고칼륨혈증에서 심전도의 진단적 의의

윤수영,박원녕,정성필,김승호,이한식 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background: Hyperkalemia is a common and potentially life-threatening metabolic disorder. The electrocardiogram(ECG) is known to be a relatively sensitive diagnostic tool for hyperkalemia. However many exceptions, in which patients showed normal ECG findings even though hyperkalemic, have been reported. The purpose of this study was to determine the extent of correlation between the ECG findings and hyperkalemia and to determine when the ECG has value for diagnosing hyperkalemia. Methods: Patients who had been diagnosed as having hyperkalemia at two university hospitals during three years were enrolled in this study. We reviewed the medical records of the patients and evaluated the following 6 ECG abnormalities: tall T waves, narrow T waves, QRS widening, atrioventricular block, loss of P waves, and sine waves. We defined tall T waves and narrow T waves as 20 percentiles of heights and widths of the T waves from the 100 patients with normokalemia. Results: During the study period, there were 100 hyperkalemic patients, and we analyzed 69 available electrocardiograms. Abnormal ECG findings were revealed in 67%of 69 patients. The higher the serum potassium level, the more abnormal ECG findings. The common ECG abnormalities were tall T waves and loss of P waves. The patients with normal ECGs even though hyperkalemic had relatively low potassium levels. And whether chronic renal disease was not correlated to the ECG abnormality. Conclusion: The electrocardiogram is a good diagnostic tool for hyperkalemia if it is used with accurate diagnostic criteria. Thus, hyperkalemia should be considered when the ECG shows tall T waves or loss of P waves.

음전하를 띤 아미노산 잔기들(E132, E133)이 Cu,Zn-superoxide dismutase의 촉매 활성에 미치는 영향

박수진, 배윤정, 곽한식 배재대학교 자연과학연구소 2014 自然科學論文集 Vol.25 No.1

The amino acids near the active site of SOD have negative charges. The present study was aimed to investigate the function of these acidic amino acids in the enzyme reactions and to find out the effects of them on the dismutase and peroxidase activities of SOD. E132 and E133 residues were replaced with alanines, the neutral amino acid, and these mutated proteins were purified and characterized with respect to their dismutation and peroxidation activities. This replacement gave increase of dismutase activity and decrease of peroxidase activity, indicating that these amino acids may play an important role in the catalytic cycle of SOD. SOD 활성 부위 근처의 아미노산들은 음전하를 띠고 있다. 본 연구의 목적은 이 산성 아미노산들의 효소 반응에서의 기능을 조사하고 이것들이 SOD의 디스뮤테이스 활성과 퍼옥시데이스 활성에 미치는 영향을 알아내고자 하는 것이다. E132와 E133 잔기들을 중성 아미노산인 알라닌으로 치환하였고, 돌연변이된 이 단백질들을 순수정제하여 그 디스뮤테이스 활성과 퍼옥시데이스 활성에 대한 특징을 조사하였다. 아미노산의 치환으로 인해 디스뮤테이스 활성은 증가하였고, 퍼옥시데이스 활성은 감소하였는데, 이는 이 아미노산들이 SOD의 촉매 주기에서 중요한 역할을 할 것이라는 것을 의미하는 것이다.

