1995-96년 한반도 남동부 지역의 미소지진 자료를 이용한 지각구조 모델의 비교 연구

이기화,정태웅,Lee, Gi Hwa,Jeong, Tae Ung 한국지구물리물리탐사학회 1999 지구물리 Vol.2 No.1

한국자원연구소 지진관측망의 1995-96년 미소지진 자료를 바탕으로 한반도 남동지역의 지각구조에 대하여, Lee (1979), 김상조·김소구(1983), 김성균·정부흥(1985)의 세 지각 모델 중 어느 것이 잔차의 최소자승을 만족하는지 검증하였다. 세 모델 잔차의 뚜렷한 차이가 관찰되지 않았으나, Lee 의 지각 모델이 약간 깊은 진원을 산출하는 경향이 있다. 한반도 지각의 층상구조는 아직 명백하지 않으므로 앞으로 더 많은 자연지진 자료 또는 인공지진 자료를 통해서 규명되어져야 한다. Using the microearthquake data acquired from 1995 to 1996 through the seismic network operated by the Korea Institute of Geology, Mining & Materials (KIGAM), the three P-wave velocity models proposed by Lee (1979), Kim·Kim (1983) and Kim·Jung (1985) concerning the structure of the southeastern part of the Korean peninsula were examined in terms of the least square errors of the P-wave arrival times. The three models do not differ significantly in arrival time residuals except that the Lee's model gives slightly deeper focuses than the others. The layering of the crust of the peninsula is not clear as yet and to be studied by more earthquake and explosion data in the future.

기구인영맥(氣口人迎脈)에 관한 연구

석진한,심철웅,최현배,이시형,Seok, Jin-Han,Sim, Cheol-Ung,Choi, Hyun-Bae,Lee, Si-Hyeong 대한한의정보학회 2012 大韓韓醫情報學會誌 Vol.18 No.1

Pulse diagnosis has been highly valued in many East Asian medical books, since "Huangdaineijing(黃帝內經)" published. Gigoo-inyoung pulse method(氣口人迎脈法) is one of the four pulse diagnostic methods originally written in"Huangdaineijing(黃帝內經)". At the late 3rd century, "Maijing(脈經)" redefined the positions of Gigoo-inyoung pulse(氣口人迎脈). According to "Maijing(脈經)", both spots were 1fen(分) in front of guan(關) but Gigoo on the right hand and Inyoung on the left hand. At the middle of 13th century, "Maekgyolejijangbyungsikdoseol(脈訣指掌病式圖說)" had detailed view points about the manner of reading Gigoo-inyoung pulse. "Maekgyolejijangbyungsikdoseol(脈訣指掌病式圖說)" explained clearly the position of 1fen(分) in front of guan(關) by sketch of wrist. The location indicated the border of cun(寸) and guan(關). It also explained clearly corresponding certain cun-guan-chi(寸關尺) with Gigoo-inyoung pulse by sketch. "Euihackipmoon(醫學入門)" is a comprehensive book on medicine written by Lee-Cheon(李?) in Ming(明) dynasty. In this book, pulse diagnosis is the most emphasized method among the four techniques of diagnosis(四診). Furthermore, it introduces detailed information about Gigoo-inyoung pulse method(氣口人迎脈法) in "Gigoo-inyoungmaekgyole(氣口人迎脈訣)". Lee-Cheon concured in the theory of "Yeongruegumbang(永類鈐方)" and "Maekgyolejijangbyungsikdoseol(脈訣指掌病式圖說)" and put a short essay about Gigoo-inyoung pulse named "Gigoo-inyoungmaekgyole(氣口人迎脈訣)" quoted from the two books. Therefore, throughout many chapters of "Euihackipmoon(醫學入門)", Gigoo-inyoung pulse is used in order to distinguish internal damage(內傷) and external contraction(外感). "Maekgyolejijangbyungsikdoseol(脈訣指掌病式圖說)" and "Euihackipmoon(醫學入門)" understood Gigoo-inyoung pulse commonly by corresponding certain cun-guan-chi(寸關尺) with Gigoo-inyoung pulse. Therefrom, Gigoo-inyoung pulse can distinguish seven emotions(七情) of internal damage(內傷) or six excesses(六淫) of external contraction(外感).

