DW1029M, a novel botanical drug candidate, inhibits advanced glycation end-product formation, rat lens aldose reductase activity, and TGF-β₁ signaling

Yoon, Joobyoung,Lee, Hyunyong,Chang, Hwan Bong,Choi, Hyunsik,Kim, Yong Sung,Rho, Yang Kook,Seong, Seungkyoo,Choi, Dong Hwa,Park, Dongeun,Ku, Bonchul American Physiological Society 2014 American Journal of Physiology Vol.306 No.10

<P>DW1029M is a botanical extract consisting of Morus bark and Puerariae radix, produced by Dong-Wha Pharmaceutical, for nephroprotective drug development; it has been in phase II clinical trials in Korea. In our mechanistic investigations, we found that DW1029M inhibits advanced glycation end products (AGEs), rat lens aldose reductase (RLAR), and transforming growth factor (TGF)-beta(1) signaling, all of which are implicated in diabetic complications such as diabetic nephropathy and diabetic retinopathy. DW1029M inhibits AGE formation via Fe2+ chelation. The extract contains 13 active constituents that inhibit AGE formation, 8 active constituents that inhibit RLAR activity, and 1 inhibitor of TGF-beta(1) signaling. Our results suggest DW1029M protects against diabetic nephropathy via blockade of AGE formation, RLAR activity, and TGF-beta(1) signaling.</P>

Evaluation of the Efficacy and Safety of DA-9601 versus Its New Formulation, DA-5204, in Patients with Gastritis: Phase III, Randomized, Double-Blind, Non-Inferiority Study

Choi, Yoon Jin,Lee, Dong Ho,Choi, Myung-Gyu,Lee, Sung Joon,Kim, Sung Kook,Song, Geun Am,Rhee, Poong-Lyul,Jung, Hwoon-Yong,Kang, Dae-Hwan,Lee, Yong Chan,Lee, Si Hyung,Choi, Suck Chei,Shim, Ki-Nam,Seol, KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.11

<P>This study compared the efficacy of DA-9601 (Dong-A ST Co., Seoul, Korea) and its new formulation, DA-5204 (Dong-A ST Co.), for treating erosive gastritis. This phase III, randomized, multicenter, double-blind, non-inferiority trial randomly assigned 434 patients with endoscopically proven gastric mucosal erosions into two groups: DA-9601 3 times daily or DA-5,204 twice daily for 2 weeks. The final analysis included 421 patients (DA-5204, 209; DA-9601, 212). The primary endpoint (rate of effective gastric erosion healing) and secondary endpoints (cure rate of endoscopic erosion and gastrointestinal [GI] symptom relief) were assessed using endoscopy after the treatment. Drug-related adverse events (AEs), including GI symptoms, were also compared. At week 2, gastric healing rates with DA-5204 and DA-9601 were 42.1% (88/209) and 42.5% (90/212), respectively. The difference between the groups was −0.4% (95% confidence interval, −9.8% to 9.1%), which was above the non-inferiority margin of −14%. The cure rate of gastric erosion in both groups was 37.3%. The improvement rates of GI symptoms with DA-5204 and DA-9601 were 40.4% and 40.8%, respectively. There were no statistically significant differences between the two groups in both secondary endpoints. AEs were reported in 18 (8.4%) patients in the DA-5204 group and 19 (8.8%) in the DA-9601 group. Rates of AE were not different between the two groups. No serious AE or adverse drug reaction (ADR) occurred. These results demonstrate the non-inferiority of DA-5204 compared to DA-9601. DA-5204 is as effective as DA-9601 in the treatment of erosive gastritis. Registered randomized clinical trial at ClinicalTrials.gov (NCT02282670)</P>

첨가제 적용을 통한 전분 접착제의 접착 효율 및 내수성 향상

장동욱(Dong-Wook Jang),윤상구(Sang-Gu Yoon1),박종문(Jong-Moon Park) 한국펄프·종이공학회 2015 한국펄프·종이공학회 학술발표논문집 Vol.2015 No.10

