히스테리시스 효과의 컴퓨터 시뮬레이션

류연국,양계준,한운동,박용만 충주대 산업과학기술연구소 1993 産業科學論文集 Vol.1 No.-

Usefulness of recent versions of PSPICE, personal computer implementation of the SPICE, circuit simulation computer software rogram is demonsterated in simulation of the hysteresis loops magnetic materials. In order to model the hysteresis loop of a particular magnetic core's B-H characteristics, the values of five parameters, which affect the shape of the hysteresis loops, must be established. There is no efficient procedure for selecting the values of five parameters. Neither the PSPICE instruction munual nor any current books or papers address this problem. This paper presents a method for illustrating the effect that each parameter has on the shape of the hysteresis loop.

Osteotome Sinus Floor Elevation Procedure를 이용한 임프란트 매식

송종운,조용기,박홍주,김영운,오희균,유선열 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.2

Maxillary sinus has an anatomic limitation to bone support available for dental implant. When there is less than 10㎜ of bone remaining between the upper alveolar ridge crest and the maxillary sinus floor, bone augmentation should be considered. In 1994, Summers reported two sinus floor elevation techniques of limmediate implant insertion, using osteotomes, for patients who have at least 5㎜ of bone remaining between the alveolar ridge crest and the maxillary sinus floor. One technique is osteotome sinus floor elevation (OSFE) procedure in which uses osteotomes to elevate the sinus floor. The other is bone-added OSFE (BAOSFE) procedure in which bone graft is added into osteotomy site. Both procedures conserve all of the remaining bone and selectively displace it upward, thereby raising sinus floor. This study was aimed to evaluate the long-term success rate of implants which had been placed by osteotome sinus floor elevation procedure. Between February 1996 and June 1998, 10 implants were placed using OSFE or BAOSFE procedures in 6 patients who had at least 6㎜ of bone remaining between the alveolar ridge crest and the sinus floor. OSFE procedures were performed in patiens, 2∼4㎜ sinus floor elevation was needed, whereas BAOSFE procedures were done in patines, more than 4㎜ sinus floor elevation was needed. During the mean follow-up period of 4 years 4 months (3 years 6 months ∼ 5 years 9 months), no implant was failed and all patients showed good functional results. OSFE and BAOSFE procedures seemed technically easier and less invasive compared to conventional sinus lift procedure. And both procedure have good success rate.

구내신연장치를 이용한 치조골증대술 후 임프란트 매식 : 치험 5예 REPORT OF 5 CASES

이용욱,박충열,송종운,박홍주,김영운,오희균,유선열 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.2

Successful alveolar ridge augmentation by distraction osteogenesis method has been reported previously. There are several types of devices for alveolar ridge augmentation. In this paper, a new intraoral distraction device was used on the severe atrophic mandible in order to distract an alveolar ridge vertically in 5 patients. Mean amount of distracted alveolar ridge was 7.4㎜ (5∼9.5㎜). Dental implants were placed in the distracted alveolar bone and good osseointegration was obtained in all patients. Mean follow up period is 2years 6months (7months∼4years 9months). No complications, such as infection or resorption was observed in all patients. Alveolar ridge augmentation by gradual distraction seems to be a safe, simple and reliable procedure.

외과적 보조의 급속상악확장술 : 치험 5예 REPORT OF 5 CASES

박충열,이용욱,송종운,김영운,박홍주,오희균,유선열,이기현,황현식 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Five adults (3 cases of bilateral posterior crossbite, 2 cases of unilateral posterior crossbite) with intermaxillary discrepancy of over 5㎜ due to maxillary transverse deficiency were treated by surgically assisted rapid maxillary expansion (SARME). Bilateral maxillary horizontal osteotomies, osteotomies of pterygomaxillary junction and anterior lateral nasal wall, ans anterior palatal osteotomy were performed in 4 cases, and unilateral osteotomies in 1case, followed by palatal expansion with tooth-borne orthopedic applicance. No significant complication was observed. The mean palatal expansion was 7.2㎜ (5.8∼10.0㎜) in the maxillary first molar region. During the mean follow-up period of 4 years (5 months∼8 years 7 months), no recurrence of crossbite was observed in all cases. The SARME seemed to be a simple, stable, and reliable procedure for achieving a permanent increase of over 5㎜ in skeletal maxillary transverse width of adults.

구개부에 발생한 다형선종의 처치

하주원,백승,송종운,박충열,이용욱,박홍주,오희균,유선열,김옥준 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

Pleomorphic adenoma of the palate is the most common of all intraoral salivary tumors. It can occur at any age but it presents most commonly in the 40∼60 age group, and there is no significant sex preponderance. It grows slowly and is usually painless, firm, well-circumscribed nodule. Because of high rate of recurrence, extra-capsular excision including the overlying mucosa and margin of normal tissue is recommended. We report 10 cases of palatal pelomorphic adenoma which have been successfully treated by extra-capsular excision. The surgical defects smaller than 3㎝ in diameter were covered with palatal acrylic splint for the secondary healing. The larger defects were repaired using palatal island flap in 3 cases, rotation flap and buccal fat graft in each 1 case. No patient showed any recurrence or malignant change during the mean follow-up period of 4 years and 9 months. These repair methods seem to be simple, reliable and uncomplicated procedures in the palatal surgical defects.

