데페록사민 전처치가 토끼 심근경색 크기의 감소에 미치는 효과

양관모,오동렬,박승현,박규남,이원재,김형국,황두영,최승필,채장성 대한응급의학회 1998 대한응급의학회지 Vol.9 No.4

Background: Reperfusion of ischemic myocardium has been postulated to result in a specific oxygen radical mediated tissue injury. Iron may liberate during ischemia and we hypothesized that administration of the iron chelator, deferoxamine during ischemia would result in improved recovery after postischemic reperfusion. Purpose: To test whether iron-catalyzed processes contribute to myocardial necrosis during ischemia and reperfusion, deferoxamine was administered to block iron catalyzed hydroxyl radical formation in rabbits. Methods: Eleven rabbits were divided into two groups : control group (n=5) and deferoxamine pretreatment group (n=6). The left circumflex coronay artery was ligated for 30 minutes and reperfused for 180 minutes. Area at risk (AR) was measured by non-stained area with methylene blue injection into left atrium after left circumflex coronary artery ligation. Infarct size was measured by weighing after triphenyltetrazolium chloride staining. Heart rate was measured using electrocardiographic recording and systemic blood pressure was monitored by pressure transducer connected to the catheter in the left ventricle. Results: 1. There was no significant difference of heart rate and blood pressure in deferoxamine pretreatment group compared with control group. 2. There was significant decrease of serum iron concentration after continuous infusion of deferoxamine compared with serum iron concentration before ligation of coronary artery(P<0.05). 3. There was no significant difference of area at risk between control and deferoxamine pretreatment group. 4. Area at necrosis to area at risk was significantly reduced in deferoxamine pretreatment group compared with control group(P<0.05). The results suggest that deferoxamine infusion prior to coronary artery occlusion has a significant benefit in reducing infarct size in this model.

국내산 및 제초제 내성 콩(HS2906)의 일반성분, 무기질 및 지방산 조성

양윤형,이정희,김형진,윤원기,김환묵,김미리 동아시아식생활학회 2005 동아시아식생활학회지 Vol.15 No.1

Proximate analysis, mineral and fatty acid composition of three conventional domestic soybean cultivars and two imported ones including glyphosate-tolerant HS2906 were evaluated by AOAC method, ICP-AES and gas chromatography. There were several differences in the proximate analysis among three conventional domestic soybean cultivars ; higher crude fat in the cultivar Hwanggumkong, higher crude protein in Pungsankong, and higher carbohydrate and crude ash in Duyukong. The ranges of contents of proximate components of domestic cultivars were similar to the data previously reported. There were no significant differences in proximate analysis between conventional soybean WS82 and glyphosate-tolerant HS2906 ; 23.55~23.90% of crudefat, 34.22~35.55% of crude protein, 6.25~6.45% of crude ash, and 25.35~26.47% of carbohydrate. The mineral and fatty acid compositions of HS2906 were similar to those of conventional soybeans previously reported.

성인 Ⅲ급 부정교합자의 SELLA TURCICA의 형태 및 크기에 관한 연구 : The Possibility of Sella Turcica as Class Ⅲ Growth Prediction Indicator SELLA TURCICA 부피의 Ⅲ급 부정교합 예측 지표로서의 가능성

