입원된 정신활성물질 남용자의 사회정신의학적 특징

이혁,김유광,김경빈 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.1

This study was attempted to clarify sociopsychiatric characteristics according to the class of psychoactive substances which were classified into 8 groups such and methamphetamin, cocaine, inhalants(bond/gas), dextromethorphan(Romilar), sedatives marijuana, analgesics and etc. The data of the study were collected from 134 psychoactive substance abusers(89men, 45women), who had admitted to SNMH during past 5 years. The results were as follows ; 1) The mean age of patients was 26.5±9.6 years and according to the class of psychoactive substance, inhalant and dextromethorphan abusers were significantly younger than sedatives and analgesics abusers(P〈0.01). 2) 43.1% of patients were grown up in broken family until puberty and 27.9% of married patients showed unstable marital state such as a divorce or seperation. 3) 41.4% of patients had past history of delinquent behavior and especially, inhalants and dextromethorphan abusers had more past history of delinquent behavior than sedatives and analgesics abusers(P〈0.01). 4) The main motive of mitiation of psychoactive substance was peer pressure, relief of psysical symptoms, curiosity in that order. 75% of inhalants abusers were itiated by peer pressure, but most of sedatives and analygesics abusers used it for the purpose of relieving of physical symptoms, and methamphetamine abusers used it mainly due to peer pressure or for the purpose of increasing sexual plesure(P〈0.01). 5) 57.5% of patients reported the experience of unwanted response such as unpleasant hallucinatory state, loss of control, and psychotic state after use of psychoactive substances. Especially the unwanted respose was reported more frequently in methamphetamin and inhalants abusers. 6) 38.5% of patients abused more than two classes of psychoactive substances, and their significant combination types were not found but inhalant-dextromethorphan, analygesics-sedatives and methamphetamine-marijuana combination types were relatively common.

Spheroid 조합자극치료 적용이 신체구성에 미치는 영향

홍성찬,김영빈,정동혁,박병근,김유성,이성진 원광대학교 체력과학연구소 2008 體力科學硏究 Vol.30 No.1

The present study aims to explore the effects of applying spheroid-combined stimulating therapy on body composition. For this aim. 20 persons were selected as subjects and 10 of them each were assigned to the experimental group and control group, respectively. The experimental group was applied a 12-week combined stimulating therapy and changes in physical constitution of the members were measured before application and 4, 8 and 12 weeks after application. From the study, following conclusions could be drawn: First, body weights of the experimental group decreased from 59.9kgs before application of the spheroid-combined stimulating therapy to 57.2kgs 12 weeks after application, no significant but 4.51% change. Second, body fats of the experimental group changed from 18.8kgs before application to 16.4kgs 12 weeks after application, no significant but 12.77% reduction. Third, % fats of the experimental group decreased from 31.2% before application to 28.6% 12 weeks after application, no significant change but 8.33% reduction. Fourth, body mass index(BMI) of the experimental group decreased from 23.23 kg/㎡ before application of the therapy to 21.43kg/㎡ after application, no significant but 8.03% reduction. As seen above, the 12-week application of the spheroid-combined stimulating therapy produced no significant changes in physical constitution as physical exercise did, but improved physical constitution by reducing certain amount of boy weight, body fat, % fat and BMI. In order to detect more positive and significant changes in physical constitutions, continued studies and clinical experiments should be performed to more diverse subjects using technically reinforced equipment for spheroid-combined stimulating therapy.

Potential Utility of Fecal Calprotectin in Discriminating Colorectal Polyps From Other Major Etiologies in Children Presenting With Isolated Hematochezia

Kim Yu Bin,Kim Ju Young,Choi Sujin,Kim Hyun Jin,Lee Yoo Min,Lee Yoon,Jang Hyo-Jeong,Lee Eun Hye,Lee Kyung Jae,Kim Soon Chul,Choi So Yoon,Kang Yunkoo,Yi Dae Yong,Choi You Jin,Choe Byung-Ho,Kang Ben 대한의학회 2022 Journal of Korean medical science Vol.37 No.9