Characterization of Pubertal Development Phases in Female Longtooth Grouper, Epinephelus bruneus via Classification of Bodyweight

Ryu, Yong-Woon,Hur, Sang-Woo,Hur, Sung-Pyo,Lee, Chi-Hoon,Lim, Bong-Soo,Lee, Young-Don The Korean Society of Developmental Biology 2013 발생과 생식 Vol.17 No.1

Puberty is the developmental period which animals obtain the ability of reproducing sexually for the first time in life. In commercially important aquaculture fish species, the onset of puberty is a matter of major interest due to controlling of sexual maturation to improve broodstock management. To investigate pubertal characteristics of female longtooth grouper (Epinephelus bruneus), specimens were classified into three groups by the bodyweight, including 1, 2, and 3 kg group. Thereafter, we focused on ovarian development and level changes of endocrine regulation factors (GnRH, GTHs, steroid hormone). In the non-breeding season (April), the levels of endocrine regulation factors showed increasing trends in accordance with bodyweight gaining; nevertheless, the oocytes were growth phase belongs to almost peri-nucleous stages in all groups. In the breeding season (June), the levels of endocrine regulation factors were fluctuated that decreases in levels of sbGnRH and $FSH{\beta}$ mRNA expressions along with serum $E_2$ concentrations in 3 kg of group. However, $LH{\beta}$ mRNA expression levels sustained increasing trends by the bodyweight. Moreover, the oocytes developed that 2 kg and 3 kg groups obtained plentiful vitellogenic oocytes while 1 kg group was still composed with greater part of pre-vitellogenic oocytes. Especially, the oocytes of 3 kg group reached over 450 ${\mu}m$ of diameters that indicating possibility to enter the final maturations. These results suggest that the progress of pubertal development in female E. bruneus could be classify into three phases via bodyweight, including pre-puberty (1 kg), early-puberty (2 kg) and puberty (3 kg).

Characterization of Pubertal Development Phases in Female Longtooth Grouper, Epinephelus bruneus via Classification of Bodyweight

Yong-Woon Ryu,허상우,허성표,이치훈,임봉수,이영돈 한국발생생물학회 2013 발생과 생식 Vol.17 No.1

Puberty is the developmental period which animals obtain the ability of reproducing sexually for the first time in life. In commercially important aquaculture fish species, the onset of puberty is a matter of major interest due to controlling of sexual maturation to improve broodstock management. To investigate pubertal characteristics of female longtooth grouper (Epinephelus bruneus), specimens were classified into three groups by the bodyweight, including 1, 2,and 3 kg group. Thereafter, we focused on ovarian development and level changes of endocrine regulation factors (GnRH,GTHs, steroid hormone). In the non-breeding season (April), the levels of endocrine regulation factors showed increasing trends in accordance with bodyweight gaining; nevertheless, the oocytes were growth phase belongs to almost peri-nucleous stages in all groups. In the breeding season (June), the levels of endocrine regulation factors were fluctuated that decreases in levels of sbGnRH and FSHβ mRNA expressions along with serum E2 concentrations in 3 kg of group. However, LHβmRNA expression levels sustained increasing trends by the bodyweight. Moreover, the oocytes developed that 2 kg and 3 kg groups obtained plentiful vitellogenic oocytes while 1 kg group was still composed with greater part of pre-vitellogenic oocytes. Especially, the oocytes of 3 kg group reached over 450 μm of diameters that indicating possibility to enter the final maturations. These results suggest that the progress of pubertal development in female E. bruneus could be classify into three phases via bodyweight, including pre-puberty (1 kg), early-puberty (2 kg) and puberty (3 kg).

위장관 ( 胃腸管 ) : 소화기암과 연관되어 발생한 다발적 원발성 악성종양

윤용범(Yong Bum Yoon),송인성(In Sung Song),김정룡(Chung Yong Kim),이효석(Hyo Suk Lee),최상운(Sang Woon Choi),최규완(Kyu Wan Choi),김용태(Yong Tae Kim),한철주(Cheol Joo Han),이준혁(Joon Hyeok Lee),류지곤(Ji Kon Ryu),정현채(Hyun Chae C 대한소화기학회 1991 대한소화기학회지 Vol.23 No.3

