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Brake Lining Can be Applied to Super High Speed Vehicle
Nakano Satoru,Maejima Takashi 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
A new material was developed to achieve improvement of heat durability, improvement of wear resistance, stability of friction coefficient and reduction in aggression to counterpart, because it is difficult to maintain braking properties by using currently available materials in the train wagons used for high-speed transportation. As a result, the new material showed a stable wear resistance even in the speed range of 350km/h, where improvement was also confirmed in reduction of aggression to counterpart material by more than approximately 10%. This development was adopted for the brake lining in the Taiwan High Speed Rail project.
<sup>123</sup>I-Labeled oxLDL Is Widely Distributed Throughout the Whole Body in Mice
Nakano, Atushi,Kawashima, Hidekazu,Miyake, Yoshinori,Zeniya, Tsutomu,Yamamoto, Akihide,Koshino, Kazuhiro,Temma, Takashi,Fukuda, Tetsuya,Fujita, Yoshiko,Kakino, Akemi,Kanaya, Shigehiko,Sawamura, Tatsuy 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.2
Purpose Oxidized low-density lipoprotein (oxLDL) plays a key role in endothelial dysfunction, vascular inflammation, and atherogenesis. The aim of this study was to assess blood clearance and in vivo kinetics of radiolabeled oxLDL in mice. Methods We synthesized $^{123}I-oxLDL$ by the iodine monochloride method, and performed an uptake study in CHO cells transfected with lectin-like oxLDL receptor-1 (LOX-1). In addition, we evaluated the consistency between the $^{123}I-oxLDL$ autoradiogram and the fluorescence image of DiI-oxLDL after intravenous injection for both spleen and liver. Whole-body dynamic planar images were acquired 10 min post injection of $^{123}I-oxLDL$ to generate regional time-activity curves (TACs) of the liver, heart, lungs, kidney, head, and abdomen. Regional radioactivity for those excised tissues as well as the bladder, stomach, gut, and thyroid were assessed using a gamma counter, yielding percent injected dose (%ID) and dose uptake ratio (DUR). The presence of $^{123}I-oxLDL$ in serum was assessed by radio-HPLC. Results The cellular uptakes of $^{123}I-oxLDL$ were identical to those of DiI-oxLDL, and autoradiograms and fluorescence images also exhibited consistent distributions. TACs after injection of $^{123}I-oxLDL$ demonstrated extremely fast kinetics. The radioactivity uptake at 10 min post-injection was highest in the liver ($40.8{\pm}2.4%$ ID). Notably, radioactivity uptake was equivalent throughout the rest of the body ($39.4{\pm}2.7%$ ID). HPLC analysis revealed no remaining $^{123}I-oxLDL$ or its metabolites in the blood. Conclusion $^{123}I-oxLDL$ was widely distributed not only in the liver, but also throughout the whole body, providing insight into the pathophysiological effects of oxLDL.
Yoshiko Nakano,Toshitatsu Takao,Yoshinori Morita,Shinwa Tanaka,Takashi Toyonaga,Eiji Umegaki,Yuzo Kodama 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.5
Background/Aims: Mucosal cutting biopsy (MCB) is useful for the histopathological diagnosis of gastric subepithelial tumors (SETs). However, there is little information on cases in which MCB did not establish a diagnosis. In the current study, we aimed to investigatethe characteristics of cases in which MCB was unsuccessful. Methods: Cases in which MCB was used to histopathologically diagnose gastric SETs at Kobe University Hospital between August 2012and October 2018 were retrospectively reviewed. Results: Forty-five cases in which MCB was used to diagnose 43 gastric SETs in 43 patients were analyzed. The median tumor sizewas 20 mm (range, 8–50 mm). Pathological examinations resulted in definitive and suspected diagnoses and no diagnosis in 29(gastrointestinal stromal tumor: n=17, leiomyoma: n=7, aberrant pancreas: n=3, others: n=2), 6, and 10 cases, respectively. Failure toexpose the tumor according to retrospective examinations of endoscopic images was significantly associated with no diagnosis. Otherpossible explanations included a less elevated tumor, biopsy of the surrounding field instead of the tumor due to the mobility, and poorendoscope maneuverability due to the tumor being close to the cardia. Conclusions: Clear exposure of gastric SETs during MCB may improve the diagnostic rate of such examinations.
String Cavitation and 3D PIV in Multi-Hole Injector
( Hiroaki Nakano ),( Rubby Prasetya ),( Shinichiro Deguchi ),( Takashi Miwa ),( Akira Sou ),( Keiya Nishida ),( Akira Nakashima ),( Yoshitaka Wada ),( Yoshiharu Ueki ),( Hideaki Yokohata ) 한국액체미립화학회 2017 한국액체미립화학회 학술강연회 논문집 Vol.2017 No.-
It is essential to control fuel spray characteristics in diesel engines for cleaning up exhaust gases and improving combustion efficiency. Turbulent cavitating flow in fuel injectors plays an important role in fuel spray characteristics. String cavitation may occur in a sac and nozzles of multi-hole fuel injectors, which strongly affects fuel spray characteristics. It should be caused by the vortex flow in the sac. However, the occurrence mechanism of string cavitation has not been clarified yet. The purpose of this study is to clarify the mechanism and condition of string cavitation occurrence by conducting a high-speed visualization experiment in a transparent injector of cavitation and a discharged liquid jet at various needle lifts and flow rates. We also measure the three-dimensional flow field in the sac by 3D PIV. The transparent acrylic multi-hole mini-sac nozzle is designed to visualize cavitation. Sodium iodide aqueous solutions or diesel oil with α-methyl naphthalene is used as a working fluid to avoid the refraction at the surface of the acrylic walls and these liquids. As a result, it is found that at low needle lift string cavitation often occurs which is surrounded by a vortical flow in the sac and increases the discharged hollow-cone liquid jet angle, while at high needle lift thin and short string cavitation may occur, which does not strongly influence discharged liquid jet and spray. The probability of the string cavitation appearance under various conditions as well as the transient motion of string cavitation and liquid jet is also clarified.