Comparative Infestation of Paragonimus westermani Metacercaria from Crayfish in Endemic Areas

Choi, Dong Wik,Kim, Min Sang,Joo, Chong Yoon 慶北大學校 醫科大學 1983 慶北醫大誌 Vol.24 No.1

慶尙北道내 肺吸蟲 浸潤地 溪谷에서의 가재의 最近 棲息狀과 가재에서의 폐흡충 피낭유충의 最近 寄生狀을 究明코저 1981年 10月부터 1982年 9月까지 6個處(達城郡 嘉昌面 蛇洞, 玉盆洞, 上院洞과 榮豊郡 豊基邑 錦溪, 英陽郡 英陽面 化川 및 靑松郡 府東面 上宣溪谷)를 調査對象溪谷으로 選定하여 調査한 後 1974年 朴 및 崔의 調査 成績과 比較하였다. 6個處의 肺吸蟲 浸潤地에서의 가재의 棲息密度는 1974年의 그 密度에 比하여 顯著히 低下되었으며 가재에서의 폐흡충 피낭유충의 寄生率과 그 寄生程度도 1974年의 成績에 比하여 낮았다. 가재의 體部位別 폐흡충 피낭유충의 寄生狀에 있어서는 1974年에는 가재의 全體部位에서 本피낭유충을 찾아 볼 수 있었는데 比하여 이번 調査에서는 가재의 頭胸部, 아가미 및 肝에서만 찾아볼 수 있었으며 가재 한마리當 폐흡충 피낭유충數도 全浸潤地에서 1974年에 比하여 1982年에는 甚히 적었다. 폐흡충 피낭유충이 寄生하는 가재의 數와 이들 가재에서의 本피낭유충의 數가 1982年에는 너무 적으므로 가재의 크기와 本피낭유충數 및 1974年의 調査成績과의 相關을 求할 수 없었다. 이번 調査 結果 1974年에서 1982年까지의 지난 8年間 폐흡충 浸潤地에서 가재의 棲息密度와 폐흡충 피낭유충이 寄生하는 가재의 數가 急激히 減少되었음을 알았다. In an attempt to determine the recent patterns of population density of the crayfish, Cambaroides similis, and infestation of the crayfish with the metacercaria of Paragonimus westermani in Kyungpook Province, Korea, the crayfish collected in the six endemic areas, Kum-ge, Wha-cheon, Sang-seon, Ju-dong, Ok-bun dong, and Sang-weon dong streams were examined from April, 1981 to September, 1982. The results obtained in 1982 were compared with the data derived from the crayfish collected at the same streams by Park and Choi(1974). The population density of crayfish in the six endemic areas of P. westermani in the present study decreased markedly compared with those in 1974. The infestation rate for the metacercaria of P. westermani in the crayfish examined and the intensity of infestation in the positive crayfish also decreased compared with those reported by Park and Choi(1974). In the 1974 survey, the metacercaria was found in all parts of the crayfish whereas it was found only in the cephalothorax, the gills, and the liver in the present suevey. In the average number of metacercariae perpositive crayfish (M.P.P.C), a pronounced reduction was encountered in all endemic areas between 1974 and 1982. The number of infested crayfish and the metacercaria of P. westermani in infested crayfish in 1982 was so small that it was impossible to analyze the relationship between the number of metacercaria and the length of crayfish and to compare the data between 1974 and 1982. It was found in the present study that the population density of crayfish in the endemic areas and the infestation of the crayfish with the metacercaria of P. westermani has decreased drastically over the eight-year period from 1974 to 1982.

