Prediction of the compressive and tensile strength of HPC concrete with fly ash and micro-silica using hybrid algorithms

Yin, Hang,Liu, Shuxian,Lu, Shasha,Nie, Wei,Jia, Baoxin 테크노프레스 2021 Advances in concrete construction Vol.12 No.4

Evaluating the impact of fly ash (FA) and micro-silica (MS) on the tensile (TS) and compressive strength (CS) of concrete in different ages provokes to find the effective parameters in predicting the CS and TS, which not only could be usable in the practical works but also is extensible in the future analysis. In this study, in order to evaluate the effective parameters in predicting the CS and TS of concrete containing admixtures and to present a fitted equation, the multivariate adaptive regression splines (MARS) method has been used, which could find a relationship between independent and dependent variables. Next, for optimizing the output equation, hybrid genetic algorithm (GA), particle swarm optimization (PSO), and grey wolf optimization (GWO) methods have been utilized to find the optimal conclusions. It could be concluded that for both predictions of CS and TS, all models have the coefficient of determination (R²) larger than 0.949 and 0.9138, respectively. Furthermore, between three hybrid algorithms, MARS-PSO could be proposed as the best model to obtain the most accuracy in the prediction of CS and TS. The usage of hybrid MARS-PSO techniques causes a noticeable improvement in the prediction procedure.

Activation of Small GTPases RhoA and Rac1 Is Required for Avian Reovirus p10-induced Syncytium Formation

Hung-Jen Liu,Ping-Yuan Lin,Ling-Rung Wang,Hsue-Yin Hsu,Ming-Huei Liao,Wen-Ling Shih 한국분자세포생물학회 2008 Molecules and cells Vol.26 No.4

The first ORF of the ARV S1133 S1 segment encodes the nonstructural protein p10, which is responsible for the induction of cell syncytium formation. However, p10-dependent signaling during syncytium formation is fully unknown. Here, we show that dominant negative RhoA, Rho inhibitor C3 exoenzyme, ROCK/Rho-kinase inhibitor Y-27632 and Rac1 inhibitor NSC23766 inhibit p10-mediated cell fusion. p10 over-expression is concomitant with activation and membrane translocation of RhoA and Rac1, but not cdc42. RhoA and Rac1 downstream events, including JNK phosphorylation and transcription factor AP-1 and NF-B activation, as well as MLC expression and phosphorylation are simultaneously activated by p10. p10 point mutant T13M possessed 20% fusion-inducing ability and four p10 fusion-deficient mutants V15M, V19M, C21S and L32A reduced or lost their ability to activate RhoA and Rac1 signaling. We conclude that p10-mediated syncytium formation proceeds by utilizing RhoA and Rac1-dependent signaling.

Synthesis of ginsenoside Rb₁-imprinted magnetic polymer nanoparticles for the extraction and cellular delivery of therapeutic ginsenosides

Liu, Kai-Hsi,Lin, Hung-Yin,Thomas, James L.,Shih, Yuan-Pin,Yang, Zhuan-Yi,Chen, Jen-Tsung,Lee, Mei-Hwa The Korean Society of Ginseng 2022 Journal of Ginseng Research Vol.46 No.5

Background: Panax ginseng (ginseng) is a traditional medicine that is reported to have cardioprotective effects; ginsenosides are the major bioactive compounds in the ginseng root. Methods: Magnetic molecularly imprinted polymer (MMIP) nanoparticles might be useful for both the extraction of the targeted (imprinted) molecules, and for the delivery of those molecules to cells. In this work, plant growth regulators were used to enhance the adventitious rooting of ginseng root callus; imprinted polymeric particles were synthesized for the extraction of ginsenoside Rb₁ from root extracts, and then employed for subsequent particle-mediated delivery to cardiomyocytes to mitigate hypoxia/reoxygenation injury. Results: These synthesized composite nanoparticles were first characterized by their specific surface area, adsorption capacity, and magnetization, and then used for the extraction of ginsenoside Rb₁ from a crude extract of ginseng roots. The ginsenoside-loaded MMIPs were then shown to have protective effects on mitochondrial membrane potential and cellular viability for H9c2 cells treated with CoCl₂ to mimic hypoxia injury. The protective effect of the ginsenosides was assessed by staining with JC-1 dye to monitor the mitochondrial membrane potential. Conclusion: MMIPs can play a dual role in both the extraction and cellular delivery of therapeutic ginsenosides.

