Percutaneous catheter drainage for abscess after surgery

Wen-Bo Zhu,Xiao-Hui Zhao,Hai-Liang Li,Chen-Yang Guo,Quan-Jun Yao,Xiang Geng,Ke Zhao,Hong-Tao Hu 소화기인터벤션의학회 2022 Gastrointestinal Intervention Vol.11 No.4

Percutaneous abscess drainage (PAD) has been proven to be a safe, effective, and widely used technique for the treatment of patients with abscesses after gastrointestinal surgery. The indications for PAD are expanding and most postoperative abscesses of the gastrointestinal tract are susceptible to PAD. PAD uses various imaging methods, including ultrasound, computed tomography, and several safe and reliable catheter insertion methods.

Mest Attenuates CCl4-Induced Liver Fibrosis in Rats by Inhibiting the Wnt/β-Catenin Signaling Pathway

( Wen Ting Li ),( Chuan Long Zhu ),( Yi Li ),( Quan Wu ),( Ren Tao Gao ) 대한소화기학회 2014 Gut and Liver Vol.8 No.3

Background/Aims: The Wnt/β-catenin signaling pathway has been reported to play an important role in liver fibrosis. This study was designed to investigate whether mesoderm-specific transcript homologue (Mest), a strong negative regulator of Wnt/β-catenin signaling, could inhibit liver fibrosis. Methods: pcDNA-Mest was transfected into hepatic stellate cells (HSCs) and rats. Rats were randomly divided into four groups: normal group (normal saline), treatment group (pcDNA- Mest+CCl4), control group (pcDNA-neo+CCl4), and model group (normal saline+CCl4). Changes in liver pathology were evaluated by hematoxylin and eosin and Masson’s trichrome staining. The levels of alanine transaminase, aspartate transaminase, lactic dehygrogenase, hyaluronic acid, and laminin in the serum and hydroxyproline in the liver were detected by biochemical examination and radioimmunoassay, respectively. The expression and distribution of β-catenin, α-smooth muscle actin (α-SMA), Smad3, and tissue inhibitor of metalloproteinase type I were determined, and the viability of the HSCs was tested. Results: Our data demonstrate that Mest alleviated CCl4-induced collagen deposition in liver tissue and improved the condition of the liver in rats. Mest also significantly reduced the expression and distribution of β-catenin, α-SMA and Smad3 both in vivo and in vitro, in addition to the viability of HSCs in vitro. Conclusions: We found that Mest attenuates liver fibrosis by repressing β-catenin expression, which provides a new therapeutic approach for treating liver fibrosis.

Timosaponin B-Ⅱ Inhibits Pro-inflammatory Cytokine Induction by Lipopolysaccharide in BV2 Cells

Wen-Quan Lu,Wan-Sheng Chen,Yan Qiu,Tie-Jun Li,Xia Tao,Lian-Na Sun 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.9

It was reported that the total polysaccharides extracts from Anemarrhenae asphodeloides Bge(Liliaceae, rhizome) could inhibit inflammatory responses in various models. In the present study, the effects of Timosaponin B-II, a purified extract from A. asphodeloidesb, on the expressions of IL-1β, TNF-α and IL-6, the activity of NF-κB and the activation of signal pathway related to NF-κB were explored in vitro. Timosaponin B-Ⅱ significantly attenuated increase of these cytokines on both mRNA and protein levels from LPS-stimulated BV2 cells in a dose-dependent manner. The reporter gene assay also showed that the activation of NF-κB induced by LPS was inhibited by pre-treatment with Timosaponin B-Ⅱ. Moreover, western blot results showed that the activation of p38, JNK and P65 had been decreased. These results suggest that both NF-κB signal pathway and MAPK pathway were involved in the inhibitory effects of Timosaponin B-II on the expression of pro-inflammatory cytokines.

The Ability of Bone Mineral Density and Microstructural Indices to Reflect the Mechanical Properties of Trabecular Bone in the Intertrochanteric Region

Wen Quan Cui(최문권),Ye-Yeon Won(원예연),Kwang-Kyoun Kim(김광균),Myong-Hyun Baek(백명현),Sung-Gu Yeo(여성구),Han-Sung Kim(김한성),Han Ter Min(민한터) 대한정형외과학회 2005 대한정형외과학회지 Vol.40 No.8