Background: Colorectal polyps are the most common cause of isolated hematochezia in children, which requires a colonoscopy for diagnosis. We aimed to investigate the potential utility of fecal calprotectin (FC) in assessing colorectal polyps detected by colonoscopy among children presenting with isolated hematochezia. Methods: Pediatric patients of the age of < 18 years who had undergone both colonoscopy and FC tests for isolated hematochezia from June 2016 to May 2020 were included in the present multicenter, retrospective, cross-sectional study. Comparative analysis was conducted between major causes of isolated hematochezia and FC cut-offs for discriminating colorectal polyps were explored. Results: A total 127 patients were included. Thirty-five patients (27.6%) had colorectal polyps, followed by anal fissure (14.2%), ulcerative colitis (UC; 12.6%), and others. A significant difference in FC levels was observed between patients with colorectal polyps (median, 278.7 mg/kg), anal fissures (median, 42.2 mg/kg), and UC (median, 981 mg/ kg) (P < 0.001). According to receiver operating characteristic curve analysis, among patients diagnosed with colorectal polyp or anal fissure, the most accurate FC cut-off for discriminating colorectal polyps from anal fissures on colonoscopy was 225 mg/kg (sensitivity, 59.4%; specificity, 94.4%; positive predictive value [PPV], 95.0%; negative predictive value [NPV], 56.7%; area under the curve [AUC], 0.8; 95% confidence interval [CI], 0.678–0.923; P < 0.001), while among patients diagnosed with colorectal polyp or UC, the most accurate FC cut-off for discriminating colorectal polyps from UC on colonoscopy was 879 mg/kg (sensitivity, 81.2%; specificity, 56.2%; PPV, 78.8%; NPV, 60.0%; AUC, 0.687; 95% CI, 0.521–0.852; P < 0.001). Conclusion: FC may assist in assessing the cause of lower gastrointestinal tract bleeding in children who present with isolated hematochezia.

Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: a Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19

Eu Suk Kim,Bum Sik Chin,강창경,Nam Joong Kim,Yu Min Kang,Jae-Phil Choi,Dong Hyun Oh,Jeong-Han Kim,Boram Koh,Seong Eun Kim,Na Ra Yun,Jae Hoon Lee,Jin Yong Kim,Yeonjae Kim,Ji Hwan Bang,송경호,Hong Bin Kim,Ki- 대한의학회 2020 Journal of Korean medical science Vol.35 No.13

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pneumonia emerged in Wuhan, China in December 2019. In this retrospective multicenter study, we investigated the clinical course and outcomes of novel coronavirus disease 2019 (COVID-19) from early cases in Republic of Korea. Methods: All of the cases confirmed by real time polymerase chain reaction were enrolled from the 1st to the 28th patient nationwide. Clinical data were collected and analyzed for changes in clinical severity including laboratory, radiological, and virologic dynamics during the progression of illness. Results: The median age was 40 years (range, 20–73 years) and 15 (53.6%) patients were male. The most common symptoms were cough (28.6%) and sore throat (28.6%), followed by fever (25.0%). Diarrhea was not common (10.7%). Two patients had no symptoms. Initial chest X-ray (CXR) showed infiltration in 46.4% of the patients, but computed tomography scan confirmed pneumonia in 88.9% (16/18) of the patients. Six patients (21.4%) required supplemental oxygen therapy, but no one needed mechanical ventilation. Lymphopenia was more common in severe cases. Higher level of C-reactive protein and worsening of chest radiographic score was observed during the 5–7 day period after symptom onset. Viral shedding was high from day 1 of illness, especially from the upper respiratory tract (URT). Conclusion: The prodromal symptoms of COVID-19 were mild and most patients did not have limitations of daily activity. Viral shedding from URT was high from the prodromal phase. Radiological pneumonia was common from the early days of illness, but it was frequently not evident in simple CXR. These findings could be plausible explanations for the easy and rapid spread of SARS-CoV-2 in the community.

Changes in the Prevalence of Childhood Asthma in Seoul from 1995 to 2008 and Its Risk Factors

Kwon, Ji-Won,Kim, Byoung-Ju,Song, Younghwa,Seo, Ju-Hee,Kim, Tae-Hee,Yu, Jinho,Kim, Hyo Bin,Lee, So Yeon,Kim, Woo-Kyung,Kim, Kyoung-Won,Ji, Hye-Mi,Kim, Kyu-Earn,Kim, Ho,Hong, Soo-Jong The Korean Academy of Asthma, Allergy and Clinical 2011 Allergy, Asthma & Immunology Research Vol.3 No.1

