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윤성필(Sung-Pil Yoon),임성욱(Sung-Uk Lim),박만희(Man-Hee Park),조인희(In-Hee Cho) 한국엔터테인먼트산업학회 2010 한국엔터테인먼트산업학회논문지 Vol.4 No.3
본 연구는 선행연구에서 조사된 핸드폰의 고객요구속성을 Kano 모델의 품질특성에 적용하여 시간의 흐름에 따라 어떤 변화가 있는지를 살펴보고자 한다. 또한 고객들의 새로운 요구속성이 나타났는지도 함께 살펴보고자 한다. 많은 문헌과 선행연구에서 나타나고 있는 시간에 따른 품질특성의 이동이 매력적 품질에서 일원적 품질로 일원적 품질에서 당연적 품질로 변화하는 진부화(陳腐化)현상이 나타나는지도 함께 살펴보고자 한다. In this study, previous research (Sung-Uk Lim, 2004) surveyed in customer demand for mobile phones the quality characteristics of properties applied to the Kano model, the flow of time, depending on whether any changes will be discussed. In addition, our customers" new requirements will be examined along with the property map appeared. The movement of time-dependent quality characteristics appeared in many previous studies Obsolescence Phenomenon - from Attactive Quality Element to One-Dimensional Quality Element, from One-Dimensional Quality Element to Must-Be Quality Element - may appear be examined together.
( Pil Soo Sung ),( Jeong Won Jang ),( Jaejun Lee ),( Soon Kyu Lee ),( Hae Lim Lee ),( Hyun Yang ),( Hee Chul Nam ),( Sung Won Lee ),( Si Hyun Bae ),( Jong Young Choi ),( Nam Ik Han ),( Seung Kew Yoon 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Real-world results of nivolumab monotherapy against HCC are lacking in the hepatitis B virus (HBV)-endemic, Asia-Pacific regions. Moreover, heterogeneous responses to immune checkpoint inhibitors have rarely been described in advanced HCC. The aim of this study is to evaluate the efficacy and safety of nivolumab monotherapy in a real-world setting in 33 Korean patients with unresectable HCC. Methods: Data was collected between October 2016 and November 2019 from 33 consecutive patients treated at three university- affiliated hospitals in Korea. Among the enrolled patients, 31 patients were enrolled between February 2018 and November 2019. Clinical parameters and outcome were assessed. Results: In our cohort, twenty-nine patients (88%) showed HBsAg positivity. At the time of nivolumab initiation, 4 among 33 patients (12%) were classified as Barcelona Clinic Liver Cancer (BCLC)-B stage and 29 (88%) as BCLC-C stage, respectively. Prior sorafenib treatment was given to 31 (94%) patients, and 13 (39%) received prior regorafenib treatment. For the liver reserve, patients were classified as Child-Pugh class A (79%) and B (21%), respectively. Grade 3 toxicities occurred in one patient, who developed pneumonitis after 5 cycles of nivolumab treatment. Best overall responses were complete response in 2 patients out of the 33 enrolled patients (6%), partial response in 4 patients (12%) and stable disease in 4 patients (12%). With 29 patients having images for the response evaluation, the objective response rate was 21.4%. The median overall survival (OS) of the cohort was 26.4 weeks (range 2.3-175.1). Achieving objective responses, pre-treatment small tumours (maximal diameter less than 5 cm) and favourable liver function as assessed by Albumin-Bilirubin grade were significant factors for the favourable OS. Interestingly, differential responses to nivolumab among multiple tumours in a single patient were noted in 6 patients (18%). In these patients, small metastatic tumours were regressed, although their larger tumours did not respond to nivolumab monotherapy. Conclusions: In summary, nivolumab treatment seems clinically efficacious in treating unresectable HCC in an endemic area of HBV infection. Further prospective evaluation is required to overcome the heterogeneous efficacy of nivolumab monotherapy according to the baseline tumour burden.
