만성 통증 질환들의 새로운 분류 및 진단 기준 : 류마티스 관절염, 섬유근육통 및 척추관절염

김근태 고신대학교 의과대학 2011 고신대학교 의과대학 학술지 Vol.26 No.1

Rheumatoid arthritis, fibromyalgia, and spondylarthritis are important diseases causing chronic pain and disability in rheumatologic areas. The classification and diagnostic criterias of them were made on the basis of clinical features, radiologic and laboratory findings and have been used decades ago. According to the development of new knowledge about etiology and pathogenesis of rheumatic diseases, the need for new criteria has been increased. In recent years, new criteria for these diseases have been developed, and they allow the early assignment of diseases and early start of therapy. In this review, the author summarizes recent advances and changes in diagnosis of rheumatoid arthritis, fibromyalgia, and spondylarthritis.

강낭콩의 식물체 부위와 생육시기에 따른 무기영양성분 함량과 흡수량에 대한 질소의 사용효과

오태근,이경아,송범헌 忠北大學校 農業科學硏究所 2012 農業科學硏究 Vol.28 No.2

This study was conducted to examine the nitrogen effects on uptake and utilization of major mineral nutrients of the kidney bean (Phaseolus vulgaris L.). The N treatments were five levels, 0, 3, 6, 9, 12 N kg/10a. The kidney bean was cultivated on the upland experimental field in the agricultural ???? research & extensions service of Chungbuk province. The contents and uptake amounts of mineral nutrients were investigated throughout the growth stages of the kidney bean. Higher content of total N in the stem was maintained until 8 days before flowering stage and then decreased gradually. Also, total N content of leaves was increased in the vegetative growth stage, and it was decreased rapidly to 8 days after the flowering stage, and then increased gradually to the initial maturity stage. Total N content of roots was tended to decrease until 8 days after the flowering stage, while that of seed was increased from the flowering stage to the maturity stage. The amount of uptake N of the shoot parts was increased until the flowering stage, maintained similarly from the flowering to 14 days after the flowering stage, and then increased rapidly to the maturity stage, while that of root was increased slowly to the flowering stage and then maintained similarly to the maturity.

[논문]ZCS를 이용한 간단한 long pulse CO2 레이저 전원

김태균,이임근,김희제 釜山大學校生産技術硏究所 2004 生産技術硏究所論文集 Vol.63 No.-

30Torr 이하 저압 공진기에서 ms order의 long pulse duration을 가진 간단한 펄스 CO2 레이저를 구현하였다. 레이저 시스템의 새로운 전원은 직접 상용전원을 스위칭한다. 이 새로운 전원의 방전 회로에는 정류기, 축전용 커패시터, 또는 전류 제한용 저항이 필요하지 않다. 레이저 출력을 제어하기 위해 펄스 반복률을 최대 60Hz까지 조절했고,SCR의 스위칭각은 30°에서 150°까지 변화시켰다. ZCS circuit과 PIC one-chip microprocessor는 SCR 게이트 신호를 제어하기 위해서 사용되었다. 18 Torr 압력,60Hz 의 펄스 반복률,SCR 스위칭각 90°에서 최대 레이저 출력 35 W를 얻었다. 또한 다른 CO2 레이저와 비교해서 long 펄스를 얻을 수 있었고 이는 대략 3ms(FWHM) 였다.

신피질 세포에서 organic hydroperoxide에 의해 유발된 세포사망

김근태 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

Background : Previous studies have shown that the hydrogen peroxide induces the cell injury through a lipid peroxidation-independent mechanism in renal epithelial cells. This study was therefore undertaken to examine the roles of lipid peroxidation in t-butylhydroperoxide (tBHP)-induced cell death to renal epithelial cells. Methods : Opossum kidney (OK) cell cultures, a renal tubular epithelial cell line, were used as the renal epithelial cell model. tBHP caused cell death in a dose-dependent manner over the concentration range of 0.05-2 mM. Results : The cell death was effectively prevented by the hydroxyl radical scavenger (dimethylthiourea), iron chelators (deferoxamine and phenanthroline), and antioxidants (DPPD and BHA), but not by the hydrogen peroxide scavenger catalase. tBHP caused a marked increase in lipid peroxidation, which was completely inhibited by DPPD and deferoxamine. tBHP-induced ATP depletion was prevented by deferoxamine and DPPD. Similar protective effects of antioxidants were observed in cell death induced by cumene hydroperoxide, another organic hydroperoxide. However, inorganic hydroperoxide (H2O2)-induced cell death was not altered by antioxidants. tBHP-induced apoptosis was prevented by DPPD and deferoxamine. Conclusions : These results indicate that organic hydroperoxide induces cell death through a lipid peroxidation-dependent mechanism, unlike inorganic hydroperoxide, in renal epithelial cells. 배경:신장 세뇨관 상피세포에서 inorganic hydroperoxide 인 H2O2가 lipid peroxidation-independent mechanism을 통해 세포 상해를 유도한다는 이전 연구 결과가 있었고, 본 연구에서는 신장 세뇨관 상피세포에 organic hydroperoxide인 t-butylhydroperoxide (tBHP)에 의해 유도된 세포사망에 있어 lipid peroxidation이 어떤 역할을 하는지 조사하였다. 방법 : 신피질 세포로는 Opossum Kidney (OK) cell이 이용되었다. tBHP는 0.05-2mM의 범위에서 농도 의존적으로 세포사망을 유도했다. 이러한 세포사망이 hydroxyl기 제거제인 dimethylthiourea, iron chelator인 deferoxamine과 phenanthroline, 항산화제인 DPPD와 BHA, 그리고 H2O2 제거제인 catalase에 의해 어떠한 차이를 나타내는 지를 관찰하였다. 결과 : 세포사망은 dimethylthiourea, deferoxamine과 phenanthroline, DPPD와 BHA에 의해 효과적으로 방지되었으나, catalase에 의해서는 방지되지 않았다. tBHP는 lipid peroxidation을 확연하게 증가시켰으며 이러한 효과는 DPPD와 deferoxamine에 의해 완전히 억제되었다. 또 tBHP에 의해 유도된 ATP 소모도 deferoxamine 과 DPPD에 의해 방지되었다. 항산화제의 이와 같은 방지효과가 다른 organic hydroperoxide인 cumene hydroperoxide에 의해 유도된 세포사망에서도 나타났으나, H2O2에 의해 유도된 세포사망은 영향을 받지 않았다. tBHP가 apoptosis를 유도하였으며, 이는 DPPD와 deferoxamine에 의해 방지되었다. 결론 : 이상의 결과는 신장 세뇨관 상피세포에서 organic hydroperoxide가 inorganic hydroperoxide와 달리 lipid peroxidation-dependent mechanism을 통해 세포사망을 유발함을 의미한다.

