Risk Factors, Patterns, and Outcomes of Late Recurrence after Liver Resection for Patients with Hepatocellular Carcinoma (Analysis of a Multicenter Cohort over 15 Years)

( Xin-fei Xu ),( Jiong-jie Yu ),( Ju-dong Li ),( Hao Xing ),( Jun Han ),( Zhen-li Li ),( Han Wu ),( Han Zhang ),( Jian-hong Zhong ),( Yi- Sheng Huang ),( Ya-hao Zhou ),( Ting-hao Chen ),( Hong Wang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Late recurrence (> 2 years) after liver resection of hepatocellular carcinoma (HCC) is usually considered as multi-centric tumors or de novo cancer formation. We aimed to investigate risk factors, patterns and outcomes of late recurrence after HCC resection. Methods: From a multicenter database from 2001 to 2015, 734 patients who were alive and recurrence-free at 2 years after curative resection of initial HCC were enrolled into this retrospective study. Univariate and multivariate Cox-regression analysis were used to identify independent risk factors of late recurrence. Patterns, treatments and outcomes of late recurrence were investigated and analyzed. Results: During a median follow-up of 78.0 months after surgery, 303 patients (41.3%) developed late recurrence. Multivariate analysis revealed that cirrhosis, macroscopic vascular invasion, satellites, and tumor size > 5cm were independent risk factors of late recurrence. Among them, 273 (90.1%) were sole intrahepatic recurrence, 30 (9.9%) were concurrent intrahepatic and extrahepatic recurrence, and none of them was sole extrahepatic recurrence; 165 (54.4%) patients received curative treatments for recurrent HCC, including re-resection, transplantation and local ablation. Multivariate analysis showed regular postoperative surveillance and receiving curative treatments were two independent protective factors of prolonging survival for those patients with late recurrence. Conclusions: Late recurrence is correlated with cirrhosis and certain tumor-related characteristics of initial HCC. The patterns of late recurrence suggest that postoperative surveillance after 2 years of surgery could be adjusted and more targeted. Regular postoperative surveillance improves the probability to receive curative treatments again, yielding to better outcomes for patients with late recurrence.

Fault identification of a chain conveyor based on functional data feature engineering and optimized multi-layer kernel extreme learning machine

Hao Wen,Baolin Hou,Xin Jin 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.5

The functional time series signals generated during the operation of electromechanical systems contain fault characteristic information. This study proposes a fault identification method for electromechanical systems based on functional data feature engineering and multi-layer kernel extreme learning machine (MLKELM) optimized by sparrow search algorithm (SSA). First, multiple time series signals under different fault conditions are functionalized under the B-spline basis function system, and the feature reduction space is constructed by functional principal component analysis (FPCA) and principal differential analysis (PDA) to extract fault features. Second, the minimum redundancy and maximum relevance (mRMR) method is performed on the initial feature set for feature selection. In addition, the size of the optimal feature subset is determined by the class separability of feature subset (CSFS) criterion. Finally, deep feature learning and fault identification are implemented by MLKELM and the pre-defined parameters are optimized based on the SSA in this process to improve its performance. The experimental results show that the proposed method can effectively extract the fault features of function time series signals, and then accurately identify the faults of electromechanical systems.

Identification and Mapping of a Thermo-Sensitive Genic Self-Incompatibility Gene in Maize

Xin Ge Lin,Hui Ling Xie,Zhang Ying Xi,Yan Min Hu,Guang Yuan Zhao,Liu Jing Duan,Zong You Hao,Zong Hua Liu,Ji Hua Tang 한국유전학회 2009 Genes & Genomics Vol.31 No.3

