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Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4
The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway
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( Won Mook Choi ),( Jeong Hoon Lee ),( Young Ju Lee ),( Young Youn Cho ),( Minjong Lee ),( Jeong Ju Yoo ),( Yuri Cho ),( Dong Hyeon Lee ),( Yun Bin Lee ),( Su Jong Yu ),( Yoon Jun Kim ),( Jung Hwan Yo 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is closely related to metabolic syndrome and obesity which are associated with an increased cancer risk. In this study, we investigated the association between NAFLD and prostate cancer biochemical recurrence (BCR) after radical prostatectomy using imaging modalities. Methods: In total, consecutive 312 prostate cancer patients who underwent radical prostatectomy between 2005 and 2008 in Seoul National University Hospital (Seoul, Korea) were included in this study. The presence of NAFLD, body mass index (BMI), prediagnostic prostate-specific antigen (PSA), and pathologic findings including Gleason score were analyzed with regard to their associations with BCR. NAFLD was diagnosed based on clinical information and ultrasonography or non-contrast CT images. BCR-free survival rates were calculated using the Kaplan-Meier method. Results: A total of 222 patients were analyzed after 90 patients were excluded. We excluded patients with double primary cancers or evidence of liver disease of other etiologies including viral hepatitis, and patients who were treated with neoadjuvant hormone therapy or who failed to achieve PSA nadir < 0.1 ng/ mL. During a median follow-up period of 54 (range, 51-57) months, 45 (20.3%) patients developed BCR. Patients with NAFLD showed significantly better BCR-free survival (P=0.001 by log rank test), while patients grouped according to BMI failed to show any statistical significance (P=0.861). In the multivariate analysis, the presence of NAFLD (hazard ratio [HR], 0.25; 95% confidence interval [CI], 0.08-0.76; P=0.014) and pathological Gleason score (compared to <7, 7: HR, 2.69; 95% CI, 0.92-7.87, >7: HR, 6.02; 95% CI, 1.42-25.52; P=0.049) were independent predictive factors of BCR. Conclusions: Unexpectedly, the results of our study have shown that NAFLD may play a protective role against BCR after radical prostatectomy for prostate cancer. It is warranted to elucidate the mechanism of protective effect, such as the change in male hormone level, in patients with NAFLD.
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HBV : The Effect of Therapeutic Vaccination in the Treatment of Chronic Hepatitis B Virus Infection
( Yun Bin Lee ),( Jeong Hoon Lee ),( Young Youn Cho ),( Won Mook Choi,),( Jeong Ju Yoo ),( Minjong Lee ),( Dong Hyeon Lee ),( Yuri Cho ),( Su Jong Yu ),( Yoon Jun Kim ),( Jung Hwan Yoon ),( Chung Yong 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background/Aim: Although currently available antiviral drugs can efficiently suppress serum hepatitis B virus (HBV) viral load to an undetectable level, they usually fail to achieve seroclearance of HBV surface antigen (HBsAg) that indicates eradication of HBV infection. In this study, we compared the effect of therapeutic vaccination in patients in an inactive carrier phase with control patients. Methods: We included chronic hepatitis B (CHB) patients who were in an inactive HBsAg carrier state from January 2009 to November 2011. Seventeen patients who received therapeutic HBV vaccine were included in the vaccination group. The same number of matched patients were randomly selected and enrolled as the control group. HBsAg, HBeAg, anti-HBe, serum alanine aminotransferase and HBV DNA levels were assessed at 6 and 12 months from last administration of vaccine or from enrollment in both groups. Results: Three patients experienced HBsAg seroclearance at follow-up month 6: two patients (11.8%) in the vaccination group and one patient (5.9%) in the control group (P=1.000). At month 12, the majority of patients in both groups remained in an inactive phase (the vaccination group, 64.7% vs. the control group, 47.1%). In the vaccination group, only a low base- line HBsAg titer (≤100 IU/mL) was significantly related to a high frequency of HBsAg seroclearance (P=0.044). Conclusions: Therapeutic HBV vaccination is a potential therapeutic option for the control and eradication of CHB in inactive carriers with a low HBsAg titer. To enhance the efficacy and safety of such treatment, rational patient selection and novel therapeutic approaches are needed.
