An Improved RF Detection Algorithm Using EMD-based WT

( Xue Lv ),( Zekun Wang ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.8

More and more problems for public security have occurred due to the limited solutions for drone detection especially for micro-drone in long range conditions. This paper aims at dealing with drones detection using a radar system. The radio frequency (RF) signals emitted by a controller can be acquired using the radar, which are usually too weak to extract. To detect the drone successfully, the static clutters and linear trend terms are suppressed based on the background estimation algorithm and linear trend suppression. The principal component analysis technique is used to classify the noises and effective RF signals. The automatic gain control technique is used to enhance the signal to noise ratios (SNR) of RF signals. Meanwhile, the empirical mode decomposition (EMD) based wavelet transform (WT) is developed to decrease the influences of the Gaussian white noises. Then, both the azimuth information between the drone and radar and the bandwidth of the RF signals are acquired based on the statistical analysis algorithm developed in this paper. Meanwhile, the proposed accumulation algorithm can also provide the bandwidth estimation, which can be used to make a decision accurately whether there are drones or not in the detection environments based on the probability theory. The detection performance is validated with several experiments conducted outdoors with strong interferences.

Port four: Others : Preventing Mother-to-Child transmission of HIV impact and factors

( Xue Xia Lv ),( Chong Hua Wan ),( Liang Chen ) 한국환경보건학회(구-한국환경위생학회) 2004 Current Challenges and Advances in Environmental H Vol.- No.-

Inhibition of microRNA-214 promotes epithelial mesenchymal transition process and induces interstitial cystitis in postmenopausal women by upregulating Mfn2

Jian-Wei Lv,Wei Wen,Chen Jiang,Qi-Bo Fu,Yin-Jun Gu,Ting-Ting Lv,Zhen-Dong Li,Wei Xue 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

Our study aims to investigate the roles that microRNA-214 (miR-214) plays in the epithelial mesenchymal transition (EMT) process and the development of interstitial cystitis (IC) in postmenopausal women by targeting Mitofusin 2 (Mfn2). IC bladder tissues and adjacent normal bladder tissues were collected from postmenopausal women. Immunohistochemistry (IHC) staining was conducted. The target relationship between miR-214 and Mfn2 was determined by a dual luciferase reporter gene assay. Adipose-derived mesenchymal stem cells (ADMSCs) were extracted from postmenopausal rats and assigned to the blank, mimics, miR-214 inhibitors, mimics negative control (NC), inhibitors NC, Mfn2 siRNA, miR-214 inhibitors and Mfn2 siRNA groups. Exosomes secreted by transfected ADMSCs were instilled into the bladders of postmenopausal rats. The expression of miR-214 and Mfn2 mRNA and EMT markers was assessed by qRT-PCR and western blotting. It was confirmed that Mfn2 was the target gene of miR-214 in IC. Compared with the normal bladder tissues, miR-214 decreased, but Mfn2 increased in IC bladder tissues. Compared with the blank group, the expression of miR-214 and the expression levels of N-cadherin, Fibronectin, Twist1, Snail and Vimentin mRNA and protein increased, whereas the expression levels of Mfn2, E-cadherin and ZO-1 mRNA and protein decreased in the miR-214 mimics and Mfn2 groups. The expression of MiR-214 and the expression levels of N-cadherin, Fibronectin, Twist1, Snail and Vimentin mRNA and protein decreased, whereas the expression levels of Mfn2, E-cadherin and ZO-1 mRNA and protein increased in the miR-214 inhibitors group. Our findings indicate that the inhibition of miR-214 promotes the EMT process and contributes to bladder wall fibrosis by up-regulating Mfn2, thus leading to the occurrence of IC in postmenopausal women.

The sealing effect of magnetic-sealing uterine manipulator in isolated uterus from patients with early-stage cervical cancer: a pre-clinical study

Xue Zhou,Dongxin Liang,Qing Li,Lanbo Zhao,Yadi Bin,Feng Ma,Rongqian Wu,Yi Lv,Qiling Li 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.6

Objective: Traditional uterine manipulator is considered as the main reason for short survival of patients with early-stage cervical cancer during minimally invasive surgery. This study aims to assess the sealing effect of magnetic-sealing uterine manipulators (MUMs) in isolated uteruses. Methods: The study was performed on isolated uterus from patients with early-stage cervical cancer who underwent open abdominal radical hysterectomy between November 2019 to April 2021. Right-angle forceps closure tests (groups 1 and 3) were defined as control tests. One experimental MUM closure test (group 2) and 2 control tests were respectively carried out in each of the isolated uterus. DNA ploidy analysis system was used to observe exfoliated cells. Statistical analysis was performed using Wilcoxon signed-rank test to assess the sealing effect of MUM. Results: We identified 36 patients. No regional node metastasis was discovered and only one tumor was larger than 4.0 cm in diameter. The mean of exfoliated tumor cells in groups 1, 2, and 3 were 1, 1, and 2, respectively. There was no significant difference in the quantity of exfoliated cells between groups 1 and 3 (p=0.476), so the results of the 2 groups were merged. Subsequently, a significant difference was observed between combined right-angle forceps closure tests and MUM closure tests (p=0.022). Conclusion: The sealing effect of MUM was better than that of right-angle forceps. MUM can effectively seal cervical cancer cells in the cup cover, avoiding the dissemination of tumor cells.

