기관지폐 이형성증의 임상 양상: 다기관 연구

성기혜 ( Ki Hye Sung ),김민희 ( Min Hee Kim ),김은령 ( Eun Ryoung Kim ),심재원 ( Jae Won Shim ),이정주 ( Jung Ju Lee ),임재우 ( Jae Woo Im ),진현승 ( Hyun Seung Jin ) 대한주산의학회 2009 Perinatology Vol.20 No.3

목적: 최근 극소 저출생 체중아의 생존율의 개선으로 기관지폐 이형성증(bronchopulmonary dysplasia, BPD)이 늘고 있다. 다기관 연구에 의해 전국적인 BPD의 역학, 임상 양상과 각 병원 간의 차이를 조사하여 향후 우리나라의 BPD 감소와 중증도를 줄이는 것을 목적으로 본 연구를 시행하였다. 방법: 2005년 6월부터 2007년 5월까지 건국대학교병원, 영등포 성애병원, 강북삼성병원, 중앙대학교병원, 건양대학교병원, 강릉아산병원의 신생아 집중 치료실에 입원하였던 신생아 4,476명을 대상으로 하였다. BPD의 진단 기준은 비전형적인 BPD를 포함하여 병인적인 분류를 하고 있는 Ogawa 등의 분류법을 이용하여 신생아 호흡 곤란 증후군(respiratory distress syndrome, RDS)과 전형적 또는 미만성 혼탁의 방사선 소견, 산전 감염의 유무에 따라 6가지 type으로 분류하였다. 또한 전체 신생아의 출생체중 분포와 생존율, 각 출생체중 군별 BPD의 발생률, 병태 비율, 사망률 등을 조사하고, 이 후 재택 산소요법 시행 여부와 미숙아 망막증, 괴사성 장염 등의 합병증 여부를 조사하였다. 결과: 생후 28일째 산소 치료가 필요한 신생아는 89명이었고, 이 중 Ogawa 분류법에 의한 BPD 환아는 70명(1.6%)이었으며, 특히 1,500 g 미만의 환아 237명 중 60명(25.3%)이었다. 생후 28일 이상 생존율은 98.7%이고, 사망 예는 없었으며 평균 재원 기간은 97.8±51.2일(43~405일)이었다. BPD는 900~999 g, 1,000~1,249 g의 체중 군에서 발생률이 각각 15명(21.4%)으로 가장 높았으며, 교정 36주 이후에도 산소투여가 필요한 중증 BPD의 경우 900~999 g의 체중 군에서 7명(23.3%)로 가장 높았다. Ogawa 분류법으로 BPD의 각 병태 비율로는 RDS 이후에 나타나는 I, II형이 각각 전체의 17예(24.3%), 44예(62.9%)로 대다수를 차지하였다. 이외에도 III`형은 2예(2.9%), IV형은 2예(2.9%), V형은 5예(7.1%)이었고, III형, VI형은 없었다. 재택 산소요법은 8예에서 시행되어 전체의 11.4%였으며, 이 중 BPD I형이 7예로 87.5%를 차지하였다. 미숙아 망막증은 35명(50.0%)에서 발생하였으며, 700 g 이하 신생아에서 9예(26.5%)로 가장 많았다. 또한 괴사성 장염은 3명(4.3%)이었다. 결론: 본 연구는 국내에서 처음으로 진행된 BPD의 전국적인 다기관 역학 조사로, 대상 신생아의 Ogawa 분류에 의한 BPD 유병률은 1.6% 이었고 1,500 g 미만 신생아의 25.3%이었으며, 전체 신생아의 BPD 70명 중 Ogawa 분류의 I, II형이 각각 24.3%, 62.9%로 대다수를 차지하였다. Purpose: As the neonatal intensive care advanced, the incidence of neonatal bronchopulmonary dysplasia (BPD) has increased. We conducted a multi-center investigation of the prevalence of BPD in six hospitals to investigate the epidemiology of BPD in Korea. Methods: Retrospective reviews ware performed for survival rate, prevalence of BPD of total 4,476 newborn infants who were admitted to neonatal intensive care unit in Konkuk university hospital, Sung-Ae General hospital, Kangbuk Samsung hospital, Chung-Ang university hospital, Konyang university hospital, and Gangneung Asan hospital between June, 2005 and May, 2007. By Ogawa, BPD was defined as oxygen dependency at 28 days after birth, with respiratory distress symptoms and the change of chest x-ray finding, and classified as 6 subtypes. Classic BPD was defined as oxygen dependency at 36 weeks of postmenstrual age. Results: Survival rate at 28 day after birth was 98.7%. BPD infants by Ogawa classification were 70 (1.6% of overall newborn infants), classic BPD infants were 30 (0.7%). Especially, among 237 preterm infants with birth weight less than 1,500 gram who survived to 28 days of life, 60 (25.3%) had BPD by Ogawa classification and 23 (9.7%) had classic BPD. In Ogawa classification, infants with RDS as type I and II, were 17 infants (24.3%) and 44 infants (62.9%). Home oxygen therapy was performed 8 infants (11.4%). Prevalence of retinopathy of prematurity was 35 infants (50.0%), necrotizing enterocolitis was 3 infants (4.3%), and intraventricular hemorrhage was 6 infants (8.6%). Conclusion: Prevalence of BPD infants was 1.6% of overall newborn, 25.3% of preterm infants with birth weight less than 1,500 gram. Among 70 BPD infants, BPD by Ogawa classification with history of RDS as type I and II were 24.3%, 62.9% as the majority of BPD. This study would be the first report of epidemiology of Korean BPD infants by multi-center study.

