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      • SCIESCOPUSKCI등재

        Extended cognitive reliability and error analysis method for advanced control rooms of nuclear power plants

        Xiaodan Zhang,Shengyuan Yan,Xin Liu Korean Nuclear Society 2024 Nuclear Engineering and Technology Vol.56 No.9

        This study proposes a modified extended cognitive reliability and error analysis method (CREAM) for achieving a more accurate human error probability (HEP) in advanced control rooms. The traditional approach lacks failure data and does not consider the common performance condition (CPC) weights in different cognitive functions. The modified extended CREAM decomposes tasks using a method that combines structured information analysis (SIA) and the extended CREAM. The modified extended CREAM performs the weight analysis of CPCs in different cognitive functions, and the weights include cognitive, correlative, and important weights. We used the extended CREAM to obtain the cognitive weight. We determined the correlative weights of the CPCs for different cognitive functions using the triangular fuzzy decision-making trial and evaluation laboratory (TF-DEMATEL), and evaluated the importance weight of CPCs based on the interval 2-tuple linguistic approach and ensured the value of the importance weight using the entropy method in the different cognitive functions. Finally, we obtained the comprehensive weights of the different cognitive functions and calculated the HEPs. The accuracy and sensitivity of the modified extended CREAM were compared with those of the basic CREAM. The results demonstrate that the modified extended CREAM calculates the HEP more effectively in advanced control rooms.

      • KCI등재

        Stable Cu-Co/C carbon-based composites for efficiency catalytic degradation of Orange II by PMS: Effect factors, application potential analysis, and mechanism

        Xiaodan Huang,Caihua Liu,Zhiyong Zhang,V. Vasanthakumar,Huiying Ai,Lei Xu,Ming-Lai Fu,Baoling Yuan 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.126 No.-

        Carbon-based metallic catalysts (CMCs) have emerged as efficient materials for removing water contaminants,but preparing CMCs with high efficiency and stability remains a great challenge. In this study, weprepared a bimetallic composite of Cu-Co/C catalyst via a gelation and calcination method to degradeOrange II by activating peroxymonosulfate (PMS). The characterization results demonstrated that thespecific surface area and pore size of Cu-Co/C catalysts were 1.675 m2/g and 6.313 nm, respectively,which can provide larger catalytic active sites for boosting PMS activation. Moreover, the effects of differentfactors on Orange II degradation efficiency, cyclic experiments, and possible application in realwater bodies were investigated. The Cu-Co/C catalyst can effectively activate PMS, and 50 mg/L ofOrange II was almost completely removed within 15 min. Additionally, the Cu-Co/C catalyst exhibitedhigh degradation efficiency for other organic dye pollutants. The radical quenching experiments indicatedthat the main active species for Cu-Co/C catalyzed degradation of Orange II were SO4and singlet oxygen(1O2). The catalyst demonstrated good stability and performance in real water bodies. We believe thatthis study will promote the application of carbon-based bimetallic catalysts in the environmental remediationprocess that utilize SO4based advanced oxidation.

      • KCI등재

        Chemical constituents and their acetyl cholinesterase inhibitory and antioxidant activities from leaves of Acanthopanax henryi: potential complementary source against Alzheimer’s disease

        Xiaodan Zhang,Xiang Qian Liu,김영희,황완균 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.5

        The aim of this study was to investigatechemical constituents of the leaves of Acanthopanax henryi,and their antioxidant, acetyl cholinesterase inhibitoryactivities. Caffeoyl quinic acid derivates and flavonoidswere obtained from A. henry, through column chromatographytechnologies, and the content of major constituentswas determined by the HPLC–UV method. Anti-oxidantactivity of the isolated metabolites was evaluated by freeradical scavenging (DPPH, ABTS radicals) and superoxideanion scavenging. The results showed that di-caffeoylquinic acid derivates had stronger antioxidant activity thanpositive controls (ascorbic acid, trolox and allopurinol). Acetyl cholinesterase inhibitory activity was estimated onthe constituents, among which, quercetin, 4-caffeoyl-quinicacid and 4,5-caffeoyl quinic acid were found to have strongacetyl cholinesterase inhibitory activity with IC50 valuesranging from 62.6 to 121.9 lM. The present study showedthat some of the tested constituents from the leaves of A. henryi exhibit strong antioxidant and acetyl cholinesteraseinhibitory effects. This suggest that the leaves of A. henryi can be used as a new natural complementary source ofacetyl cholinesterase inhibitors and anti-oxidant agents,thus being a promising potential complementary sourceagainst Alzheimer’s disease.

