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U. Ullmann,J. Metzner,C. Schulz,J. Perkins,B. Leuenberger 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.3
Commercial Coenzyme Q10 (CoQ10, ubiquinone) formulations are often of poor intestinal absorption. We investigated the bioavailability of DSM Nutritional Products Ltd. (Kaiseraugst, Switzerland) CoQ10 10% TG/P (all-Q??), a new tablet-grade formulation, with CoQ10 Q-Gel?? Softsules?? based on the Bio-Solv?? technology (Tishcon Corp., Salisbury, MD; marketed by Epic4Health™, Smithtown, NY) and Q-SorB?? (Nature’s Bounty™, Bohemia, NY). Twelve healthy male subjects participated in a randomized, three-period crossover bioequivalence study. Plasma CoQ10 was determined from pre-dose until 36 hours. To compare bioavailability, corrected maximum concentration (Cmax) and area under the curve from 0 to 14 hours [AUC(0-14 h)] were assessed and tested for bioequivalence. The bioequivalence ranges of 0.8–1.25 hour g/mL for AUC(0-14 h) and 0.75–1.33 g/mL for Cmax were applied. In summary, the kinetic profiles of all CoQ10 preparations revealed a one-peak plasma concentration–time course. Highest Cmax values were seen after Q-Gel application, whereas time to Cmax was nearly identical across all treatments. The AUC(0-14 h) values were highest for Q-Gel, narrowly followed by all-Q. The tests for bioequivalence showed a bioequivalence between Q-Gel and all-Q, and both preparations were found to have better bioavailability properties than Q-SorB. Although all-Q and Q-Gel have equivalent bioavailability properties, all-Q can be directly used in tablets, while this is not the case for Q-Gel or other similar forms.
J. L. Ullmann,A. J. Couture,A. L. Keksis,D. J. Vieira,,J. M. ODonnell,J. M. Wouters,M. Jandel,R. C. Haight,R. S. Rundberg,T. A. Bredeweg,T. Kawano,C. Y. Wu,J. A. Becker,A. Chyzh,B. Baramsai,G. E. Mitc 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
A careful new measurement of the ^(238)U(n,γ) cross section from 10 eV to 100 keV has been made using the DANCE detector at LANSCE. DANCE is a 4π calorimetric scintillator array consisting of 160 BaF^2 crystals. Measurements were made on a 48 mg/cm^2 depleted uranium target. The cross sections are in general in good agreement with previous measurements. The gamma-ray emission spectra, as a function of gamma multiplicity, were also measured and compared to model calculations.
Carsten Müller,Kristina Ullmann,Pablo Steinberg 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.1
Vineatrol^ⓡ30 (developed and produced jointly by Breko GmbH [Bremen, Germany] and Actichem [Montauban, France]) is a grapevine-shoot extract that contains resveratrol as well as considerable amounts of resveratrol oligomers. In the present study it is shown that Vineatrol30 at a noncytotoxic concentration of 2.3μg/mL significantly reduced the number of malignantly transformed foci induced by a sequential treatment of BALB/c-3T3 cells with 3-methylcholanthrene and 12-O-tetradecanoylphorbol 13-acetate in the so-called BALB/c-3T3 cell transformation assay. At a higher concentration Vineatrol30 drastically decreased the relative plating efficiency of the cells. Furthermore, the results suggest that the resveratrol oligomers present in Vineatrol30, independently from resveratrol itself, were indeed able to inhibit the formation of malignantly transformed BALB/c-3T3 foci.
An oil-tolerant and salt-resistant aqueous foam system for heavy oil transportation
Jie Sun,Jiaqiang Jing,Neima Brauner,Li Han,Amos Ullmann 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.68 No.-
An oil-tolerant and salt-resistant aqueous foam system was screened out as a possible lubricant to enable cold heavy oil transportation. The microstructures and viscoelasticity and effects of heavy oil, salt and temperature on the foam stability were investigated and new rheological and drainage models were established. The results indicate the foam with multilayered shells belongs to a special microcellular foam. The viscoelasticity could be neglected due to its low relaxation time. The drainage process can be divided into three stages. The foam with quality of 67.9% maintains great stability at high oil and salt concentrations and appropriate elevated temperature.
Kim, Hyung-Goo,Ahn, Jang-Won,Kurth, Ingo,Ullmann, Reinhard,Kim, Hyun-Taek,Kulharya, Anita,Ha, Kyung-Soo,Itokawa, Yasuhide,Meliciani, Irene,Wenzel, Wolfgang,Lee, Deresa,Rosenberger, Georg,Ozata, Metin Elsevier 2010 American journal of human genetics Vol.87 No.4
<P>By defining the chromosomal breakpoint of a balanced t(10;12) translocation from a subject with Kallmann syndrome and scanning genes in its vicinity in unrelated hypogonadal subjects, we have identified <I>WDR11</I> as a gene involved in human puberty. We found six patients with a total of five different heterozygous <I>WDR11</I> missense mutations, including three alterations (A435T, R448Q, and H690Q) in WD domains important for β propeller formation and protein-protein interaction. In addition, we discovered that WDR11 interacts with EMX1, a homeodomain transcription factor involved in the development of olfactory neurons, and that missense alterations reduce or abolish this interaction. Our findings suggest that impaired pubertal development in these patients results from a deficiency of productive WDR11 protein interaction.</P>
Kim, H.G.,Kim, H.T.,Leach, Natalia T.,Lan, F.,Ullmann, R.,Silahtaroglu, A.,Kurth, I.,Nowka, A.,Seong, I.,Shen, Y.,Talkowski, Michael E.,Ruderfer, D.,Lee, J.H.,Glotzbach, C.,Ha, K.,Kjaergaard, S.,Levin University of Chicago Press [etc.] 2012 American journal of human genetics Vol.91 No.1
Potocki-Shaffer syndrome (PSS) is a contiguous gene disorder due to the interstitial deletion of band p11.2 of chromosome 11 and is characterized by multiple exostoses, parietal foramina, intellectual disability (ID), and craniofacial anomalies (CFAs). Despite the identification of individual genes responsible for multiple exostoses and parietal foramina in PSS, the identity of the gene(s) associated with the ID and CFA phenotypes has remained elusive. Through characterization of independent subjects with balanced translocations and supportive comparative deletion mapping of PSS subjects, we have uncovered evidence that the ID and CFA phenotypes are both caused by haploinsufficiency of a single gene, PHF21A, at 11p11.2. PHF21A encodes a plant homeodomain finger protein whose murine and zebrafish orthologs are both expressed in a manner consistent with a function in neurofacial and craniofacial development, and suppression of the latter led to both craniofacial abnormalities and neuronal apoptosis. Along with lysine-specific demethylase 1 (LSD1), PHF21A, also known as BHC80, is a component of the BRAF-histone deacetylase complex that represses target-gene transcription. In lymphoblastoid cell lines from two translocation subjects in whom PHF21A was directly disrupted by the respective breakpoints, we observed derepression of the neuronal gene SCN3A and reduced LSD1 occupancy at the SCN3A promoter, supporting a direct functional consequence of PHF21A haploinsufficiency on transcriptional regulation. Our finding that disruption of PHF21A by translocations in the PSS region is associated with ID adds to the growing list of ID-associated genes that emphasize the critical role of transcriptional regulation and chromatin remodeling in normal brain development and cognitive function.