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      • KCI등재

        교원 교육과정 연수의 교육과정 문해력 수준 분석 연구 : 2015개정 교육과정 교원 연수를 중심으로

        박태은 ( Park¸ Taeeun ),홍후조 ( Hong¸ Hoo-jo ),김한승 ( Kim¸ Hanseung ),임태원 ( Lim¸ Taewon ),정희엽 ( Jung¸ Heeyeop ) 안암교육학회 2021 한국교육학연구 Vol.27 No.3

        오늘날 교육과정의 패러다임은 학생의 흥미와 적성, 진로 등 요구에 따른 맞춤형 교육을 제공을 우선순위로 하여 학교 수준의 교육과정을 강조하고 있다. 이때 효과적인 교육과정의 수립과 운영을 위한 필수적인 요소로 교원의 교육과정 문해력이 필요하며 이를 향상시키기 위한 교육의 필요성이 대두되고 있다. 이러한 배경에서 본 연구는 2017년부터 2020년까지 교육부 주최로 시행된 교육과정 연수를 주제, 내용 및 교육방법, 다루고 있는 교육과정 문해력 수준으로 나누어 분석하고, 향후 교육과정 문해력 중심의 연수 프로그램 개발의 시사점을 도출하고자 하였다. 연구결과 2015 개정 교육과정의 도입기인 2017년과 2018년의 교육과정 연수에서는 새로 개정된 교육과정의 총론과 각론의 이해를 주요 목적으로 기능적·구성적 수준의 교육과정 문해력 연수 프로그램이 제공되었다. 이후 교육과정 확대기인 2019년 연수는 교육과정 문해력을 핵심 키워드로 연수 프로그램이 구성되었으며, 교육과정 문해력의 수준 또한 기능적 수준에서 비판적 수준까지 아우르는 프로그램이 제공되었다. 마지막으로 개정 교육과정의 전면 시행기인 2020년에는 코로나-19로 인한 원격 수업 확대에 따른 교육내용이 주를 이루었으며, 차기 교육과정에 대한 논의를 위한 차원에서 비판적 수준의 교육과정 문해력이 다루어졌다. 이러한 연구결과를 토대로 기존 연수의 한계와 연속성이 있는 교육과정 문해력 신장 연수 프로그램 제공의 필요성을 제언하였다. Today's curriculum paradigm emphasizes the curriculum at the school level by providing customized education that meets the needs of students' interests, aptitude, and career pathways. At this time, teachers' understanding of the curriculum is essential for the establishment and operation of effective curricula, and the need for education is emerging to foster them. Against this background, this study divided the core teacher training program hosted by the Ministry of Education from 2017 to 2020 into themes, contents, and methods of education, and the level of curriculum literature. According to the results of the study, the curriculum training program for 2017 and 2018 during the introduction of the 2015 revised curriculum was provided with a functional and comprehensive level of curriculum comprehension program. Since then, the 2019 training period, which is the expansion period of the curriculum, has been organized with the literacy of the curriculum as its core keyword, and the literacy level of the curriculum has been adjusted from functional to critical. Finally, in 2020, when the 2015 revised curriculum was fully implemented, the main focus was on education through the expansion of remote education due to COVID-19, and the critical level of understanding of the curriculum was discussed. Based on the results of these studies, the necessity of providing comprehension-enhancing training programs that are continuous with the limitations of existing training courses is proposed.

      • SCISCIESCOPUS

        Assessment of cytomegalovirus and cell-mediated immunity for predicting outcomes in non-HIV-infected patients with <i>Pneumocystis jirovecii</i> pneumonia

        Kim, Taeeun,Park, Se Yoon,Lee, Hyun-Jung,Kim, Sun-Mi,Sung, Heungsup,Chong, Yong Pil,Lee, Sang-Oh,Choi, Sang-Ho,Kim, Yang Soo,Woo, Jun Hee,Kim, Sung-Han Williams & Wilkins Co 2017 Medicine Vol.96 No.30

        <▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>The clinical importance of pulmonary cytomegalovirus (CMV) co-infection in patients with <I>Pneumocystis jirovecii</I> pneumonia (PCP) is uncertain. We therefore determined the association of CMV infection with outcomes in non-HIV-infected patients with PCP by assessing CMV viral load and CMV-specific T-cell response.</P><P>We prospectively enrolled all non-HIV-infected patients with confirmed PCP, over a 2-year period. Real-time polymerase chain reaction from bronchoalveolar lavage was performed to measure CMV viral load, and CMV enzyme-linked immunospot assays of peripheral blood were used to measure CMV-specific T-cell responses. The primary outcome was 30-day mortality.</P><P>A total of 76 patients were finally analyzed. The mortality in patients with high BAL CMV viral load (>2.52 log copies/mL, 6/32 [18%]) showed a nonsignificant trend to be higher than in those with low CMV viral load (2/44 [5%], <I>P</I> = .13). However, the mortality in patients with low CMV-specific T-cell responses (<5 spots/2.0 × 10<SUP>5</SUP> PBMC, 6/29 [21%]) was significantly higher than in patients with high CMV-specific T-cell response (2/47 [4%], <I>P</I> = .048). Moreover, the 2 strata with high CMV viral load and low CMV-specific T-cell responses (4/14 [29%]) and low CMV viral load and low CMV-specific T-cell responses (2/15 [13%]) had poorer outcomes than the 2 strata with high CMV viral load and high CMV-specific T-cell responses (2/18 [11%]) and low CMV viral load and high CMV-specific T-cell responses (0/29 [0%]).</P><P>These data suggest that the CMV replication and impaired CMV-specific T-cell responses adversely affect the outcomes in non-HIV-infected patients with PCP.</P></▼2>

