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- 저자 : Yin Huang (검색결과 219 건)
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Yin Huang,Yaoyao Pan,Xiaoyu Huang,Jialu Zhao,Xiuhua Wang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.118 No.-
During water electrolysis, multifunctional electrocatalysts with outstanding functionality and endurancemust be thoughtfully constructed and designed. Below, we report a hollow NiS@Ni2P nanoframeheterostructure that works well as a substitute catalyst for the urea oxidation and general water splittingreactions. The hollow NiS@Ni2P nanoframe was synthesized by ion exchange, sulfurization and phosphating,which is favorable for achieving a heterostructure. The NiS@Ni2P catalyst exhibits excellent catalyticactivity and strong long-term stability in 1.0 M KOH solutions for the hydrogen evolution reaction, whichneeds 121 mV to achieve 10 mA cm2. And for the oxygen evolution reaction, the catalyst needs 311 mVto acquire 50 mA cm2. These advantages come from the optimal electronic structural configuration,hierarchical hollow nanoframe structure, and large surface area. It could attain 10 mA cm2 at 1.41 Vwhen utilized as a urea oxidation reaction anode, which is lower than the oxygen evolution reaction. For total water splitting and urea oxidation process, NiS@Ni2P as a bifunctional catalyst holds tremendouspromise due to its strong electrocatalytic activity, ease of manufacture, and low cost of raw ingredients.
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Yin, Fugui,Yin, Yulong,Kong, Xiangfeng,Liu, Yulan,He, Qinghua,Li, Tiejun,Huang, Ruilin,Hou, Yongqing,Shu, Xugang,Tan, Liangxi,Chen, Lixiang,Gong, Jianhua,Kim, Sung Woo,Wu, Guoyao Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.9
This study was conducted to investigate the effects of Acanthopanax senticosus extract (ASE) as a dietary additive on gut microflora in weaned piglets. A total of sixty pigs were weaned at 21 d of age (BW = $5.64{\pm}0.23kg$) and allocated on the basis of BW and litter to three dietary treatments in a randomized complete block design. The dietary treatments were: control group (basal diet), antibiotics group (basal diet+0.02% colistin), and ASE group (basal diet+0.1% ASE). On d 7, 14 and 28 after consuming the experimental diets, five piglets per group were sacrificed and then the contents from the jejunum, ileum and cecum were collected to determine changes in the microbial community by using a polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) technique and estimating the contents of Lactobacillus and E. coli by in vitro culturing methods. The results showed that the ASE promoted the microflora diversity in the cecum. Enumeration of bacteria in the gut contents showed that the number of Lactobacillus increased (p<0.05), while that of E. coli decreased (p<0.05) when compared with the other 2 groups as the days of age progressed post-weaning. These findings suggested that the ASE, as a substitute for dietary antimicrobial products, could improve the development of the normal gut microflora and suppress bacterial pathogens, and effectively promote a healthy intestinal environment.
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Pharmaceutical R&D Project Management under Risk
Yin Huang,Xiamial Li,Dapeng Liu 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10
Market pressure and tough socio-political regulations are among the current factors that are changing the way in which the pharmaceutical business is operated. The pharmaceutical industries and faced with the question of the best use of the limited resources available to obtain the highest possible profit from a potential product portfolio. Pharmaceutical products differ somewhat from other products. In the sense, pharmaceutical R&D project management under risk is crucial for quick responses to changing market trends. For this reason, a great deal of the recent research has focused on the research and development(R&D) projects. This article reviews the current literature in R&D project management under risk for medical and pharmaceutical products., The review discusses some interesting open research questions in this field, and points out new directions for future research.