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( Jun Hee Lee ),( Chul Won Yun ),( Sang Hun Lee ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.3
Anti-cancer drug resistance is a major problem in colorectal cancer (CRC) research. Although several studies have revealed the mechanism of cancer drug resistance, molecular targets for chemotherapeutic combinations remain elusive. To address this issue, we focused on the expression of cellular prion protein (PrPC) in 5-FU-resistant CRC cells. In 5-FU-resistant CRC cells, PrPC expression is significantly increased, compared with that in normal CRC cells. In the presence of 5-FU, PrPC increased CRC cell survival and proliferation by maintaining the activation of the PI3K-Akt signaling pathway and the expression of cell cycle-associated proteins, including cyclin E, CDK2, cyclin D1, and CDK4. In addition, PrPC inhibited the activation of the stress-associated proteins p38, JNK, and p53. Moreover, after treatment of 5-FU-resistant CRC cells with 5-FU, silencing of PrPC triggered apoptosis via the activation of caspase-3. These results indicate that PrPC plays a key role in CRC drug resistance. The novel strategy of combining chemotherapy with PrPC targeting may yield efficacious treatments of colorectal cancer.
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YUN, CHUL WON,YUN, SEUNGPIL,LEE, JUN HEE,HAN, YONG-SEOK,YOON, YEO MIN,AN, DANIEL,LEE, SANG HUN Anticancer Research USA Inc. 2016 Anticancer research Vol.36 No.9
<P>Background: The putative functions of the cellular prion protein (PrPc) are believed to be associated with cell signaling, differentiation, survival, and cancer progression. With respect to cancer development and progression, elevations and mutations of PrPc expression have been shown to increase the risk for malignancy and metastasis in breast and colorectal cancer. Since both natural supplements and direct regulation of PrPc expression contribute to inhibition of cancer progression and growth, we hypothesized that knockdown of PrPc could lead to an enhanced synergic effect on the inhibition of cancer growth by fucoidan. Materials and Methods: PrPc expression was suppressed in HT29 human colon cancer cells by utilizing small-interfering RNA (si-PRNP), and cells were subsequently used to study the antiproliferative and anticancer effects of fucoidan treatment of HT29 human colon cancer cells. Results: Fucoidan treatment significantly inhibited growth and reduced cyclin and cyclin-dependent kinase (CDK) expression in HT29 colon cancer cells. Furthermore, silencing PrPc expression with si-PRNP amplified the fucoidan-induced changes in cell proliferation, apoptosis, and migration. Intraperitoneal injection of si-PRNP with fucoidan reduced proliferation and tumor volume in Balb/c nude mice. This enhanced antitumor efficacy was associated with decreased angiogenesis. Conclusion: Combination of fucoidan with silencing of PrPc has a synergic effect on the inhibition of HT29 colon cancer cell growth. Furthermore, we provide evidence for the therapeutic application of PrPc silencing with other anticancer drugs for cancer.</P>
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Economic Burdens and Quality of Life of Family Caregivers of Cancer Patients
Yun, Young Ho,Rhee, Young Sun,Kang, Im Ok,Lee, Jung Suk,Bang, Soo Mee,Lee, Won Sup,Kim, Jun Suk,Kim, Si Young,Shin, Sang Won,Hong, Young Seon S. Karger AG 2005 Oncology Vol.68 No.2
<P><I>Objectives:</I> We conducted this study to identify factors influencing the burdens cancer brings to a patient’s family and to evaluate the association between the burdens and the caregiver’s quality of life (QOL). <I>Methods:</I> Participants were drawn from the primary family caregivers of cancer patients at 6 university hospitals and the National Cancer Center in Korea. Of the 738 eligible caregivers, 704 (95.4%) completed the questionnaire packets (Family Impact Questions and Caregiver’s QOL-Cancer). <I>Results:</I> Caregivers, who were poor (OR, 2.11; 95% CI, 1.44-3.10), whose health status was poor (OR, 1.87; 95% CI, 1.29-2.70), who were married (OR, 1.75; 95% CI, 1.12-2.72), who provided care for a long time (OR, 2.29; 95% CI, 1.59-3.28), who cared for patients with poor performance status (OR, 1.35; 95% CI, 1.00-1.82), and who paid high medical expenses (OR, 1.70; 95% CI, 1.21-2.40), were more likely to lose their family savings. In multiple regression analysis, most burden variables - including requiring caregiving assistance, major life change, inability to function normally, loss of savings, loss of income, and altered educational plans - were associated with caregiver QOL. Loss of family income, which was related to economic issues, was most strongly associated with it (16.0%). <I>Conclusions:</I> Our study suggests that to improve caregiver QOL, we should give priority to decreasing the economic burden that cancer places on patient’s family.</P><P>Copyright © 2005 S. Karger AG, Basel</P>
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A study of clinical effect of iontophoresis mask patch using reverse electrodialysis technique
( Yun Ho Lee ),( Junghwa Yang ),( Jung Yup Kim ),( Sunmin Yim ),( Jae Yun Lim ),( Ju-yeon Choi ),( Han-saem Kim ),( Joon Hong Min ),( Young Jun Choi ),( Jae-hui Nam ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Previously, the reverse electrodialysis (RED) system was found to improve transdermal drug delivery compared to passive diffusion. Objectives: To evaluate antiaging effect and safety profile of iontophoresis mask patch using RED technique. Methods: This study was a prospective, spilt-face, controlled trial comparing iontophoresis mask patch using RED technique with passive diffusion mask patch. Clinical studies were performed on 20 Korean women for 5 weeks. We applied iontophoresis mask patch using RED on the right side of the face and passive diffusion mask patch on the left side of the face and treated four times at weekly intervals. Both mask patches contain same materials (SYN-AKE, oligo hyaluronic acid, leuphasyl, argireline etc.). Clinical effect was assessed by measuring erythema index, melasma index, stratum corneum hydration, and skin roughness at baseline, week1 (after 1 treatment), week 4 (after 4 treatment), and week 5 (1 week after 4 treatment). Results: After 4 treatment, improvements in the erythema index, stratum corneum hydration and skin roughness were significantly greater in the test side than in the control side. However, there was no statistically significant improvement in the melsma index on both side. Conclusion: This study suggests that iontophoresis mask patch using RED has a greater effect on antiaging than passive mask patch.