목적: 본 연구의 목적은 골밀도와 미세 골구조의 성질이 전자부 골소주의 기계적 특성(예, 탄성계수)에 미치는 영향을 연구하는 것이다. 대상 및 방법: 인공관절 전치환술을 시행 받은 15명의 환자로부터 대퇴골 전자부에서 총 15개의 고관절 골소주 시편을 채취하여, 이들을 대상으로 PIXImus2 골밀도 측정기, 고해상도 미세 컴퓨터 단층촬영기, 유한요소법을 이용하여 골밀도와 2차 및 3차원 미세구조 지수, 그리고 기계적 특성을 분석하였다. 골밀도, 구조 지수, 탄성계수 간의 상관관계를 선형회귀분석을 이용하여 통계처리하였다. 결과: 저자들의 본 연구에서 골밀도 및 골 체적비는 기계적 특성을 예측하는데 가장 중요한 인자였으며, 삼차원 마세구조 지수(예를 들어 구조 모델 지수) 또한 51% 정도 통계적으로 의미 있게 기계적 특성을 예측하였다. 골밀도와 미세구조지수를 조합한 경우에 탄성계수의 변화량을 예측하는데 잘 반영하였다. 결론: 골밀도와 미세구조지수를 이용한 복합적인 분석은 전자부에서 탄성계수를 예측하는데 가장 좋은 방법이다. Purpose: The goal of this study was to investigate the contribution of bone mineral density (BMD) and the microstructural properties of trabecular bone to predict its mechanical property, i.e., its elastic modulus in the intertrochanteric region. Materials and Methods: A total 15 trabecular bone core specimens were obtained from the proximal femurs of patients who were to undergo to total hip arthroplasties. The BMD measurement, 2-D and 3-D microstructural parameters, and elastic modulus of each bone core were obtained with PIXImus2 densitometer, high-resolution micro-computed tomography (micro-CT), and micro-finite element analysis (FEA). The multiple relationships among the BMD, structural parameters and elastic modulus were assessed with using linear regression analysis. Results: Linear regression analysis demonstrated that the bone volume fraction (BV/TV) was the best predictor for Young's modulus, as well as the BMD. A 3-D microarchitectural parameter, the structure model index (SMI) could well explain the variance of Young's modulus by 51%. The ability to explain the variance of Young's modulus was improved by combining the structural indices with each other, as well as by supplementing the BMD with any of the examined structural indices. Conclusion: A combination of microstructural parameters with each other or with the bone mineral density measurement could provide the best predictions of the elastic modulus of cancellous bone in the intertrochanteric region.

Steel Bridge Construction of Hong Kong–Zhuhai–Macao Bridge

Wen-bo Gao,Quan-ke Su,Jin-wen Zhang,Hong-bing Xie,Feng Wen,Fang Li,Ji-zhu Liu 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.5

The 55-km-long Hong Kong–Zhuhai–Macao Bridge (HZMB) is the world’s longest sea-crossing bridge, connecting Hong Kong with Zhuhai and Macao at the mouth of the Pearl River Estuary in China, comprising 22.9-km-long steel bridges. HZMB is the leading steel bridge in China, with top-level manufacturing and installation technology. This paper outlines the steel bridge construction experiences of HZMB to provide comparisons for the construction of other long sea-crossing steel bridges at home or abroad. The main considerations of construction constraints, scheme selection, structural and aesthetic design of HZMB are presented, and the following points related to new strategies in the steel bridge construction of HZMB are elaborated: (1) construction quality assurance, (2) automatic manufacturing technology, (3) large segment off shore installation, (4) eco-friendly paint (content limitation of volatile organic compounds) and new multifunctional inspection gantry, and (5) Guss Mastic Asphalt steel deck pavement system. The successful implementation of those strategies shows that the steel bridge construction of HZMB promotes improvement in the overall construction and management level of the Chinese bridge industry. The advanced experience of HZMB has opened up broad prospects for the design and construction of off shore bridge engineering in China.

Investigation on the Effects of Welding Speed on Bobbin Tool Friction Stir Welding of 2219 Aluminum Alloy

Quan Wen,Wenya Li,Vivek Patel,Yanjun Gao,Achilles Vairis 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.12

The microstructure and mechanical properties of bobbin tool friction stir welded joints for 2219-T87 aluminum alloy usingdifferent welding speeds were investigated based on the experimental results together with a thermo-mechanical modeldeveloped. The stir zone created in the joint shows a dumbbell shape. As welding speed increases, both the width and grainsize of stir zone decrease. The symmetrical hardness distribution forms across the joint thickness, while the asymmetrichardness is measured along the width of the stir zone. The hardness of the stir zone on the retreating side is lower than thaton the advancing side. The hardness profile presents a W-shape, with the minimum values measured increasing with weldingspeed. The tensile residual stresses increase gradually towards the center of the joint from the outer surface, presentinga symmetrical feature as well. As welding speed increases, both the tensile strength and elongation show a maximum value70% of joint efficiency. Tensile fracture occurs in the stir zone and shows a symmetrical surface with three different layerfracture modes identified. In layers I and III, the fracture surface presents 45° direction, while fracture propagates along theS-line in layer II.

