Expression of toll-like receptor 2 and 4 is increased in the respiratory epithelial cells of chronic idiopathic interstitial pneumonia patients

Go, H.,Koh, J.,Kim, H.S.,Jeon, Y.K.,Chung, D.H. Baillière Tindall, in association with the 2014 Respiratory medicine Vol.108 No.5

Background: Idiopathic interstitial pneumonia (IIP) is characterized by chronic interstitial inflammation and fibrosis. Although mounting evidence has suggested that toll-like receptor (TLR) 2 and TLR4 are involved in the pathogenesis of non-infectious lung injury in vitro and in mouse models, their roles in human IIP remain unknown. Methods: To address this issue, we investigated the expression patterns of TLR2 and TLR4 by immunohistochemistry in resected lung tissues from patients with usual interstitial pneumonia (UIP) or nonspecific interstitial pneumonia (NSIP). Results: Type II pneumocytes, bronchial epithelial cells (BECs), and alveolar macrophages accounted for the majority of TLR2- and TLR4-expressing cells in both UIP and NSIP. The numbers of TLR2 and TLR4-positive respiratory epithelial (RE) cells, including type II pneumocytes and BECs, were significantly greater in UIP and NSIP than in the control. In particular, the numbers of TLR2-positive RE cells were much greater in UIP than in NSIP. The intensities of TLR2 and TLR4 expression in type II pneumocytes were also significantly stronger in UIP and NSIP than in the control. A comparison of the TLR expression patterns between the fibroblastic and fibrotic areas in UIP indicated that the numbers TLR2 and TLR4-positive RE cells were similar in fibroblastic areas, whereas the TLR2-positive RE cells outnumbered the TLR4-positive RE cells in the fibrotic areas. Conclusions: This study demonstrates that RE cells over-express TLR2 and TLR4 in the lungs of IIP patients. These findings suggest that high expression of TLRs may contribute to the pathogenesis of human IIP.

Large-Eddy Simulations of Wind and Thermal Environments around Tall Buildings

G. Oh,M. Yang,J.-I. Choi 한국전산유체공학회 2022 한국전산유체공학회 학술대회논문집 Vol.2022 No.10

A genetic system for RNase E variant-controlled overproduction of ColE1-type plasmid DNA

Go, H.,Lee, K. Elsevier Science Publishers 2011 Journal of biotechnology Vol.152 No.4

Escherichia coli endoribonuclease RNase E (Rne) regulates replication of ColE1-type plasmids by cleaving RNA I transcripts, which are synthesized from the plasmid and regulate the plasmid replication as antisense RNA. Here, we report the development of a genetic system that efficiently overproduces ColE1-type plasmid DNA when an RNase E variant that confers a hyperactive phenotype in RNA I cleavage is conditionally expressed from chromosome. This genetic system offers a method for isolation of large quantities of pure ColE1-type plasmid DNA, which have been most commonly used as molecular biology and biotechnology tools for research and industrial purposes.

Scytalidium parasiticum sp. nov., a New Species Parasitizing on Ganoderma boninense Isolated from Oil Palm in Peninsular Malaysia

Goh, Yit Kheng,Goh, Teik Khiang,Marzuki, Nurul Fadhilah,Tung, Hun Jiat,Goh, You Keng,Goh, Kah Joo The Korean Society of Mycology 2015 Mycobiology Vol.43 No.2

A mycoparasite, Scytalidium parasiticum sp. nov., isolated from the basidiomata of Ganoderma boninense causing basal stem rot of oil palm in Johor, Malaysia, is described and illustrated. It is distinct from other Scytalidium species in having smaller asci and ascospores (teleomorphic stage), longer arthroconidia (anamorphic stage), hyaline to yellowish chlamydospores, and producing a fluorescent pigment. The phylogenetic position of S. parasiticum was determined by sequence analyses of the internal transcribed spacers and the small-subunit ribosomal RNA gene regions. A key to identify Scytalidium species with teleomorphic stage is provided.

Fish Purchasing Behavior and Implications for Promoting Sustainable Consumption: A Malaysian Case

Ee Von GOH(Ee Von GOH ),Susan AZAM-ALI(Susan AZAM-ALI ),Fiona MCCULLOUGH(Fiona MCCULLOUGH ) 한국유통과학회 2023 Asian Journal of Business Environment (AJBE) Vol.13 No.2

Purpose: Motivated by the fact that Malaysians fish consumption patterns and preferences have raised sustainability concerns, this study aims to understand the key entry points to promote sustainable consumption and increased uptake of sustainably sourced fish among Malaysian consumers. This is achieved by exploring the individual determinants of Malaysian consumers’ fish purchasing behaviors and their subjective and objective knowledge of fish. Research design, data, and methodology: A survey was conducted using interviewled questionnaire on 250 consumers in selected Malaysian populations recruited via street-intercept random sampling. Results: Findings confirmed the homogeneous societal culture of fish consumption amongst Malaysians. Females and consumers with advanced degree are found to be potentially effective primary targets of sustainable consumption interventions. Future interventions should consider the solutions to the low health and sustainability literacies among Malaysian consumers, and limited availability, accessibility, and affordability of sustainable options in Malaysia. Conclusion: The study findings provide new insights for the multisectoral stakeholders in the region working on promoting sustainable fish consumption and sustainable fisheries in general.

