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바이모달 트램의 후진주차보조 알고리즘 개발에 관한 연구
최성훈(Seonghoon Choi),박태원(Taewon Park),이수호(Sooho Lee),문경호(Kyeongho Moon) 한국자동차공학회 2009 한국 자동차공학회논문집 Vol.17 No.5
The bi-modal tram is under development as a new public transportation. The features of the tram are an extended wheel base and its length. This features result in difficulties for drivers on maneuvering the tram. Therefore, the all wheel steering system is applied to the articulated vehicle. The AWS system enables the vehicle to steer all the rear wheels independently and improves its driving characteristics. However, the bi-modal tram has a problem to move backward in the limited place because of its geometric feature and the AWS system. Hence, the reverse parking assistant algorithm for articulated vehicle is developed to solve the problems of the reverse parking. Using the vehicle model which includes the reverse parking assistant algorithm, the dynamic analysis is performed for several parking cases. By the result of the analysis, the stability and validity of the reverse parking assistant algorithm is verified.
박태원(Park, Taewon),박현빈(Park, Hyunbin),장준기(Chang, Joonki),박종석(Park, Jongseok),유민숙(Yoo, Minsook) 한국과학영재교육학회 2021 과학영재교육 Vol.13 No.1
이 연구는 과학고에서 진행하는 Research & Education (R&E) 과제로 수행되었다. 본 연구에서는 기상청에서 제공하는 한반도 60개 관측소에서의 2000년부터 2019년까지의 일최고기온과 일최저기온 자료를 사용하여 한반도 폭염과 열대야 발생일수에 대한 해안과 내륙, 도시와 시골, 지리적 위치의 영향에 대해 분석하였다. 해안 지역에서 폭염은 평균 6.8일로, 내륙 지역의 14.3일의 반 정도 밖에 발생하지 않았고, 열대야는 반대로 해안 지역에서 13.4일, 내륙 지역에서 5.8일의 평균발생일수가 나타났다. 이는 해안 지역이 높은 비열의 바다와 가까운 해양성 기후의 특성을 보이는 것에 기인한다. 폭염은 도시와 시골에서 둘다 약 12일의 평균발생일수를 포함하여 발생일수 분포가 거의 차이를 보이지 않았지만, 열대야는 도시에서 평균 10.9일이 발생하여 시골의 4.1일 평균 발생일수에 비해 매우 빈번하게 발생하였다. 도시열섬이 낮에는 크게 나타나지 않지만, 밤에 인공 구조물이 많은 열을 내보내기 때문에 이로 인해 도시의 열대야 발생이 크게 늘어나게 되었다. 위도는 폭염 발생과는 거의 관련성이 없고 열대야 발생과는 -0.54의 높은 음의 상관성을 보였다. 경도는 폭염과는 양의 상관성을, 열대야와는 음의 상관성을 보였지만, 그 상관계수는 각각 0.18, -0.20으로 작아 그 관련성은 작은 편이었다. 고도가 높을수록 폭염과 열대야 모두 적게 발생하는 경향이 있었는데, 그러한 경향성은 열대야에서 더 두드러지게 나타났다. This study is based on Research and Education (R&E) project in science high school. In this study, we investigated the regional impact on occurrences of heat waves and tropical nights over Korean Peninsula using daily maximum and minimum temperature at 60 stations provided from KMA during 2000-2019. Heat waves occur 6.8 days and 14.3 days in coastal and inland stations, respectively. On the contrary, occurrences of tropical nights are 13.4 days in coastal stations and 5.8 days in inland stations. This is due to the fact that coastal stations closer to the ocean have a maritime climate with high specific heat contents. The number of heat wave occurrences is very little difference between urban and rural stations, while tropical nights occur 10.9 days in urban stations, very often compared to the 4.1-day occurrences in rural stations. The urban heat islands do not appear much during the day, but artificial structures at night emit a lot of heat, which leads to a significant increase of tropical night occurrences in the urban stations. Latitude has little to do with the heat wave occurrences and has a high negative correlation of -0.54 with the tropical night occurrences. Longitude is positively correlated with the heat waves and negatively correlated with the tropical nights, but their correlation coefficients are small, 0.18 and -0.20, respectively. The higher the altitude, the fewer occurrences of heat waves and tropical nights tend to occur.