코로나19 대응 거버넌스의 성공 요인에 관한 탐색적 연구: 성과중심적 거버넌스 모형을 활용하여

윤기웅(Yoon, Ki-Woong),공동성(Kong, Dong-Sung) 한국정부학회 2020 한국행정논집 Vol.32 No.3

본 연구는 코로나19 방역 모범국이라는 평가를 받는 한국의 코로나19 대응 전략 및 성공 요인을 살펴보는 데 그 목적이 있다. 코로나19 감염병은 사회재난 중 하나로 정부가 중심이 되는 공공거버넌스의 영역이라고 볼 수 있다. 따라서 본 연구는 공공거버넌스 유형 중 하나인 성과중심적 거버넌스 모형을 활용하여 코로나19 방역의 성과(확진자와 사망자의 통제 가능 여부)에 영향을 미치는 요인들을 탐색적으로 분석한다. 분석결과 거버넌스 맥락, 정권, 행정적 준비단계, 성과향상 실행메커니즘에 포함되는 다양한 요인들이 한국의 코로나19 방역의 성과에 이바지한 것으로 나타났다. 구체적으로 살펴보면, 첫째, 거버넌스 맥락 차원에서 2015년 메르스 대응실패 이후 이루어진 법령 개정, 중앙집권체계, 정보통신기술발달 등 방역 활동에 우호적인 외부환경 요소들이 방역의 성과향상에 기여하였다. 둘째, 정권 차원에서 방역당국에 대한 대통령의 적극적 지원과 범정부적 조직/인사/예산지원은 방역당국이 효과적으로 방역에 집중할 수 있도록 하는 밑거름이 되었다. 셋째, 행정적 준비단계 차원에서 구체적으로 마련된 표준운영절차(SOP)와 담당자에 대한 교육/훈련을 통한 역량 강화는 방역 일선 담당자들의 일사불란한 대처를 가능하게 했다. 넷째, 성과향상 실행메커니즘 차원에서 방역당국은 주어진 상황 및 여건에 맞춘 적절한 대비를 하였을 뿐만 아니라 신속한 진단검사 및 역학조사를 통해 확진자를 조기 발견하여 적시에 감염병 확산을 차단할 수 있었다. 결론적으로 피해복구 단계를 제외한 예방, 대비, 대응 단계에서 적절한 조치가 이루어졌고, 이로 인해 비록 미흡한 점이 일부 있기는 하나 한국의 코로나19 방역이 어느 정도 성공적으로 작동하였다고 볼 수 있다. South Korea is being evaluated by global media and experts for its successful response to coronavirus disease 2019 (COVID-19). The purpose of this study is to examine the Korean government’s response strategy and success factors for COVID-19 using the performancebased/managerial governance model which was presented by Kong & Yoon(2018b). It found that various factors, such as governance context, governance regime, pre-governance and execution mechanisms, all together contributed to South Korea’s success in responding to COVID-19. These findings can be considered to be of theoretical significance in that they expanded the applicability of the public governance model proposed by Kong & Yoon. In addition, the case of South Korea, which has harmoniously achieved the two conflicting goals of controlling infectious disease and minimizing economic damage, provides many practical implications for how other countries should cope in the future.

족과관절염좌 환자에 대한 동씨침법과 일반침법의 효과에 대한 비교 연구

안호진,정동화,황규선,윤기붕,김태우,문장혁,백종엽,이상무,Ahn, Ho-jin,Jeong, Dong-hwa,Hwang, Kyu-seon,Yoon, Ki-bung,Kim, Tae-woo,Moon, Jang-huyk,Baek, Jong-yeob,Lee, Sang-moo 대한침구의학회 2003 대한침구의학회지 Vol.20 No.1

Objective: The purpose of this study is to compare the effects of Dong-si acupuncture therapy and General acupuncture therapy for the patients with acute ankle sprain. Methods : This study has been carried out for 60 cases of ankle sprain patients who have visited Dong-Seo Oriental medical Hospital from May 1, 2002 to September 30, 2002. We have treated 30 cases of them by Dong-si acupuncture therapy and the other 30 cases by General acupuncture therapy. And we have compared those two group. Results : 1. There was no significant difference at the treatment period and the number of treatment times in comparing two groups. 2. The number of treatment times for good effect is that : Dong-si took $1.57{\pm}0.85$ times and General acupuncture therapy took $2.15{\pm}0.96$ times. And we have found that the effect of Dong-si acupuncture therapy is faster than the other.