Percutaneous catheter drainage for abscess after surgery

Wen-Bo Zhu,Xiao-Hui Zhao,Hai-Liang Li,Chen-Yang Guo,Quan-Jun Yao,Xiang Geng,Ke Zhao,Hong-Tao Hu 소화기인터벤션의학회 2022 International journal of gastrointestinal interven Vol.11 No.4

Percutaneous abscess drainage (PAD) has been proven to be a safe, effective, and widely used technique for the treatment of patients with abscesses after gastrointestinal surgery. The indications for PAD are expanding and most postoperative abscesses of the gastrointestinal tract are susceptible to PAD. PAD uses various imaging methods, including ultrasound, computed tomography, and several safe and reliable catheter insertion methods.

Novel HMW glutenin genes from Aegilops tauschii and their unique structures

Wen-Jie Chen,Zhong-Wei Yuan,Lian-Quan Zhang,Xing Fan,Ze-Hong Yan,Ji-Rui Wang,You-Liang Zheng,Huai-Gang Zhang,Deng-Cai Liu 한국유전학회 2012 Genes & Genomics Vol.34 No.3

A pair of novel high-molecular-weight glutenin subunits (HMW-GS) 1Dx5.3t and 1Dy12.1**t were revealed and characterized from Ae. tauschii accession PI554324. SDS-PAGE band of 1Dx5.3t was between those of 1Bx6 and 1Bx7, while 1Dy12.1**t with slightly faster migration rate than that of 1Dy12. The lengths of 1Dx5.3t and 1Dy12.1**t were 2115 bp and 1986 bp, encoding 703 and 660 amino acid residues,respectively. Their authenticity was confirmed by successful expression of the coding regions in Escherichia coli. 1Dx5.3t is the shortest of the known Dx-type alleles. 1Dy12.1**t is also a special subunit since it has an additional cysteine in the front of the central repetitive domain. This cysteine that is not existed in previously reported Dy-type genes may be useful for improving bread wheat quality. Median-joining Network analysis indicated that 1Dy12.1**t may be a key site in the genealogy of the Glu-Dy.

Development and Validation of Nomograms to Provide Individualized Predictions of Sur-vival Benefits from Surgery in Patients with Intermediate/Advanced Hepatocel-lular Carcinoma

( Wen-tao Yan ),( Jia-he Wang ),( Ming-da Wang ),( Zheng Wang ),( Bing Quan ),( Ya-hao Zhou ),( Wei-min Gu ),( Hong Wang ),( Ting-hao Chen ),( Tian Yang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: According to the BCLC treatment guidelines, surgery does not be recommended for intermediate/advanced hepatocellular carcinoma (HCC). In real world, however, liver resections are often performed in patients with intermediate/ advanced but resectable HCC, especially in the East. Methods: We retrospectively evaluated multicentric data of 1,325 patients newly diagnosed with intermediate/advanced HCC who underwent curative resection. We randomly divided the subjects into development (n = 875) and validation (n = 450) samples. Multivariate Cox proportional hazards models were developed and separately validated on the basis of patients’ clinicopathological variables assessed for associations with 1-year recurrence and 3-year mortality. The discriminatory accuracy of these models was compared with conventional tools by analyzing receiver operating characteristic (ROC) curves. Results: He statistical nomograms built based on performance status, Child-Pugh grade, portal hypertension, preoperative alpha-fetoprotein level, tumor rupture, largest tumor diameter, tumor number, macrovascular and microvascular invasion, and satellites had good calibration and discriminatory abilities, with c-indices of 0.70 (1-year recurrence) and 0.68 (3-year survival), respectively. These models showed satisfactory goodness-of-fit and discrimination abilities in the validation cohort (c-index, 0.68 for 1-year recurrence and 0.69 for 3-year survival). The areas under the ROC curve using these nomograms exceeded those of traditional staging systems, indicating superior discriminatory capability (c-indices, 0.60-0.63 and 0.56-0.62, respectively). Conclusions: Our proposed online nomograms, which present graphically postoperative prognostic models for recurrence and survival in patients with intermediate/advanced but resectable HCC, offer valuable guidance to surgeons and hepatologists for individually predicting survival benefits from surgery and planning recurrence surveillance and adjuvant therapy.

Low Molecular Weight Organic Acids in Brassica pekinensis Rupr. and Growing soil Influenced by Simulated Nitrate Deposition

( Wen Ming Xie ),( Xing Quan Liu ),( Kwang Yong Ko ),( Kyu Seung Lee ) 한국환경농학회 2008 한국환경농학회지 Vol.27 No.3