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Shin Yoo-Sub,Hwang Da-Bin,Won Dong-Hoon,Kim Shin-Young,Kim Changuk,Park Jun Won,Jeon Young,Yun Jun-Won 한국독성학회 2023 Toxicological Research Vol.39 No.3
Drug-induced liver injury (DILI) is a major cause of acute liver failure and drug withdrawal. Cytochrome P450 (CYP) 2E1 is involved in the metabolism of several drugs, and can induce liver injury through the production of toxic metabolites and the generation of reactive oxygen species. This study aimed to elucidate the role of Wnt/β-catenin signaling in CYP2E1 regulation for drug-induced hepatotoxicity. To achieve this, mice were administered cisplatin or acetaminophen (APAP) 1 h after treatment with the CYP2E1 inhibitor dimethyl sulfoxide (DMSO), and histopathological and serum biochemical analyses were performed. APAP treatment induced hepatotoxicity, as evidenced by an increase in liver weight and serum ALT levels. Moreover, histological analysis indicated severe injury, including apoptosis, in the liver tissue of APAP-treated mice, which was confirmed by TUNEL assay. Additionally, APAP treatment suppressed the antioxidant capacity of the mice and increased the expression of the DNA damage markers γ-H2AX and p53. However, these effects of APAP on hepatotoxicity were significantly attenuated by DMSO treatment. Furthermore, the activation of Wnt/β-catenin signaling using the Wnt agonist CHIR99021 (CHIR) increased CYP2E1 expression in rat liver epithelial cells (WB-F344), whereas treatment with the Wnt/β-catenin antagonist IWP-2 inhibited nuclear β-catenin and CYP2E1 expression. Interestingly, APAP-induced cytotoxicity in WB-F344 cells was exacerbated by CHIR treatment and suppressed by IWP-2 treatment. Overall, these results showed that the Wnt/β-catenin signaling is involved in DILI through the upregulation of CYP2E1 expression by directly binding the transcription factor β-cat/TCF to the Cyp2e1 promoter, thus exacerbating DILI.
Yoo Bin Shin,Yun Hee Ju,In-Seok Seo,Cheul-Ro Lee,Yong-nam Kim,Kyeong jun Kong,Jong-Woong Kim 대한금속·재료학회 2020 ELECTRONIC MATERIALS LETTERS Vol.16 No.3
Although previous studies have shown that Ag nanowire (AgNW) is among the most powerful means to replace the brittleindium tin oxide, physically fexible devices using AgNWs are not yet available on the market mainly because of the insuffcientmechanical robustness of the AgNW-based electrodes. Here we propose a modifed inverted layer processing (ILP) tofabricate mechanically robust, near-foldable transparent conductors by totally impregnating AgNWs just under the surfaceof cured polyvinyl butyral (PVB). A single demerit of the original ILP, low surface coverage of conductive pathways, wasresolved by photo-induced heating of the AgNWs to settle them on a temporary substrate before coating and curing of thePVB. This resulted in wide coverage of conducting pathways on the surface of the AgNWs/PVB without compromisingthe ultralow surface roughness. Furthermore, the high strength and excellent compatibility of the PVB with the AgNWsfacilitated the preparation of near-foldable touch sensors.
Ultra-robust bonding between MXene nanosheets and stretchable, self-healable microfibers
Shin, Yoo Bin,Kim, Youngmin,Kang, Chang Goo,Oh, Jung-Min,Kim, Jong-Woong Techno-Press 2021 Advances in nano research Vol.11 No.5
To develop a reliable fibrous device, a strong bond between conducting materials and fibers must be ensured. While the external surface of the film is relatively flat, making it easy to deposit the electrode materials uniformly, the walls of the polymer fibers inside the porous film pose a greater challenge for ensuring a uniform coating and robust bonding with electrode material. Herein, a microfibril-based porous film was prepared by electrospinning polybutadiene-based urethane (PBU), a newly synthesized self-healing polymer, and Ti<sub>3</sub>C<sub>2</sub>-based MXene nanosheets were coated thereon to fabricate a pressure sensor whose resistance decreases with pressure. The PBU microfibrils were crosslinked under mild conditions via Diels-Alder (DA) reaction by exploiting low activation energy of the PBU. An exceptionally robust bonding between the PBU and MXene was enabled by subjecting the PBU to a retro-DA and subsequent DA reactions. The temporary increase in surface fluidity of the PBU leaded to a conformal contact between the MXene and fibers without collapse of fibrous structure, resulting in an ultra-robust bond between them. A stretchable and self-healable pressure sensor was implemented by removing unnecessary MXenes by applying ultrasonic energy to the thus-fabricated sample. The fabricated sensor showed a pressure sensitivity of around 27.9 /kPa for a wide range of pressure which is the highest level among the reported stretchable self-healing pressure sensors, while maintaining its performance even after 1000 cycles of stretching and pressing. Further, sensors attached around the carotid artery could be used to precisely detect P-, T-, and D-waves arising from blood pressure.
Bio-Controlling Effect of Oyster Shell on Bacteria in Polluted Soil and Water in Seaside Areas
Yoo Bin Shin 국제과학영재학회 2016 APEC Youth Scientist Journal Vol.8 No.2
Water pollution is an alarming environmental problem. One of the largest unknown causes of ocean water pollution is the minimally used oyster shell that was wrongfully disposed of. Therefore, oyster shell waste was used to understand the degree of its effects on water pollution. In doing so, seawater and sea soil obtained from less-polluted and more-polluted areas of the Gwanganlli shore were cultivated with oyster shell or its extract. To measure the rate of bacterial growth, oyster shells were grinded into different sizes then extracted to cultivate bacteria. The growth rate was tested by measuring their absorbance. Finally to test whether oyster shell effectively suppress growth of malevolent bacteria, oyster shell extract was cultivated with 5 different malevolent bacteria. The results show that oyster shell extract is more effective in preventing the growth of bacteria collected from seawater than those collected from the soil. Specifically, oyster shell extract powder greater than 500um most effectively suppressed bacterial growth, but did not selectively inhibit the growth of malevolent bacteria caused by water pollution, instead inhibited entire growth. Moreover, >500um extract 5% solution effectively suppressed the growth of malevolent bacteria. Thus, spraying oyster shell or its extract on polluted shores can effectively suppress the growth of malevolent bacteria.