Effects of medium chain triglycerides with organic acids on growth performance, fecal score, blood profiles, intestinal morphology, and nutrient digestibility in weaning pigs

Goh Tae Wook,Hong Jin Su,You Dong Hyun,Han Yeong Geol,Nam Seung Ok,김유용 아세아·태평양축산학회 2022 Animal Bioscience Vol.35 No.6

Objective: This study was conducted to evaluate the effects of medium chain triglycerides (MCT) with organic acids (OA) on growth performance, fecal score, blood profiles, intestinal morphology, and nutrient digestibility in weaning pigs. Methods: A total of 120 weaning pigs ([Yorkshire×Landrace]×Duroc) with an average body weight (BW) of 8.00±0.87 kg were assigned in five treatments considering sex and initial BW in 3 replications with 8 pigs per pen in a randomized complete block design. The experimental diets included a corn-soybean meal based basal diet with or without 0.1% or 0.2% MCT and 0.1% OA. The pigs were fed the diets for 5 weeks (phase 1, 0 to 2 weeks; phase 2, 3 to 5 weeks). A total of 15 barrows with an average BW of 12.48±0.37 kg were used to evaluate the nutrient digestibility by total collection method. The BW and feed intake were measured at the end of each phase. Blood samples and small intestine samples were collected at the end of each phase, too. Results: Supplementing 0.1% MCT with 0.1% OA showed greater BW for week 5 and average daily gain (ADG) for overall period than control diet. Supplementing 0.1% MCT increased (p<0.05) ADG and improved (p<0.05) gain:feed ratio for phase 1. Dietary MCT and OA did not affect the fecal score and blood concentration of cortisol, immunoglobulin G, tumor necrosis factor-α, interleukin-1β (IL-1β), IL-6, and IL-10 in weaning pigs. Pigs fed the diets with 0.1% MCT had greater (p<0.05) villus height of duodenum and ileum for phase 1. Also, pigs fed the diet with 0.1% OA showed greater (p<0.05) villus height and villus height to crypt depth ratio of duodenum for phase 2. There was no significant difference in nutrient digestibility and nitrogen retention of pigs. Conclusion: Addition of 0.1% MCT with 0.1% OA in weaning pig’s diet improved growth performance partly by enhancing intestinal morphology in weaning pigs. Objective: This study was conducted to evaluate the effects of medium chain triglycerides (MCT) with organic acids (OA) on growth performance, fecal score, blood profiles, intestinal morphology, and nutrient digestibility in weaning pigs.Methods: A total of 120 weaning pigs ([Yorkshire×Landrace]×Duroc) with an average body weight (BW) of 8.00±0.87 kg were assigned in five treatments considering sex and initial BW in 3 replications with 8 pigs per pen in a randomized complete block design. The experimental diets included a corn-soybean meal based basal diet with or without 0.1% or 0.2% MCT and 0.1% OA. The pigs were fed the diets for 5 weeks (phase 1, 0 to 2 weeks; phase 2, 3 to 5 weeks). A total of 15 barrows with an average BW of 12.48±0.37 kg were used to evaluate the nutrient digestibility by total collection method. The BW and feed intake were measured at the end of each phase. Blood samples and small intestine samples were collected at the end of each phase, too.Results: Supplementing 0.1% MCT with 0.1% OA showed greater BW for week 5 and average daily gain (ADG) for overall period than control diet. Supplementing 0.1% MCT increased (p<0.05) ADG and improved (p<0.05) gain:feed ratio for phase 1. Dietary MCT and OA did not affect the fecal score and blood concentration of cortisol, immunoglobulin G, tumor necrosis factor-α, interleukin-1β (IL-1β), IL-6, and IL-10 in weaning pigs. Pigs fed the diets with 0.1% MCT had greater (p<0.05) villus height of duodenum and ileum for phase 1. Also, pigs fed the diet with 0.1% OA showed greater (p<0.05) villus height and villus height to crypt depth ratio of duodenum for phase 2. There was no significant difference in nutrient digestibility and nitrogen retention of pigs.Conclusion: Addition of 0.1% MCT with 0.1% OA in weaning pig’s diet improved growth performance partly by enhancing intestinal morphology in weaning pigs.

