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관상동맥 풍선성형술 후 발생한 관상동맥 박리의 초기 조영술적 고찰
고영엽,강지인,장재혁,강민정,정중화,장경식,홍순표 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1
Background and Objectives: Percutaneous coronary intervention (PCI) is widely utilized in the treatment of symptomatic coronary artery disease (CAD). Althouth it has numerous benefits, intimal tear or dissection, serious and potentially life-threatening complications of plain old balloon angioplasty (POBA) can occur. The aim of this study was to assess the implications of coronary dissections after ballon angioplasty. Methods: 78 consecutive patients (age, 62 +/- 11 years; 46 men, 32 women) identified to two groups as having with or without dissection (dissection (D) group or non-dissection (ND) grouP) underwent balloon angioplsty for CAD were studied. All patients with dissection could be managed by successful stent implantation to rescue the artery. The morbidity of ischemic complication and mortality were evaluated for 30days after PCI. Results: Coronary dissection developed 44 lesions (38%) in 31 patients out of 117 lesions in 78 patients after POBA and a good final angiographic result was obtained in all patients with dissection, Significant correlates of a development of dissection were the lesion morphology of ACC/AHA type B and C (P<0.05). There were no significant correlations of clinical pictures, whether POBA in single vessel disease or in multivessel disease, diameter stenosis before POBA, and balloon/coronary artery diameter ratio. Morphologic feature of dissection was type A in 15 (34%), type B in 13(30%), type C in 12 (27%), and type D in 4 (9%). After PCI, there was no ischemic complication or death related coronary dissection during follow-up period for 30days. Conclusions: Coronary dissection after angioplasty occurred in 44 lesions (38%) out of 117 lesions of 78 consecutive patients underwent POBA. Coronary dissection after POBA significantly correlated with the severity of lesion morphology. Coronary stenting is effective in the management of acute coronary dissections after angioplasty.
Young Youp Koh(Young Youp Koh) 조선대학교 의학연구원 2023 The Medical Journal of Chosun University Vol.48 No.1
The Brugada syndrome (BS) is an inherited cardiac disease, which can lead to ventricular tachyarrhythmias and sudden cardiac death in patients with structurally normal hearts. The BS is characterized by distinctive ST-segment elevation in the right precordial leads frequently associated to right ventricular conduction delay on electrocardiogram (ECG). This report presents a patient with tuberculous pericarditis, in whom a transient Brugada-like ECG pattern was induced by fever.
Acute Myocardial Infarction in a Young Adult during Vigorous Physical Activity
Young Youp Koh,Young Jae Ki,Sung Soo Kim,Hyun Wook Kim,Keun Ho Park,Dong Hyun Choi,Joong Wha Jeong,Kyoung Sig Chang 조선대학교 의학연구원 2017 The Medical Journal of Chosun University Vol.42 No.4
Acute myocardial infarction (AMI) as an acute form and a catastrophic manifestation of coronary artery disease (CAD) is the major cause of morbidity and mortality worldwide. The prevalence and incidence of myocardial infarction can be influenced by demographic, biological and psychosocial factors, and it is rare in childhood and adolescent years. Contrary to the elderly, where cardiac attack is mainly caused by CAD, exercise-induced cardiac attack is relatively more prevalent in a young adult. We report here on a case of ST-segment elevation myocardial infarction (STEMI) in a young adult during vigorous physical activity and we review the relevant literatures.