In this study, we describe a novel ecological self-incompatibility (SI) line HE97 in maize. The main environmental factors influencing the inbred line characteristics were identified through field sowing trials during a two-year study period (2001 and 2002). The results showed that daily minimum temperature had the greatest effect on floral morphology and breeding system of the SI line. In staminate floret differentiation, when the daily minimum temperature exceeded 24℃, the line exhibited complete self-compatibility; however SI was observed when the daily minimum temperature was below 20℃. Therefore, we characterized the line as exhibiting thermo-sensitive genic self-incompatibility (TGSI). A set of F2 and F2:3 populations, derived from the inbred lines HE97 and Z58, were evaluated for two years to elucidate the TGSI line patterns of inheritance. Classical genetic analyses and QTL mapping results revealed that HE97 self-incompatibility was governed by a single allele, named here as tgsi1. The tgsi1 gene was mapped to chromosome 2 between SSR markers nc131 and bnlg1633, with a distance of 2.40 cM from nc131 and 2.44 cM from bnlg1633.

Comparison of Robust Methods for Shear Wave Speed Estimation by Simulation

Hao Yin,Dong C. Liu,Xin Liu 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.8

Mechanical properties of tissue are often related to the pathological state of tissue. Therefore, non-invasively measuring tissue stiffness has important clinical applications. With the assumption of isotropy, incompressibility and linearity, the shear modulus of tissue is related to its shear wave propagation speed. Acoustic radiation force from a focused ultrasound beam can be used to generate shear waves at the focal region within tissue, which propagate orthogonally to the direction of the pushing ultrasound beam. The shear wave speed can be estimated based on the so called time-to-flight principle. The shear wave arrival time determined at several lateral positions along the shear wave propagation path can be measured by the displacement profiles, which can be tracked using correlation-based method by pulse-echo ultrasound. This approach has been successively used with various modifications by several groups. The purpose of this study is to design a simulation method to generate the pulse-echo ultrasound signal, calculate the displacement profile in the spatial and time domain, and estimate the shear wave speed using RANSAC, Radon Sum and robust linear regression method, compare and analyze the algorithm performance of these methods.

Indirect displacement monitoring of high-speed railway box girders consider bending and torsion coupling effects

Xin Wang,Zhonglong Li,Yi Zhuo,Hao Di,Jianfeng Wei,Yuchen Li,Shunlong Li 국제구조공학회 2021 Smart Structures and Systems, An International Jou Vol.28 No.6

The dynamic displacement is considered to be an important indicator of structural safety, and becomes an indispensable part of Structural Health Monitoring (SHM) system for high-speed railway bridges. This paper proposes an indirect strain based dynamic displacement reconstruction methodology for high-speed railway box girders. For the typical box girders under eccentric train load, the plane section assumption and elementary beam theory is no longer applicable due to the bend-torsion coupling effects. The monitored strain was decoupled into bend and torsion induced strain, pre-trained multi-output support vector regression (M-SVR) model was employed for such decoupling process considering the sensor layout cost and reconstruction accuracy. The decoupled strained based displacement could be reconstructed respectively using box girder plate element analysis and mode superposition principle. For the transformation modal matrix has a significant impact on the reconstructed displacement accuracy, the modal order would be optimized using particle swarm algorithm (PSO), aiming to minimize the ill conditioned degree of transformation modal matrix and the displacement reconstruction error. Numerical simulation and dynamic load testing results show that the reconstructed displacement was in good agreement with the simulated or measured results, which verifies the validity and accuracy of the algorithm proposed in this paper.

Hangzhou Community Meteorological Disaster Preparedness and Risk Assessment System

Xin Hao 위기관리 이론과 실천 2017 위기관리 이론과 실천 세미나발표논문집 Vol.2018 No.-

Constituents of the Root of Anemone tomentosa

Hao-Bin Hu,Xu-Dong Zheng,Yu-Feng Jian,Jian-Xin Liu,Ji-Hua Zhu 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.7