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Huang, Yin-Jiu,Zhang, Yu-Yuan,Liu, Gang,Tang, Jie,Hu, Jian-Guo,Feng, Zhen-Zhong,Liu, Fang,Wang, Qi-Yi,Li, Dan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
Cervical cancer is one the most common malignancies among females. In recent years, its incidence rate has shown a rising trend in some countries so that development of anticancer drugs for cervical cancer is an urgent priority. In our recent anticancer drug discovery screen, 1, 2-di (quinazolin-4-yl)diselane (LG003) was found to possess wide spectrum anticancer efficacy. In the present work, the in vitro anticancer activity of LG003 was evaluated in the SiHa cervical cancer cell line. Compared with commercial anticancer drugs 10-hydroxycamptothecin, epirubicin hydrochloride, taxol and oxaliplatin, LG003 showed better anticancer activity. Furthermore, inhibition effects were time- and dose-dependent. Morphological observation exhibited LG003 treatment results in apoptosis like shrinking and blebbing, and cell membrane damage. Lactate dehydrogenase release assay revealed that LG003 exerts such effects in SiHa cells through a physiology pathway rather than cytotoxicity, which suggests that title compound LG003 can be a potential candidate agent for cervical cancer.
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Numerical Modeling of Creep Degradation of Natural Soft Clays under One-dimensional Condition
Qi-Yin Zhu,Zhen-Yu Yin,Dong-Mei Zhang,Hongwei Huang 대한토목학회 2017 KSCE JOURNAL OF CIVIL ENGINEERING Vol.21 No.5
Creep degradation is a common phenomenon of natural soft clays. This paper focuses on developing a one-dimensional constitutive model considering the influence of bond degradation on the creep behavior for natural soft clays. First, conventional oedometer creep tests are studied and a creep based structure indicator ϖ denoting the difference between the creep coefficient of the reconstituted samples and that of intact samples is proposed. Then, the creep coefficient of intact clay is formulated by this indicator and the intrinsic creep coefficient corresponding to reconstituted clay. This formula is then incorporated into a one-dimensional creep model to describe the creep degradation behavior induced by bond degradation. The model parameters can be determined in a straightforward way from oedometer tests which leads to an easy application of the model for practice. Furthermore, coupled with the consolidation theory, the model is used to simulate oedometer tests at constant strain rate as well as long-term creep tests on sensitive Batiscan clay. The destructuration effects on the evolution of creep coefficient are analyzed. The comparisons between experimental and numerical results show that the proposed model can precisely describe the creep degradation behavior induced by destructuration of natural soft clay under one-dimensional loading.
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( Jinli Huang ),( Juan Huang ),( Tianyi Yin ),( Huiyun Lv ),( Pengyu Zhang ),( Huajun Li ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.2
Bacillus subtilis and Enterococcus faecium are commonly used probiotics. This study aimed to identify the effect of live combined Bacillus subtilis R0179 and Enterococcus faecium R0026 (LCBE) on obesityassociated hyperlipidemia and gut microbiota in C57BL/6 mice. Forty male C57BL/6 mice were divided into four groups: normal group (N group), model group (M group), low-dose group (L group), and high-dose group (H group). Mice were gavaged with LCBE at 0.023 g/mice/day (L group) or 0.23 g/mice/day (H group) and fed with a high-fat diet for 8 weeks. In vitro E. faecium R0026 showed an ability to lower the low-concentration of cholesterol by 46%, and the ability to lower the highconcentration of cholesterol by 58%. LCBE significantly reduced the body weight gain, Lee index, brown fat index and body mass index of mice on a high-fat diet. Moreover, LCBE markedly improved serum lipids (including serum triglyceride, total cholesterol, low-density lipoprotein and highdensity lipoprotein) while also significantly reducing liver total cholesterol. Serum lipopolysaccharide and total bile acid in L and H groups decreased significantly compared with M group. PCR-DGGE analysis showed that the composition of gut microbiota in the treatment groups was improved. Akkermansia muciniphila was found in H group. The PCA result indicated a similar gut microbiota structure between LCBE treatment groups and normal group while the number of bands and Shannon diversity index increased significantly in the LCBE treatment groups. Finally, qPCR showed Bifidobacterium spp. increased significantly in H group compared with M group, LCBE alleviated liver steatosis and improved brown adipose tissue index.
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Lairong Yin,Lei Tian,Long Huang,Juan Huang,Dang Zhou,Anwei Jiang 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.2
We present a solution-region based approach for the synthesis of straight-line linkages, which is based on the stationary curvature point on curve and higher order stationery point theory of infinite approximation geometry. The selection of the Ball-Burmester point and the distribution of the solution-regions are discussed in this work. Further, two alternative cases have been analyzed for finding the Ball-Burmester point positions of the crank-rocker straightline mechanism, when one side-link is collinear with the frame. The distribution diagrams of the Ball-Burmester point positions are depicted to help the designers extract complete solutions. Infinite solu-tions for the mechanism can be expressed for each case on a diagram by employing the solution-region method. These diagrams will help the designers find the inherent mechanism intuitively and streamline the selection of results. The results indicate that the efficiency of design and reliability have been effectively improved owing to the implementation of these methods.