A Novel Retractable Robotic Device for Colorectal Endoscopic Submucosal Dissection

( Sang Hyun Kim ),( Chanwoo Kim ),( Bora Keum ),( Junghyun Im ),( Seonghyeon Won ),( Byung Gon Kim ),( Kyungnam Kim ),( Taebin Kwon ),( Daehie Hong ),( Han Jo Jeon ),( Hyuk Soon Choi ),( Eun Sun Kim ) 대한소화기학회 2024 Gut and Liver Vol.18 No.4

Background/Aims: Appropriate tissue tension and clear visibility of the dissection area using traction are essential for effective and safe endoscopic submucosal dissection (ESD). In this study, we developed a retractable robot-assisted traction device and evaluated its performance in colorectal ESD. Methods: An experienced endoscopist performed ESD 18 times on an ex vivo porcine colon using the robot and 18 times using the conventional method. The outcome measures were procedure time, dissection speed, procedure-related adverse events, and blind dissection rate. Results: Thirty-six colonic lesions were resected from ex vivo porcine colon samples. The total procedure time was significantly shorter in robot-assisted ESD (RESD) than in conventional ESD (CESD) (20.1±4.1 minutes vs 34.3±8.3 minutes, p<0.05). The submucosal dissection speed was significantly faster in the RESD group than in the CESD group (36.8±9.2 mm²/min vs 18.1±4.7 mm²/min, p<0.05). The blind dissection rate was also significantly lower in the RESD group (12.8%±3.4% vs 35.1%±3.9%, p<0.05). In an in vivo porcine feasibility study, the robotic device was attached to a colonoscope and successfully inserted into the proximal colon without damaging the colonic wall, and ESD was successfully performed. Conclusions: The dissection speed and safety profile improved significantly with the retractable RESD. Thus, our robotic device has the potential to provide simple, effective, and safe multidirectional traction during colonic ESD. (Gut Liver 2024;18:677-685)

Characterization of H460R, a Radioresistant Human Lung Cancer Cell Line, and Involvement of Syntrophin Beta 2 (SNTB2) in Radioresistance

Im, Chang-Nim,Kim, Byeong Mo,Moon, Eun-Yi,Hong, Da-Won,Park, Joung Whan,Hong, Sung Hee Korea Genome Organization 2013 Genomics & informatics Vol.11 No.4

