Grenville-age orogenic event along the northeastern margin of the Quanji massif, NW China: constraints from ~1.1 Ga migmatite

Zhouxuan Xiao,Licheng Ma,Wan Jiang,Ran Wang,Yuyan Yao,Jie Cai,Jingyu Lin,Lu Li 한국지질과학협의회 2020 Geosciences Journal Vol.24 No.3

Detailed petrologic, geochemical and geochronological investigation on migmatites provide key information on the tectonic-magmatic history of the Quanji Massif, NW China. The studied migmatites are mainly composed of granitic gneisses, with lenticular refractory residua spread along its foliation. Zircon U-Pb ages of 1129.2 ± 7.4 Ma (1σ, MSWD = 0.34, N = 31) and 1135.1 ± 9.5 Ma (1σ, MSWD = 0.05, N = 22) were determined for the granitic gneiss and refractory residue, respectively. Garnet grains from the refractory residue show no distinctive intra-crystalline zonation, and are rich in Fe and Mg, but poor in Ca and Mn, akin to those from metapelite. Samples from the granitic gneisses have high contents of SiO2 (from 67.92% to 69.89%), K2O (from 3.94% to 5.00%) and A/CNK (1.11–1.17), with LREE enrichment and distinctly negative Eu anomalies (Eu/Eu* = 0.49–0.53) in the chondrite-normalized REE patterns, and significantly negative Nb, Ta, Ti and Sr anomalies in the primitive mantle-normalized spider diagrams. Granitic gneisses samples have consistent Nd isotope compositions with negative εNd(t) values ranging from –1.06 to –6.04, and TDM model ages ranging from 1.83 to 2.23 Ga. These geochemical features suggest that the granitic rocks belong to the S-type granites, which were predominately derived from a late Paleoproterozoic crustal source. The granitic gneiss was probably formed by partial melting of the sediments which had been suffered graunlite-facies metamorphism. The components with low melting points (e.g., felsic minerals) might replace the sediments to form migmatites and migmatitic granites, and thus preserved the refractory residua. Therefore, the late Mesoproterozoic orogenic event is the coeval response of the global Grenvillian orogeny, indicating an important crustal remelting episode in the Quanji Massif.

Expression and Clinical Significance of miRNA-34a in Colorectal Cancer

Ma, Zhi-Bin,Kong, Xiao-Lin,Cui, Gang,Ren, Cui-Cui,Zhang, Ying-Jie,Fan, Sheng-Jin,Li, Ying-Hua Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

Background: The aim of this study was to investigate differences of miRNA-34a expression in benign and malignant colorectal lesions. Materials and Methods: Samples of cancer, paraneoplastic tissues and polyps were selected and total RNA was extracted by conventional methods for real-time PCR to detect the miRNA-34a expression. In addition, the LOVO colorectal cancer cell line was cultured, treated with the demethylating agent 5-azacytidine and screened for differentially expressed miRNA-34a. Results: After the drug treatment, the miRNA-34a expression of colorectal cancer cell line LOVO was increased and real-time PCR showed that levels of expression in both cell line and colorectal cancer tissues were low, as compared to paraneoplastic tissue (p<0.05). Polyps tissues had significantly higher expression than paraneoplastic and colorectal cancer samples (p<0.05). Conclusions: miRNA-34a-5p may play a role as a tumor suppressor gene in colorectal cancer, with involvement of DNA methylation.

Mechanical response of rockfills in a simulated true triaxial test: A combined FDEM study

Ma, Gang,Chang, Xiao-Lin,Zhou, Wei,Ng, Tang-Tat Techno-Press 2014 Geomechanics & engineering Vol.7 No.3

The study of the mechanical behavior of rockfill materials under three-dimensional loading conditions is a current research focus area. This paper presents a microscale numerical study of rockfill deformation and strength characteristics using the Combined Finite-Discrete Element Method (FDEM). Two features unique to this study are the consideration of irregular particle shapes and particle crushability. A polydisperse assembly of irregular polyhedra was prepared to reproduce the mechanical behavior of rockfill materials subjected to axial compression at a constant mean stress for a range of intermediate principal stress ratios in the interval [0, 1]. The simulation results, including the stress-strain characteristics, relationship between principal strains, and principal deviator strains are discussed. The stress-dilatancy behavior is described using a linear dilatancy equation with its material constants varying with the intermediate principal stress ratio. The failure surface in the principal stress space and its traces in the deviatoric and meridian plane are also presented. The modified Lade-Duncan criterion most closely describes the stress points at failure.