      • KCI등재

        Extended cognitive reliability and error analysis method for advanced control rooms of nuclear power plants

        Zhang Xiaodan,Yan Shengyuan,Liu Xin 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.9

        This study proposes a modified extended cognitive reliability and error analysis method (CREAM) for achieving a more accurate human error probability (HEP) in advanced control rooms. The traditional approach lacks failure data and does not consider the common performance condition (CPC) weights in different cognitive functions. The modified extended CREAM decomposes tasks using a method that combines structured information analysis (SIA) and the extended CREAM. The modified extended CREAM performs the weight analysis of CPCs in different cognitive functions, and the weights include cognitive, correlative, and important weights. We used the extended CREAM to obtain the cognitive weight. We determined the correlative weights of the CPCs for different cognitive functions using the triangular fuzzy decision-making trial and evaluation laboratory (TF-DEMATEL), and evaluated the importance weight of CPCs based on the interval 2-tuple linguistic approach and ensured the value of the importance weight using the entropy method in the different cognitive functions. Finally, we obtained the comprehensive weights of the different cognitive functions and calculated the HEPs. The accuracy and sensitivity of the modified extended CREAM were compared with those of the basic CREAM. The results demonstrate that the modified extended CREAM calculates the HEP more effectively in advanced control rooms.

      • KCI등재

        Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway

        Jingyu Ni,Zhihao Liu,Miaomiao Jiang,Lan Li,Jie Deng,Xiaodan Wang,Jing Su,Yan Zhu,Feng He,Jingyuan Mao,Xiumei Gao,Guanwei Fan 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.2

        Background: Ginsenoside Rg3 is one of the main active ingredients in ginseng. Here, we aimed to confirm its protective effect on the heart function in transverse aortic coarctation (TAC)-induced heart failure mice and explore the potential molecular mechanisms involved. Methods: The effects of ginsenoside Rg3 on heart and mitochondrial function were investigated by treating TAC-induced heart failure in mice. The mechanism of ginsenoside Rg3 for improving heart and mitochondrial function in mice with heart failure was predicted through integrative analysis of the proteome and plasma metabolome. Glucose uptake and myocardial insulin sensitivity were evaluated using micro-positron emission tomography. The effect of ginsenoside Rg3 on myocardial insulin sensitivity was clarified by combining in vivo animal experiments and in vitro cell experiments. Results: Treatment of TAC-induced mouse models with ginsenoside Rg3 significantly improved heart function and protected mitochondrial structure and function. Fusion of metabolomics, proteomics, and targeted metabolomics data showed that Rg3 regulated the glycolysis process, and Rg3 not only regulated glucose uptake but also improve myocardial insulin resistance. The molecular mechanism of ginsenoside Rg3 regulation of glucose metabolism was determined by exploring the interaction pathways of AMPK, insulin resistance, and glucose metabolism. The effect of ginsenoside Rg3 on the promotion of glucose uptake in IR-H9c2 cells by AMPK activation was dependent on the insulin signaling pathway. Conclusions: Ginsenoside Rg3 modulates glucose metabolism and significantly ameliorates insulin resistance through activation of the AMPK pathway.

