of MTHFR C677T polymorphism impairing folic acid metabolism would be at high risk of asthma development. These results might provide additional information for recommendations regarding forced folate consumption or folic acid supplements during pregnancy based on its well-established benefits for the prevention of congenital malformations. However, currently available evidence is of low quality which is needed to further elucidate.
Yu-Guo Yuan,Shao-Zheng Song,Meng-Ming Zhu,Zheng-Yi He,Rui Lu,Ting Zhang,Fei Mi,Jin-Yu Wang,Yong Cheng 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.8
Objective: To create genetically modified goat as a biopharming source of recombinant human lacotoferrin (hLF) with transcription activator-like effector nucleases. Methods: TALENs and targeting vector were transferred into cultured fibroblasts to insert hLF cDNA in the goat beta-lactoglobulin (BLG) locus with homology-directed repair. The gene targeted efficiency was checked using sequencing and TE7I assay. The bi-allelic gene targeted colonies were isolated and confirmed with polymerase chain reaction, and used as donor cells for somatic cell nuclear transfer (SCNT). Results: The targeted efficiency for BLG gene was approximately 10%. Among 12 Bi-allelic gene targeted colonies, five were used in first round SCNT and 4 recipients (23%) were confirmed pregnant at 30 d. In second round SCNT, 7 (53%), 4 (31%), and 3 (23%) recipients were confirmed to be pregnant by ultrasound on 30 d, 60 d, and 90 d. Conclusion: This finding signifies the combined use of TALENs and SCNT can generate bi-allelic knock-in fibroblasts that can be cloned in a fetus. Therefore, it might lay the foundation for transgenic hLF goat generation and possible use of their mammary gland as a bioreactor for large-scale production of recombinant hLF.
Conceptual Graph Matching Method for Reading Comprehension Tests
Zhang, Zhi-Chang,Zhang, Yu,Liu, Ting,Li, Sheng The Korea Institute of Information and Commucation 2009 Journal of information and communication convergen Vol.7 No.4
Reading comprehension (RC) systems are to understand a given text and return answers in response to questions about the text. Many previous studies extract sentences that are the most similar to questions as answers. However, texts for RC tests are generally short and facts about an event or entity are often expressed in multiple sentences. The answers for some questions might be indirectly presented in the sentences having few overlapping words with the questions. This paper proposes a conceptual graph matching method towards RC tests to extract answer strings. The method first represents the text and questions as conceptual graphs, and then extracts subgraphs for every candidate answer concept from the text graph. All candidate answer concepts will be scored and ranked according to the matching similarity between their sub-graphs and question graph. The top one will be returned as answer seed to form a concise answer string. Since the sub-graphs for candidate answer concepts are not restricted to only covering a single sentence, our approach improved the performance of answer extraction on the Remedia test data.