<P><B>Purpose</B></P><P>To investigate the prevalence of asthma and determine its risk factors in elementary school students in Seoul.</P><P><B>Methods</B></P><P>A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 4,731 elementary school students from five areas in Seoul between April and October, 2008.</P><P><B>Results</B></P><P>In elementary school children, the lifetime and recent 12-month prevalence of wheezing were 11.7% and 5.6%, respectively. The lifetime prevalence of asthma diagnosis was 7.9%, and the recent 12-month prevalence of asthma treatment was 2.7%. Male sex (adjusted odds ratio [aOR], 1.90; 95% confidence interval [CI], 1.36-2.66), history of atopic dermatitis (AD) (aOR, 2.76; 95% CI, 1.98-3.84), history of allergic rhinitis (AR) (aOR, 3.71; 95% CI, 2.61-5.26), history of bronchiolitis before 2 years of age (aOR, 2.06; 95% CI, 1.39-3.07), use of antibiotics during infancy for >3 days (aOR, 1.88; 95% CI, 1.35-2.62), parental history of asthma (aOR, 2.83; 95% CI, 1.52-5.27), exposure to household molds during infancy (aOR, 1.84; 95% CI, 1.18-2.89), and the development or aggravation of asthma symptoms within 6 months after moving to a new house (aOR, 11.76; 95% CI, 5.35-25.86) were the independent risk factors for wheezing within 12 months.</P><P><B>Conclusions</B></P><P>The prevalence of wheezing and asthma in elementary school students in 2008 was similar to that in the past decade. Male sex, history of AD, history of AR, history of bronchiolitis before 2 years of age, parental asthma, use of antibiotics during infancy, exposure to molds in the house during infancy, and development or aggravation of asthma symptoms within 6 months after moving to a new house, could be risk factors for wheezing within 12 months.</P>

Increasing Incidence of Inflammatory Bowel Disease Among Young Men in Korea Between 2003 and 2008

Shin, Dong Hyuk,Sinn, Dong Hyun,Kim, Young-Ho,Kim, Jin Yong,Chang, Dong Kyung,Kim, Eun Jin,Ryu, Ho Yoel,Song, Han Ul,Kim, Il Young,Kim, Do Hyoung,Kim, Yun Young,Kim, Suk Hun,Seo, Yu Bin,Hwang, Ki Won Springer-Verlag 2011 Digestive diseases and sciences Vol.56 No.4

Korean Society of Infectious Diseases/National Evidence-based Healthcare Collaborating Agency Recommendations for Anti-SARS-CoV-2 Monoclonal Antibody Treatment of Patients with COVID-19

Kim Sun Bean,Kim Jimin,Huh Kyungmin,Choi Won Suk,Kim Yae-Jean,Joo Eun-Jeong,Kim Youn Jeong,Yoon Young Kyung,Heo Jung Yeon,Seo Yu Bin,Jeong Su Jin,Yu Su-Yeon,Peck Kyong Ran,Choi Miyoung,Yeom Joon Sup 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.2

Neutralizing antibodies targeted at the receptor-binding domain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein have been developed and now under evaluation in clinical trials. The US Food and Drug Administration currently issued emergency use authorizations for neutralizing monoclonal antibodies in non-hospitalized patients with mild to moderate coronavirus disease 2019 (COVID-19) who are at high risk for progressing to severe disease and/or hospitalization. In terms of this situation, there is an urgent need to investigate the clinical aspects and to develop strategies to deploy them effectively in clinical practice. Here we provide guidance for the use of anti-SARS-CoV-2 monoclonal antibodies for the treatment of COVID-19 based on the latest evidence.

Voltage Drop in a Ferroelectric Single Layer Capacitor by Retarded Domain Nucleation

Kim, Yu Jin,Park, Hyeon Woo,Hyun, Seung Dam,Kim, Han Joon,Kim, Keum Do,Lee, Young Hwan,Moon, Taehwan,Lee, Yong Bin,Park, Min Hyuk,Hwang, Cheol Seong American Chemical Society 2017 NANO LETTERS Vol.17 No.12