Influence of Nicorandil on Catecholamine Release in the Perfused Rat Adrenal Medulla
Koh, Young-Youp,Lee, Eun-Sook,No, Hae-Jeong,Woo, Seong-Chang,Chung, Joong-Wha,Seoh, Yoo-Seung,Lim, Dong-Yoon The Korean Society of Pharmacology 2007 The Korean Journal of Physiology & Pharmacology Vol.11 No.3
The present study was attempted to investigate the effect of nicorandil, which is an ATP-sensitive potassium ($K_{ATP}$) channel opener, on secretion of catecholamines (CA) evoked by cholinergic stimulation and membrane depolarization from the isolated perfused rat adrenal glands. The perfusion of nicorandil ($0.3{\sim}3.0mM$) into an adrenal vein for 90 min produced relatively dose-and time-dependent inhibition in CA secretion evoked by ACh (5.32 mM), high $k^+$ (a direct membrane depolarizer, 56 mM), DMPP (a selective neuronal nicotinic receptor agonist, $100{\mu}M$ for 2 min), McN-A-343 (a selective muscarinic $M_1$ receptor agonist, $100{\mu}M$ for 4 min), Bay-K-8644 (an activator of L-type dihydropyridine $Ca^{2+}$ channels, $10{\mu}M$ for 4 min) and cyclopiazonic acid (an activator of cytoplasmic $Ca^{2+}$-ATPase, $10{\mu}M$ for 4 min). In adrenal glands simultaneously preloaded with nicorandil (1.0 mM) and glibenclamide (a nonspecific $K_{ATP}$-channel blocker, 1.0 mM), the CA secretory responses evoked by ACh, high potassium, DMPP, McN-A-343, Bay-K-8644 and cyclopiazonic acid were recovered to the considerable extent of the control release in comparison with that of nicorandil-treatment only. Taken together, the present study demonstrates that nicorandil inhibits the adrenal CA secretion in response to stimulation of cholinergic (both nicotinic and muscarinic) receptors as well as by membrane depolarization from the isolated perfused rat adrenal glands. It seems that this inhibitory effect of nicorandil may be mediated by inhibiting both $Ca^{2+}$ influx and the $Ca^{2+}$ release from intracellular store through activation of $K_{ATP}$ channels in the rat adrenomedullary chromaffin cells. These results suggest that nicorandil-sensitive $K_{ATP}$ channels may play an inhibitory role in the regulation of the rat adrenomedullary CA secretion.
Influence of Nicorandil on Catecholamine Release in the Perfused Rat Adrenal Medulla
Young-Youp Koh,Eun-Sook Lee,Hae-Jeong No,Seong-Chang Woo,Joong-Wha Chung,Yoo-Seung Seoh,Dong-Yoon Lim 대한생리학회-대한약리학회 2007 The Korean Journal of Physiology & Pharmacology Vol.11 No.3
The present study was attempted to investigate the effect of nicorandil, which is an ATP-sensitive potassium (KATP) channel opener, on secretion of catecholamines (CA) evoked by cholinergic stimulation and membrane depolarization from the isolated perfused rat adrenal glands. The perfusion of nicorandil (0.3∼3.0 mM) into an adrenal vein for 90 min produced relatively dose-and time-dependent inhibition in CA secretion evoked by ACh (5.32 mM), high K<SUP>+</SUP> (a direct membrane depolarizer, 56 mM), DMPP (a selective neuronal nicotinic receptor agonist, 100μM for 2 min), McN-A-343 (a selective muscarinic M1 receptor agonist, 100μM for 4 min), Bay-K-8644 (an activator of L-type dihydropyridine Ca<SUP>2</SUP> channels, 10μM for 4 min) and cyclopiazonic acid (an activator of cytoplasmic Ca<SUP>2</SUP>-ATPase, 10μM for 4 min). In adrenal glands simultaneously preloaded with nicorandil (1.0 mM) and glibenclamide (a nonspecific KATP-channel blocker, 1.0 mM), the CA secretory responses evoked by ACh, high potassium, DMPP, McN-A-343, Bay-K-8644 and cyclopiazonic acid were recovered to the considerable extent of the control release in comparison with that of nicorandil-treatment only. Taken together, the present study demonstrates that nicorandil inhibits the adrenal CA secretion in response to stimulation of cholinergic (both nicotinic and muscarinic) receptors as well as by membrane depolarization from the isolated perfused rat adrenal glands. It seems that this inhibitory effect of nicorandil may be mediated by inhibiting both Ca<SUP>2</SUP> influx and the Ca<SUP>2</SUP> release from intracellular store through activation of KATP channels in the rat adrenomedullary chromaffin cells. These results suggest that nico</SUP>randil-sensitive KATP channels may play an inhibitory role in the regulation of the rat adrenomedullary CA secretion.
