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Han Ying-Hao,Mao Ying-Ying,Yu Nan-Nan,Jin Mei-Hua,Jin Ying-Hua,Wang Ai-Guo,Zhang Yong-Qing,Shen Gui-Nan,Cui Yu-Dong,Yu Li-Yun,Lee Dong-Seok,Jo Yu-Jin,Sun Hu-Nan,Kwon Jeongwoo,권태호 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
In this study, we used RNA sequencing (RNA-seq) to analyze and compare bulk cell samples from wild-type (WT) dermal mesenchymal stem cells (DMSCs) (n = 3) and Prx II knockout DMSCs (n = 3). The purpose of the study was to elucidate the role of Prx II on allogeneic immune rejection of transplanted DMSCs. The results revealed differential expression of 472 genes (176 up-regulated and 296 down-regulated; p ≤ 0.05) between the PrxII+/+ (WT) and PrxII−/− sample groups. When highly regulated genes were categorized according to the Gene Ontology (GO) molecular function classification and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the PrxII−/− samples showed a robust downward trend in allograft rejection. The study identified 43 all immunologically rejected differentially expressed genes, of which 41 showed lower expression in the PrxII−/− vs. PrxII+/+ (WT) samples. These findings suggest that Prx II gene knockout may down-regulate the allograft rejection that occurs during DMSCs transplantation and improve the survival rate of DMSCs in the host. This study provides a new perspective on the clinical treatment of stem cell transplantation.
Han Ying-Hao,Chen Dong-Qin,Jin Mei-Hua,Jin Ying-Hua,Li Jing,Shen Gui-Nan,Li Wei-Long,Gong Yi-Xi,Mao Ying-Ying,Xie Dan-Ping,Lee Dong-Seok,Yu Li-Yun,Kim Sun-Uk,김지수,권태호,Cui Yu-Dong,Sun Hu-Nan 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macrophage cells. Our results showed that hispidin treatment significantly reduced the production of cellular NO, IL-6 and reactive oxygen species (ROS) while has not inhibitory effect on TNF-α productions. Excitingly, hispidin treatment retains the phagocytosis ability of macrophages which enabling them to perform the function of removing foreign invaders. Signaling studies showed, hispidin treatment dramatic suppressed the LPS induced mitogen activated protein kinases (MAPK) and JAK/STAT activations. In conclusion, our findings suggest that hispidin may be a new therapeutic target for clinical treatment of macrophages-mediated inflammatory responses.
Hu, Ying,Chen, Liyan,Jung, Hyeseung,Zeng, Yiying,Lee, Songyi,Swamy, Kunemadihalli Mathada Kotraiah,Zhou, Xin,Kim, Myung Hwa,Yoon, Juyoung American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.34
<P>Three o-phenylendiamine (OPD) derivatives, containing 4-chloro-7-nitrobenzo [c] [1,2,5] oxadiazole (NBD-OPD), rhodamine (RB-OPD), and 1,8-naphthalimide (NAP-OPD) moieties, were prepared and tested as phosgene chemosensors. Unlike previously described methods to sense this toxic agent, which rely on chemical processes that transform alcohols and amines to respective phosphate esters and phosphoramides, the new sensors operate through a benzimidazolone-forming reaction between their OPD groups and phosgene. These processes promote either naked eye visible color changes and/or fluorescence intensity enhancements in conjunction with detection limits that range from 0.7 to 2.8 ppb. NBD-OPD and RB-OPD-embedded polymer fibers, prepared using the electrospinning technique, display distinct color and fluorescence changes upon exposure to phosgene. even in the solid state.</P>
Hu, Ying,Joung, Joonyoung F.,Jeong, Ji-Eun,Jeong, Yerin,Woo, Han Young,She, Yuanbin,Park, Sungnam,Yoon, Juyoung Elsevier 2019 Sensors and actuators. B Chemical Vol.280 No.-
<P><B>Abstract</B></P> <P>2-(Benzothiazol-2-yl)pyren-1-ol (<B>P3-NS</B>) was developed as a excited-state intramolecular proton transfer (ESIPT)- based sensor for nitroaromatic compounds (NACs). Results of studies of its photophysical and optical properties show that <B>P3-NS</B> exists in various, solvent dependent isomeric forms arising from rotation about the CC bond connecting the benzothiazole and pyren-1-ol rings and the location of the pyrene-OH proton. The results of density functional theory (DFT) calculations enabled identification of the major structures of <B>P3-NS</B> dissolved in different solvents. Upon electronic excitation in nonpolar or weakly polar solvents, <B>P3-NS</B> undergoes an ESIPT reaction to form a product that only weakly fluoresces. In contrast, <B>P3-NS</B> exists in a strongly fluorescent deprotonated form in highly polar solvents. The results of time-dependent DFT calculations indicate that fluorescence quenching of the product generated by ESIPT reaction of <B>P3-NS</B> is caused by intersystem crossing at a conical intersection between S<SUB>1</SUB> and T<SUB>2</SUB> states. The anionic form of <B>P3-NS</B>, present in highly polar solvents, was shown to be a fluorescence sensor for nitroaromatic compounds (NACs). Fluorescence quenching by NACs occurs by protonation of the anionic form of <B>P3-NS</B> (static quenching) and by photoinduced electron transfer from the anionic form to NACs (dynamic quenching).