<P>Ferroelectric (FE) capacitor is a critical electric component in microelectronic devices. Among many of its intriguing properties, the recent finding of voltage drop (V-drop) across the FE capacitor while the positive charges flow in is especially eye-catching. This finding was claimed to be direct evidence that the FE capacitor is in negative capacitance (NC) state, which must be useful for (infinitely) high capacitance and ultralow voltage operation of field-effect transistors. Nonetheless, the NC state corresponds to the maximum energy state of the FE material, so it has been widely accepted in the community that the material alleviates that state by forming ferroelectric domains. This work reports a similar V-drop effect from the 150 nm thick epitaxial BaTiO3 ferroelectric thin film, but the interpretation was completely disparate; the V-drop can be precisely simulated by the reverse domain nucleation and propagation of which charge effect cannot be fully compensated for by the supplied charge from the external charge source. The disappearance of the V-drop effect was also observed by repeated FE switching only up to 10 cycles, which can hardly be explained by the involvement of the NC effect. The retained reverse domain nuclei even after the subsequent poling can explain such behavior.</P>

Is vaginal reflux associated with urinary tract infection in female children under the age of 36 months?

Kim, Yu Bin,Tang, Chih Lung,Koo, Ja Wook The Korean Pediatric Society 2018 Clinical and Experimental Pediatrics (CEP) Vol.61 No.1

Purpose: To determine the relationship between vaginal reflux (VR) and urinary tract infection (UTI) in female children aged <36 months. Methods: A single center retrospective study was performed for 191 girls aged <36 months, with a diagnosis of febrile UTI, who underwent a voiding cystourethrography (VCUG) for assessment of vesicoureteral reflux (VUR) at Sanggye Paik Hospital. Fifty-one girls, who underwent VCUG for assessment of congenital hydronephrosis or renal pelvis dilatation, without a UTI, formed the control group. The correlation between the presence and grade of VR and UTI was evaluated. Results: The prevalence rate of VR was higher in the UTI (42.9%) than control (13.7%) group (P<0.05), with a higher VR severity grade in the UTI (mean, 0.64) than control (mean, 0.18) group (P<0.05). On subanalysis with age-matching (UTI group: n=126, age, $5.28{\pm}2.13months$; control group: n=22, age, $4.79{\pm}2.40months$; P=0.33), both VR prevalence (43.65% vs. 18.18%, P<0.05) and grade (0.65 vs. 0.22, P<0.05) remained higher in the UTI than control group. Presence and higher grade of VR were associated with UTI recurrence (P<0.05). VR was correlated to urosepsis (P<0.05). The renal defect rate of patients with VR (VR [+]/VUR [+]) was not different from that of patients without VR (74% vs. 52%, P=0.143) in the VUR group; however, it was higher than that of VR (+)/VUR (-) patients (74% vs. 32%, P=0.001). If a child with VR (+)/VUR (+) is exposed to a UTI, the risk of renal defect increases. Conclusion: Occurrence of VR is associated with UTI recurrence and urosepsis in pediatric female patients.

Diagnostic accuracy of PET/CT in early stage ovarian cancer: comparison between PET/CT and CT or MRI

( Yu Bin Lee ),( Hyun Jong Park ),( Ga Won Yim ),( Sung Hoon Kim ),( Sang Wun Kim ),( Young Tae Kim ),( Jae Wook Kim ),( Eun Ji Nam ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

The purpose of this study was to compare the diagnostic accuracy of positron emission tomography/computed tomography (PET/CT), abdomino-pelvic computed tomography (CT), and pelvic magnetic resonance imaging (MRI) for detection of early stage ovarian cancer. Medical record of 140 women who underwent PET/CT scanning with suspected early stage ovarian cancer (stage 1-2) from July 2005 to February 2012 was retrospectively reviewed. Preoperative CT, MRI, and PET/CT findings were compared with histopathologic results obtained from the surgery. The accuracy of each modality in detection of malignancy was evaluated by computing the relevant areas under a receiver operating characteristics(ROC) curve and comparisons of the area under the curve (AUC) according to the modality (MedCalc® version 9.6.3.0, Broekstraat 52, 9030 Mariakerke, Belgium). Histopathology showed 7 cases of benign tumors, 23 cases of borderline tumors, and malignant tumors in 110 cases. In detecting malignant lesions in the ovaries and the adnexa, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of PET/CT were higher than the corresponding values of CT or MRI. In discriminating between cases of benign/borderline and malignant, the accuracy of PET/CT (0.760) trended higher than that of CT or MRI (0.585). PET/CT is more accurate than abdomino-pelvic CT or pelvic MRI in diagnosis of early stage ovarian cancer and in differentiating between cases of benign/borderline and malignant ovarian tumors.