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( Sang Won Yoon ),( Jaeyoung Cho ),( Jinwoo Lee ),( Young Sik Park ),( Chang-hoon Lee ),( Sang-min Lee ),( Chul-gyu Yoo ),( Young Whan Kim ),( Sung Koo Han ),( Sun Mi Choi ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Introduction: In 2016, a new conceptual framework, acute respiratory deterioration (ARD), in patients with idiopathic pulmonary fibrosis (IPF) is proposed. ARD includes both acute exacerbation (AE) and respiratory related hospitalization, expected to be important prognostic events in IPF patients. However, there has been limited research on ARD. Therefore, we aimed to evaluate the clinical impact of ARD, especially occurred in early period from diagnosis of IPF. Method: We analyzed electrical medical records of patients with IPF diagnosed at a tertiary university hospital from December 2002 to September 2015. The Early ARD group was defined as patients experienced ARD within 1 year after diagnosis of IPF, and those having not were defined as non ARD group. Result: Total 579 of IPF patients were included in the study, and 60 patients (10.4%) were classified as the early ARD group. The median follow up period was 1.70±1.81 years in early ARD group, and 5.13±3.27 years in the non ARD group. Patients in early ARD group were more male, (OR: 1.319, 95% CI: 1.225-1.421, p<0.001), older (OR: 1.050, 95% CI: 1.039-1.062, p<0.001), have lower FVC and DLCo at the time of diagnosis (OR: 0.992, 95% CI: 0.987-0.998, p=0.007 and OR: 0.993, 95% CI: 0.988-0.998, p=0.01, respectively) in the multivariable analysis. Early ARD was associated with higher mortality (HR:3.4895, 95% CI: 2.529-4.782, p<0.001). The subgroup of ARD was Acute exacerbation ARD (28.3%), parenchymal ARD (49.2%), non-parenchymal ARD (9.2%), subacute ARD (13.3%), respectively. Among ARD, AE was associated with the worst prognosis (HR: 16.384, 95% CI: 5.641-47.591, p<0.001). Conclusion: Risk factors of early ARD were male gender, older age, low FVC and DLCo at baseline in patient with IPF. Early ARD was significantly associated with lower survival in patients with IPF.
Yoo Chul Kim,Young Kyu Hong,Se Jin Oh,Seung Min Oh,Won Hyun Ji,Jae E. Yang,Sung Chul Kim 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.2
Heavy metal pollution has been a critical problem in agricultural field near at the abandoned metal mines and chemical amendments are applied for remediation purpose. However, biological activity can be changed depending on chemical amendments affecting crop productivity. Main purpose of this research was to evaluate biological parameters after applying chemical amendments in heavy metal polluted agricultural field. Result showed that soil respiration (SR) and microbial biomass carbon (MBC) were changed after chemical amendments were applied. Among three different amendments, lime stone (LS), steel slag (SS), and acid mine drainage sludge(AMDS), AMDS had an effect to increase SR in paddy soil. Comparing to control (93.98-170.33 mg kg<SUP>-1</SUP> day<SUP>-1</SUP>), average of 30% increased SR was observed. In terms of MBC, SS had an increased effect in paddy soil. However, no significant difference of SR and MBC was observed in upland soil after chemical amendment application. Overall, SR can be used as an indicator of heavy metal remediation in paddy soil.
Spinal Epidural Lipomatosis in Korean
Yoo, Je Chul,Choi, Jeong Jae,Lee, Dong Woo,Lee, Sang Pyung The Korean Neurosurgical Society 2014 Journal of Korean neurosurgical society Vol.55 No.6
Spinal epidural lipomatosis (SEL) is a rare disorder, regarded in literature as a consequence of administration of exogenous steroids, associated with a variety of systemic diseases, endocrinopathies and the Cushing's syndrome. Occasionally, SEL may occur in patients not exposed to steroids or suffering from endocrinopathies, namely, idiopathic SEL. Thus far, case studies of SEL among Korean have been published rather sporadically. We reviewed the clinical features of SEL cases, among Koreans with journal review, including this report of three operated cases. According to this study, there were some differences between Korean and western cases. Koreans had higher incidences of idiopathic SEL, predominant involvement in the lumbar segments, very few thoracic involvement and lower MBI, as opposed to westerners.