양원식,하태헌 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.2

Sella는 오랜 동안 교정학에 있어 필수적인 landmark로서 중요한 위치를 차지해 왔다. 그러나 sella turcica는 그 안에 성장호르몬을 비롯한 많은 중요 호르몬을 분비하는 뇌하수체를 함유하고 있는 구조물로서 sella turcica의 크기는 뇌하수체의 크기를 비교적 정확히 반영한다고 알려져 있다. 따라서 뇌하수체의 크기가 그 기능이 서로 비례한다면 두부방사선 사진에서 관찰되는 sella turcica의 크기와 성장호르몬을 비롯한 여러 뇌하수체 호르몬의 분비 차이에 의한 악골부조화와 이로 인한 Ⅲ급 부정교합과의 상관관계도 의심해 볼 수 있다. 따라서 본 연구에서는 50명의 정상교합자 남녀와 50명의 Ⅲ급 부정교합자 남녀를 대상으로 하여 측모 두부방사선사진과 전후방 두부방사선 사진에서 관찰되는 sella turcica의 부피를 구하고 두부방사선 분석을 통해 Ⅲ급 부정교합간의 상관관계를 구하였다. 연구결과 정상교합군보다 Ⅲ급 부정교합군에서 sella turcica의 부피가 유의하게 큰 것으로 나타났으며 (p<0.001), Ⅲ급 부정교합군에서 여성이 남성보다 더 큰 sella turcica 부피를 갖는 것으로 나타났다(P<0.05). 또한 Ⅲ급 부정교합을 반영하는 APDI, ANB, effective mandibular length등의항목에서 sella turcica 부피와 높은 상관관계를 나타냈고 전두개저 길이에 대한 sella turcica 부피의 비를 표시하는 Sella Index는 sella turcica부피자체보다 Ⅲ급 부정교합을 더 정확히 반영하였다. 따라서 악안면 발육에 대한 성장호르몬의 효과나 sella turcica 부피와 뇌하수체 호르몬 분비량과의 관계에 대한 지속적인 연구, sella turcica 부피에 따른 악안면 성장에 대한 장기적인 연구를 바탕으로 Sella Index를 Ⅲ급 부정교합을 예측하는 지표로서 활용할 수 있을 것이다. Sella turcica contains pituitary gland that has influence on craniofacial growth. So, if the volume of sella turcica correlate to the function of pituitary gland, we can assume that the volume of sella turcica in skeletal Class Ⅲ patients has some difference to that of normal occlusion group. The purpose of this study was to evaluate the difference of shape and volume of sella turcica between normal occlusion group and Class Ⅲ patients. The shape of sella turcica was Classified by Inaba method and the volume of sella turcica was measured in lateral and P-A cephalograms by Di Chiro method. To find out the possibility of the volume of sella turcica as diagnostic aid to predict Class Ⅲ growth pattern, the correlation coefficients between the volume of sella and cephalometric variables were calculated. The results were as follows. 1. The volume of sella turcica in Class Ⅲ patients is larger than that of normal occlusion groups 2. The volume of sella turcica in female was larger than that of male in Class Ⅲ patients 3. The volume of sella turcica has close correlation with APDI, ANB, SNA, SNB, ODI, gonial angle, post. cranial base length 4. Sella Index(vloume of sella/ ant. cranial base length) can be a more accurate indicator that represent Class Ⅲ growth pattern that volume of sella itself. 5. The morphologic pattern of sella turcica had no significant difference between two groups.

하수슬러지의 固形化 특성에 관한 연구

원양수,안승표 嶺南大學校 環境問題硏究所 1994 環境硏究 Vol.14 No.1

대구시 신천 및 달서천 하수처리장에서 발생되는 하수슬러지 탈수케익의 고형화 특성에 관한 연구를 위해 고화제로 보통 포틀랜드시멘트와 특수(초조강) 시멘트를 사용하였다. 대구시 하수슬러지의 고형화 특성에 대한 영향을 분석하기 위해 배합비, 양생조건, 양생기간을 변화시켰을때의 감용율, 감량율, 압축강도, pH, 재침수율 및 중금속 용출시험의 결과를 통한 적정 처리방법을 검토하였으며 주요 실험결과는 다음과 같다. 기건양생 조건일 경우, 시멘트의 배합비는 높을수록 감용율, 감량율 및 재침수율은 낮게 나타났으나, 반대로 압축강도는 크게 증가하였다. 중금속 (Cu, Pb, Cr, Cd) 용출시험 결과 기준치보다는 낮은 용출농도를 나타내었다. This study was carried out to estimate the solidification characteristics of sewage sludge emitted from Dalseochun and Shinchun Sewage treatment Plant. The solidification binders used were two types, portland cement and special(super high early strength) cement. The solidification tests were conducted to observe reducing weight, reducing volumn, compressive strength, pH of the extract solution, water immersion ratio and concentration of heavy metals leached from cured sewage sludge by varing cement/sludge ratio, curing condition and curing time. In case of dry curing condition, reducing weight, reducing volumn and water immersion ratio decreased, but compressive strength increased significantly as the cement/sludge ratio increased. The concentration of heavy metals (Cu, Pb, Cr, Cd) leached from cured sewage sludge was less than that of standard regulation.