      • KCI등재

        An electrochemical sensor based on [Ru(bpy)2dpp]2+/SMWCNTs/Au modified glassy carbon electrode for the detection of 5ʹ‑GMP

        Yu Ying,Huan Siqi,Wang Xiaodan,Yang Cong,Liu Dengyong 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.4

        A sensitive electrochemical sensor for the selective detection of 5ʹ-guanylic acid (5ʹ-GMP) was prepared by combining sulfonated-multiwalled carbon nanotubes (SMWCNTs) and [Ru(bpy)2dpp]Cl2, which were dripped on the surface of a glass carbon electrode (GCE) immobilized with gold nanoparticles. The 5ʹ-GMP electrochemical biosensor was fabricated using [Ru(bpy)2dpp]2+/SMWCNTs/Au/GCE as working, Ag/AgCl as reference and Pt as auxiliary electrode connected by an electrochemical workstation. The modified electrode was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The results showed the sensor’s response current had the best peak shape and maximum peak when the pH of electrolyte was 3, scan speed of CV was in the range of 100 to 180 mV/s, and the enrichment time was in the range of 200 to 300 s. Under the optimum conditions, a linear analytical curve was obtained for 5ʹ-GMP concentrations in the range of 0.01 to 0.5 mmol L− 1, with a detection limit of 0.0014 mmol L− 1. The analytical results of the 5ʹ-GMP sensor were exhibited good consistent with the data from liquid chromatography. The sensor has good reproducibility, long-term stability and strong immunity to interference, and may be a powerful device for 5ʹ-GMP detection, with great advantages such as simple preparation and operation, low equipment cost.

      • KCI등재

        Macroscopic Zn-doped a-Fe2O3/graphene aerogel mediated persulfate activation for heterogeneous catalytic degradation of sulfamonomethoxine wastewater

        Shuying Dong,Xuanxuan Yan,Wenli Li,Yafei Liu,Xiaoxu Han,Xiaodan Liu,Jinglan Feng,Chongfei Yu,Chunyan Zhang,Jianhui Sun 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-

        In order to obtain a robust, durable and efficient heterogeneous catalyst, macroscopic monolithic Zndopeda-Fe2O3/graphene aerogel (GA) hybrid architecture with integrated morphology and hierarchicallyporous structure were controllably synthesized via a facile in-situ hydrothermal method and then used aspersulfate (PS) activator for sulfamonomethoxine (SMM) wastewater purification. Several key reactionparameters including the initial SMM concentration, reaction temperature, coexisting inorganic anionsand SMM in real natural water samples had different influence on the SMM removal efficiency. The catalyticefficiency of Zn-doped a-Fe2O3/GA with the molar ratio of Fe/Zn = 2:1.5 was about 66%, 62%, 66%and 11%33% higher than that of GA, a-Fe2O3/GA, Zn/GA and other Fe/Zn molar ratio. The improvedactivity of Fe/Zn = 2:1.5 benefits from the synergistic effects of the sp2 hybridized carbon and porousframework, as well as the surface oxygenic functional groups, which accelerate the pollutant/oxidant dispersionand electron transfer. Electron paramagnetic resonance results indicate that OH, 1O2 and SO4radicals account for the catalytic degradation of SMM and the activation of PS in present system is differentfrom conventional homogeneous systems, and speculate mechanism was proposed based on theobtained data.

      • SCIESCOPUSKCI등재

        Effects of Supplementing Different Levels of a Commercial Enzyme Complex on Performance, Nutrient Availability, Enzyme Activity and Gut Morphology of Broilers

        Yuan, Jiu,Yao, Junhu,Yang, Fengxia,Yang, Xiaodan,Wan, Xinjie,Han, Jincheng,Wang, Yaojie,Chen, Xinke,Liu, Yurui,Zhou, Zhenfeng,Zhou, Ningbo,Feng, Xinyu Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.5