Takuya Misugi,Takashi Juri,Koichi Suehiro,Kohei Kitada,Yasushi Kurihara,Mie Tahara,Akihiro Hamuro,Akemi Nakano,Masayasu Koyama,Takasi Mori,Daisuke Tachibana 대한산부인과학회 2022 Obstetrics & Gynecology Science Vol.65 No.4
ObjectiveThis study aimed to investigate the accuracy and precision of continuous, non-invasive blood pressure obtained usingthe ClearSight system by comparing it with invasive arterial blood pressure, and to assess the hemodynamic changesusing invasive methods and the ClearSight system in patients undergoing cesarean section. MethodsArterial pressure was measured invasively with an intra-arterial catheter and non-invasively using the ClearSightsystem during cesarean section in patients with placenta previa or placenta accreta. Blood pressure measurementsobtained using these two means were then compared. ResultsTotal 1,277 blood pressure measurement pairs were collected from 21 patients. Under Bland-Altman analysis, theClearSight system demonstrated an acceptable accuracy with a bias and standard deviation of 8.8±13.4 mmHg forsystolic blood pressure, -6.3±7.1 mmHg for diastolic blood pressure, and -2.7±8.0 mmHg for median blood pressure. Cardiac index levels were significantly elevated during fetal delivery and 5 minutes after placental removal, andsystemic vascular resistance index levels were significantly decreased during fetal delivery and 40 minutes afterplacental removal. ConclusionIn patients undergoing cesarean section, the ClearSight system showed excellent accuracy and precision compared tothat of the currently used invasive monitoring system. 영어
Naoki Kakuta,Ryuichi Nakano,Akiyo Nakano,Yuki Suzuki,Ayako Tanouchi,Takashi Masui,Saori Horiuchi,Shiro Endo,Risako Kakuta,Yasuo Ono,Hisakazu Yano 대한진단검사의학회 2020 Annals of Laboratory Medicine Vol.40 No.1
Background: Mutations in the quinolone resistance-determining regions (QRDRs) of Acinetobacter baumannii DNA gyrase (gyrA) and topoisomerase IV (parC) are linked to fluoroquinolone (FQ) resistance. We developed a mismatched PCR-restriction fragment length polymorphism (RFLP) assay to detect mutations in the gyrA and parC QRDRs associated with FQ resistance in A. baumannii. Methods: Based on the conserved sequences of A. baumannii gyrA and parC, two primer sets were designed for mismatched PCR-RFLP to detect mutations in gyrA (codons 83 and 87) and parC (codons 80 and 84) by introducing an artificial restriction enzyme cleavage site into the PCR products. This assay was evaluated using 58 A. baumannii strains and 37 other Acinetobacter strains that have been identified by RNA polymerase β-subunit gene sequence analysis. Results: PCR amplification of gyrA and parC was successful for all A. baumannii strains. In 11 FQ -susceptible strains, the gyrA and parC PCR products were digested by the selected restriction enzymes at the site containing gyrA (codons 83 and 87) and parC (codons 80 and 84). PCR products from 47 FQ-resistant strains containing mutations in gyrA and parC were not digested by the restriction enzymes at the site containing the mutation. As for the non-baumannii Acinetobacter strains, although amplification products for gyrA were obtained for 28 strains, no parC amplification product was obtained for any strain. Conclusions: This assay specifically amplified gyrA and parC from A. baumannii and detected A. baumannii gyrA and parC mutations with FQ resistance.
Tabata, Chiharu,Tabata, Rie,Nakano, Takashi Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
Malignant pleural mesothelioma (MPM), an aggressive malignant tumor of mesothelial origin associated with asbestos exposure, shows a limited response to conventional chemotherapy and radiotherapy. Therefore, the overall survival of MPM patients remains very poor. Progress in the development of therapeutic strategies for MPM has been limited. We recently reported that the calpain inhibitor, calpeptin exerted inhibitory effects on pulmonary fibrosis by inhibiting the proliferation of lung fibroblasts. In the present study, we examined the preventive effects of calpeptin on the cell growth of MPM, the origin of which is mesenchymal cells, similar to lung fibroblasts. Calpeptin inhibited the proliferation of MPM cells, but not mesothelial cells. It also prevented 1) the expression of angiopoietin (Ang)-1 and Tie-2 mRNA in MPM cells, but not mesothelial cells and 2) the Ang-1-induced proliferation of MPM cells through an NF-kB dependent pathway, which may be the mechanism underlying the preventive effects of calpeptin on the growth of MPM cells. These results suggest potential clinical use of calpeptin for the treatment of MPM.