Exploring the beneficial role of telmisartan in sepsis-induced myocardial injury through inhibition of high-mobility group box 1 and glycogen synthase kinase-3β/nuclear factor-κB pathway

Yan Jin,Hong Wang,Jing Li,Minyan Dang,Wenzhi Zhang,Yan Lei,Hao Zhao 대한생리학회-대한약리학회 2020 The Korean Journal of Physiology & Pharmacology Vol.24 No.4

In the present experimental study, cecal ligation and puncture significantly increased the myocardial injury assessed in terms of excess release of creative kinase-MB (CK-MB), cardiac troponin I (cTnI), interleukin (IL)-6 and decrease of IL-10 in the blood following 12 h of laparotomy procedure as compared to normal control. Also, a significant increase in protein expression levels of high-mobility group box 1 (HMGB1) and decreased phosphorylation of glycogen synthase kinase-3β (GSK-3β) was observed in the myocardial tissue as compared to normal control. A single independent administration of telmisartan (2 and 4 mg/kg) and AR-A014418 (1 and 2 mg/kg) substantially reduced sepsis-induced myocardial injury in terms of decrease levels of CK-MB, cTnI and IL-6, HMGB1, GSK-3β and increase in IL-10 and p-GSK-3β in the blood in sepsis- subjected rats. The effects of telmisartan at dose 4 mg/kg and AR-A014418 at a dose of 2 mg/kg were significantly higher than the telmisartan at a dose of 2 mg/kg and AR-A014418 1 mg/kg respectively. Further, no significant effects on different parameters were observed in the sham control group in comparison to normal. Therefore it is plausible to suggest that sepsis may increase the levels of angiotensin II to trigger GSK-3β-dependent signaling to activate the HMGB1/receptors for advanced glycation end products, which may promote inflammation and myocardial injury in sepsis-subjected rats.

Job Satisfaction Effects on Performance: Moderating Effect of Ability

( Yan Jin ) 한국인터넷비즈니스학회 2011 인터넷비지니스연구 Vol.12 No.1

Researchers have developed a relationship between job satisfaction and job performance, but the moderating effect on job satisfaction and performance like ability remains unexplored. This research, based on a study of employees of retail stores of KT, SK and LG telecommunication, it was hypothesized that job satisfaction effected on performance, and ability as a moderator developed the effect of them Questionnaire was collected 200 from these corporate retail stores, the statistic result provided ability The statistic analysis result provided that ability didn`t have influence on effect of job satisfaction on performance, but people need ability, like knowledge, skills and abilities (KSA) to compete with others in a corporate, the findings suggest that ability of an employee is an important part for a corporate, and requires due attention of individual ability. The research extends the findings of individual ability study pursued in a corporate, especially in retail stores of company.

Continuous Production of Immunoliposomes using a Microvalve-controlled Microfluidic Device (μFD)

Yan Jin,김소현,김명희,박성수 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.10

Immunoliposomes (antibody-conjugated liposomes) are highly useful as both a drug carrier in drug delivery and as a reporting probe in immunodiagnostics. However, antibody conjugation is lengthy and cumbersome, because this includes several steps such as derivatization of the antibody, conjugation of the derivatized antibody to liposomes, and separation of the unbound antibodies from immunoliposomes. Recently, liposome preparation steps have simplified by using microfluidic devices (μFDs) where liposomes are formed when a stream of lipids in solvent is hydrodynamically focused between two oblique buffer streams in a microchannel. Herein, we report a simple method for the production of immunoliposomes (rabbit IgG-conjugated liposomes) using microvalve-controlled μFD. The presence of antibody on the liposome was verified by observing the binding of immunoliposomes to rabbit IgG on the surface. The results suggest that immunoliposomes can be easily prepared through sequential mixing of antibody, conjugation reagents, preformed liposomes using microvalve-controlled μFD.

A simple and reliable analytical method based on HPLC–UV to determine oleanonic acid content in Chios gum mastic for quality control

Yan Jin,Jing Zhao,정경민,유다은,한세영,최수영,고동현,김현지,성나혜,이정미 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.1

A reliable analytical method based on highperformanceliquid chromatography-ultraviolet detectionwas established for the determination of oleanonic acid(OA) content in Chios gum mastic (CGM). A simplemethod involving methanol extraction of CGM powderfollowed by basification and ether extraction was developedto isolate the triterpenic fraction including OA. Thetriterpenic fraction was chromatographed on a PhenomenexGemini C18 column (150 9 4.6 mm, 5 lm) under asimple gradient elution of a mobile phase containing acetonitrileand water at a flow rate of 1.0 mL min-1. Thedetection wavelength was set at 210 nm. Good linearitywas achieved in the range of 100.0–1000.0 lg mL-1 withr2[0.9993, and the limit of quantification was32.22 lg mL-1. Accuracy measured at three concentrationlevels was in the range of 93.72–99.56%, while intra-dayand inter-day precisions estimated using both OA standardand CGM samples were no more than 2.83 and 4.57%RSD, respectively. Finally, this method was applied to realCGM samples from various batches, revealing that the OAcontents were between 88.13 and 100.83 lg mg-1. Theseresults suggest that the current method can be applied as anefficient analytical method for quality control of CGM.