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Yun-Beom Sim,Soo-Hyun Park,Yu-Jung Kang,Sung-Su Kim,Chea-Ha Kim,Su-Jin Kim,Su-Min Lim,Jun-Sub Jung,Ohk-Hyun Ryu,Moon-Gi Choi,Hong-Won Suh 대한생리학회-대한약리학회 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.6
We have recently demonstrated that some anti-diabetic drugs such as biguanide and thizolidi-nediones administered centrally modulate the blood glucose level, suggesting that orally administered anti-diabetic drugs may modulate the blood glucose level by acting on central nervous system. The present study was designed to explore the possible action of another class of anti-diabetic drugs, glinidies, administered centrally on the blood glucose level in ICR mice. Mice were administered intracerebroventricularly (i.c.v.) or intrathecally (i.t.) with 5 to 30 μg of repaglinide or nateglinide in D-glucose-fed and streptozotocin (STZ)-treated models. We found that i.c.v. or i.t. injection with repaglinide dose-dependently attenuated the blood glucose level in D-glucose-fed model, whereas i.c.v. or i.t. injection with nateglinide showed no modulatory action on the blood glucose level in D-glucose-fed model. Furthermore, the effect of repaglinide administered i.c.v. or i.t. on the blood glucose level in STZ-treated model was studied. We found that repaglinide administered i.c.v. slightly enhanced the blood glucose level in STZ-treated model. On the other hand, i.t. injection with repaglinide attenuated the blood glucose level in STZ-treated model. The plasma insulin level was enhanced by repaglinide in D-glucose-fed model, but repaglinide did not affect the plasma insulin level in STZ-treated model. In addition, nateglinide did not alter the plasma insulin level in both D-glucose-fed and STZ-treated models. These results suggest that the anti-diabetic action of repaglinide appears to be, at least, mediated via the brain and the spinal cord as revealed in both D-glucose fed and STZ-treated models.
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Non-clinical pharmacokinetic behavior of ginsenosides
Won, Hyo-Joong,Kim, Hyun Il,Park, Taejun,Kim, Hyeongmin,Jo, Kanghee,Jeon, Hyojin,Ha, Seo Jun,Hyun, Jung Min,Jeong, Aeri,Kim, Jung Sik,Park, Ye Jin,Eo, Yun Ho,Lee, Jaehwi The Korean Society of Ginseng 2019 Journal of Ginseng Research Vol.43 No.3
Ginsenosides, the major active ingredients of ginseng and other plants of the genus Panax, have been used as natural medicines in the East for a long time; in addition, their popularity in the West has increased owing to their various beneficial pharmacological effects. There is therefore a wealth of literature regarding the pharmacological effects of ginsenosides. In contrast, there are few comprehensive studies that investigate their pharmacokinetic behaviors. This is because ginseng contains the complicated mixture of herbal materials as well as thousands of constituents with complex chemical properties, and ginsenosides undergo multiple biotransformation processes after administration. This is a significant issue as pharmacokinetic studies provide crucial data regarding the efficacy and safety of compounds. Moreover, there have been many difficulties in the development of the optimal dosage regimens of ginsenosides and the evaluation of their interactions with other drugs. Therefore, this review details the pharmacokinetic properties and profiles of ginsenosides determined in various animal models administered through different routes of administration. Such information is valuable for designing specialized delivery systems and determining optimal dosing strategies for ginsenosides.
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