Benson's Group Additivity Method를 이용한 다환방향족 탄화수소화합물의 열역학적 물성치에 대한 평가

원양수,박자영 嶺南大學校 環境問題硏究所 1993 環境硏究 Vol.13 No.1

넓은 온도범위에 따른 정확한 열역학적 물성치들은 연소나 Rocket propulsion등 반응 메카니즘을 이해하기 위해서 기본적으로 필요하다. Benson's group additivity method는 기체상분자들과 라디칼의 엔탈피, 엔트로피, 열용량을 평가하는 방법이다. 본 연구의 목적은 문헌치를 이용할 수 없는 종류들의 열역학적 물성치들을 평가하는 것이다. Benson's method에 의한 computer code인 THERM 을 이용해 PAHs 와 할로겐 화합물의 열역학적 물성치들을 평가해 보았다. PAH's와 할로겐 화합물의 엔탈피를 문헌치와 비교해 본 결과 문헌치와 평가치와의 편차는 클로로벤젠 0.0KJ/mol에서 Pyrene 15.11KJ/mol의 범위를 나타내었으며, 평가오차는 0.0%에서 7.0%의 범위를 나타낸다. 또한 온도에 따른 반응열, 엔트로피변화량, Gibbs 자유에너지와 평형상수를 계산했다. Accurate thermodynamic property data over a wide temperature range is required to know detailed reaction mechanisms in combustion, rocket propulsion, and so on. Benson's group additivity method is an accurate method for the estimation of ideal gas phase enthalpies, entropies and heat capacities of molecules and radicals. The purpose of this study is to estimate thermodynamic properties for species which are not available in literature. The thermodynamic properties(enthalpy, entropy, heat capacity) of PAHs and halogen compounds are estimated by THERM based on Benson's group additivity method. Enthalpies(H) for PAHs and halogen compounds are compared with literature values obtained from various sources. Deviations between literature values and estimates range from 0.0 KJ/mol for chlorobenzene to 15.11 KJ/mol for pyene and % errors do from 0.0% to 7.0%. In addition, heat of reation, entropy change, Gibbs free energy change, and equilibrium constant are calculated as functions of temperature.

수동식 시료채취기를 이용한 사무실 직장인의 이산화질소 노출평가 및 예측 : 한국의 서울과 호주의 브리스베인 비교 연구 Comparative Study of Seoul in Korea and Brisbane in Australia

양원호,손부순,김종오 한국환경과학회 2002 한국환경과학회지 Vol.11 No.3

Indoor and outdoor nitrogen dioxide (NO_2) concentrations were measured and compared with measurements of personal exposures of 95 persons in Seoul, Korea and 57 persons in Brisbane, Australia, respectively. This activity diary was used to determine the impact on NO_2 exposure assessment and microenvironmental model to estimate the personal NO_2 exposure. Most people both Seoul and Brisbane spent their times more than 90% of indoor and more than 50% in home, respectively. Personal NO_2 exposures were significantly associated with indoor NO_2 levels with Person coefficient of 0.70 (p<0.01) and outdoor NO_2 levels with Person coefficient of 0.66 (p<0.01) in Seoul and of 0.51 (p<0.01) and of 0.33 (p<0.05) in Brisbane, respectively. Using microenvironmental model by time weighted average model, personal NO_2 exposures were estimated with NO_2 measurements in indoor home indoor office and outdoor home. Estimated NO_2 measurements were significantly correlated with measured personal Exposures (r = 0.69, p<0.001) in Seoul and in Brisbane (r = 0.66, p<0.001), respectively. Difference between measured and estimated NO_2 exposures by multiple regression analysis was explained that NO_2 levels in near workplace and other outdoors in Seoul (p = 0.023), and in transportation in Brisbane (p = 0.019) affected the personal NO_2 exposures.

