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Influence of zircon on cristobalite crystallization of silicabased ceramic cores
Jing-jing Liang,Quan-hong Lin,Xuan Zhang,Tao Jin,Xiao-feng Sun,최백규,김인수,도정현,조창용 한양대학교 세라믹연구소 2016 Journal of Ceramic Processing Research Vol.17 No.8
Zircon is usually used as a main additive to silica-based ceramic core materials in precise investment casting in order toimprove their high temperature properties. But there is still a disagreement in its effect on crystallization behavior of fusedsilica. In this study, cristobalite crystallization of fused silica in three silica-based core materials containing 10, 30 and 50 wt%zircon respectively were investigated through X-ray diffraction (XRD) and scanning electron microscopy equipped with energydispersive spectrometer (SEM/EDS). Results showed that zircon addition had neglected effect on cristobalite crystallizationduring sintering at 1180 oC, 1200 oC, and 1220 oC, but could decrease crystallization during simulated casting process at1500 oC. It was suggested that diffusion of zirconium atoms played a crucial role in this suppressing behavior of zircon on thecristobalite crystallization. During cooling from 1500 oC, cristobalite transformation from β to α caused microcracks in thesesamples that containing 10% or 30% zircon. But when zircon content increased to 50%, crack was prevented. Less phasetransformation of fused silica → cristobalite and enhanced strength by zircon was supposed to be the reason that wasresponsible for prevented cracks.
Gene-metabolite network analysis in different nonalcoholic fatty liver disease phenotypes
Xiao-Lin Liu,Ya-Nan Ming,Jing-Yi Zhang,Xiao-Yu Chen,Min-De Zeng,Yi-Min Mao 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
We sought to identify common key regulators and build a gene-metabolite network in different nonalcoholic fatty liver disease (NAFLD) phenotypes. We used a high-fat diet (HFD), a methionine-choline-deficient diet (MCDD) and streptozocin (STZ) to establish nonalcoholic fatty liver (NAFL), nonalcoholic steatohepatitis (NASH) and NAFL+type 2 diabetes mellitus (T2DM) in rat models, respectively. Transcriptomics and metabolomics analyses were performed in rat livers and serum. A functional network-based regulation model was constructed using Cytoscape with information derived from transcriptomics and metabolomics. The results revealed that 96 genes, 17 liver metabolites and 4 serum metabolites consistently changed in different NAFLD phenotypes (42-fold, Po0.05). Gene-metabolite network analysis identified ccl2 and jun as hubs with the largest connections to other genes, which were mainly involved in tumor necrosis factor, P53, nuclear factor-kappa B, chemokine, peroxisome proliferator activated receptor and Toll-like receptor signaling pathways. The specifically regulated genes and metabolites in different NAFLD phenotypes constructed their own networks, which were mainly involved in the lipid and fatty acid metabolism in HFD models, the inflammatory and immune response in MCDD models, and the AMPK signaling pathway and response to insulin in HFD+STZ models. Our study identified networks showing the general and specific characteristics in different NAFLD phenotypes, complementing the genetic and metabolic features in NAFLD with hepatic and extra-hepatic manifestations.
Research on Online rumor Based on SEIR Model with Nonlinear Incidence Rates
Xiao-Jing Lin,Ya-Ming Zhuang 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10
The internet changes the way of human communication, netizens can publish and receive information whenever and wherever, which promote efficiency and speed up rumor dissemination, and highlight dangers of online rumors. Because of many similarities between online rumors dissemination and virus dissemination, in this paper, the SEIR model with nonlinear incidence rates is proposed to research on the diffusion process of online rumors. Aiming at the increasing number of the new netizens in our country, use the Logistic curve to describe the number of netizens, build SEIR online tumor dissemination model with nonlinear incidence rate and population dynamics. By analyzing the equilibrium point, development trend of online tumor can be predicted, and analytical expressions of threshold value be obtained when it is exist. The online rumors dissemination can be controlled by adjusting the parameters of threshold expression. Finally the accuracy and validation has been verified by simulation experiment.
