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Metformin inhibits early stage diethylnitrosamine-induced hepatocarcinogenesis in rats
JO, WOORI,YU, EUN-SIL,CHANG, MINSUN,PARK, HYUN-KYU,CHOI, HYUN-JI,RYU, JAE-EUN,JANG, SUNGWOONG,LEE, HYO-JU,JANG, JA-JUNE,SON, WOO-CHAN SPANDIDOS PUBLICATIONS 2016 MOLECULAR MEDICINE REPORTS Vol. No.
<P>Antitumor effects of metformin have recently emerged despite its original use for type II diabetes. In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)-induced rat model of HCC. Tumor foci were characterized by gross examination and by histopathological characteristics, including proliferation, hepatic progenitor cell content and the expression of hepatocarcinoma-specific molecular markers. Potential target molecules of metformin were investigated to determine the molecular mechanism underlying the inhibitory effects of metformin on chemically induced liver tumorigenesis. The antitumor effects of metformin were increased by the reduction of surface nodules and decreased the incidence of altered hepatocellular foci, hepatocellular adenoma and carcinoma. Also, decreased expression levels of glutathione S-transferase placental form, proliferating cell nuclear antigen and cytokeratin 8 described the inhibitory effects of metformin on HCC. In the present study, Wistar rats receiving treatment with DEN were administered metformin for 16 weeks. In addition, metformin suppressed liver tumorigenesis via an AMPK-dependent pathway. These results suggested that metformin has promising effects on the early stage of HCC in rats. Therefore, metformin may be used for the prevention of HCC recurrence following primary chemotherapy for HCC and/or for high-risk patients, including chronic hepatitis and cirrhosis.</P>
Woori Na,Jiyu Kim,Bong Hee Chung,Dai-Ja Jang,Cheongmin Sohn 한국영양학회 2020 Nutrition Research and Practice Vol.14 No.4
BACKGROUND/OBJECTIVES: Given the increasing proportion of the Korean population that is aged 65 years and older, the present study analyzed the relationship between diet quality and sarcopenia in elderly persons by using data from the 2008–2011 Korea National Health and Nutrition Examination Survey (KNHANES). SUBJECTS/METHODS: Data for 3,373 persons aged 65 years and over (men: 1,455, 43.1%) were selected from the 2008–2011 KNHANES. Sarcopenia assessments are based on a formula that divides a subject"s appendicular skeletal muscle mass (ASM) by their weight (wt) and multiplies that result by 100 ([ASM/wt] × 100). Sarcopenia is present if the subject"s result was less than one standard deviation (SD) below the sex-specific mean for a young reference group. For evaluation of diet quality, data obtained via the 24-hour recall method were used to calculate the Diet Quality Index for Koreans (DQI-K). A general linear model was applied in order to analyze general information and nutritional intake according to sarcopenia status. For analysis of the relationship between diet quality and sarcopenia, a binominal logistic regression analysis was undertaken. RESULTS: The sarcopenia prevalence rate among the study subjects aged 65 years and over was 37.6%. The DQI-K of those without sarcopenia was 3.33 ± 0.04 points, while that of those with sarcopenia was 3.45 ± 0.04 points (P < 0.05). The relationship between diet quality and sarcopenia revealed that subjects aged 75 and older had a poor diet quality, and their odds ratio (OR) of sarcopenia presence was significantly higher (OR: 1.807, 95% confidence interval: 1.003–3.254, P < 0.05). CONCLUSIONS: This study revealed that poor diet quality was related to sarcopenia presence in Koreans aged 75 and older. In order to improve the diet quality of the elderly (aged 75 and older), it is necessary to develop dietary improvement guidelines.