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Scaling up the in-hospital hepatitis C virus care cascade in Taiwan
( Chung-feng Huang ),( Pey-fang Wu ),( Ming-lun Yeh ),( Ching-i Huang ),( Po-cheng Liang ),( Cheng-ting Hsu ),( Po-yao Hsu ),( Hung-yin Liu ),( Ying-chou Huang ),( Zu-yau Lin ),( Shinn-cherng Chen ),( 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.1
Background/Aims: Obstacles exist in facilitating hepatitis C virus (HCV) care cascade. To increase timely and accurate diagnosis, disease awareness and accessibility, in-hospital HCV reflex testing followed by automatic appointments and a late call-back strategy (R.N.A. model) was applied. We aimed to compare the HCV treatment rate of patients treated with this strategy compared to those without. Methods: One hundred and twenty-five anti-HCV seropositive patients who adopted the R.N.A. model in 2020 and another 1,396 controls treated in 2019 were enrolled to compare the gaps in accurate HCV RNA diagnosis to final treatment allocation. Results: The HCV RNA testing rate was significantly higher in patients who received reflex testing than in those without reflex testing (100% vs. 84.8%, P<0.001). When patients were stratified according to the referring outpatient department, a significant improvement in the HCV RNA testing rate was particularly noted in patients from non-hepatology departments (100% vs. 23.3%, P<0.001). The treatment rate in HCV RNA seropositive patients was 83% (83/100) after the adoption of the R.N.A. model, among whom 96.1% and 73.9% of patients were from the hepatology and non-hepatology departments, respectively. Compared to subjects without R.N.A. model application, a significant improvement in the treatment rate was observed for patients from non-hepatology departments (73.9% vs. 27.8%, P=0.001). The application of the R.N.A. model significantly increased the in-hospital HCV treatment uptake from 6.4% to 73.9% for patients from non-hepatology departments (P<0.001). Conclusions: The care cascade increased the treatment uptake and set up a model for enhancing in-hospital HCV elimination. (Clin Mol Hepatol 2021;27:136-143)
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Pei-Ying Huang,Xin Yin,Yue-Ting Huang,Qi-Qing Ye,Si-Qing Chen,Xun-Jie Cao,Tian-Ao Xie,Xu-Guang Guo 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.5
Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen of coronavirus disease 2019. Diagnosticmethods based on the clustered regularly interspaced short palindromic repeats (CRISPR) have been developed to detect SARSCoV-2 rapidly. Therefore, a systematic review and meta-analysis were performed to assess the diagnostic accuracy of CRISPR fordetecting SARS-CoV-2 infection. Materials and Methods: Studies published before August 2021 were retrieved from four databases, using the keywords “SARS-CoV-2”and “CRISPR.” Data were collected from these publications, and the sensitivity, specificity, negative likelihood ratio (NLR), positivelikelihood ratio (PLR), and diagnostic odds ratio (DOR) were calculated. The summary receiver operating characteristic curve wasplotted for analysis with MetaDiSc 1.4. The Stata 15.0 software was used to draw Deeks’ funnel plots to evaluate publication bias. Results: We performed a pooled analysis of 38 independent studies shown in 30 publications. The reference standard was reversetranscription-quantitative PCR. The results indicated that the sensitivity of CRISPR-based methods for diagnosis was 0.94 (95% CI0.93–0.95), the specificity was 0.98 (95% CI 0.97–0.99), the PLR was 34.03 (95% CI 20.81–55.66), the NLR was 0.08 (95% CI 0.06–0.10), and the DOR was 575.74 (95% CI 382.36–866.95). The area under the curve was 0.9894. Conclusion: Studies indicate that a diagnostic method based on CRISPR has high sensitivity and specificity. Therefore, this wouldbe a potential diagnostic tool to improve the accuracy of SARS-CoV-2 detection.
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