Risk of Trastuzumab-Related Cardiotoxicity in Early Breast Cancer Patients: A Prospective Observational Study

Jian Xue,Zefei Jiang,Fan Qi,Shuanghong Lv,Shaohua Zhang,Tao Wang,Xiaozhong Zhang 한국유방암학회 2014 Journal of breast cancer Vol.17 No.4

Purpose: In the present study, we investigated the incidence ofcardiotoxicity within 5 years of trastuzumab treatment and evaluatedpotential risk factors in clinical practice. Methods: The studycohort included 415 patients diagnosed with early breast cancer(EBC). Cardiotoxicity incidence was evaluated in patients receivingtrastuzumab and those who did not. Multivariate Cox proportionalhazards regression models were used to estimate hazardratios and 95% confidence intervals of potential risk factorsfor trastuzumab-related cardiotoxicity after appropriate adjustments. Results: Incidence of cardiotoxicity in patients treatedwith trastuzumab was significantly higher than that in controls(23.7% vs. 10.8%, p<0.001). This result was adjusted for factorsthat might increase the risk of cardiotoxicity, such as historyof coronary artery diseases or the use of anthracyclines for morethan four cycles. Conclusion: Our findings indicated that treatmentwith trastuzumab was strongly associated with cardiotoxicityin EBC patients.

Improved temperature stability of Ba0.5Sr0.5TiO3/ZnAl2O4 ceramics by controlling microstructure with sintering behavior

Yuze Xue,Mingwei Zhang,Le Xin,Luchao Ren,Panpan Lv,Hang Zhan,Jing He,Jiwei Zhai 한양대학교 청정에너지연구소 2023 Journal of Ceramic Processing Research Vol.24 No.2

0.2ZnAl2O4/0.8Ba0.5Sr0.5TiO3 ceramics with good dielectric temperature stability were synthesized by controlling sinteringbehavior. The relationship between sintering conditions, microstructure, and dielectric properties of ceramics was studied. Cubic structures were confirmed in all ceramics. Double sintering (DS) behavior can effectively improve the density, and thegrain size has no obvious change compared with non-repeated sintering. The maximum dielectric permittivity (220 at 10 kHz)and minimum leakage current (3.98×10-6 A/cm2 at 0.25 kV/cm) are obtained in the DS ceramics, which is superior to thoseof the single sintering ceramics. This can be ascribed to the higher relative density of the DS ceramics in contrast to the singlesintering ceramics. More importantly, the temperature stability of the DS sample in all samples is optimal due to the highsurface energy at grain boundaries and improved density. This work demonstrates a route to produce ceramics with weaktemperature sensitivity for microwave applications.

Preparation of ZnO Nanoparticles by Combustion Method and Their Gas Sensing Properties

Xiao-xue Lian,Yan Li,Tan Lv,Yun-ling Zou,Dongmin An,Nan Zhang 대한금속·재료학회 2016 ELECTRONIC MATERIALS LETTERS Vol.12 No.1

In this study, ZnO nanoparticles were fabricated using a simpleand novel combustion method without calcination. The sensormaterial was structurally and morphologically characterizedusing simultaneous differential scanning calorimetry (DSC),thermogravimetric analysis (TGA), x-ray diffraction (XRD),scanning electron microscopy (SEM), Brunauer-Emmett-Teller(BET), and transmission electron microscopy (TEM). Thesample containing 3 mol tartaric acid (ZTC-3) exhibitedexcellent ethanol sensing properties at the optimum temperatureof 330°C. The relationships among the gas response, temperature,response time (recovery time), concentration, and gas specieswere investigated. The ZTC-3 exhibited response and recoverytimes of 7 and 38 s to 100 ppm ethanol, as well as excellentresponse and good selectivity to ethanol gas. Such a ZnOnanoparticle structure could be potentially use for fabricatingethanol sensors.

Production and immunogenicity of chimeric virus-like particles containing the spike glycoprotein of infectious bronchitis virus

Lishan Lv,Xiaoming Li,Genmei Liu,Ran Li,Qiliang Liu,Huifang Shen,Wei Wang,Chunyi Xue,Yongchang Cao 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.2

Infectious bronchitis virus (IBV) poses a severe threat to thepoultry industry and causes heavy economic losses worldwide. Vaccination is the most effective method of preventing infectionand controlling the spread of IBV, but currently availableinactivated and attenuated virus vaccines have somedisadvantages. We developed a chimeric virus-like particle(VLP)-based candidate vaccine for IBV protection. The chimericVLP was composed of matrix 1 protein from avian influenzaH5N1 virus and a fusion protein neuraminidase (NA)/spike 1 (S1)that was generated by fusing IBV S1 protein to the cytoplasmicand transmembrane domains of NA protein of avian influenzaH5N1 virus. The chimeric VLPs elicited significantly higherS1-specific antibody responses in intramuscularly immunizedmice and chickens than inactivated IBV viruses. Furthermore,the chimeric VLPs induced significantly higher neutralizationantibody levels than inactivated H120 virus in SPF chickens. Finally, the chimeric VLPs induced significantly higher IL-4production in mice. These results demonstrate that chimericVLPs have the potential for use in vaccines against IBV infection.