Effect of Dietary Vitamin E on the Release of Iron and Generation of Mitochondrial Hydrogen Peroxide in Rat

이웅수 忠州大學校 2003 한국교통대학교 논문집 Vol.38 No.2

In this research, whether dietary vitamin E has a direct functional effect on the production of reactive oxygen species(ROS) in mitchondria, and whether dietary vitamin E influence the formation of free iron in rat tissues were determined. Additionally, if altered iron release is linked to the degree of peroxidative damage was determined. The results clearly showed that dietary vitamin E markedly reduced hydrogen peroxide production in the mitochondria of liver and skeletal muscle of both male and female rats in a dose-dependent manner. Also, the data showed that deprivation of vitamin E resulted in an increase of free iron in the skeletal muscle and spleen of male rats and liver, skeletal muscle, heart, kidney, and spleen of female rats. Supplementation with vitamin E significantly decreased the levels of free iron in the skeletal muscle of both male and female rats. Also, the levels of free iron were significantly inversely related to the concentration of supplemented vitamin E in the skeletal muscle, kidney, and spleen of male rats and liver, skeletal muscle, heart, kidney, and spleen of female rats. Deprivation of vitamin E caused a significant increase in the levels of thiobarbituric acid reactants(TBARS) in the liver, skeletal muscle, heart, kidney, and spleen of both male and female rats. Vitamin E does-dependently decreased TBARS in the liver and kidney of male rats and liver, skeletal muscle, and kidney of female rats. The results obtained from this research indicate that vitamin E regulates mitochondrial generation of ROS and attenuates the release of iron from its protein complexes. The results also suggest that the overprodution of mitochondrial ROS is the first event leading to tissue damage observed in vitamin E-deficiency syndromes and that formation of free iron is the first event of oxidative tissue damage.

장내세균에 의한 Trichothecene Mycotoxins의 대사 : (I) T-2 toxin의 대사

이웅수 忠州大學校 2008 한국교통대학교 논문집 Vol.43 No.-

Trichothecene mycotoxins are a chemically related group of toxic fungal metabolites produced by a number of species of the fungi such as Fusarium, Cephalosporium, Trichothecium, Myrothecium, Stachybotrys and Trichoderma, and are responsible for mycotoxicoses as causative agents in a wide variety of animal and human health problems. Especially, T-2 toxin is a secondary metabolite produced by Fusarium spp. such as F. tricinctum, F. poae and F. sporotrichioides etc., and is often found in agricultural products and feeds including cereals, and is a potent cytotoxic and immunodepressive trichothecene mycotoxin, and causative agent of moldy corn toxicosis and alimentary toxic aleukia(ATA), and induces acute toxicity such as leukocytosis, hemorrhage and dermal edema, followed by death in animals. In order to elucidate the possible metabolism of T-2 toxin by rat and human intestinal bacteria, this research was carried out. T-2 toxin transformed into HT-2 toxin and unknown metabolite by cultured intestinal bacteria in the anaerobic condition. The amount of HT-2 toxin was decreased, but unknown metabolite was increased by subsequent incubation. This metabolite was elucidated to deepoxy HT-2 toxin by NMR and mass spectra data. It was suggested that T-2 toxin was deepoxidized after deacetylation to HT-2 toxin by the intestinal bacteria. This deepoxy HT-2 toxin was transformed into HT-2 toxin and 15-deacetyl-deepoxy HT-2 toxin by liver microsome of PCB-treated rat in the presence of NADPH and oxygen. These results suggest that the epoxide group of trichothecene mycotoxins is reduced by intestinal bacteria and re-oxidized by hepatic microsomal enzyme of rat.

Rat의 간세포 항산화계 및 지질 과산화에 미치는 Mycotoxins의 영향 : I. Effects of Fumonisin B₁, a Mycotoxin produced by Fusarium moniliforme I. Fumonisin B₁의 영향

李雄洙 忠州大學校 1994 한국교통대학교 논문집 Vol.29 No.2

The purpose of this study was to determine if fumonisin B₁(FB₁), a promoter for hepa tocarcinogenesis in rat, induces lipid peroxidation and alters the concentrations of antioxidant systems in rat liver cell. The hepatocytes were isolated from male Harlan Sprague-Dawley rat by using aseptic procedures, and treated with varying concentrations of FB₁(1μM,10μM and 50μM). The levels of malondialdehyde(MDA), conjugated diene(CD), vitamin A(V-A), vitamin E(V-E),γ-tocopheryl quinone(γ-TQ), vitaminC(V-C), glutathione(GSH), total lipids(TL), and protein were determined to assess oxidative damage and antioxidant status on the hepatic cell. FB₁ increased the levels of MDA and CD, oxidative products of cellular lipid. And FB₁ decreased the levels of cellular antioxdants such as V-E, and V-A, and V-C, but increased GSH level. This study shows that the adiministration of FB₁, a mycotoxin produced by Fusarium moniliforme, did increase indices of lipid peroxidation, but that cellular antioxidant defences were inhibited by FB₁.