</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new hydroxypyrene derivative <B>P3-NS</B> bearing benzothiazole is developed as a fluorescent sensor for nitroaromatic compounds. </LI> <LI> <B>P3-NS</B> undergoes excited-state intramolecular proton transfer reaction in nonpolar or weakly polar solvents. </LI> <LI> <B>P3-NS</B>, as a sensor, exhibits a selective strong response to picric acid over other nitroaromatic compounds. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Electrochemical Reductive Removal of Nitrate from Water and Wastewater
Hu, Hong-Ying,Fujie, Koichi,Goto, Naohiro 영남대학교 환경문제연구소 2000 環境硏究 Vol.20 No.1
The purpose of this study is to evaluate the possibility of some zero-valent metals such as aluminum, zinc and iron as reductants to convert nitrate in water into nitrogen gas under acidic conditions. Based on the results of comparative studies on the reduction of nitrate by metallic iron, zinc and aluminum, respectively, metallic iron was selected as a reductant of nitrate in this study. The effect of pH on the reduction rate and products of nitrate was investigated with a fixed dosage of iron powder (size: 80 mesh) of 12 mol-Fe/mol-N under acidic (pH=2-5) and aerobic conditions. The reduction of nitrate by metallic iron was a pseudo-first order reaction under our experimental conditions. The reduction rate of nitrate was increased with decreasing pH of the reaction solution, arid the pseudo-first order reaction rate constants were 0.49, 0.40, 0.75 and 0.01 1/h at pH =2, 3, 4 and 5, respectively. The reduction products of nitrate were ammonia and nitrogen, and their yields were strongly affected by pH. The yields of nitrogen was 30%, 31% and 45% at pH=3, 4 and 5, respectively, but no formation of nitrogen was found at pH=2. It was also demonstrated that the indirect reduction of nitrate by hydrogen generated from the reaction between proton and metallic iron was a major mechanism for the reduction of nitrate under the experimental conditions.
FOXA1: a Promising Prognostic Marker in Breast Cancer
Hu, Qing,Luo, Zhou,Xu, Tao,Zhang, Jun-Ying,Zhu, Ying,Chen, Wei-Xian,Zhong, Shan-Liang,Zhao, Jian-Hua,Tang, Jin-Hai Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Accurate diagnosis and proper monitoring of cancer patients remain important obstacles for successful cancer treatment. The search for cancer biomarkers can aid in more accurate prediction of clinical outcome and may also reveal novel predictive factors and therapeutic targets. One such prognostic marker seems to be FOXA1. Many studies have shown that FOXA1 is strongly expressed in a vast majority of cancers, including breast cancer, in which high expression is associated with a good prognosis. In this review, we summarize the role of this transcription factor in the development and prognosis of breast cancer in the hope of providing insights into utility of FOXA1 as a novel biomarker.
Hu Ying,Liu Rongbo,Gao Fabao 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.7
Objective: To investigate the age-dependent changes in regional cerebral blood flow (CBF) in healthy adults by fitting mathematical models to imaging data. Materials and Methods: In this prospective study, 90 healthy adults underwent pseudo-continuous arterial spin labeling imaging of the brain. Regional CBF values were extracted from the arterial spin labeling images of each subject. Multivariable regression with the Akaike information criterion, link test, and F test (Ramsey’s regression equation specification error test) was performed for 7 models in every brain region to determine the best mathematical model for fitting the relationship between CBF and age. Results: Of all 87 brain regions, 68 brain regions were best fitted by cubic models, 9 brain regions were best fitted by quadratic models, and 10 brain regions were best fitted by linear models. In most brain regions (global gray matter and the other 65 brain regions), CBF decreased nonlinearly with aging, and the rate of CBF reduction decreased with aging, gradually approaching 0 after approximately 60. CBF in some regions of the frontal, parietal, and occipital lobes increased nonlinearly with aging before age 30, approximately, and decreased nonlinearly with aging for the rest of life. Conclusion: In adults, the age-related perfusion patterns in most brain regions were best fitted by the cubic models, and age-dependent CBF changes were nonlinear.