Diagnostic Role of Ct Enterography Differentiating Intestinal Tuberculosis from Crohn`s Disease
( Yoon Hea Park ),( Jae Hee Cheon ),( Tae Il Kim ),( Won Ho Kim ),( Joon Seok Lim ),( Sung Pil Hong ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
INTRODUCTION/OBJECTIVES: Because intestinal tuberculosis (ITB) has similar clinical, pathological, and endoscopic findings with Crohn``s disease (CD), it is challenge to differentiate from each other. Recently CT enterography (CTE) is widely used to evaluate the small bowel involvement, complication and disease activity in patients with CD. The aim of the present study was to evaluate the diagnostic value of CTE in the distinguishing ITB from CD. AIMS &METHODS: From January 2006 to January 2011, 67 patients with suspected ITB or CD who received CTE on initial work-up were included in the present study. The final diagnosis was made after histology, microbiology, and follow-up by experimental treatment. The CTE findings were reviewed by two radiologists who were blind to patient histories, endoscopic findings and final diagnosis. In CTE, degree of bowel involvement (number and length), mural change (mural hyperenhancement, stratification, wall thickening, distribution), adjacent mesenteric change (Comb sign, fibrofatty proliferation, fistula, abscess, lymphadenopathy) and peritoneal change (peritoneal thickening, ascites) were assessed. Medical records and endoscopic findings were reviewed retrospectively. RESULTS: Among 67 patients, 54 patients had CD and 13 patients had ITB. The male-to-female ratio was 46:8 in patients with CD and 5:8 in patients with ITB (p<0.001). The median age at the time of diagnosis was 25 years (range, 14-71 years) in patients with CD and 53 years (range, 31-62 years) in patients with ITB (p<0.001). Patients with CD had significantly more small bowel lesions than patients with ITB (83.3% vs. 46.2%, p=0.009). Segmental involvements (6-40 cm), Comb sign and fibrofatty changes of adjacent mesentery were significantly more common in patients with CD than in patients with ITB (31.5% vs. 0%, p=0.028; 61.1% vs. 7.7%, p=0.001; 35.2% vs. 0%, p=0.013). Mural hyperenhancement, stratification, asymmetric distribution and size of lymphadenopathy (>8 mm) were not significant but frequently observed in CD (83.3% vs. 53.8%, p=0.057; 46.3% vs. 15.4%, p=0.059; 64.4% vs. 16.7%, p=0.070; 27% vs. 16.7%, p=0.079). CONCLUSION: CTE is a useful diagnostic modality differentiating ITB from CD.
Anatomic Variations of Cervical and High Thoracic Ligamentum Flavum
( Sang Pil Yoon ),( Hyun Jung Kim ),( Yun Suk Cho ) 대한통증학회 2014 The Korean Journal of Pain Vol.27 No.4
Background:Epidural blocks are widely used for the management of acute and chronic pain. The technique of loss of resistance is frequently adopted to determine the epidural space. A discontinuity of the ligamentum flavum may increase the risk of failure to identify the epidural space. The purpose of this study was to investigate the anatomic variations of the cervical and high thoracic ligamentum flavum in embalmed cadavers.Methods:Vertebral column specimens of 15 human cadavers were obtained. After vertebral arches were detached from pedicles, the dural sac and epidural connective tissue were removed. The ligamentum flavum from C3 to T6 was directly examined anteriorly.Results:The incidence of midline gaps in the ligamentum flavum was 87%-100% between C3 and T2. The incidence decreased below this level and was the lowest at T4-T5 (8%). Among the levels with a gap, the location of a gap in the caudal third of the ligamentum flavum was more frequent than in the middle or cephalic portion of the ligamentum flavum. Conclusions:The cervical and high thoracic ligamentum flavum frequently has midline intervals with various features, especially in the caudal portion of the intervertebral space. Therefore, the ligamentum flavum is not always reliable as a perceptible barrier to identify the epidural space at these vertebral levels. Additionally, it may be more useful to insert the needle into the cephalic portion of the intervertebral space than in the caudal portion. (Korean J Pain 2014; 27: 321-325)
Anatomic Variations of Cervical and High Thoracic Ligamentum Flavum
Yoon, Sang Pil,Kim, Hyun Jung,Choi, Yun Suk The Korean Pain Society 2014 The Korean Journal of Pain Vol.27 No.4
Background: Epidural blocks are widely used for the management of acute and chronic pain. The technique of loss of resistance is frequently adopted to determine the epidural space. A discontinuity of the ligamentum flavum may increase the risk of failure to identify the epidural space. The purpose of this study was to investigate the anatomic variations of the cervical and high thoracic ligamentum flavum in embalmed cadavers. Methods: Vertebral column specimens of 15 human cadavers were obtained. After vertebral arches were detached from pedicles, the dural sac and epidural connective tissue were removed. The ligamentum flavum from C3 to T6 was directly examined anteriorly. Results: The incidence of midline gaps in the ligamentum flavum was 87%-100% between C3 and T2. The incidence decreased below this level and was the lowest at T4-T5 (8%). Among the levels with a gap, the location of a gap in the caudal third of the ligamentum flavum was more frequent than in the middle or cephalic portion of the ligamentum flavum. Conclusions: The cervical and high thoracic ligamentum flavum frequently has midline intervals with various features, especially in the caudal portion of the intervertebral space. Therefore, the ligamentum flavum is not always reliable as a perceptible barrier to identify the epidural space at these vertebral levels. Additionally, it may be more useful to insert the needle into the cephalic portion of the intervertebral space than in the caudal portion.