건강검진에서 발견된 폐결절에 대한 임상경과

최강현,박진우,한윤수 충북대학교 의과대학 충북대학교 의학연구소 2010 忠北醫大學術誌 Vol.20 No.1

연구목적 : 최근 건강검진에서 흉부 전상화단층촬영을 흔히 시행하면서 비석회화 폐결절의 발견이 증가하고 있다. 그러나 이들 폐결절이 여러 번의 추적검사에서 악성으로 밝혀지는 경우는 많지 않다. 따라서 이러한 폐결절에 대해 추적검사를 반드시 필요한 경우를 알아보고자 하였다. 대상 및 방법 : 2007년부터 건강검진을 받은 후 흉부 전산화단층촬영에서 비석회화 폐결절이 발견된 환자를 대상으로 폐결절의 위치, 크기 및 성상을 조사하였다. 추적 전산화단층촬영은 3,6,9,12 및 24개월 후로 계획하였고 폐결정의 변화를 알아보았다. 결과 : 대상환자는 모두 122명으로 남자 107명(87.7%), 여자 15명(12.3%), 이들의 평균연령은 53±10세이었고, 흡연자는 71명(85.2%)이었다. 폐결절이 1개인 경우는 62명(50.8%)으로 가장 많았고, 2개인 경우가 29명(23.8%), 3개인 경우가 12명(9.8%), 4개 이상인 경우가 19명(15.6%)이었다. 결절의 내무가 견고(solid)하며 경계가 분명(distinct)한 경우가 89례, 내부가 견고하지만 경계가 불분명(fuzzy)한 경우가 10례, 내부가 간유리형(ground-glass)이며 경계가 분명한 경우는 7례, 내부가 간유리형이며 경계가 불분명한 경우가 16례로, 내부가 견고하면서 경계가 분명한 경우가 가장 많았다. 흉부 전산화단층촬영상 비특이적이거나 양성으로 여겨지는 경우는 108(88.5%)이었고, 14명(11.54%)에서는 악성 또는 양성으로 구분할 수 없는 상태였다. 추적관찰은 116명(95.1%)에서 한번 이상의 추적 흉부 전산화단층촬영이 시행되었다. 추적관찰은 116명(95.1%)에서 한번 이상의 추적 흉부 전산화단층촬영이 시행되었다. 추적관찰의 기간은 평균 10.8±7.3개월이었다. 추적관찰 중에 5명(4.1%)에서는 결절이 완전히 소실되었고, 8명(6.6%)에서는 일부 호전되었고, 95명(77.9%)에서는 결절의 변화가 없었다. 2명(1.6%)에서는 한 개의 결절이 있었는데, 그 크기가 증가하였다. 3명(2.5%)에서는 결절수가 증가하였다가 다시 감소하였고, 또 다른 3명(2.5%)에서는 결절 수가 감소하였다가 다시 증가하였다. 크기가 증가한 결정 환자 3명 중 1명은 선암으로 판명되었고, 다른 한명은 폐결핵으로 진단되었다. 1년 이상 추적관찰을 한 48명의 환자 중, 처음 추정진단이 '비특이적 결절' 이거나 '양성 결절'인 경우에는 악성으로 진단된 환자는 없었다. 결론 : 건강검진시 발견된 폐결절 환자 중, 처음 추정진단이 '비특이적 결절' 또는 '양성 결절' 일 경우에는 반드시 추적검사가 필요하지 않을 수 있으나 더 대규모의 장기간 연구가 필요하다. Purpose : The number of patients with pulmonary nodules detected by computed tomography in general health evaluation has recently been increased. A very little portion of these patients, however, turned to have malignant nodule, and the rest of the patients had to be checked follow-up computed tomography repeatedly. This study was performed to evaluate any condition that avoid repeated tomography in these patients. Materials and Methods : Patients with noncalcified pulmonary nodules detected in general health evaluation were enrolled. Their symptoms, smoking history, location, size and nature of the pulmonary nodules were evaluated. Follow-up chest computed tomoraphy was checked after 3, 6, 9, 12 and 24 months later. Results : One hundred twenty-two patients (male:female, 107:15) were enrolled and their mean age was 53 ± 10 years. Seventy-one (85.2%) patients were smoker. Sixty-two (50.8%) patients had one nodule, 29 (23.8%) patients had 2 nodules, 12 (9.8%) patients had 3 nodules, and 19 (15.6%) patients had 4 or more nodules. The mean size of the biggest nodule in each patients is 5.7 ± 3.0mm. Solid nodules with distinct margin were most frequent. There was a tendency that solid nodules had distinct margin, whereas ground-glass nodules had fuzzy margin (p < 0.001). One hundred sixteen (95.1%) patients were followed-up at least once. In two patients, their nodules increased in size within 3 and 6 months. One was adenocarcinoma and the other was pulmonary tuberculosis. Among the patients who was followed-up over one year, no patients had malignant nodules. The patients with initial presumptive diagnosis as 'nonspecific' or 'benign' nodule, had no malignancy after one year. Conclusion : In 1.6% of patients, the pulmonary nodule increased in size within 6 months, one was adenocarcinoma, and the other was tuberculosis. In the patients with initial presumptive diagnosis as 'nonspecific' or 'benign' nodule on computed tomography, no nodule turned to be malignant. A longer and larger-scale study is needed.