A radioresistant cell line was established by fractionated ionizing radiation (IR) and assessed by a clonogenic assay, flow cytometry, and Western blot analysis, as well as zymography and a wound healing assay. Microarray was performed to profile global expression and to search for differentially expressed genes (DEGs) in response to IR. H460R cells demonstrated increased cell scattering and acidic vesicular organelles compared with parental cells. Concomitantly, H460R cells showed characteristics of increased migration and matrix metalloproteinase activity. In addition, H460R cells were resistant to IR, exhibiting reduced expression levels of ionizing responsive proteins (p-p53 and ${\gamma}$-H2AX); apoptosis-related molecules, such as cleaved poly(ADP ribose) polymerase; and endoplasmic reticulum stress-related molecules, such as glucose-regulated protein (GRP78) and C/EBP-homologous protein compared with parental cells, whereas the expression of anti-apoptotic X-linked inhibitor of apoptosis protein was increased. Among DEGs, syntrophin beta 2 (SNTB2) significantly increased in H460R cells in response to IR. Knockdown of SNTB2 by siRNA was more sensitive than the control after IR exposure in H460, H460R, and H1299 cells. Our study suggests that H460R cells have differential properties, including cell morphology, potential for metastasis, and resistance to IR, compared with parental cells. In addition, SNTB2 may play an important role in radioresistance. H460R cells could be helpful in in vitro systems for elucidating the molecular mechanisms of and discovering drugs to overcome radioresistance in lung cancer therapy.

Real-Life Experience of Ledipasvir and Sofosbuvir for HCV Infected Korean Patients: A Multicenter Cohort Study

( Sung Won Lee ),( Hae Lim Lee ),( Hee Yeon Kim ),( Chang Wook Kim ),( Do Seon Song ),( U Im Chang ),( Jin Mo Yang ),( Sun Hong Yoo ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Seok-hwan Kim ),( Myeong Jun 대한간학회 2021 춘·추계 학술대회 (KASL) Vol.2021 No.1

P085 : Objective analysis of poly-L-lactic acid (PLLA) injection efficacy in different setting

( Sang Young Byun ),( Jung Won Shin ),( Soon Hyo Kwon ),( Koo Il Seo ),( Mi Sook Park ),( Joshua Lee ),( Kyoung Chan Park ),( Jung Im Na ),( Chang Hun Huh ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: A Poly-L-lactic acid (PLLA) is a soft tissue filler known to stimulate collagen production. Objectives: The purpose of this study is to analyze objective volumetric effect of PLLA in different setting of injection schedule on the cheek. Methods: A split-face, evaluator-blind randomized study in 24 volunteers was conducted. One side was injected 3 times with dose of 4cc per visit at week 0, 4, and 8, and the other side was injected 2 times with dose of 6cc per visit at week 4 and 8, respectively. Volunteers were evaluated with facial volume loss scale (FVLS) from 1 to 5(most severe) and objective volumetric values using Vectra-CR 3D camera system. Results: Improvement of FVLS was statistically significant (p<0.05) and maintained until 12 months in both injection side. Vectra showed volumetric difference (cc) between before and after injection. In 3 times injection side, it was increased from 2.12cc (after 1 month) to 3.17cc (after 12 months). In 2 times injection side, it was increased from 2.26cc (after 1 month) to 3.19cc (after 12 months). Gradual volumetric improvement over 12 months was statistically significant in both sides (P<0.05, generalized linear model). There was not statistically significant difference between three and two times injection side in both FVLS and Vectra. There was no severe adverse event. Conclusion: PLLA filler has continuous volumetric effect and there was not a significant difference by injection times at the same total injection volume.

[P10-260] Chemical Compositions and Antioxidant Activity of the Colored Rice Cultivars

Sang-Won Choi,Ji-Hae Oh,Eun-Ok Kim,Sung-Soo Kim,Jung-Gyo Im,Kee-Taek Lee,Hak-Soo Suh 한국식품영양과학회 2006 한국식품영양과학회 학술대회발표집 Vol.2006 No.10

[P10-261] Effects of Scutellaria baicalensis Georgi. on the osteoblastic Activity

Sang-Kyung Jeon,Ji-Won Lee,Syng-Ook Lee,Mi-Hyang Hwangbo,Mi-Hee Yu,Hyo Gwon Im,In-Seon Lee 한국식품영양과학회 2006 한국식품영양과학회 학술대회발표집 Vol.2006 No.10

A Case of Achieving Partial Remission with the Combination of Sorafenib and Nivolumab in a Patient with Hepatocellular Carcinoma Showing Disease Progression after Nivolumab Therapy