PTEN mutation predicts unfavorable fertility preserving treatment outcome in the young patients with endometrioid endometrial cancer and atypical hyperplasia

Yu Xue,Youting Dong,Yaochen Lou,Qiaoying Lv,Weiwei Shan,Chao Wang,Xiaojun Chen 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.4

Objective: This study aimed to investigate the impact of molecular classification and PTEN, KRAS and PIK3CA gene mutation on the outcome of fertility-preserving treatment in the patients with endometrioid endometrial cancer (EEC) and endometrial atypical hyperplasia (EAH). Methods: This is a single-center retrospective study. A total of 135 patients with EEC and EAH receiving fertility-preserving treatment and molecular classification were reviewed. The distribution of the four types of molecular classification was described. The impact of non-specific molecular profile (NSMP), mismatch repair-deficiency (MMRd), and PTEN, KRAS and PIK3CA gene mutation on the outcome of fertility-preserving treatment was analyzed. Results: Of the patients analyzed, 86.7% (117/136) were classified as having NSMP; 14 (10.4%), MMRd; 1 (0.7%), POLEmut EAH; and 3 (2.2%), p53abn EEC. The patients having NSMP and MMRd achieved similar 16-, 32-, and 48-week complete response rates. The patients harboring tier I and tier II PTEN mutations (PTENmut-Clin) achieved lower cumulative 32-week CR rates than those with PTEN-others (without PTENmut-Clin) (22/47, 46.8% vs. 50/74, 67.6%; p=0.023; odds ratio=0.422; 95% confidence interval [CI]=0.199–0.896). Insulin-resistance (hazard ratio [HR]=0.435; 95% CI=0.269–0.702; p=0.001) and PTENmut-Clin (HR=0.535; 95% CI=0.324–0.885; p=0.015) were independent negative predictors for lower 32-week CR rates. Conclusion: PTENmut-Clin is an independent risk factor for unfavorable fertility-preserving treatment outcomes in the patients with EEC and EAH. The patients with MMRd receiving fertility-preserving treatment achieved outcomes similar to those of the patients with NSMP. The molecular profiles might guide fertility-preserving treatment in the prognosis and clinical decisions.

Susceptibility of Lung Cancer with Polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1 Genotypes in the Population of Inner Mongolia Region

Jiang, Xue-Yan,Chang, Fu-Hou,Bai, Tu-Ya,Lv, Xiao-Li,Wang, Min-Jie,Wang, Guang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Background: To study the relationship of susceptibility to lung cancer with the gene polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1, GSTP1 and smoking status in Han and Mongolian populations of Inner Mongolia, an autonomous region of China. Materials and Methods: PCR-RFLP, allele-specific and multiplex PCR were employed to identify the genotypes of CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1 in a case-control study of 322 lung cancer patients diagnosed by bronchoscopy and 456 controls free of malignancy. Results: There is a significant difference in genotypic frequency of GSTT1 of healthy Mongolian and Han subjects. A statistically prominent association was found between CYP1A1 Msp1 (vt/vt) (OR=4.055, 95%CI:2.107-7.578, p=0.000), GSTM1 (-) (OR=2.290, 95%CI:1.467-3.573, p=0.000) and lung cancer in Mongolians. Similarly, in the Han population, CYP1A1 Msp1 (vt/vt) (OR=3.194, 95%CI:1.893-5.390, p=0.000) and GSTM1 (-) (OR=1.884, 95%CI:1.284-2.762, p=0.001) carriers also had an elevated risk of lung cancer. The smokers were more susceptible to lung cancer 2.144 fold and 1.631 fold than non-smokers in Mongolian and Han populations, respectively. The smokers who carried with CYP1A1 Msp1 (wt/vt+vt/vt), exon7 (Val/Val+Ile /Val), GSTM1 (-), GSTM3 (AB+BB), and GSTT1 (-) respectively were found all to have a high risk of lung cancer. Conclusions: CYP1A1 Msp1 (vt/vt) and GSTM1 (-) are risk factors of lung cancer in Han and Mongolian population in the Inner Mongolia region. The smokers with CYP1A1 Msp1 (wt/vt+vt/vt), CYP1A1 exon7 (Val/Val+Ile /Val), GSTM1 (-), GSTM3 (AB+BB), and GSTT1 (-) genotypes, respectively, are at elevated risk of lung cancer.