http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
An alternative spliced mouse presenilin-2 mRNA encodes a novel γ-secretase inhibitor
Suzuki, Y.,Ohta, K.,Itoh, M.,Sakoh-Sumitomo, Y.,Mitsuda, T.,Ueda, M.,Hayakawa-Yano, Y.,Li, S.,Hida, Y.,Inuzuka, T.,Jung, Y.K.,Nakagawa, T. North-Holland Pub ; Elsevier Science Ltd 2009 FEBS letters Vol.583 No.9
The γ-secretase, composed of presenilin-1 (PS1) or presenilin-2 (PS2), nicastrin (NCT), anterior pharynx-defective phenotype 1 (APH-1), and PEN-2, is critical for the development of Alzheimer's disease (AD). PSs are autoproteolytically cleaved, producing an N-terminal fragment (NTF) and a hydrophilic loop domain-containing C-terminal fragment. However, the role of the loop domain in the γ-secretase complex assembly remains unknown. Here, we report a novel PS2 isoform generated by alternative splicing, named PS2β, which is composed of an NTF with a hydrophilic loop domain. PS2β disturbed the interaction between NCT and APH-1, resulting in the inhibition of amyloid-β production. We concluded that PS2β may inhibit γ-secretase activity by affecting the γ-secretase complex assembly. Structured summary: MINT-7025654: APH1 (uniprotkb:Q96BI3) physically interacts (MI:0218) with PEN2 (uniprotkb:Q9NZ42), PS2 beta (uniprotkb:Q61144-2) and PS1 (uniprotkb:P49769) by anti tag coimmunoprecipitation (MI:0007) MINT-7025631: APH1 (uniprotkb:Q96BI3) physically interacts (MI:0218) with NCT (uniprotkb:Q92542), PEN2 (uniprotkb:Q9NZ42) and PS1 (uniprotkb:P49769) by anti tag coimmunoprecipitation (MI:0007)
Experimental Approach to Explosive Nucloeosynthesis with RI Beams
S. Kubono,Y. Yamaguchi,G. Amadio,S. Hayakawa,Y. Wakabayashi,Y. Kurihara,J. J. He,A. Saito,H. Fujikawa,Le Hong Khiem,M. Niikura,T. Teranishi,N. Iwasa,S. Kato,S. Nishimura,C. S. Lee,Y. K. Kwon,I. S. Hah 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.54 No.1
Experimental efforts to investigate stellar reactions under high-temperature and high density conditions have been made as a major program using the RI beams from the Center for Nuclear Study (CNS) low-energy in-flight RI beam separator (CRIB) at University of Tokyo in order to understand the evolution of the universe, as well as various stellar phenomena. Specically, two subjects of hydrogen burning are discussed here. One is a reaction study of the pp-chain and the second is of the explosive hydrogen burning, the rp-process. Some s-wave resonances have been identified by the thick target method in the crucial reaction processes in the hydrogen burning. The resonant scattering with the thick target method also succeeded in identifying inelastic resonant scattering, giving proton widths for the first excited state of the target nucleus. This provided very efficiently the reaction rate estimate for the process under high-temperature equilibrium conditions. Possibilities of the CRIB facility in near future are also briey discussed. Experimental efforts to investigate stellar reactions under high-temperature and high density conditions have been made as a major program using the RI beams from the Center for Nuclear Study (CNS) low-energy in-flight RI beam separator (CRIB) at University of Tokyo in order to understand the evolution of the universe, as well as various stellar phenomena. Specically, two subjects of hydrogen burning are discussed here. One is a reaction study of the pp-chain and the second is of the explosive hydrogen burning, the rp-process. Some s-wave resonances have been identified by the thick target method in the crucial reaction processes in the hydrogen burning. The resonant scattering with the thick target method also succeeded in identifying inelastic resonant scattering, giving proton widths for the first excited state of the target nucleus. This provided very efficiently the reaction rate estimate for the process under high-temperature equilibrium conditions. Possibilities of the CRIB facility in near future are also briey discussed.