Research on Innovative protection and Cultural IP Development of “Intangible Cultural Heritage” in Shandong Province under the background of “Internet Plus”

Xuesen Ma,Cong Lin,Wang Xiao Ya,Pei Pei,Fan Shou Zhong 한국글로벌무역학회 2022 한국글로벌무역학회 학술대회자료집 Vol.2022 No.-

The Gender-Sensitive Social Risk Factors for Internet Addiction in College Undergraduate Students

Xia Lin,Jing-yan Gu,Wan-jun Guo,Ya-jing Meng,Hui-yao Wang,Xiao-jing Li,Wei Deng,Lian-sheng Zhao,Xiao-hong Ma,Ming-li Li,Ting Chen,S,K,Cheng,Tao Li 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.7

Objective The current study aims to explore precipitating and social risk factors for internet addiction (IA) in university undergraduate students, and to provide evidence for interventions and the early prevention of IA in different genders. Methods Four thousand eight hundred and fifty-eight college sophomores completed an online survey on their internet use-related behaviours and social risk factors. Results We found that more male (8.3%) than female students (5.4%) had moderate and severe IA. The main online activity in the moderate and severe IA groups was online gaming in males and online streaming in females. Roommates engaging in similar internetbased entertainment was a risk factor of IA only for males, while not being in a romantic relationship was a risk factor of IA for females only. Infatuation with the internet before college and adjustment problems for college life were shared risk factors for both genders in the mild and moderate IA groups. Conclusion IA was a common phenomenon in college students with shared and unique precipitating and social risk factors in males and females. The gender-sensitive risk factors for IA warranted earlier and individualized intervention and prevention strategies for IA in this population.

Chronic Kidney Disease and Associated Cardiovascular Risk Factors in Chinese with Type 2 Diabetes

Qing-Lin Lou,Xiao-Jun Ouyang,Liu-Bao Gu,Yong-Zhen Mo,Ronald Ma,Jennifer Nan,Alice Kong,Wing-Yee So,Gary Ko,Juliana Chan,Chun-Chung Chow,Rong-Wen Bian 대한당뇨병학회 2012 Diabetes and Metabolism Journal Vol.36 No.6

Background: To determine the frequency of chronic kidney disease (CKD) and its associated risk factors in Chinese type 2 diabetic patients, we conducted a cross-sectional study in Nanjing, China, in the period between January 2008 and December 2009. Methods: Patients with type 2 diabetes under the care by Jiangsu Province Official Hospital, Nanjing, China were invited for assessment. CKD was defined as the presence of albuminuria or estimated glomerular filtration rate <60 mL/min/1.73 m2. Albuminuria was defined as urinary albumin-to-creatinine ratio ≥30 mg/g. Results: We recruited 1,521 urban Chinese patients with type 2 diabetes (mean age, 63.9±12.0 years). The frequency of CKD and albuminuria was 31.0% and 28.9%, respectively. After adjusted by age and sex, hypertension, anemia and duration of diabetes were significantly associated with CKD with odds ratio (95% confidence interval) being 1.93 (1.28 to 2.93), 1.70 (1.09 to 2.64), and 1.03 (1.00 to 1.06), respectively. Conclusion: In conclusion, CKD was common in the urban Nanjing Chinese with type 2 diabetes. Strategies to prevent or delay progression of kidney disease in diabetes should be carried out at the early disease course of type 2 diabetes.

A Secure Encryption-Based Malware Detection System

( Zhaowen Lin ),( Fei Xiao ),( Yi Sun ),( Yan Ma ),( Cong-cong Xing ),( Jun Huang ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.4

Malware detections continue to be a challenging task as attackers may be aware of the rules used in malware detection mechanisms and constantly generate new breeds of malware to evade the current malware detection mechanisms. Consequently, novel and innovated malware detection techniques need to be investigated to deal with this circumstance. In this paper, we propose a new secure malware detection system in which API call fragments are used to recognize potential malware instances, and these API call fragments together with the homomorphic encryption technique are used to construct a privacy-preserving Naive Bayes classifier (PP-NBC). Experimental results demonstrate that the proposed PP-NBC can successfully classify instances of malware with a hit-rate as high as 94.93%.