      • KCI등재

        Diagnostic usefulness of the cytomegalovirus (CMV)-specific T cell-based assay for predicting CMV infection after kidney transplant

        ( Taeeun Kim ),( Hyun-jeong Lee ),( Sun-mi Kim ),( Joo Hee Jung ),( Sung Shin ),( Young-hoon Kim ),( Heungsup Sung ),( Yong Pil Chong ),( Sang-oh Lee ),( Sang-ho Choi ),( Yang Soo Kim ),( Jun Hee Woo 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.2

        Background/Aims: We evaluated the usefulness in kidney transplant (KT) candidates of cytomegalovirus (CMV)-specific enzyme-linked immunospot (ELISPOT) assays for predicting the development of post-transplant CMV infections. Methods: All adult recipients admitted for living-donor KT between March 2014 and March 2015 were prospectively enrolled except donor CMV-seropositive and recipient seronegative (D+/R-) recipients. All the enrolled patients underwent CMV-specific ELISPOT assays before transplant, and a researcher blinded to the results of these assays examined the patients for CMV infection at least 6 months post-transplant. Results: Of 133 KT recipients, 44 (33%) developed CMV infections. When we used the cut-off determined by receiver operator characteristic curve, 16 of the 34 patients (47%) with negative pp65-specific ELISPOT results (< 11 spots/200,000 cells) developed CMV infections, whereas 28 of the 99 patients (39%) with positive pp65-specific ELISPOT results at baseline (≥ 11 spots/200,000 cells) developed CMV infections after KT (p = 0.02). Based on the multivariable Cox regression model, negative pp65-specific ELISPOT assay results was an independent risk factor for CMV infection (adjusted hazard ratio [AHR], 1.87; 95% confidence interval [CI], 1.01 to 3.46; p = 0.047) as well as age (AHR, 1.05; 95% CI, 1.01 to 1.08; p = 0.007). Conclusions: Pre-transplant CMV-specific ELISPOT assay appears to predict the development of CMV infections after KT in recipients at moderate risk such as CMV-seropositive recipients (Clinical Trial Registration Number NCT 02025335).

      • SCIESCOPUSKCI등재

        Review : Rabbit Hemorrhagic Disease Virus Variant Recombinant VP60 Protein Induces Protective Immunogenicity

        ( Hyejin Kim ),( Irfan A. Rather ),( Hyunwook Kim ),( Sungsoo Kim ),( Taeeun Kim ),( Jaeyoung Jang ),( Jimin Seo ),( Jeongheui Lim ),( Yongha Park ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.11

        Rabbit hemorrhagic disease virus (RHDV) is highly contagious and often causes fatal disease that affects both wild and domestic rabbits of the species Oryctolagus cuniculus. A highly pathogenic RHDV variant (RHDVa) has been circulation in the Korean rabbit population since 2007 and has a devastating effect on the rabbit industry in Korea. A highly pathogenic RHDVa was isolated from naturally infected rabbits, and the gene encoding the VP60 protein was cloned into a baculovirus transfer vector and expressed in insect cells. The hemagglutination titer of the Sf-9 cell lysate infected with recombinant VP60 baculovirus was 131,072 units/50 μl and of the supernatant 4,096 units/50 μl. Guinea pigs immunized twice intramuscularly with a trial inactivated RHDVa vaccine containing recombinant VP60 contained 2,152 hemagglutination inhibition (HI) geometric mean titers. The 8-week-old white rabbits inoculated with one vaccine dose were challenged with a lethal RHDVa 21 days later and showed 100% survival rates. The recombinant VP60 protein expressed in a baculovirus system induced high HI titers in guinea pigs and rendered complete protection, which led to the development of a novel inactivated RHDVa vaccine.

      • Parenting Beliefs and Achievement Pressure of Korean Mothers with Five to Seven Year Old Children According to Child's Gender, Mother's Education Level, and Employment Status

        Kim, Taeeun,Kim, Gilsook,Min, Hyunsuk The Korean Home Economics Association 2012 International Journal of Human Ecology Vol.13 No.2

        This study examined the parenting beliefs and the achievement pressure of Korean mothers with five to seven year old children. The maternal parenting beliefs criterion (Ahn, 2001) and achievement pressure criterion (Hong, 2001) have been applied to 212 mothers living in Seoul or Kyonggi-Do area and analyzed. The results showed that the maternal parenting beliefs were influenced by the child's gender, while the maternal achievement pressure was not. And significant difference was seen only in between the educational background and the maternal parenting beliefs, and the employment status and interaction effects were not shown.