저서성 (底棲性) 대형무척추동물에 (大型無脊椎動物) 의한 금호강 (琴湖江) 수계의 (水系) 생물학적 수질평가

윤일병,공동수,이상협 ( Il Byong Yoon,Dong Soo Kong,Sang Hyeop Lee ) 한국하천호수학회 1992 생태와 환경 Vol.25 No.3

Keumho river is flowing across Taeku city, which is α-mesosaprobic according to annual and situal average level. Sillyong stream inflowing to upper branch is β-mesosaprobic, and Omok stream is α-mesosaprobic, and Namchon, Pulno, and Palkye stream were polysaprobic, respectively. Then, these streams impact on main branch. But Tonghwa stream is a little clean and dilutes a very polluted middle main branch. Among them, Namchon, Pulno, Pakye, and lower main branch are polysaprobic zones with McNaughton`s dominance DI above 0.8, Kno¨pp`s B.E.O.L. above 90, Pantle-Buck`s S above 3.2, Beck-Tsuda`s BI below 10, Shannon`s diversity below 1.5, Yoon-Kong`s TBS below 30. Therefore these zones seem to be target area to be ameliorated in Keumho basin. In the fluctuation of biotic indices, B.E.O.L., Saprobic index S, SI, dominance DI in last season of 1990 were lower than those in same period of 1991, but diversity H`, BI, and TBS were higher.

대두품종(大豆品種)과 선발(選拔) Rhizobium japonicum간의 숙주(宿主) 친화성(親和性)

김창진,이윤,김성훈,유익동,민태익,Kim, Chang-Jin,Rhee, Yoon,Kim, Sung-Hoon,Yoo, Ick-Dong,Mheen, Tae-Ick 한국토양비료학회 1986 한국토양비료학회지 Vol.19 No.4

우수(優秀) 대두접종제(大豆接種劑)로 이용할 균주(菌株)의 선발을 목적으로 국내(國內)에서 선발한 R. japonicum 균주(菌株)들과 현재 대두장려품종으로 보급되고 있는 대두품종들과의 상호(相互) 접종실험(接種實驗)을 통하여 숙주친화성(宿主親和性) 정도를 조사하였다. 얻어진 결과는 다음과 같다. 1. 공시(供試) 근류균주별(根瘤菌株別) 대두품종(大豆品種)과의 친화성(親和性) 정도를 보면 R. japonicum R-214, R-138 균주(菌株)가 근류형성능(根瘤形成能), 질소고정활성(窒素固定活性) 및 총(總) 질소흡수량(窒素吸收量)도 높아 대두품종(大豆品種)과 친화성(親和性) 범위가 비교적 넓었으며 R. japoncum R-224 균주(菌株)는 아주 낮은 것으로 판단되었다. 2. 대두품종별(大豆品種別) 근류균(根瘤菌)과의 친화성(親和性)은 황금(黃金)콩, 장백(長白)콩 등이 높았으며 그 다음이 장엽(長葉)콩, 단엽(短葉)콩, 백운(白雲)콩, 동북태(東北太) 등의 순이었고 방사(放射)콩이 제일 낮았다. 3. 일반적으로 질소고정활성(窒素固定活性)이 우수(優秀)한 균주(菌株)가 열등한 균주(菌株)보다 숙주친화성(宿主親和性) 범위가 넓은 것으로 판단되었다. In order to select suitable strains for utilization as soybean inoculants, the affinity between Rhizobium japonicum strains isolated from the domestic field and the several soybean varieties being distributed as recommended species was investigated by cross-inoculation experiments. The results obtained are as follows: 1. Rhizobium japonicum R-214 and R-138 showed broad affinity range to varies soybean species in terms of the nodule forming ability, the nitrogen fixing activity and the amount of total nitrogen absorption. In contrast, Rhizobium japonicum R-224 showed very low affinity to the same soybean groups. 2. The affinity of Hwang-Keum Kong and Jang-Paeck Kong to the rhizobium strains was the most signigicant, and that of Jang-Yeop Kong, Dong-Buk Tae, Paeck-Woon Kong and Dan-Yeop Kong was also significant. On the other hand, Pang-Sa Kong showed low affinity to the strains. 3. In general, the strains having high nitrogen-fixing activity seemed to possess the broad affinity range to the soybean hosts.