Lin, Xiao-Li,Niu, De,Hu, Zi-Liang,Kim, Dae Heon,Jin, Yin Hua,Cai, Bin,Liu, Peng,Miura, Kenji,Yun, Dae-Jin,Kim, Woe-Yeon,Lin, Rongcheng,Jin, Jing Bo Public Library of Science 2016 PLoS genetics Vol.12 No.4
<P>COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1), a ubiquitin E3 ligase, is a central negative regulator of photomorphogenesis. However, how COP1 activity is regulated by post-translational modifications remains largely unknown. Here we show that SUMO (small ubiquitin-like modifier) modification enhances COP1 activity. Loss-of-function siz1 mutant seedlings exhibit a weak constitutive photomorphogenic phenotype. SIZ1 physically interacts with COP1 and mediates the sumoylation of COP1. A K193R substitution in COP1 blocks its SUMO modification and reduces COP1 activity in vitro and in planta. Consistently, COP1 activity is reduced in siz1 and the level of HY5, a COP1 target protein, is increased in siz1. Sumoylated COP1 may exhibits higher transubiquitination activity than does non-sumoylated COP1, but SIZ1-mediated SUMO modification does not affect COP1 dimerization, COP1-HY5 interaction, and nuclear accumulation of COP1. Interestingly, prolonged light exposure reduces the sumoylation level of COP1, and COP1 mediates the ubiquitination and degradation of SIZ1. These regulatory mechanisms may maintain the homeostasis of COP1 activity, ensuing proper photomorphogenic development in changing light environment. Our genetic and biochemical studies identify a function for SIZ1 in photomorphogenesis and reveal a novel SUMO-regulated ubiquitin ligase, COP1, in plants.</P>
The Gender-Sensitive Social Risk Factors for Internet Addiction in College Undergraduate Students
Xia Lin,Jing-yan Gu,Wan-jun Guo,Ya-jing Meng,Hui-yao Wang,Xiao-jing Li,Wei Deng,Lian-sheng Zhao,Xiao-hong Ma,Ming-li Li,Ting Chen,S,K,Cheng,Tao Li 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.7
Objective The current study aims to explore precipitating and social risk factors for internet addiction (IA) in university undergraduate students, and to provide evidence for interventions and the early prevention of IA in different genders. Methods Four thousand eight hundred and fifty-eight college sophomores completed an online survey on their internet use-related behaviours and social risk factors. Results We found that more male (8.3%) than female students (5.4%) had moderate and severe IA. The main online activity in the moderate and severe IA groups was online gaming in males and online streaming in females. Roommates engaging in similar internetbased entertainment was a risk factor of IA only for males, while not being in a romantic relationship was a risk factor of IA for females only. Infatuation with the internet before college and adjustment problems for college life were shared risk factors for both genders in the mild and moderate IA groups. Conclusion IA was a common phenomenon in college students with shared and unique precipitating and social risk factors in males and females. The gender-sensitive risk factors for IA warranted earlier and individualized intervention and prevention strategies for IA in this population.
IGF-1 from Adipose-Derived Mesenchymal Stem Cells Promotes Radioresistance of Breast Cancer Cells
Yang, Hui-Ying,Qu, Rong-Mei,Lin, Xiao-Shan,Liu, Tong-Xin,Sun, Quan-Quan,Yang, Chun,Li, Xiao-Hong,Lu, Wei,Hu, Xiao-Fang,Dai, Jing-Xing,Yuan, Lin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Purpose: The aim of this study was to investigate effects of adipose-derived mesenchymal stem cells (AMSCs) on radioresistance of breast cancer cells. Materials and Methods: MTT assays were used to detect any influence of AMSC supernatants on proliferation of breast cancer cells; cell migration assays were used to determine the effect of breast cancer cells on the recruitment of AMSCs; the cell survival fraction post-irradiation was assessed by clonogenic survival assay; ${\gamma}$-H2AX foci number post-irradiation was determined via fluorescence microscopy; and expression of IGF-1R was detected by Western blotting. Results: AMSC supernatants promoted proliferation and radioresistance of breast cancer cells. Breast cancer cells could recruit AMSCs, especially after irradiation. IGF-1 derived from AMSCs might be responsible for the radioresistance of breast cancer cells. Conclusions: Our results suggest that AMSCs in the tumor microenvironment may affect the outcome of radiotherapy for breast cancer in vitro.