Potent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1
Jang Yongwoo,Kim Woori,Leblanc Pierre,Kim Chun-Hyung,Kim Kwang-Soo 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Until recently, Nurr1 (NR4A2) was known as an orphan nuclear receptor without a canonical ligand-binding domain, featuring instead a narrow and tight cavity for small molecular ligands to bind. In-depth characterization of its ligand-binding pocket revealed that it is highly dynamic, with its structural conformation changing more than twice on the microsecond-to-millisecond timescale. This observation suggests the possibility that certain ligands are able to squeeze into this narrow space, inducing a conformational change to create an accessible cavity. The cocrystallographic structure of Nurr1 bound to endogenous ligands such as prostaglandin E1/A1 and 5,6-dihydroxyindole contributed to clarifying the crucial roles of Nurr1 and opening new avenues for therapeutic interventions for neurodegenerative and/or inflammatory diseases related to Nurr1. This review introduces novel endogenous and synthetic Nurr1 agonists and discusses their potential effects in Nurr1-related diseases.
수열탄화를 이용한 커피찌꺼기 Biochar의 최적 생성 조건 및 중금속 흡착 평가
김장영 ( Jang Yeong Kim ),조우리 ( Woori Cho ),이진주 ( Jin Ju Lee ),최정우 ( Jeong Woo Choi ),이재섭 ( Jae Seop Lee ),이재영 ( Jai-young Lee ) 한국폐기물자원순환학회 2020 한국폐기물자원순환학회지 Vol.37 No.8
Coffee drinks are one of the most popular beverages around the world, and coffee beans are grown in about 80 countries. In addition, the consumption of coffee beans in Korea is about 150,000 tons as of 2018, the world's sixth largest, and the annual consumption of coffee per capita by people over 20 years old is about 353 cups, up 21 percent from 291 cups in 2015, which is about three times the consumption per capita of 132 cups by the world's population. However, despite the continued increase in coffee bean consumption, 99.8% of the coffee beans used remain as dregs, with the cost of handling them reaching 764.2 billion won a year, and environmental problems caused by CO<sub>2</sub> from the process cannot be ignored. Common coffee wastes have the advantage of high moisture content and high absorbency due to porous surface. Here, hydrothermal carbonization (HTC) is one of the thermal treatment methods and is a method of carbonation using temperatures of 180 ~ 300℃ and high pressure in a closed environment with limited oxygen. Unlike other pyrolysis methods, thermo-degradation methods have the advantage of cost-benefit that does not require pre-treatment of dryness because they conduct at a relatively low temperature and use water vapor pressure caused by evaporating moisture in the raw material itself. Therefore, it is suitable to recycle coffee wastes effectively using thermal water pressure carbonation reaction. We also want to evaluate the performance of adsorption by generating Activated Biochar through chemical activation as a method of utilizing Biochar produced after HTC reaction. Therefore, in this study, the optimum generation conditions of Biochar are derived by applying HTC method, which is suitable for utilizing the high moisture content and porous properties for recycling coffee wastes, and after deriving the optimal generation conditions for chemical activation of the Biochar produced, PAC(Powdered Activated Carbon) is compared with the characteristics analysis of coffee wastes and Biochar and Activated Biochar to check and evaluate the absorption performance of heavy metals.
열수가압탄화를 이용한 커피찌꺼기 Biochar의 최적 생성 및 Toluene 흡착 평가
김장영 ( Jang Yeong Kim ),조우리 ( Woori Cho ),이재영 ( Jai-young Lee ) 한국폐기물자원순환학회 2021 한국폐기물자원순환학회지 Vol.38 No.2
In this study, biochar was created from coffee wastes with a high moisture content by applying a hydrothermal carbonization (HTC) method. Environmental problems during the treatment and optimal conditions were derived based on the adsorption performance of biochar. In addition, we compared biochar and activated biochar to evaluate their potential as adsorbents for VOCs by chemical activation using KOH to activate micro-secessions of biochar. The highest yield was obtained at 260 ℃ for 1 h and the iodine adsorption performance at approximately 687.11 mg/L. Therefore, the HTC optimal reaction conditions using coffee wastes increased its potential for use as an adsorbent. KOH was used as a chemical activator to activate the biochar under optimal generative conditions. A second batch test was conducted and analyzed for yield and iodine adsorption performance. The second batch test showed that the optimal activation temperature was about 700℃, the optimal mixing ratio of biochar and KOH was 1 : 0.5, and the optimal activation time was 1 h for 1,105.33 mg/g iodine adsorption performance. Toluene adsorption experiments were conducted to evaluate the VOC adsorption potential of coffee wastes, biochar, activated biochar, and GAC (Granular Activated Charcoal, Untreated). As a result, activated biochar, which was adsorbed at 240 minutes, was considered a more efficient adsorbent than coffee wastes, biochar, and GAC. Therefore, this study conducted an adsorbent evaluation of activated biochar produced from the HTC process. The resultant biochar showed higher efficiency in a shorter period and was sufficient to be used as an adsorbent.