강박증 환자에서의 인격장애 공존병리에 관한 연구

이동우,강웅구,류인균,정도언,조맹제,우종인,김용식,권준수 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3

연구목적 : 강박증의 동반인격장애에 관한 연구들은 기존의 개념과 달리 강박성 인격장애와 강박증 간에는 특이적인 관계가 없으며, 강박증 환자들은 다양한 인격장애를 동반한다는 결과를 보여주었다. 그러나 이러한 연구들은 동반 인격장애에 관한 기술적인 분석에 그쳤고, 강박증 환자군의 임상 증상과 동반 인격장애 양상간의 연관성에 관한 분석을 시행하지 않았다. 본 연구의 목적은 강박증 환자군에서의 동반 인격장애를 평가하고 강박증 환자의 다양한 증상과 동반 인격특성 간의 연관성에 대해 연구하는 것이다. 방 법 : DSM-IV의 강박증의 진단기준을 만족하는 59명의 환자군과 32명의 정상대조군을 대상으로 인격장애 질문지를 적용한 후 4∼6점의 절단점을 기준으로 인격장애의 진단이 내려졌다. 먼저 환자군과 정상대조군 간의 특정 인격장애 빈도의 차이를 알아보기 위하여 Fisher's exact test를 시행한 후, 두집단 간에 유의한 차이가 있는 것으로 밝혀진 인격장애 척도 점수에 미치는 Y-BOCS,BDI,BAI점수의 영향을 알아보기 위하여 다중선형회귀 분석을 시행하였다. 결 과 : 1) Fisher's exact test 결과 강박증 환자군은 정상 대조군에 비해 경계성 인격장애(18.6%vs 0%, p=0.007). 회피성 인격장애(55.9% vs 18.8%, p=0.001), 우울성 인격장애(40.7% vs 0%, p=0.000)의 비율이 유의하게 높았다. 2) 다중선형회귀분석 결과 Y-BOCS 점수 (t=2.10, p=0.043)와 BAI점수(t=2.60, p=0.014)는 경계성 인격장애 점수에 유의한 영향을 주는 것으로 나타났다. 또한 BAI점수(t=3.23, p<0.003)는 회피성 인격장애 저수에, BDI점수 (t=3.08, p=0.004)는 우울성 인격장애 점수에 유의한 영향을 주는 것으로 나타났다. 결 론 : 강박증 환자군은 정상 대조군에 비해 회피성 인격장애, 우울성 인격장애, 경계성 인격장애의 동반율이 높고, 강박증이 경계성 인격장애의 심각도에 유의한 영향을 미치는 것으로 사료된다. The purpose of this study was to assess the comorbid axis-Ⅱ disorders of obsessive compulsive disorder(OCD) patients and to investigate the relationship between symptoms of OCD and the comorbid personality traits. The subjects were 59 patients who met DSM-IV criteria for obsessive-compulsive disorder and 32 normal controls. All subjects completed personality Disorder Questionnaire-IV(PDQ-IV). The patients completed Beck Depression Inventory(BDI) and Beck Anxiety Inventory(BAI), and were rated with Yale-Brown Obsessive Compulsive Scale(YBOCS). The results were as follows. 1) The OCD patients showed significantly higher prevalence of avoidant, depresssive and borderline personality disorder(p<0.01) compared to controls. 2) The BAI score had significant effect on the avoidant personality score(t=3,23, p<0.003). The BDI score had significant effect on the depressive personality score(t=3.08, p=0.004). The YBOCS(t=2.10, p=0.043) and BAI(t=2.60, p=0.014) scores had significant effects on the borderline personality score. We found that OCD patients had higher prevalence of avoidant, depressive, and borderline personality disorders. We also found that obsessive-compulsive symptoms have significant effect on the severity of borderline personalty traits. We suggest that it would be very helpful to consider Axis-Ⅱ disorders for managing patients with obsessive-compulsive disorder.