Engineered exosomes enriched in netrin-1 modRNA promote axonal growth in spinal cord injury by attenuating inflammation and pyroptosis

Lu Xiao,Xu Guangyu,Lin Zhidi,Zou Fei,Liu Siyang,Zhang Yuxuan,Fu Wei,Jiang Jianyuan,Ma Xiaosheng,Song Jian 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Spinal cord injury (SCI) brings a heavy burden to individuals and society, and there is no effective treatment at present. Exosomes (EX) are cell secreted vesicles containing molecules such as nucleic acids and proteins, which hold promise for the treatment of SCI. Netrin-1 is an axon guidance factor that regulates neuronal growth. We investigated the effects of engineered EX enriched in netrin-1 chemically synthetic modified message RNA (modRNA) in treating SCI in an attempt to find a novel therapeutic approach for SCI.Netrin-1 modRNA was transfected into bone marrow mesenchymal stem cells to obtain EX enriched with netrin-1 (EX-netrin1). We built an inflammatory model in vitro with lipopolysaccharide (LPS) in vitro to study the therapeutic effect of EX-netrin1 on SCI. For experiments in vitro, ELISA, CCK-8 assay, immunofluorescence staining, lactate dehydrogenase release experiments test, real-time quantitative polymerase chain reaction, and western blot were conducted. At the same time, we constructed a rat model of SCI. MRI, hematoxylin-eosin and Nissl staining were used to assess the extent of SCI in rats.In vitro experiments showed that EX had no effect on the viability of oligodendrocytes and PC12 cells. EX-netrin1 could attenuate LPS-induced inflammation and pyroptosis and accelerate axonal/dentritic growth in PC12 cells/oligodendrocytes. In addition, netrin-1 could activate the PI3K/AKT/mTOR signalling pathway upon binding to its receptor unc5b. When Unc5b and PI3K were inhibited, the effect of EX-netrin1 was weakened, which could be reversed by PI3K or mTOR activator. Our in vivo experiments indicated that EX-netrin1 could promote recovery in rats with SCI.We found that EX-netrin1 regulated inflammation, pyroptosis and axon growth in SCI via the Unc5b/PI3K/AKT/mTOR pathway, which provides a new strategy for the treatment of SCI.

Validity of Glycated Hemoglobin in Screening and Diagnosing Type 2 Diabetes Mellitus in Chinese Subjects

( Yun Yu ),( Xiao Jun Ouyang ),( Qing-lin Lou ),( Liu Bao Gu ),( Yong Zhen Mo ),( Gary T. Ko ),( Chun Chung Chow ),( Wing Yee So ),( Ronald Ma ),( Alice Kong ),( Nicola Brown ),( Jennifer Nan ),( Juli 대한내과학회 2012 The Korean Journal of Internal Medicine Vol.27 No.1

Background/Aims: The application of glycated hemoglobin (HbA1c) for the diagnosis of diabetes is currently under extensive discussion. In this study, we explored the validity of using HbA1c as a screening and diagnostic test in Chinese subjects recruited in Nanjing, China. Methods: In total, 497 subjects (361 men and 136 women) with fasting plasma glucose (PG) ≥ 5.6 mmol/L were recruited to undergo the oral glucose tolerance test (OGTT) and HbA1c test. Plasma lipid, uric acid, and blood pressure were also measured. Results: Using a receiver operating characteristic curve, the optimal cutoff point of HbA1c related to diabetes diagnosed by the OGTT was 6.3%, with a sensitivity and specificity of 79.6% and 82.2%, respectively, and the area under the curve was 0.87 (95% confidence interval, 0.83 to 0.92). A HbA1c level of 6.5% had a sensitivity and specificity of 62.7% and 93.5%, respectively. When comparing the HbA1c ≥ 6.5% or OGTT methods for diagnosing diabetes, the former group had significantly higher HbA1c levels and lower levels of fasting and 2-hour PG than the latter group. No significant difference was observed in the other metabolism indexes between the two groups. Conclusions: Our results suggest that HbA1c ≥ 6.5% has reasonably good specificity for diagnosing diabetes in Chinese subjects, which is in concordance with the American Diabetes Association recommendations.

Seismic performance of the concrete-encased CFST column to RC beam joints: Analytical study

Dan-Yang Ma,Lin-Hai Han,Xiao-Ling Zhao,Wei-Biao Yang 국제구조공학회 2020 Steel and Composite Structures, An International J Vol.36 No.5

A finite element analysis (FEA) model is established to investigate the concrete-encased concrete-filled steel tubular (CFST) column to reinforced concrete (RC) beam joints under cyclic loading. The feasibility of the FEA model is verified by a set of test results, consisting of the failure modes, the exposed view of connections, the crack distributions and development, and the hysteretic relationships. The full-range analysis is conducted to investigate the stress and strain development process in the composite joint by using this FEA model. The internal force distributions of different components, as well as the deformation distributions, are analyzed under different failure modes. The proposed connections are investigated under dimensional and material parameters, and the proper constructional details of the connections are recommended. Parameters of the beam-column joints, including material strength, confinement factor, reinforcement ratio, diameter of steel tube to sectional width ratio, beam to column linear bending stiffness ratio and beam shear span ratio are evaluated. Furthermore, the key parameters affecting the failure modes and the corresponding parameters ranges are proposed in this paper.