        A trial was conducted to study the influence of different levels of a commercial enzyme complex on performance, nutrient availability, blood parameters, digestive tract measurements, amylase and trypsin activity of the digestive tract and gut morphology in broilers fed the typical diets in north China. There were four treatments: the control diet and the other three enzyme complex supplemented diets which were 180 mg/kg, 360 mg/kg and 720 mg/kg enzyme complex supplemented to the control diet, respectively. The birds fed the diets supplemented with 180 mg/kg and 360 mg/kg enzyme complex had better performance and nutrient availability, the activities of amylase and trypsin in the digestive tract in the two treatments were improved, the villus height and surface area of villus in the small intestine increased and the crypt depth and epithelial thickness of small intestine decreased. Relative weights of pancreas and relative weights and lengths of small intestine decreased. However, the addition of 720 mg/kg enzyme complex had no effects on these parameters and increased crypt depth and epithelial thickness of the small intestine. The data suggested that suitable supplementation of enzyme complex was beneficial for the birds, while excess enzyme complex inhibited secretion of endogenous enzyme and destroyed the structure of the small intestine.

      • KCI등재

        Three sesquiterpene lactones suppress lung adenocarcinoma by blocking TMEM16A-mediated Ca2+-activated Cl− channels

        Ruilian Xiu,Jie Jia,Qing Zhang,Fengjiao Liu,Yaxin Jia,Yuanyuan Zhang,Beibei Song,Xiaodan Liu,Jingwei Chen,Dongyang Huang,Fan Zhang,Juanjuan Ma,Honglin Li,Xuan Zhang,Yunyun Geng 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.6

        Transmembrane protein TMEM16A, which encodes calcium-activated chloride channel has been implicated in tumorigenesis. Overexpression of TMEM16A is associated with poor prognosis and low overall survival in multiple cancers including lung adenocarcinoma, making it a promising biomarker and therapeutic target. In this study, three structure-related sesquiterpene lactones (mecheliolide, costunolide and dehydrocostus lactone) were extracted from the traditional Chinese medicine Aucklandiae Radix and identified as novel TMEM16A inhibitors with comparable inhibitory effects. Their effects on the proliferation and migration of lung adenocarcinoma cells were examined. Whole-cell patch clamp experiments showed that these sesquiterpene lactones potently inhibited recombinant TMEM16A currents in a concentration- dependent manner. The half-maximal concentration (IC50) values for three tested sesquiterpene lactones were 29.9 ± 1.1 μM, 19.7 ± 0.4 μM, and 24.5 ± 2.1 μM, while the maximal effect (Emax) values were 100.0% ± 2.8%, 85.8% ± 0.9%, and 88.3% ± 4.6%, respectively. These sesquiterpene lactones also significantly inhibited the endogenous TMEM16A currents and proliferation, and migration of LA795 lung cancer cells. These results demonstrate that mecheliolide, costunolide and dehydrocostus lactone are novel TMEM16A inhibitors and potential candidates for lung adenocarcinoma therapy.

      • KCI등재

        Effects of ultrasonic treatment on the gel properties of microbial transglutaminase crosslinked soy, whey and soy–whey proteins

        Qiang Cui,Xibo Wang,Guorong Wang,Rui Li,Xiaodan Wang,Shuang Chen,Jingnan Liu,Lianzhou Jiang 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.5

        This paper studied the influences of diverse ultrasonic power treatments on the physico-chemical properties of soy–whey mixed protein induced by microbial transglutaminase. Two groups of 15% (m/v) of protein solution-sole protein (as control group) and mixed protein were prepared and processed under different ultrasonic powers for 30 min. After ultrasonic power treatments, gel properties were significantly increased: under 300 W, the gel hardness of mixed protein reached a maximum of 998.9 g, with its water binding capacity scoring a maximum of 87%. According to the analysis of fluorescence emission spectrum, the fluorescence intensity and maximum absorption peak had changed, for different ultrasonic power treatments had exposed more groups. The Fourier Transform Infrared Spectroscopy also suggested that ultrasonic power treatments could change the secondary structure of gel samples. The scanning electron microscope demonstrated that the network structure of mixed protein gel displayed more regular and uniform after ultrasonic treatments.

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