Rapid Phase Selection Method based on Multi-resolution Morphological Gradient with Series Structure

Yuheng Yin,Lei Wang,Hang Liu,Qi Fan 보안공학연구지원센터 2013 International Journal of Control and Automation Vol.6 No.2

Ginsenoside Rk1 inhibits HeLa cell proliferation through an endoplasmic reticulum signaling pathway

Qiuyang Li,Hang Sun,Shiwei Liu,Jinxin Tang,Shengnan Liu,Pei Yin,Qianwen Mi,Jingsheng Liu,Lei yu,Yunfeng Bi 고려인삼학회 2023 Journal of Ginseng Research Vol.47 No.5

Background: Changes to work-life balance has increased the incidence of cervical cancer among youngerpeople. A minor ginseng saponin known as ginsenoside Rk1 can inhibit the growth and survival ofhuman cancer cells; however, whether ginsenoside Rk1 inhibits HeLa cell proliferation is unknown. Methods and results: Ginsenoside Rk1 blocked HeLa cells in the G0/G1 phase in a dose-dependentmanner and inhibited cell division and proliferation. Ginsenoside Rk1 markedly also activated theapoptotic signaling pathway via caspase 3, PARP, and caspase 6. In addition, ginsenoside Rk1 increasedLC3B protein expression, indicating the promotion of the autophagy signaling pathway. Protein processingin the endoplasmic reticulum signaling pathway was downregulated in Gene Ontology (GO) andKyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, consistent with tealtimequantitative PCR and western blotting that showed YOD1, HSPA4L, DNAJC3, and HSP90AA1expression levels were dramatically decreased in HeLa cells treated with ginsenoside Rk1, with YOD1was the most significantly inhibited by ginsenoside Rk1 treatment. Conclusion: These findings indicate that the toxicity of ginsenoside Rk1 in HeLa cells can be explained bythe inhibition of protein synthesis in the endoplasmic reticulum and enhanced apoptosis, with YOD1acting as a potential target for cervical cancer treatment.

Effect of patient decision aids on choice between sugammadex and neostigmine in surgeries under general anesthesia: a multicenter randomized controlled trial

Wang Li-Kai,Lin Yao-Tsung,Chen Jui-Tai,Lan Winnie,Hung Kuo-Chuan,Chen Jen-Yin,Liu Kuei-Jung,Yen Yu-Chun,Chou Yun-Yun,Cherng Yih-Giun,Tam Ka-Wai 대한마취통증의학회 2023 Korean Journal of Anesthesiology Vol.76 No.4

Background: Shared decision making using patient decision aids (PtDAs) was established over a decade ago, but few studies have evaluated its efficacy in Asian countries. We therefore evaluated the application of PtDAs in a decision conflict between two muscle relaxant reversal agents, neostigmine and sugammadex, and sequentially analyzed the regional differences and operating room turnover rates.Methods: This multicenter, outcome-assessor-blind, randomized controlled trial included 3,132 surgical patients from two medical centers admitted between March 2020 and August 2020. The patients were randomly divided into the classical and PtDA groups for pre-anesthesia consultations. Their clinicodemographic characteristics were analyzed to identify variables influencing the choice of reversal agent. On the day of the pre-anesthesia consultation, the patients completed the four SURE scale (sure of myself, understand information, risk-benefit ratio, encouragement) screening items. The operating turnover rates were also evaluated using anesthesia records. Results: Compared with the classical group, the PtDA group felt more confident about receiving sufficient medical information (P < 0.001), felt better informed about the advantages and disadvantages of the medications (P < 0.001), exhibited a superior understanding of the benefits and risks of their options (P < 0.001), and felt surer about their choice (P < 0.001). Moreover, the PtDA group had a significantly greater tendency to choose sugammadex over neostigmine (P < 0.001). Conclusions: PtDA interventions in pre-anesthesia consultations provided surgical patients with clear knowledge and better support. PtDAs should be made available in other medical fields to enhance shared clinical decision-making.