      • Pulmonary Metastasectomy Could Prolong Overall Survival in Select Cases of Metastatic Urinary Tract Cancer

        Kim, Taeeun,Ahn, Jin-Hee,You, Dalsan,Jeong, In-Gab,Hong, Bumsik,Hong, Jun Hyuk,Ahn, Hanjong,Lee, Jae Lyun Elsevier 2015 Clinical genitourinary cancer Vol.13 No.4

        <P><B>Abstract</B></P> <P><B>Background</B></P> <P>The purpose of the study was to evaluate the efficacy of metastasectomy for urinary tract carcinoma (UTC) and to determine prognostic factors that affect survival.</P> <P><B>Patients and Methods</B></P> <P>Data from a total of 30 patients with metastatic UTC who underwent a metastasectomy between February 2000 and July 2014 were analyzed retrospectively. Time to disease progression (TTP) and overall survival (OS) from metastasectomy, and potential prognostic factors were evaluated.</P> <P><B>Results</B></P> <P>The lung was the most frequent site of metastasectomy (n = 24) followed by the liver (n = 3) and lymph nodes (n = 3). With a median follow-up duration of 54.2 months, the median TTP was 15.2 months and the median OS was 30.0 months (95% confidence interval, 15.1-42.9) with a 3-year survival rate of 41%. In multivariate analysis, initial stage IV disease (<I>P</I> = .047), pure urothelial pathology (<I>P</I> = .034), and nonpulmonary metastasectomy (<I>P</I> = .040) were independent prognostic factors for a shorter TTP. Nonpulmonary metastasectomy was an independent factor affecting OS (<I>P</I> = .001).</P> <P><B>Conclusion</B></P> <P>A metastasectomy has the potential to contribute to better oncologic outcome in select patients with metastatic UTC, especially those with a single rather than multiple and pulmonary rather than nonpulmonary metastases due to recurrent rather than initially metastatic urinary tract cancer.</P>

      • KCI등재후보

        Comprehensive Molecular Genetic Analysis in Glioma Patients by Next Generation Sequencing

        ( Taeeun Kim ),( Ahwon Lee ),( Stephan Ahn ),( Jae Sung Park ),( Sin Soo Jeun ),( Youn Soo Lee ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2024 Brain Tumor Research and Treatment Vol.12 No.1

        Background Glioma is caused by multiple genomic alterations. The evolving classification of gliomas emphasizes the significance of molecular testing. Next generation sequencing (NGS) offers the assessment of parallel combinations of multiple genetic alterations and identifying actionable mutations that guide treatment. This study comprehensively analyzed glioma patients using multi-gene NGS panels, providing powerful insights to inform diagnostic classification and targeted therapies. Methods We conducted a targeted panel-based NGS analysis on formalin-fixed and paraffinembedded nucleic acids extracted from a total of 147 glioma patients. These samples underwent amplicon capture-based library preparation and sequenced using the Oncomine Comprehensive Assay platform. The resulting sequencing data were then analyzed using the bioinformatics tools. Results A total of 301 mutations, were found in 132 out of 147 tumors (89.8%). These mutations were in 68 different genes. In 62 tumor samples (42.2%), copy number variations (CNVs) with gene amplifications occurred in 25 genes. Moreover, 25 tumor samples (17.0%) showed gene fusions in 6 genes and intragenic deletion in a gene. Our analysis identified actionable targets in several genes, including 11 with mutations, 8 with CNVs, and 3 with gene fusions and intragenic deletion. These findings could impact FDA-approved therapies, NCCN guideline-based treatments, and clinical trials. Conclusion We analyzed precisely diagnosing the classification of gliomas, detailing the frequency and co-occurrence of genetic alterations and identifying genetic alterations with potential therapeutic targets by NGS-based molecular analysis. The high-throughput NGS analysis is an efficient and powerful tool to comprehensively support molecular testing in neurooncology.

      • Text Analysis on Vocabprofile and Frequency: ESL reading material vs AE material for L2 learners

        Taeeun Kim(김태은) 새한영어영문학회 2019 새한영어영문학회 학술발표회 논문집 Vol.2019 No.5

        This study investigates textbook materials for English vocabulary to second language learners by using linguistic analysis computer programs. Two linguistic programs, Vocabprofile and Frequency, were used to analyse about fifty words per L2 reading against texts (English as A Second Language Material) in comparison with L1 reading texts (American Education Material). Evaluation of the materials demonstrated the variances between the tokens used in ESL text and tokens used in AE text such as the ESL material primarily focuses on function words, e.g. conjunctions; whereas, the AE material token frequency of important content words is much higher.

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