The Relationship between Epidemiologic Factors and Usage Pattern of Hair Care Products in Korea
( Kyung-duck Park ),( Byung Cheol Park ),( Ki Hyun Sung ),( Eunyoung Lee ),( Taewon Lee ),( Daeki Yoon ),( Kyu Bong Kim ),( Gyeong Hun Park ),( Il Yong Park ),( Myung Hwa Kim ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.3
Background: For hair care products that are used almost everyday, it is important to estimate the cumulative dosage of long-term exposure and to assess the effects on the human body. Little data are available to evaluate actual daily usage in Asian populations. Objective: Reliable exposure data for hair care products is essential to conduct safety assessments. Methods: We evaluated the actual usage pattern and amounts by checking the daily log over a 2-week period, to obtain all the data regarding the participants’ hair care preferences. And, statistical analyses were conducted to analyze the daily use amount (g/d) and daily usage per hair length (g/cm/d), and other variables by sex, age group, and hair oiliness. Results: Throughout this study, we found that female users consumed significantly larger daily amounts of shampoo and rinse. Male groups used more hair gel and spray than female groups. Interestingly, all the hair care products studied scored higher levels of usage among men when calibrated per unit length. Koreans tend to use lesser amount of rinse although their hairs are usually thicker than the Western hairs. Conclusion: This study provides exposure information for commonly used hair care products, which will be useful for risk assessment purposes. (Ann Dermatol 31(3) 307∼314, 2019)
Park, Yeonah,Kang, Eunah,Kwon, Oh-Joon,Hwang, Taewon,Park, Hongkwan,Lee, Jung Min,Kim, Jung Hyun,Yun, Chae-Ok Elsevier 2010 Journal of controlled release Vol.148 No.1
<P><B>Abstract</B></P> <P>For effective cancer gene therapy, systemic administration of tumor-targeting adenoviral (Ad) complexes is critical for delivery to both primary and metastatic lesions. Electrospinning was used to generate nanocomplexes of Ad, chitosan, poly(ethylene glycol) (PEG), and folic acid (FA) for effective FA receptor-expressing tumor-specific transduction. The chemical structure of the Ad/chitosan–PEG–FA nanocomplexes was characterized by NMR and FT-IR, and the diameter and surface charge were analyzed by dynamic light scattering and zeta potentiometry, respectively. The average size of Ad/chitosan–PEG–FA nanocomplexes was approximately 140nm, and the surface charge was 2.1mV compared to −4.9mV for naked Ad. Electron microscopy showed well-dispersed, individual Ad nanocomplexes without aggregation or degradation. Ad/chitosan nanocomplexes retained biological activity without impairment of the transduction efficiency of naked Ad. The transduction efficiency of Ad/chitosan–PEG–FA was increased as a function of FA ratio in FA receptor-expressing KB cells, but not in FA receptor-negative U343 cells, demonstrating FA receptor-targeted viral transduction. In addition, the transduction efficiency of Ad/chitosan–PEG–FA was 57.2% higher than chitosan-encapsulated Ad (Ad/chitosan), showing the superiority of FA receptor-mediated endocytosis for viral transduction. The production of inflammatory cytokine, IL-6 from macrophages was significantly reduced by Ad/chitosan–PEG–FA nanocomplexes, implying the potential for use in systemic administration. These results clearly demonstrate that cancer cell-targeted viral transduction by Ad/chitosan–PEG–FA nanocomplexes can be used effectively for metastatic tumor treatment with reduced immune reaction against Ad.</P> <P><B>Graphical abstract</B></P> <P>Ad nanocomplexes composed with chitosan–PEG–FA and processed via electrospinning showed high transduction efficacy and low immune responses.</P> <P>[DISPLAY OMISSION]</P>
Hitting Set 문제를 이용한 차세대 염기서열 분석 리드의 처리속도 개선 방법
박태원(TaeWon Park),김소라(Sora Kim),최석문(SeokMoon Choi),조환규(Hwan-Gue Cho),이도훈(DoHoon Lee) 한국정보과학회 2011 정보과학회논문지 : 시스템 및 이론 Vol.38 No.6
최근에 등장한 Next Generation Sequencing(NGS)은 전통적인 방법에 비해 빠르고 저비용으로 대용량의 단편 서열 데이터를 얻을 수 있는 차세대 염기서열 분석 기술을 말한다. 이렇게 얻어진 NGS 데이터를 분석하는 단계 중에서 얼라인먼트(alignment) 단계는 시퀀서에서 얻은 대량의 리드(read)를 참조 염기서열에 맵핑하는 단계로 NGS 데이터 분석의 가장 기본이면서 핵심인 단계이다. 얼라인먼트 도구는 긴 참조 염기서열을 색인화해서 짧은 리드를 빠르게 맵핑하는 용도로 사용된다. 현재 많이 사용되고 있는 일반적인 얼라인먼트 도구들은 입력데이터에 대한 별도의 전처리 과정이 없으며 나열된 리드를 순차적으로 맵핑하는 단순한 구조를 가지고 있다. 본 논문은 NGS 데이터의 특징 중에 특히 리드간의 중복성을 이용한 리드의 효율적 공통 부분서열을 찾는 방법을 보여준다. 중복된 공통 부분서열과 그것이 포함된 리드의 관계를 그래프 이론의 Hitting Set 문제로 모델링하고 여러 리드가 포함하는 공통 부분서열을 사용해서 얼라인먼트 단계의 효율을 높일 수 방법을 제안한다. Next Generation Sequencing(NGS) is a faster and lower cost new sequencing technique getting huge-large scale fragment, called reads, sequence data than traditional sequencing. The next step to analyze the large-scale reads is to align to the reference genome sequence which is a fundamental and most important stage. Alignment tools in NGS are used for mapping short reads quickly using a indexed reference sequence. Most general alignment tools process listed reads sequentially without analyzing redundancy of inter-read of NGS data. In this paper, we explore efficient common subsequences using redundancy of inter-read in characteristics of NGS data. Relation between redundant common subsequences and reads containing them is modeled as hitting set problem in graph theory. Also we suggest a way to improve performance of alignment stage.
다중 전사체 서열의 시각화와 불리언 질의를 이용한 비교
박태원 ( Taewon Park ),조환규 ( Hwan-gue Cho ),이도훈 ( Dohoon Lee ) 한국정보처리학회 2012 한국정보처리학회 학술대회논문집 Vol.19 No.2
생물정보학 데이터를 분석하는 과정에서 서열 데이터의 시각화는 연구자에게 방대한 서열 데이터의 특성을 눈으로 쉽게 이해하기 위한 필수 과정이다. 대조 실험 데이터나 다중 서열 데이터를 시각화해주는 많은 도구들이 있지만 방대한 유전체 서열에서 사용자가 원하는 다중 데이터간의 비교 영역을 찾아서 시각화해주는 기능이 부족한 것이 현 상황이다. 본 논문은 불리언 질의를 통해서 다중 전사체 서열을 효율적으로 비교하고 그 결과를 시각화해주는 방법을 제안한다.