Synergistic effect of adsorption and photocatalysis of BiOBr/lignin-biochar composites with oxygen vacancies under visible light irradiation

Qiang Yang,Xiang Li,Qingwen Tian,Aixiang Pan,Xingjian Liu,Hang Yin,Yingqiao Shi,Guigan Fang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.117 No.-

Effective utilization solar energy through photocatalysis is an ideal way to solve environmental problemsand achieve sustainable development. Herein, a novel BiOBr/Lignin-Biochar photocatalyst has been successfullysynthesized by a simple hydrothermal method. The number of oxygen vacancies of BiOBrincreased after C doping, which improves visible-light absorbance, reduces the recombination ofphoto-generated carriers and promotes O2 activation to produce O2. UV–vis DRS result demonstratedthat the visible-light absorption capacity of BiOBr improved significantly with the addition of lignin. Compared with BiOBr, the adsorption and photocatalytic ability of BiOBr/Lignin-Biochar composites weregreatly enhanced due to enriched oxygen vacancies and the congenerous effect between BiOBr andlignin-biochar. The RhB removal with pure BiOBr and BiOBr/Lignin-Biochar under visible-light irradiationat 60 min was 54.5% and 99.2%, respectively, owing to the interface interaction between BiOBr and ligninbiocharpromoted the separation between electron and holes and the enrichment of RhB around the photocatalysts. Notably, the bandgap of BiOBr/Lignin-Biochar composites decreased from 2.65 eV to 2.56 eVafter C doping, useful for visible-light-driven photocatalysis. The superoxide radical anions (O2) were themain active species, as demonstrated by free radical capture experiments and ESR characterizationresults. Hence, the present work provides new insights into constructing cost-effective, high-efficiencycomposite materials for environmental remediation.

Scaling up the in-hospital hepatitis C virus care cascade in Taiwan

( Chung-feng Huang ),( Pey-fang Wu ),( Ming-lun Yeh ),( Ching-i Huang ),( Po-cheng Liang ),( Cheng-ting Hsu ),( Po-yao Hsu ),( Hung-yin Liu ),( Ying-chou Huang ),( Zu-yau Lin ),( Shinn-cherng Chen ),( 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.1

Background/Aims: Obstacles exist in facilitating hepatitis C virus (HCV) care cascade. To increase timely and accurate diagnosis, disease awareness and accessibility, in-hospital HCV reflex testing followed by automatic appointments and a late call-back strategy (R.N.A. model) was applied. We aimed to compare the HCV treatment rate of patients treated with this strategy compared to those without. Methods: One hundred and twenty-five anti-HCV seropositive patients who adopted the R.N.A. model in 2020 and another 1,396 controls treated in 2019 were enrolled to compare the gaps in accurate HCV RNA diagnosis to final treatment allocation. Results: The HCV RNA testing rate was significantly higher in patients who received reflex testing than in those without reflex testing (100% vs. 84.8%, P<0.001). When patients were stratified according to the referring outpatient department, a significant improvement in the HCV RNA testing rate was particularly noted in patients from non-hepatology departments (100% vs. 23.3%, P<0.001). The treatment rate in HCV RNA seropositive patients was 83% (83/100) after the adoption of the R.N.A. model, among whom 96.1% and 73.9% of patients were from the hepatology and non-hepatology departments, respectively. Compared to subjects without R.N.A. model application, a significant improvement in the treatment rate was observed for patients from non-hepatology departments (73.9% vs. 27.8%, P=0.001). The application of the R.N.A. model significantly increased the in-hospital HCV treatment uptake from 6.4% to 73.9% for patients from non-hepatology departments (P<0.001). Conclusions: The care cascade increased the treatment uptake and set up a model for enhancing in-hospital HCV elimination. (Clin Mol Hepatol 2021;27:136-143)