이동통신 채널환경에서 공간다이버시티 수신시 합성 변조 기법을 채용한 DS-CDMA시스템의 성능해석

양원일 조선대학교 에너지.자원신기술연구소 1999 에너지·자원신기술연구소 논문지 Vol.21 No.1

본 논문에서는 합성변조기법인 MFSK-MDRSK/DS-CDMA 시스템을 이용하였으며 Nakagami 페이딩 환경에서 MRC 다이버시티 수신기법을 채용한 시스템을 제안하였으며 오율을 평가하였다. Nakagami 페이딩 환경에서 MFSK-MDRSK/DS-CDMA 시스템에서 다이버시티 기법을 채용하여 성능의 개선 정도를 알아보았으며, 또한, 전력효율과 대역폭효율이 기존의 방식인 MFSK/DS-CDMA, MDRSK/DS-CDMA시스템 보다 합성변조기법인 MFSK-MDRSK/DS-CDMA 시스템의 전력효율 및 주파수 대역폭 효율을 개선시킬 수 있음을 알았다.

토끼 태자에 형성시킨 구순열상의 치유과정에서 세포외기질 분포에 관한 연구

양원식,백승학 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.1

태아와 성체의 상처치유과정에서 다른 점으로는 태아 상처가 염증반응과 반흔조직의 생성이 없이 신속히 치유됨을 들수 있다. 태자상처의 비반흔성 치유와 세포외기질의 역할을 연관지어 해석하려는 노력이 진행중에 있으나, 각 실험 동물종간의 차이 및 세포외기질 구성요소의 다양성 등 많은 변수가 아직 미결의 과제로 남아 있다. 본 연구의 목적은 토끼 태자의 상처 치유과정에서 반흔조직의 형성과 관련이 있는 세포외 기질의 주요성분인 교원질 Ⅰ,Ⅲ,Ⅳ,Ⅴ형, fibronectin, laminin의 시기적 출현 및 분포양상을 조사하기 위한 것이다. 뉴질랜드산 흰 토끼를 임신 3기의 중반인 24일 째에 자궁절개술을 시행하고 태자에 인위적으로 구순열상을 만든 후, 봉합한 군(봉합군)과 봉합하지 않은 군(비봉합군), 정상대조군(sham operation group)으로 나누고 이들을 각각 수술 후 1,2,3,5,7일째에 희생시켜 상처치유에 대한 육안관찰 소견과 H&F염색소견 및 교원질Ⅰ,Ⅲ,Ⅳ,Ⅴ형, fibronectin, laminin의 면역조직화학적 염색 소견을 관찰하여 다음과 같은 결론을 얻었다. 1. 봉합군과 비봉합군에서 전기간동안 염증반응은 없었다. 2. 비봉합군의 재상피화가 봉합군에 비해 다소 느렸다. 3. 교원질 Ⅰ,Ⅲ,Ⅴ형은 봉합군과 비봉합군에서 2일군까지는 발견되지 않았고 3일군 이후 존재하였으나 염색정도가 인접정상조직이나 정상대조군에 비하여 증가하지 않았다. 4. 상피 기저막에서 교원질 Ⅳ형의 염색소견은 봉합군과 비봉합군에서 3일군이 다소 증가하였으나 그후 감소하여 인접정상조직이나 정상조직이나 정상대조군과 차이가 없었고, laminin의 염색소견은 봉합군과 비봉합군에서 5일군이후 발견되었고 염색정도의 증감없이 7일군까지 유지되었고 인접정상조직이나 정상대조군과 차이가 없었다. 5. 혈관내피세포 기저막에서 laminin과 교원질 Ⅳ형의 염색소견은 인접정상조직이나 정상대조군에 비해서 증가하지 않았다. 6. Fibronectin은 봉합군과 비봉합군에서 fibrin clot과 창상 기저부 및 창상연을 따라 3일군까지 염색소견이 증가하였다가 그후 감소하여 인접정상조직이나 정상대조군과 차이가 없었다. Adult wound healing is accompanied with inflammation and eventual scar formation, whereas fetal wounds heal rapidly by mesenchymal prpliferation without significant inflammatory cell participation and with minimal or no scar formation. The cellular mechanisms underlying these differing forms of wound healing are unknown but the extracellular matrix, through its effects on cell function, may play a key role. Therefore the purpose of this study is to investigate the spatial and temporal deposition of several component of extracellular matrix, which are known to be involved with scar formation, in the artificially created cleft lip wound healing of fetuses. The author had undergone hysterotomy and created cleft lip-like defects on fetuses of New Zealand White Rabbit in mid-third trimester(24 days). Fetuses were divided into the repaired group, the unrepaired group and the sham-operated control group. At 1,2,3,5,7 days after procedure, fetuses were obtained by Caeserean section. After documenting the viability of fetuses, they were photographed to compare size and facial morphology and sectioned for histological examination by H&E stain and spatial and temporal deposition of collagen typeⅠ,Ⅲ,Ⅳ,Ⅴand fibronectin, laminin by immunohistochemical method. The findings are summarized as follows 1. There were lack of inflammation in the repaired and the unrepaired group during experimental periods. 2. The reepithelialization of the unrepaired group was slower than that of the repaired group. 3. Collagen Ⅰ,Ⅲ,Ⅴ were found from post-op. third day. There were no difference of distribution in the control, the repaired and the unrepaired group. Collagen typesⅠ,Ⅲ,Ⅴ were present in all groups with restoration of the normal collagen pattern in the fetus. This implies that lack of scarring in fetal wounds is due to the difference of collagen organization pattern within wound and not simply lack of collagen formation. 4. Collagen Ⅳ was slightly increased at post-op. third day and decreased after post-op. fifth day. Eventually there were no difference in control, the repaired and the unrepaired group. Laminin was found at post-op. fifth day and maintained staining density until post-op. seventh day. There were no differences in the control, the repaired and the unrepaired group. According to staining of laminin and collagen typeⅣ in epithelial basement membrane, formation of epithelial basement membrane was not completed until reepithelialization was finished. 5. According to staining of laminin and collagen typeⅣ, there were no increase of neovascularity in the repaired and the unrepaired group. 6. Fibronectin was increased until post-op. third day at fibrin clot, wound base and margin and decreased after post-op. fifth day. Eventually, there were no differences in the control, the repaired and the unrepaired group. So it implies fibronectin plays a role as provisional matrix for fetal wound healing.