最近 8年間의 精神神經科 入院 外來 및 患者에 對한 統計的 考察(1960年∼1967年)

李哲奎,盧英一,張煥一,金明源,任允明,韓東洙,吳承煥,金光日 大韓神經精神醫學會 1969 신경정신의학 Vol.8 No.1

1) The number of the out-and in-patients had increased year after year (Table Ⅰ & Ⅲ). 2) Schizophrenia was the greatest number of the in-patients and its rate to whole was 49.1 percent, and neurosis was the greatest number of the out-patients and its rate to whole was 41.66 per cent (Table Ⅰ & Ⅶ). 3) In in-patients, hysteria revealed relatively large in percentage as 11.8% than the other groups (Table Ⅰ). 4) The rate of the male hysteria patients to all male patients was 3.5 per cent and the rate of female hysteria was 20.5 per cent (Table Ⅱ). 5) In in-patients, all the patients of general paresis and alcoholism were only males in sex(Table Ⅱ). 6) In in-patients of schizophrenia, the ratio of the male patients to the female patients was 57.0 : 43.0, but the each rate of each total numbers of the all diseases of the both sexes was almost same (Table Ⅲ). 7) The largest age group of the all patients was between 21∼30 years old, and the next was between 31∼40 years in in-patients (Table Ⅲ). 8) The largest age group of schizophrenia patients was between 21∼30 years and that of M.D.R patients was between 31∼40 years in in-patients (Table Ⅲ). 9) In in-patients of hysteria, the largest age group was between 31∼40 years, and the next was between 21∼30 years (Table Ⅲ). 10) The results of treatment in in-patients were as followings; Recovered; 27.6% Much improved; 43.1% Slightly improved and no changed; 28.2% (Table Ⅳ) 11) The results of treatment in schizophrenia of the in-patients were as followings; Recovered; 19.1% Much improved; 48.3% Slightly improved and no changed; 32.1% (Table Ⅴ) 12) The mode of treatment had been somewhat changed during last 8 years from 1960 to 1967 in treatment of the in-patients (Table Ⅵ). (1) The combined therapy of tranquilizers and EST had been increased, but the therapy of tranquilizer alone or EST alone had been decreased, compared to 1960. (2) The therapy of ICT in the treatment of in-patients had been much decreased.

Poster Session 1 : Analytical biochemistry Biochemical pharmacology and natural product chemistry Biotechnology Carbohydrate chemistry and metabolism ; A new JavaScript-coded unified interface to web-based database search engines used for protein identifi

( Sung Soo Kang ),( Yoon Soo Hahn ),( Sang Soo Kim ) 한국생화학분자생물학회 (구 한국생화학회) 2001 생화학분자생물학회 춘계학술발표논문집 Vol.2001 No.-

하천-충적대수층계의 강변여과수를 열원으로 이용하는 지하수 열펌프 시스템의 계절별 입구온도와 효율성 평가

한찬(Chan Hahn),전재수(Jae-soo jeon),윤운상(Yoon-Sang Yoon),한혁상(Hyok-Sang Han),한정상(Jeong-Sang Hahn) 한국지열·수열에너지학회 2007 한국지열에너지학회논문집 Vol.3 No.2