Indoprofen 및 Indoprofen Lysinate와 Human Serum Albumin의 結合에 관한 硏究

李琬夏,柳柄泰,智雄吉,金東吉 成均館大學校 科學技術硏究所 1984 論文集 Vol.35 No.1

Indoprofen, 4- (1, 3-dihydro-1-oxo-2H-isoindol-2-yl)-α-methylbenzene acetic acid, has many advantages over the other antiinflammatory drugs, such as salicylates, naproxen. Although indoprofen is widely used as an antiinflammatory agent, it shows poor solubility in water. In order to inhance water solubility, indoprofen was made as lysine salt. The purpose of this study was to inspect the binding of the 1-anilinonaphthalene-8-sulfonatc(ANS) to human serum albumin (HSA) and to be to comparative studies on indoprofen lysinate and indoprofen in aspect of the binding to HSA and the number of binding sites was obtained using a fluorescent probe technique. The numbers of binding sites for indoprofen and indoprofen lysinate appear to be 3.35, 3.4, respectively and the association constants were found as follows; HSA-Indoprofen. ; K_b1 = 6.62 × 10 exp(5), K_b2 = 5.44 × 10 exp(4) HSA-Indoprofen lysinate ; K_b1 = 2.32 × 10 exp(5), K_b2 = 5.03 × 10 exp(4)

경피제제로서 수종의 플루비프로펜 Vehicle과 O/W 마이크로에멀젼의 평가

이계원,지웅길 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-

In order to reduce systemic side effects following administration, flurbiprofen was formulated as O/W microemulsion consisting of the surfactant, oil phase and aqueous phase. Particle size distribution, apparent viscosity, solubility and skin permeation of flurbiprofen in various vehicles and microemulsion were evaluated. The domain of O/W microemulsion's phase diagram had difference between oil types and the area of O/W microemulsion was wide distributed by adding to PG and cosurfactant than that of water alone. As increasing 10, 15 and 20% of Brij 97 content and 1, 2.5, 5% of oil content, the solubility of flurbiprofen in O/W microemulsions and various vehicles was 400~1,000 and 10~500 times higher than that of control. Also apparent viscosity of soybean oil microemulsions was higher than that of IPM microemulsions and that of vehicle were increased as increasing vehicle content. Since skin permeation of flurbprofen decreased as increasing viscosity, in each vehicle, it was not affected 2% β-CD and decreased as increasing PG content and to 2, 5 and 10% of HP-β-CD. In O/W microemulsion, 5% soybean oil, 20% Brij 97 and 75% water(A-1) with high viscosity showed low skin penetration.

IS 조직의 직무스트레스에 관한 연구

이선규,이웅희 금오공과대학교 산업기술개발연구원 2001 産業技術開發硏究 Vol.17 No.-

The IS(information systems) organization is a stressful organization. However, there is little theoretical or empirical research on the effects of job stress on IS organization. A major reason is because IS organization and researchers are unaware of the consequences of job stress and unfamiliar with the job stress literature. The purpose of this paper is to propose a theoretical framework of job stress on IS organization. Based on a review of the IS, psychology, and general management literature,12 job stress models are identified. These stress models are analyzed along the two dimensions of focus and theoretical foundation. The analysis shows that most of the job stress models consider stress to be the consequence of the interaction between an environmental stimulus and the idiosyncratic response of the individual. Further analysis of these models suggests that nine key points are critical in developing a theoretical framework of jon stress on IS organization. A mapping of how the existing stress models incorporate the nine key points is also presented. The findings of this paper can provide a theoretical basis for further research on the job stress of IS organization. Finally, an agenda for further research into this issue is presented.

Aflatoxin B₁의 간발암성에 대한 nivalenol의 영향

李雄洙 충주대 산업과학기술연구소 1999 産業科學論文集 Vol.7 No.2

This research was carried out to investigate the toxicological effect of long-term intake of nivalenol(NIV), a trichothecene mycotoxin produced by Fusarium nivale Fn 2B, and the combined toxicity of NIV and aflatoxin Bl(Af-Bl), a potent hepatocarcinogenic mycotoxin, in mice. In male mice, liver tumors developed to all Af-Bl treated groups, and most of them were hepatocellular carcinomas. The incidence of Af-Bl induced liver tumors was not altered by feeding of NIV containing diet. In female mice, however, the incidences of liver tumors were 31%, 20% and 0% in Af-Bl alone group, Af-Bl plus NIV 6ppm group and Af-Bl plus NIV 12ppm group, respectively. NIV dose dependent pattern on hepatocarcinogenesis by Af-Bl showed a decreasing tendency. Incidence of liver tumors in NIV 12ppm group was significantly lower than in Af-Bl alone group. Most of liver tumors in female mice were hepatocellular adenomas, and the malignancy of Af-Bl induced liver tumors was lower than that of male mice. The remarkable change of biochemical factor on serum was not observed by administration of NIV. In these results, NIV has no tumorous effect in mice, and increased significantly life span. And the inhibition effect of NIV on Af-Bl induced hepatocarcinogenesis was suggested in mice.