적십자간호사업의 역사적 고찰

양원영,강윤숙,이옥철,조인재 적십자간호전문대학 2000 적십자간호전문대학논문집 Vol.22 No.-

교정 진단을 위한 피개교합심도지수 (Overbite Depth Indicator,ODI)의 새로운 평가

양원식,김태우,장영일 대한치과교정학회 1992 대한치과교정학회지 Vol.22 No.1

Since 1984, many patients have been treated with Multiloop Edgewise Archwire(MEAW) Technique and diagnosed with ODI(Overbite Depth Indicator) and APDI(Anteroposterior Dysplasia Indicator) by the authors. 234 samples of them were selected randomly for the statistical analysis(age, sex, Angle's classification, treatment period,, extraction, ODI etc.). Especially, ODI was analysed statistically and its application methods were reviewed. The results ad conclusions were as follows: 1.On the 150 patients with normal overbite, the mean values of Class Ⅰ,Ⅱ,Ⅲ malocclusion were 67.5。, 72.2。 and 59.0。. They were significantly different on the level of p<0.01. 2.In normal overbite samples, ODI decreased with the increase of APDI and the correlation coefficient was - 0.54.It seems that this result reflects the characteristics of AB to mandibular plane angle. 3.The regression equation was Y=-0.57X+114.64, where X is APDI and Y is ODI. In cases of small or large APDI, it seems to be absurd that the patient's ODI is compared with the mean ODI to differentiate diagnostically the open bite or deep bite tendency from the normal.