Prevalence and risk indicators of peri-implantitis in Korean patients with a history of periodontal disease: a cross-sectional study

Goh, Mi-Seon,Hong, Eun-Jin,Chang, Moontaek Korean Academy of Periodontology 2017 Journal of Periodontal & Implant Science Vol.47 No.4

Purpose: The aim of this study was to analyze the prevalence and risk indicators of peri-implantitis in Korean patients with history of periodontal disease. Methods: A total of 444 patients with 1,485 implants were selected from patients who had been treated at the Department of Periodontology, Chonbuk National University Dental Hospital between July 2014 and June 2015. A group with a history of peri-implantitis (HP) (370 patients with 1,189 implants) and a group with a current peri-implantitis (CP) (318 patients with 1,004 implants) were created based on the radiographic and clinical assessments of implants. The prevalence of peri-implantitis was calculated at both the patient and implant levels. The influence of risk variables on the occurrence of peri-implantitis was analyzed using generalized estimating equations analysis. Results: The prevalence of peri-implantitis in the HP and CP groups ranged from 6.7% to 19.7%. The cumulative peri-implantitis rate in the HP group estimated with the Kaplan-Meier method was higher than that in the CP group over the follow-up period. Among the patient-related risk variables, supportive periodontal therapy (SPT) was the only significant risk indicator for the occurrence of peri-implantitis in both groups. In the analysis of implant-related variables, implants supporting fixed dental prosthesis (FDP) and implants with subjective discomfort was associated with a higher prevalence of peri-implantitis than single implants and implants without subjective discomfort in the HP group. The presence of subjective discomfort was the only significant implant-related variable predictive of peri-implantitis in the CP group. Conclusions: Within the limitations of this study, the prevalence of peri-implantitis in Korean patients with a history of periodontal disease was similar to that reported in other population samples. Regular SPT was important for preventing peri-implantitis. Single implants were found to be less susceptible to peri-implantitis than those supporting FDP. Patients' subjective discomfort was found to be a strong risk indicator for peri-implantitis.

Exporting Education Services and Institutional Branding:The Case of National Institute of Education(NIE) International

Goh Chor Boon 부산대학교 교육발전연구소 2009 교육혁신연구 Vol.19 No.1

Implementing Time-triggered Communication for Embedded Ethernet Real-time Network using IEEE 1588 Time Synchronization

Goh, Ju Han,Mohamad Khairi Ishak 대한전자공학회 2021 IEIE Transactions on Smart Processing & Computing Vol.10 No.5

A time-triggered embedded system has become a ubiquitous technique in safety-critical systems, such as automotive, aerospace, and medical sectors. Thus, precision is of utmost importance to determine if the application is synchronized correctly. The Network Time Protocol is the traditional protocol used for clock synchronization in wired networks. On the other hand, the protocol lacks hardware timestamping features, and it collects many timestamping errors because of the diversification of the queuing time in the switches and router. This drawback was implemented into a new protocol, and new features on the Precision Time Protocol, known as IEEE 1588-2008, were added. This paper proposes a real-time network for a time-triggered Embedded system, the Precision Time Protocol synchronize, on a Spartan 3E Field Programmable Gate Array (FPGA). Two approaches were also introduced to evaluate the performance using Precision Time Protocol: hardware and software implementations. MATLAB Simulink software was used to evaluate the software approaches. The result showed that the Precision Time Protocol used 0.83μs to complete the clock synchronization compared to the 4.65μs used by the Network Time Protocol, which was six times faster.

한국산 벼멸구 생태형의 계량형태적 분류

Goh H. G.,R. C. Saxena,A. A. Barrion,K. M. Choi,J. W. Kim 한국응용곤충학회 1993 한국응용곤충학회지 Vol.32 No.1

우리나라에 발생하고 있는 벼멸구 생태형의 형태적 차이를 구명하고자 생태형 1, 2, 3의 단시형 암컷과 숫컷의 다리부분의 형태를 관찰하였다. 앞다리, 가운데 다리 그리고 뒷다리의 제3부절의 형태를 51개 부위에서 조사한 다음 통계학적 분석을 위하여 정준 판별 분석법을 도입하였다. 각 생태형간의 Mahalanobis distance는 숫컷의 경우 생태형 2와 3 사이에서 가장 짧았고, 암컷은 생태형 1과 2 사이에서 가장 길었다. Scatter plot diagram상에서 각 생태 형간 분리현상이 뚜렷하여 중심점이 각각 다르게 나타났고 각 생태형에 속하는 개체는 중심점 부근에 고르게 분포하였다. 각 생태형간의 Group membership 조사에서 암수 모두 각 생태형은 각각 동일한 생텨형을 분류되었다. Morphometric investigations of the leg characters of both sexes of brachypterous Korean N. lugens biotypes were made. Simple and multivariate statistical analyses revealed that the three N. lugens biotypes differed from one another. The amount of variation and segregation between and among the three biotype populations were approximated by the scatter plot diagrams based on the computed discriminant scores. The variables of leg characters provided the most significant segregations of three biotype populations, thus, categorizing the three biotypes as distinct intraspecific populations of N. lugens.