Yoo, Kwang Ha,Chung, Wou Young,Park, Joo Hun,Hwang, Sung Chul,Kim, Tae-Eun,Oh, Min Jung,Kang, Dae Ryong,Rhee, Chin Kook,Yoon, Hyoung Kyu,Kim, Tae-Hyung,Kim, Deog Kyeom,Park, Yong Bum,Kim, Sang-Ha,Yum, The Korean Academy of Tuberculosis and Respiratory 2017 Tuberculosis and Respiratory Diseases Vol.80 No.4
Background: Proper education regarding inhaler usage and optimal management of chronic obstructive pulmonary disease (COPD) is essential for effectively treating patients with COPD. This study was conducted to evaluate the effects of a comprehensive education program including inhaler training and COPD management. Methods: We enlisted 127 patients with COPD on an outpatient basis at 43 private clinics in Korea. The patients were educated on inhaler usage and disease management for three visits across 2 weeks. Physicians and patients were administered a COPD assessment test (CAT) and questionnaires about the correct usage of inhalers and management of COPD before commencement of this program and after their third visit. Results: The outcomes of 127 COPD patients were analyzed. CAT scores ($19.6{\pm}12.5$ vs. $15.1{\pm}12.3$) improved significantly after this program (p<0.05). Patients with improved CAT scores of 4 points or more had a better understanding of COPD management and the correct technique for using inhalers than those who did not have improved CAT scores (p<0.05). Conclusion: A comprehensive education program including inhaler training and COPD management at a primary care setting improved CAT scores and led to patients' better understanding of COPD management.
TNF-like ligand 1A is a promising biomarker of disease activity in rheumatoid arthritis
( Yoo Jin Hong ),( Yun Jong Lee ),( Ki Chul Shin ),( Byoong Yong Choi ),( Sung Hae Chang ),( Hae Won Kim ),( In Ah Choi ),( Eun Young Lee ),( Eun Bong Lee ),( Yeong Wook Song ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of multiple joints. TN -like ligand 1A (TL1A), a ligand belonging to the TNF superfamily, is expressed by endothelial cells, lymphocytes, monocytes and plasma cells. These are also the key cell lineages participating in the pathogenesis of RA. Moreover, TL1A is up-regulated by proinflammatory cytokines TNF- and IL-1. We thereby examined the serum and synovial fluid levels of TL1A in patients with RA. In addition, we investigated the relationship between serum TL1A concentration and clinical parameters in RA patients. Methods: Serum samples were obtained from 232 patients with RA and 29 with osteoarthritis (OA). Thirty-eight and 27 synovial fluid (SF) samples were collected from respective group of patients. Additional 45 serum samples before and after (14 weeks) anti-TNF- treatment were collected from RA patients. TL1A concentrations were measured by ELISA. Clinical parameters were acquired at the time of sampling. Results: Serum concentrations of TL1A in RA patients were significantly higher than those in OA patients (mean±SD, 1327.4±3858.8 pg/ml vs. 150.3±269.6 pg/ml, p<0.0001). The SF levels of TL1A were elevated in patients with RA compared with those in OA (965.7±1617.2 vs. 271.4±238.9, p=0.013). Levels of TL1A were significantly increased in SF than serum in matched samples (RA; p=0.006, OA; p<0.0001). Serum levels of TL1A decreased substantially with anti-TNF- treatment (p=0.002). Serum levels of TL1A correlated well with DAS28-ESR (r=0.170, p=0.021), DAS28-CRP (r=0.166, p=0.037), SDAI (r=0.201, p=0.016), CDAI (r=0.195, p=0.011) and rheumatoid factor positivity (r=0.876, p=0.044). Conclusion: Serum and SF levels of TL1A were significantly increased in RA patients compared with OA patients, and correlated well with clinical parameters representing disease activity.Our results support that TL1A could be a potential biomarker in assessing disease activity and treatment response in RA patients.