고혈압(高血壓) 뇌졸중(腦卒中) 환자(患者)에 대한 사혈(瀉血)의 강압효과(降壓效果)

문장혁,안호진,정동화,윤형선,장재원,김경선,문익렬,백종엽,이상무,Mon, Jang-hyuk,Ahn, Ho-jin,Jeong, Dong-hwa,Yoon, Hyung-sun,Jang, Jae-won,Kim, Kyung-sun,Moon, Ik-ryoul,Baek, Jong-yeob,Lee, Sang-moo 대한침구의학회 2003 대한침구의학회지 Vol.20 No.2

Objective : The aim of this research was to investigate the depressive effect of depletion of B15(心兪), B23(腎兪), L5(尺澤), B40(委中) in hypertentive stroke patients. Methods : Depletion on B15(心兪), B23(腎兪), L5(尺澤), B40(委中) in hypertentive stroke patient who were admitted in Dong-Seo Oriental Medical Hospital every other day form 4 weeks, without western antihypertensive drug. Results : After treatment in 2nd week, depletion on B15(心兪), B23(腎兪), L5(尺澤), B40(委中) without western antihypertensive drug increased the systolic and diastolic blood pressure. After treatment in 4th week, depletion on B15(心兪), B23(腎兪), L5(尺澤), B40(委中) without western antihypertensive drug decreased the systolic and diastolic blood pressure. After treatment in 4th week, values of RBC and hemoglobine were not significantly changed. Conclusions : Continous depletion on B15(心兪), B23(腎兪), L5(尺澤), B40(委中) in hypertentive stroke patient without western antihypertensive drug implies decreasement of blood pressure, without change of values of RBC and hemoglobine.

Effects of Early Operation in Patients Who Diagnosed Complicated Parapneumonic Effusion

( Sung Jun Chung ),( Hyo Jun Jang ),( Jee Yea Choi ),( Joonkyung Kim ),( Jun Ho Lee ),( Hyun Lee ),( Dong Won Park ),( Sang-heon Kim ),( Jang Won Sohn ),( Hyuck Kim ),( Ho Joo Yoon ),( Won Sang Chung 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Purpose Thoracic empyema is defined as active suppuration within the pleural space and its treatment is controversial. Recently treatment of empyema is changing observation of empyema formation to early invasive treatment with the operation. This study compared the outcomes of early surgery and delayed surgery Method We retrospectively reviewed 40 patients who underwent surgery for complicated parapneumonic effusion from January of 2013 to May of 2020. The early group was defined as operation with empyema diagnosed within 1 week. Results Among 40 patients, 22 patients received early surgery, and 18 patients received delayed surgery. Stage III empyema was prevalent in the delayed group (27.3% vs 76.9%, p=0.004). Operative time was longer in the delayed group (87.5 vs 132.5 min, p=0.004). Intraoperative blood loss was more in the delayed group (200ml vs 750ml, p=0.009). The hospital stay was longer in the delayed group (18.5 days vs 30.0 days, p<0.001). The complication rate was not different between groups (31.8% vs 33.3%, p=0.919). The mortality rate was no significance between the two groups (4.5% vs 5.6%, p=0.884). Conclusion Delayed surgical treatment make operation difficult. Although inactive infected phase, early surgical treatment did not increase postoperative morbidity and mortality.