Jing Du,Lei Wang,Xiaochen Zhang,Xuan Xiao,Fang Wang,Pingliang Lin,Fang Bao,Yong Hu,Yi-Kun He 한국식물학회 2016 Journal of Plant Biology Vol.59 No.2
Salinity stress is a major limiting factor in agriculture and adversely affecting the whole plant. As a halophyte, the moss Physcomitrella patens, has been suggested to be an ideal model plant to study salinity tolerance and adaption. Two abiotic stress-responsive Group 3 Late Embryogenesis Abundant protein genes had been identified in P. patens and named as PpLEA3-1 and PpLEA3-2, respectively. Functions of these two genes were analyzed by heterologous expressions in Arabidopsis, driven either by their native P. patens promoters or by the 35S CaMV constitutive promoter. Phenotype analysis revealed that pLEA3::LEA3, pLEA3::LEA3::GFP and 35S::LEA3::GFP transgenic lines had stronger salinity resistance than that in the wild type and empty-vector control. Further analysis showed that the contents of proline and soluble sugar were increased and the malondialdehyde (MDA) were repressed in these transgenic plants after exposure to salinity stress. Our observations indicate that these two Group 3 PpLEA genes played a role in the adaption to salinity stress.
Enhanced electrochemical oxidation of dye wastewater with Fe2O3 supported catalyst
Lin Yue,Jianbo Guo,Kaihong Wang,Jingliang Yang,Xiao Luo,Jing Lian,Li Wang 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.2
Electrochemical oxidation of Acid Red 3R was investigated in the presence of Fe2O3/γ-Al2O3 as Fenton-like catalyst in the reactor. The results showed that the catalyst had catalytic activity in theelectrochemical process. Under the optimal conditions, the decolorization efficiency reached 77.2% in100 min. UV–vis spectrum and LC–MS analysis revealed that the dye molecule was firstly decomposed toaromatic intermediates, further degraded to ring opening products and finally mineralized. The azo dyedegradation might be attributed to strong oxidant -OH that produced from the synergetic effect ofbetween Fe2O3/γ-Al2O3 catalyst and electrochemical system.
Jing-Feng Li,Zhen-Yu Lin,Qi-Xin Zheng,Xiao-Dong Guo,Shu-Hua Yang,Hong-Wei Lu,Sheng-Hui Lan 한국생물공학회 2010 Biotechnology and Bioprocess Engineering Vol.15 No.5
Bone morphogenetic proteins (BMPs) play an important role in regulating osteoblast differentiation and subsequent bone formation, mainly evidenced by the induced osteogenic ability of BMP-2 from BMPs. However, BMP-2 alone does not induce the expected efficacy due to its short retention in vivo. In this study, a novel BMP-2-related peptide (designated P24) derived from the “knuckle epitope”of BMP-2 was coupled covalently to type I collagen derived from rat tail and observed under scanning electron microscopy (SEM) in low vacuum mode. The BMP-2-related peptide/collagen composite was implanted in vivo into the pocket of the quadriceps musculature of Sprague-Dawley (SD) rats and then harvested 3 or 6 weeks after surgery. It was found that lyophilized collagen retained a porous network structure with an average inner-diameter of 90 ~ 160 μm. Based on radiographic evaluation and histological examination, BMP-2-related peptide/collagen induced significant ectopic bone formation compared to that of rat tail collagen alone as a control. Our results indicate collagen served as a good carrier for newly synthesized BMP-2-related peptide and that the BMP-2-related peptide/collagen composite was an effective substitute in bone tissue engineering.