Recent Reform in College English Testing in China

Yan Jin 한국영어평가학회 2007 영어평가 Vol.1 No.1

In the context of the recent reform in college English teaching in China, the College English Test (CET), one of the biggest EFL tests in the world, is undergoing major changes. The paper will begin with a brief introduction to the CET designers understanding of the social responsibilities of this large-scale high-stakes test and the continuous reform of the test over the past 18 years. The dilemma facing the CET in recent years is that the test s stakeholders have high expectations for the test reform, hoping that it will have a more positive impact on teaching and learning, but as the stakes of the test become higher, it is increasingly difficult or risky to make changes to the test in order to achieve the intended washback. The perplexing situation echoes the growing awareness in the field of language testing that washback does exist but it is a hugely complex matter. Simply changing the test content and format may not necessarily bring about the intended changes in teaching and learning. In the second part, the author will present language testers understanding and definition of washback, which is viewed as an integral part of test validity. In this part, recent innovations and reforms made by some influential large-scale standardized English tests like TOEFL and IELTS will also be reviewed. The paper will then provide an analysis of the reasoning behind the recent reform of the CET and the package of measures that were taken recently, which aimed at addressing the negative washback of the test. The third part of the paper will report the rationale, the research questions and the methodology of the on-going research of the CET washback, which is necessitated by the desire to monitor the process of the reform and look into the effects brought about by the recent reform on college English teaching and learning.

Understanding and Leading Through Crises: The Contingency Theory and Beyond

Yan Jin,Wenqing Zhao Korean Academic Society For Public Relations 2023 Asian Journal of Public Relations Vol.6 No.1

Based on the essentials of the Korean Academic Society for Public Relations (KASPR) 2022 Distinguished Lecture given by Dr. Glen T. Cameron and Dr. Yan Jin, this conceptual piece provides an overview of the contingency theory of strategic conflict management, its application to research, and future directions, with a focus on the theory-practice interconnections of the contingency theory in public relations across multiple contexts. How the contingency theory has been and can be further applied to advancing crisis communication and conflict management research and practice in Asia is further discussed.

Serodiagnosis of Echinococcosis by ELISA Using Cystic Fluid from Uzbekistan Sheep

Yan Jin,Khikmat Anvarov,Abdukhakim Khajibaev,Samin Hong,Sung-Tae Hong 대한기생충학열대의학회 2013 The Korean Journal of Parasitology Vol.51 No.3

Serodiagnosis of Toxocariasis by ELISA Using Crude Antigen of Toxocara canis Larvae

Yan Jin,Chenghua Shen,Sun Huh,Woon-Mok Sohn,Min-Ho Choi,Sung-Tae Hong 대한기생충학열대의학회 2013 The Korean Journal of Parasitology Vol.51 No.4

The Relation between the United States and the Countries of the Korean Peninsula in the 1970s: A Survey of the Chinese Academic Literature

Yan Jin 건국대학교 인문학연구원 2018 통일인문학 Vol.4 No.1

In recent years, the relations between the United States (US) and the countries of the Korean Peninsula began to play a more important role for China. With the improvement of the level of Chinese scholarship, as well as the rapid declassification of the archival material on pre-1980 Cold War history, there emerged a lot of academic publications in China on the 1970s history of US relations with the two Koreas. Although Chinese scholars took different perspectives on this subject, the mainstream view maintains that with the ease of the Cold War tensions in the Northeast Asia, the relations between the United States and the countries on the Peninsula changed in the varying degrees in the 1970s: on the one hand, although the United States and South Korea still maintained their alliance, their relationship was characterized by friction and contradictions, as the issue of the withdrawal of the US troops and the human rights debates had vividly demonstrated; on the other hand, US-North Korean relations were marked by the rapid process of bilateral relaxation. In general, Chinese academic literature on US-South Korean relations is much more profound compared to the scholarly work on American relations with North Korea. And while in recent years remarkable progress has been made by Chinese scholars, there is still plenty of room for improvement, especially in terms of broadening interdisciplinary studies and theory, utilizing multi-archival material, conducting in-depth research of the political systems, the decision-making processes in the relevant countries, as well as the politics within the lower levels of government, etc.

Understanding and Leading Through Crises: The Contingency Theory and Beyond

( Yan Jin ),( Wenqing Zhao ) 한국PR학회 2023 AJPR Vol.6 No.1

Based on the essentials of the Korean Academic Society for Public Relations (KASPR) 2022 Distinguished Lecture given by Dr. Glen T. Cameron and Dr. Yan Jin, this conceptual piece provides an overview of the contingency theory of strategic conflict management, its application to research, and future directions, with a focus on the theory-practice interconnections of the contingency theory in public relations across multiple contexts. How the contingency theory has been and can be further applied to advancing crisis communication and conflict management research and practice in Asia is further discussed.