주간보호센터 시설 이용 인지장애 노인의 노쇠와 영양상태와의 관련성
나우리(Woori Na),김지유(Jiyu Kim),김혜지(Hyeji Kim),이예지(Yeji Lee),손정민(Cheongmin Sohn),장대자(Dai-Ja Jang) 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.1
본 연구는 주간보호센터의 인지장애 노인을 대상으로 노쇠예방 및 관리를 위해 노쇠와 관련된 요인을 도출하고 영양상태와의 관련성을 분석하였다. 노쇠에 유의하게 영향을 미치는 요인을 도출하기 위해 관련 요인을 성별, 연령, 일상생활능력, 욕창위험도(Braden scale), 낙상위험도(Huhn scale), 식욕부진(SNAQ), 영양상태(MNA)로 하여 다중회귀분석을 실시한 결과, 노쇠에 유의하게 영향을 미치는 요인은 연령(β=0.273, P=0.007), MNA(β=-0.244, P=0.047)로 나타났다. 영양상태에 따른 노쇠와의 관련성을 분석하기 위해 MNA 점수에 따라 성별, 연령, 만성질환 개수를 보정하여 전노쇠의 교차비를 분석한 결과 0.788배(95% confidence interval(CI): 0.643-0.965, P=0.021)로 나타났으며, 노쇠의 교차비는 0.654배(95% CI: 0.477-0.879, P=0.008)로 나타났다. 본 연구를 통해 노쇠에 영향을 미치는 주요한 요인이 영양상태임을 보였고, 이는 노쇠 정도에도 관련을 보였다. 따라서 상대적으로 낮은 수준의 돌봄 수준을 가진 주간보호센터의 인지장애 노인의 영양상태 개선을 위한 적극적인 영양관리 방안이 마련되어야 할 것으로 보인다. The cognitive disorder in elderly can cause various malfunctions, so it requires steady caring. Daycare centers for elderly are proper as a facility to take care of the elderly with cognitive disorders that are able to lead a normal life and that need relatively low level of caring. This study analyzed the relation with the frail of the elderly who have cognitive disorders among those who use adult daycare centers in order to provide basic resources of nutrition management to manage and improve their frail. The participants of the study were 88 persons whose Korean version of Mini-Mental State Examination (MMSE-K) is less than 19 among the elderly at three adult daycare centers in Jeollabuk-do. The questionnaire items were gender, age, number of chronic diseases, BMI, hand grip, nutritional status (mini nutritional assessment, MNA) and health status (activity of daily living (K-ADL), pressure ulcer (Braden scale), fall (Huhn scale), appetite assessment (simplified nutritional appetite questionnaire, SNAQ), and K-FRAIL is used for frail assessment. For statistical analysis, the logistic regression was used for the analysis of relation between frail and nutritional condition. The result of analyzing the odds ratio of pre-frail by revising gender, age and the number of chronic diseases according to MNA scores for analysis of frail by nutritional condition was 0.788 (95% confidence interval (CI): 0.643∼0.965, P=0.021), and the odds ratio of frail was 0.654 (95% CI: 0.477∼0.879, P=0.008). This indicates that it is necessary to establish an active nutrition management plan to improve health condition of the elderly with cognitive disorders in elderly care facilities.