N/A Owing to the development of diagnostic techniques and treatment modalities, more and more cases of multiple primary cancers are being discovered and active researches concerning maltiple primary cancers are being done. The mortrality due to cancers of gastrointestinal tract occupies more than two thirds (68.4%) of total number of deathes due to cancers in Korea, but researches on multiple primary cancers concerning gastrointestinal tract are lacking. We reviwed 70 cases of multiple primary cancers concerning gastrointestinal tract, we experienced in the past decade. The ratio of male to female was 3.7:1, the mean age was 52.8 years. From 70 patients with multiple primary cancers, sixty patients had synchronous multiple primary cancers and ten patients had metachronous ones. The frequent sites involved were stomach (51.9%) and liver (21.2%). The most frequent combination of primary and secondary cancer was stomach cancer and primary liver cancer (27%). These results may be contributed to the actual incidence of each cancer, and routine staging work-up of liver for stomach cancer and routine gastroopy for primary liver cancer. In synchronous cancers, majority of the second cancers were found incidentally during routine staging work-up (58.3%) or during operation (8.4%), whereas only 33.3% of second cancers were found due to concomittent symtoms. Thus the incidence of each multiple primary cancer in our study may reflect the relative frequency of each cancer in Korea. In order to determine the true risk of occurrence of multiple primary cancers in Korea, prospective studies based on the large population of community should be conducted.

The merlin tumor suppressor interacts with Ral guanine nucleotide dissociation stimulator and inhibits its activity

Ryu, Chung Hun,Kim, Sae-Woong,Lee, Kyu Hwa,Lee, Joo Yong,Kim, Hongtae,Lee, Woon Kyu,Choi, Byung Hyune,Lim, Young,Kim, Young Hoon,Lee, Kweon-Haeng,Hwang, Tae-Kon,Jun, Tae-Youn,Rha, Hyoung Kyun Nature Publishing Group 2005 Oncogene Vol.24 No.34

Neurofibromatosis type 2 (NF2) is the most commonly mutated gene in benign tumors of the human nervous system such as schwannomas and meningiomas. The NF2 gene encodes a protein called schwannomin or merlin, which is involved in regulating cell growth and proliferation through protein–protein interactions with various cellular proteins. In order to better understand the mechanism by which merlin exerts its function, yeast two-hybrid screening was performed and Ral guanine nucleotide dissociation stimulator (RalGDS), a downstream molecule of Ras, was identified as a merlin-binding protein. The direct interaction between merlin and RalGDS was confirmed both in vitro and in the NIH3T3 cells. The domain analyses revealed that the broad C-terminal region of merlin (aa 141–595) is necessary for the interaction with the C-terminal Ras-binding domain (RBD) of RalGDS. Functional studies showed that merlin inhibits the RalGDS-induced RalA activation, the colony formation and the cell migration in mammalian cells. These results suggest that merlin can function as a tumor suppressor by inhibiting the RalGDS-mediated oncogenic signals.Oncogene (2005) 24, 5355–5364. doi:10.1038/sj.onc.1208633; published online 27 June 2005

Alcaligenes eutrophus의 배양액으로부터 균체 분리 효율에 미치는 철(Fe)계 응집제의 효과

류희욱,조경숙,곽종운,장용근 한국산업미생물학회 1998 한국미생물·생명공학회지 Vol.26 No.3

Alcaligenes eutrophus의 세포배양액(23-21Og dry weight/L)으로부터 균체 회수 효율에 미치는 철계 응집제 첨자 효과에 대해 연구하였다. 응집제로는 무기 응집제인 Fe_2(SO_4)_3과 무기 고분자 응집제인 Ferix-3를 사용하였다. 철계 응집제는 3-13의 넓은 pH 범위에서 응집효과를 나타내었으며, 배양액의 pH가 증가할수록 floc의 크기는 증가하였다. 균체 회수를 위한 배양액의 최적 pH는 10-13이었다. 최적 응집제의 첨가량은 세포농도가 증가함에 따라 증가하였는데, 무기응집제인 Fe_2(SO_4)_3보다는 무기고분자응집제인 Ferix-3이 적은 농도에서 응집효율이 우수함을 알 수 있었다. 210 g/L의 세포농도 배양액에 Ferix-3을 1300 mg Fe/L를 첨가하면 45×g의 낮은 원심력에 의해 95% 이상의 균체를 회수 가능하였다. 응집제의 요구량은 배양액 중의 NH^+_4, 농도에 비례하여 증가하였고, 배양액 중의 NH^+_4 농도가 1 g 증가하면 응집제가 0.066 g Fe^3+ 정도 더 요구되었다. Alcaligenes eutrophus was successfully recovered from high cell density broth by pre-treatment with Fe-based coagulants. An inorganic coagulant, Fe_2(SO_4)_3, and a polymerized coagulant, Ferix-3, were used. Good coagulation was observed in broad pH range of 3 to 13, the floc size was increased with increasing pH of culture broth. The optimum pH of fermentation broth for cell recovery was 10 to 13. The optimum coagulant dosages to recover cells with 95% cell recovery were increased with increasing cell concentration. Optimal coagulant dosage was lower when the polymerized coagulant was used rather than the inorganic coagulant. The coexistence of NH^+_4 was increased coagulant requirement, and the coagulant requirement was 0.066g Fe^3+/g NH^+_4.