Unconsolidated and permeable alluvial deposit composed of sand and gravel is distributed along the fluvial plain at the Iryong study area. Previous studies on the area show that a single alluvial well can produce at least 1,650m3d-1 of bank infilterated shallow groundwater(BIGW) from the deposit. This study is aimed to evaluate and simulate the influence that seasonal variation of water levels and temperatures of the liver have an effect on those of BIGW under the pumping condition and also to compare seasonal variation of COPs when indirectly pumped BIGW or directly pumped surface water are used for a water to water heat pump system as an heat source and sink using 3 D flow and heat transport model of Feflow. The result shows that the magnitude influenced to water level of BIGW by fluctuation of river water level in summer and winter is about 48% and 75% of Nakdong river water level separately. Seasonal change of river water temperature is about 23.7 ℃, on other hand that of BIGW is only 3.8℃. The seasonal temperatures of BIGW are ranged from minimum 14.5℃ in cold winter(january) and maximum 18.3℃ in hot summer(July). It stands for that BIGW is a good source of heat energy for heating and cooling system owing to maintaining quite similar temperature(16℃) of background shallow groundwater. Average COPh in winter time and COPc in surnmer time of BIGW and surface water are estimated about 3.95, 3.5, and about 6.16 and 4.81 respectively. It clearly indicates that coefficient of performance of heat pump system using BIGW are higher than 12.9% in winter time and 28.1% in summer time in comparision with those of surface water.

[PF-0007] Morphological and glucosinolate characterization of leaves of landrace mustard (Brassica juncea) germplasm from Korea

Awraris Derbie Assefa(Awraris Derbie Assefa ),Bum-Soo Hahn(Bum-Soo Hahn),Ho Chul Ko(Ho Chul Ko),Onsook Hur(Onsook Hur),Aejin Hwang(Aejin Hwang),Bichsaem Kim(Bichsaem Kim),Yoon-Jung Lee(Yoon-Jung Lee) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

[PF-0006] Morphological characterization of mustard (Brassica juncea) germplasm from Korea

Seong-Hoon Kim(Seong-Hoon Kim),Bum-Soo Hahn(Bum-Soo Hahn),Ho Chul Ko(Ho Chul Ko),Onsook Hur(Onsook Hur),Aejin Hwang(Aejin Hwang),Bichsaem Kim(Bichsaem Kim),Yoon-Jung Lee(Yoon-Jung Lee),Parthiban Subra 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

前頭洞粘液囊腫으로 因한 眼球突出症 2例

韓英洙,申東烈,尹東浩,朴孝淑,咸毅根 大韓眼科學會 1969 大韓眼科學會雜誌 Vol.10 No.1

전신성 흥반성 낭창에서의 생존율에 관한 연구

한지숙,박금수,조철호,고윤웅,윤진우,전상일 대한내과학회 1986 대한내과학회지 Vol.30 No.1

We retrospectively analyzed clinical and laboratory features of 58 patients with SLE for the survival and the factors which may have influenced the outcome from 1970 through 1983. The survival was calculated using the method of Merill and Shulman, taking the time of diagnosis and the onset of symptom as the starting point. We divided 58 patients with SLE into 2 groups, those whose survival was less than or equal to 2 years and those greater than 2 years, and compared clinical and laboratory features between them with particular emphasis on those factors which may have influenced the outcome. The results obtained as follows: 1) The estimated survival from diagnosis was 76.7% in 1 year, 62.3% in 2 years, 62.3% in 3 years, 59.6% in 4 years, 53.8% in 5 years and 50.6% in 10 years. The estimated survival from the onset of symptom was 65.5%, in 1 years, 59.54% in 2 years, 56.2% in 3 years, 52.2% in 4 years, 52.5% in 5 years, and 46.l% in 10 years. 2) There was a statisticaly significant difference in prognosis between 2 groups with regard to CNS involvement, serositis, and increased serum creatinine level(≥3.0mg/dl).