A new diterpene glycoside, tomentoside I (1), along with eleven known compounds, including the four coumarins, 4,5-dimethoxyl-7-methylcoumarin (2), 4,7-dimethoxyl-5-methylcoumarin (3), isofraxidin (4) and fraxidin (5) as well as the seven triterpenoids, oleanolic acid (6), oleanolic acid 3-O-α-L-arabinopyranoside (7), oleanolic acid 3-O-β-D-galactopyranosyl-(1→3)-β-Dglucopyranoside (8), hederagenin 3-O-α-L-arabinopyranoside (9), betulinic acid (10), 18-hydroxyursolic acid (11) and 2α,3β,23-trihydroxyurs-12-en-28-oic acid (12) were isolated from the ethanolic extract of the root of Anemone tomentosa and their chemical structures were elucidated by spectroscopic methods. The antimicrobial activities of compounds 1-12 were measured using the agar disc-diffusion method. Also, their antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) were evaluated.

Mechanical Properties and Microstructure of Basalt Fiber Reinforced Concrete Under the Single-Side Salt-Freezing–Drying–Wetting Cycles

Hao Zeng,Jin Zhang,Yang Li,Xin Su,CongZhi Gu,Kai Zhang 한국콘크리트학회 2022 International Journal of Concrete Structures and M Vol.16 No.6

In the past, the salt freezing test does not often accord with the actual service environment of engineering, thus, we designed a test method of single-side salt-freezing–drying–wetting cycles. The mechanical properties and microstructure of ordinary concrete and basalt fiber reinforced concrete were studied. The mechanical property test is aimed at the splitting tensile strength and compressive strength of concrete after different cycles. The microstructure test is to study the hydration products by scanning electron microscope (SEM) and the pore structure of concrete by mercury intrusion porosimetry (MIP) test. The results indicate that the addition of basalt fiber can improve the compactness and pore structure of concrete. It is beneficial to enhance the durability of concrete under single-side salt-freezing–drying–wetting cycles. The improving effect of basalt fiber is better on the splitting tensile strength of concrete than the compressive strength. Basalt fiber exerts the best effect on reducing harmful holes in concrete. However, there is an optimal range of basalt fiber content, the performance of concrete will deteriorate with excessive fiber content. The cycles will destroy the hydration products of concrete and the synergistic effect between hydration products and fibers, but has little effect on the three-dimensional network constructed by basalt fibers. The pore structure of concrete is correlated with the mechanical properties of it under cyclic conditions, which is worth further study.

Chiral Pool Synthesis of N-Cbz-cis-(3R,4R)-3-methylamino-4-methylpiperidine from L-Malic acid

Hao, Bao-Yu,Liu, Jin-Qiang,Zhang, Wei-Han,Chen, Xin-Zhi Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.5

A new synthetic route to N-Cbz-cis-(3R,4R)-3-methylamino-4-methylpiperidine, key intermediate for CP-690,550, was disclosed with L-malic acid as the chiral pool starting material. The title compound was obtained in 16 steps with a total yield of 26% and more than 98% ee.

Experimental Comparison of Bernoulli Gripper and Vortex Gripper

Xin Li,Ning Li,Guoliang Tao,Hao Liu,Toshiharu Kagawa 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.

A Bernoulli gripper and a vortex gripper are types of pneumatic grippers that have similar functions but different working principles. They are widely used for performing gripping, transferring, and placing operations in automated production lines. This study systematically compares the two grippers and provides an objective reference to enable users to choose an appropriate gripper. First, we present the working principles of both grippers. Then, we measure the curves of suction force, air consumption, and upstream pressure; furthermore, we analyze and compare the energy consumption from the viewpoint of the entire pneumatic system. The results reveal the relationships with the air consumption and total energy consumption. Next, we measure the pressure distribution formed on the upper surface of the workpiece. From the experimental results, the principles of the two grippers are stated and compared. Furthermore, we use the pressure distribution data to estimate the deformation and inner stress of the workpiece. The influence of the grippers on the workpiece are analyzed and compared from a material mechanics viewpoint. Finally, we use three types of rough surfaces to qualitatively evaluate and compare the performance of the grippers when gripping a workpiece with a rough surface