( Sang Youn Hwang ),( Seon-mi Lee ),( Jung Woo Im ),( Ki Jeong Jeon ),( Cheol-won Choi ),( Kyung-su Kim ),( Wan Jeon ) 대한간암학회 2019 대한간암학회지 Vol.19 No.1

Sorafenib is a well-known approved systemic therapeutic agent used in patients with advanced hepatocellular carcinoma (HCC). Regorafenib and nivolumab are approved as second-line therapeutic drugs in patients showing disease progression after sorafenib therapy. However, there is no established third- or fourth-line therapy in patients with progression after regorafenib or nivolumab treatment. Recently, the combination of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICPIs) has been attempted as a firstline treatment strategy in advanced HCC patients based on the hypothesis that combination therapy may overcome resistance in ICPI monotherapy. On the basis of this suggestion, we herein describe the case of an HCC patient demonstrating macrovascular invasion, whereby partial remission was achieved via the combination of sorafenib and nivolumab following disease progression after nivolumab therapy. Further studies on the combination of TKIs and ICPIs are necessary to determine ways to manage HCC patients showing disease progression after ICPI therapy. (J Liver Cancer 2019;19:74-78)

Tailored radiotherapeutic strategies for disseminated uterine cervical cancer patients

Im, Jung Ho,Yoon, Hong In,Kim, Sunghoon,Nam, Eun Ji,Kim, Sang Wun,Yim, Ga Won,Keum, Ki Chang,Kim, Young Tae,Kim, Gwi Eon,Kim, Yong Bae BioMed Central 2015 Radiation oncology Vol.10 No.-

<P><B>Background</B></P><P>To investigate the role of radiotherapy (RT) in and to suggest radiotherapeutic strategies for patients presenting with disseminated cervical cancer.</P><P><B>Methods</B></P><P>We retrospectively analyzed 50 patients diagnosed as the disseminated cervical cancer with distant lymph nodal or visceral organ metastasis between September 1980 and August 2012. Patients were divided into two subgroups according to visceral organ metastasis: 35 patients diagnosed with distant lymph node metastasis only (group A) and 15 patients with visceral organ metastasis (group B). All patients received external beam RT to the pelvis (median dose 45 Gy) and high-dose rate intracavitary RT (median dose 30 Gy). Thirty-nine patients (78%) received chemotherapy.</P><P><B>Results</B></P><P>Median follow-up time was 74 months. The 5-year pelvic control rate (PCR) was 85.8%, and the progression-free survival (PFS), and overall survival (OS) rates were 28.7%, and 36.2%, respectively. The major treatment failure was systemic progression (32 patients, 64%). The 5-year PCRs in groups A and B were 87.4% and 74.7%, respectively (<I>p</I> > 0.05). Meanwhile, PFS and OS rates for group A were significantly better than those for group B (35.3% vs. 13.3%, <I>p</I> = 0.010; and 46.3% vs. 13.3%, <I>p</I> = 0.009, respectively).</P><P><B>Conclusion</B></P><P>Our data revealed considerable prognostic heterogeneity in disseminated cervical cancer. Even though a high PCR was achieved in patients treated with definitive RT, survival outcomes were dependent on progression of visceral organ metastasis. Therefore, personalized RT and chemotherapy treatment strategies according to the presence of visceral organ metastasis in disseminated cervical cancer patients may help improve clinical outcomes.</P>

Ozone-Free Portable Microwave Atmospheric Air Plasma Jet

Im Hee Won,Sung Kil Kang,Jae-Yoon Sim,Jae Koo Lee IEEE 2014 IEEE transactions on plasma science Vol.42 No.10

<P>A 1.29-GHz microwave excited atmospheric pressure ambient air plasma jet has been developed as a portable plasma device. A 10-mm stable air plasma jet was generated with a pin-to-hole structure coaxial resonator. Ozone problem was also solved by high temperature of the formed air plasma. Appropriate ambient air flow was supplied to reduce the plasma gas temperature up to 36 °C at treating point. The ozone-free nonthermal portable air plasma system is expected to be useful in biomedical area for its components investigated by optical emission analysis.</P>