Study on α-cluster levels in non-4n nuclei using low-energy RI beams
Yamaguchi, H,Kahl, D,Hayakawa, S,Sakaguchi, Y,Abe, K,Nakao, T,Suhara, T,Iwasa, N,Kim, A,Kim, D H,Cha, S M,Kwag, M S,Lee, J H,Lee, E J,Chae, K Y,Wakabayashi, Y,Imai, N,Kitamura, N,Lee, P,Moon, J Y,Lee, IOP Publishing 2017 Journal of physics. Conference series Vol.863 No.-
Experimental investigation of a linear-chain structure in the nucleus <sup>14</sup>C
Yamaguchi, H.,Kahl, D.,Hayakawa, S.,Sakaguchi, Y.,Abe, K.,Nakao, T.,Suhara, T.,Iwasa, N.,Kim, A.,Kim, D.H.,Cha, S.M.,Kwag, M.S.,Lee, J.H.,Lee, E.J.,Chae, K.Y.,Wakabayashi, Y.,Imai, N.,Kitamura, N.,Lee North-Holland Pub. Co 2017 Physics letters. Section B Vol.766 No.-
It is a well-known fact that a cluster of nucleons can be formed in the interior of an atomic nucleus, and such clusters may occupy molecular-like orbitals, showing characteristics similar to normal molecules consisting of atoms. Chemical molecules having a linear alignment are commonly seen in nature, such as carbon dioxide. A similar linear alignment of the nuclear clusters, referred to as linear-chain cluster state (LCCS), has been studied since the 1950s, however, up to now there is no clear experimental evidence demonstrating the existence of such a state. Recently, it was proposed that an excess of neutrons may offer just such a stabilizing mechanism, revitalizing interest in the nuclear LCCS, specifically with predictions for their emergence in neutron-rich carbon isotopes. Here we present the experimental observation of α-cluster states in the radioactive <SUP>14</SUP>C nucleus. Using the Be10+α resonant scattering method with a radioactive beam, we observed a series of levels which completely agree with theoretically predicted levels having an explicit linear-chain cluster configuration. We regard this as the first strong indication of the linear-chain clustered nucleus.
Study of 19F Levels with Ex = 6.7 - 7.7 MeV by the 15N+α Scattering Experiment
D. Kim,G. W. Kim,S. Y. Park,A. Kim,한인식,K. Abe,O. Beliuskina,S. Hayakawa,N. Imai,N. Kitamura,Y. Sakaguchi,H. Yamaguchi,S. M. Cha,K. Y. Chae,M. S. Kwag,S. W. Hong,E. J. Lee,J. H. Lee,E. K. Lee,J. Y. Moo 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.73 No.3
The intense γ-rays from classical novae are emitted due to the β-decay of 18F which is produced by the Hot-CNO cycle. The reaction rate of 18F(p,α)15O affects the prediction of the abundance of 18F. The main contribution to this reaction rate is from the resonances in 19Ne near and above the proton threshold. Hence, many experiments and theoretical works have been performed on the low-lying 18F+p resonances. One of the methods for investigating 19Ne parameters is studying the mirror nucleus 19F. α elastic scattering experiment was performed with a 7 MeV/u 15N beam for investigating the resonance parameters in 19F using the thick target method in inverse kinematics at the radioactive beam facility CRIB of the Center for Nuclear Study, the University of Tokyo. The excitation function of 19F was obtained for the excitation energy Ex = 6.7 - 7.7 MeV, and the parameters of the resonance states in 19F were determined using an R-matrix analysis.
김아람,N. H. Lee,I. S. Hahn,J. S. Yoo,M. H. Han,S. Kubono,H. Yamaguchi,S. Hayakawa,Y. Wakabayashi,D. Binh,H. Hashimoto,T. Kawabata,D. Kahl,Y. Kurihara,Y. K. Kwon,T. Teranishi,S. Kato,T. Komatsubara,B. Gu 한국물리학회 2010 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.57 No.1
For the study of astrophysically important states in 18Ne, the 14O(α, α)14O cross section was measured in inverse kinematics using a radioactive 14O beam. This reaction was investigated for properties of resonant states of 18Ne for determining the 14O(α, p)17F reaction rate, which is one of the most important reactions for understanding the breakout mechanism from the Hot CNO cycle to the rp-process. Alpha-induced elastic scattering on 14O was performed using the lowenergy radioactive ion (RI) beam separator at the Center for Nuclear Study (CNS) in the RIKEN Accelerator Research Facility. The energy range Ex = 7.2 ∽ 13.1 MeV of 18Ne was scanned with the thick target method. Recoiled alpha particles were measured with Si dE-E telescopes. Spins and widths of three resonances at Ex = 8.6, 9.22, and 10.06 MeV were calculated using the R-matrix analysis, and a new state of 18Ne at Ex = 12.0 MeV was found in this experiment.
A New Resistor Series For Chip/Network Applications
Yamamoto, Y.,Hayakawa, K.,Matsuno, H.,Sato, T.,Smith, J.,Tojo, M. 한국마이크로전자및패키징학회 1994 Seminar on Hybrid Microelectronics and Multichip P Vol.1 No.1
A new series of resistor compositions has been developed for chip applications. The new series, DuPont 00X0 $quot;INVAROX$quot; has been designed to give well rounded performance on chip resistors of all existing sixes including low TCR effects on small resistors. Because of their low process sensitivity, the 00X0 resistors can also be advantageously used in resistor network applications. To ensure good overall performance, we devised some screening tests that allowed us to easily visualize and understand the effects of composition and processing on resistor performance. The thorough screening of experimental compositions was a key in ensuring that no member of the series has severely limiting flaws. In this paper, we will discuss the development concepts for the new series, our screening tests for experimental compositions, and aspects of performance from a large and growing database.