영구적 심방세동 환자에서 동시 발병한 급성 ST 분절 상승 심근경색과 다발성 말초 및 전신동맥 색전증
고영엽(Young Youp Koh) 조선대학교 의학연구원 2023 The Medical Journal of Chosun University Vol.48 No.1
Acute myocardial infarction(AMI) is myocardial necrosis resulting from acute obstruction of a coronary artery, which is a significant cause of morbidity and mortality among adults worldwide. Coronary artery plaque rupture, erosion, thrombosis, and dissection account for nearly all obstruction of a coronary artery. However, coronary artery embolism is also one of the rare but important causes of AMI. It is imperative that practicing clinicians be aware of coronary embolism as a cause of AMI, particularly in high-risk populations such as those with atrial fibrillation. Atrial fibrillation(AF) is one of the most common dysrhythmias, in general, the most concerning complication of AF is thromboembolic events including cardioembolic stroke and systemic embolism. For many patients with AF, anticoagulation therapy is the cornerstone of management to prevent thromboembolic events. Here, we report a very rare case of not only acute ST segment elevation myocardial infarction(STEMI) due to coronary artery embolism but also several systemic embolic events(SEE) including acute unilateral renal infarction and the sudden occlusion of the superior mesenteric artery and right popliteal artery caused by multiple peripheral or systemic arterial embolism simultaneously developed in a 77-year-old man with permanent atrial fibrillation after discontinuing anticoagulation arbitrarily.
Youngkeun Ahn,Keun-Ho Park,Young-Youp Koh,Young-Jae Ki,Sung Soo Kim,Hyun Kuk Kim,Dong-Hyun Choi,Young Joon Hong,Jin-Yong Hwang,Do Hoi Kim,Jay-Young Rhew,Jae Kean Ryu,Jong-Seon Park,Tae Ho Park,Tae-Hyu 대한심장학회 2019 Korean Circulation Journal Vol.49 No.8
Background and Objectives: Diffuse long coronary artery disease (DLCAD) still has unfavorable clinical outcomes after successful percutaneous coronary intervention (PCI). Therefore, we aimed to evaluate the effectiveness and safety of Resolute™ zotarolimus-eluting stent (R-ZES; Resolute™ Integrity) for patients with DLCAD. Methods: From December 2011 to December 2014, 1,011 patients who underwent PCI using R-ZES for CAD with longer than 25 mm lesion were prospectively enrolled from 21 hospitals in Korea. We assessed the clinical outcome of major adverse cardiac events (MACE) defined as the composite of cardiac death, non-fatal myocardial infarction (MI), and clinically-driven target vessel revascularization at 12 months. Results: Mean age was 63.8±10.8 years, 701 (69.3%) patients were male, 572 (87.0%) patients had hypertension, 339 (33.8%) patients had diabetes, 549 (54.3%) patients diagnosed with acute MI and 545 (53.9%) patients had multi-vessel disease (MVD). A total of 1,697 stents were implanted into a total of 1,472 lesions. The mean diameter was 3.07±0.38 mm and the length was 28.27±6.97 mm. Multiple overlapping stents were performed in 205 (13.8%) lesions. A 12-month clinical follow-up was available in 1,004 patients (99.3%). The incidences of MACE and definite stent thrombosis at 12-month were 3.0% and 0.3% respectively. On multivariate Cox-regression analysis, multiple overlapping stents implantation, previous congestive heart failure, MVD, and age ≥75 years were independent predictors of one-year MACE. Conclusions: Our study shows that R-ZES has an excellent 1-year clinical outcome in Korean patients with DLCAD.