特殊한 Infinite State Markov Chain의 Steady-state Probability Distribution의 存在에 대한 小考

吳根泰 수원대학교 산업기술연구소 1990 산업기술연구소논문집 Vol.5 No.-

The existance of steady-state probability distribution for a specific infinite state Markov chain which is often appeared in the application area of queueing theory is proved. The explicit expression of steady-state probability distribution for this Markov chain is derived in the process of proof.

A Study on the Comparison of wind pressure on the member of Container Crane using Wind tunnel test and CFD

한근조,안태원,이성욱,한동섭 동아대학교 생산기술연구소 2006 生産技術硏究所硏究論文集 Vol.11 No.-

Because strong wind is one of the few forces that, although considered in container crane design, still cause significant damage, a container crane was tested to investigate wind load characteristic in uniform flows. So, this study measured an external point pressure at the each members of a container crane according to a wind direction and a shape of members in a wind-tunnel test. The result of this test was compared to those of computation fluid dynamics using a CFX 10. The scale of a container crane model for wind tunnel test applied similarity scales to consider the size of the wind tunnel test section and the boundary condition for CFD is like wind tunnel test.

精密測定 計器用 Stainless Steel의 諸性質에 미치는 熱處理의 影響

金善泰,安幸根,韓泰鍾 Natural Science Research Institute JEONJU UNIVERSI 1987 전주대학교 자연과학연구소 학술논문집 Vol.2 No.2

The changes of microstructure and hardness with the various heat treatments on the properties of Fe-13.36% Cr-0.37%C stainless steel for precision measuring gauge have been investigated. Type 420 stainless steel has the self-hardenability, because the nose of isothermal transformation diagram located greatly to the right. The highest hradness in the martensite martrix with undissolved carbide is obtained by oil and air cooling treatment after austenizing at 1000-1050℃, for 1/6-1/3hr. In case of low temperature tempering, internal stress is reduced without dissolution of martensite matrix, and hardness reduced slightly. In case of high temperature tempering, hardness is reduced greatly, because the martensite matrix is dissolved into a ferrite and carbide.

Agrobacterium을 이용한 고추의 형질전환체계개발

최근원,박영두,박승국,전영주,유일웅,김인태,백운돈 경희대학교 생명자원과학연구원 1997 硏究論文集 Vol.18 No.-

본 실험은 고추의 형질전환체 선발을 위한 최소의 항생제농도를 결정하고 그 결과를 이용하여 형질전환체를 유기하고 효율을 최대화하기 위하여 수행한 바 그 결과는 다음과 같다. 1. 항생제 감응성 검정결과 kanamycin 40㎎/ℓ와 hygromycin 20 ㎎/ℓ에서 신초형성이 완전히 억제되었다. 2. Agrobacterium 제거에 사용되는 carbenicillin과 cefotaxime 처리시 재분화에 아무런 영향을 미치지 않았으며 cefotaxime 200㎎/ℓ 처리에서는 무처리구보다 신초형성이 더 활발하였다. 3. 회복친인 135Q와 276F에서는 형질 전환시 높은 재분화율을 보였으나 형질전환율은 각각 10%와 11.1%의 낮은 빈도를 보였다. 4. 재분화된 신초들을 대상으로 histochemical GUS assay를 실시한 결과 부분적으로 푸른발색이 확인되었다. 5. GUS활성을 보인 신초들에 대한 NPTⅡprimer를 이용한 PCR검정에서 NPTⅡ 유전자의 존재가 확인되었다. A transformation system using Agrobacterium tumefaciens was developed with different genotypes of hot peppers (Capsicum annuum). Four antibiotics commonly used in Agrobacterium-mediated transformation were tested for their effects on shoot regeneration. Shoot induction was completely inhibited by kanamycin at 40㎎/ℓ and hygromycin at 20㎎/ℓ or higher, but not by carbenicillin and cefotaxime. Cotyledon explants of hot peppers were cocultivated with Agrobacterium turnefaciens LBA4404 which carries a binary. vector pBI121 harboring the neomycin phosphotransferase, type Ⅱ (NPT Ⅱ) gene and β-glucuronidase (GUS) gene. For selection of transformed cells, 40㎎/ℓ kanamycin were used because the sensitivity test showed that 40㎎/ℓ kanamycin completely inhibited shoot induction from nontransformed cells. Histochemical GUS assay showed the presence of the GUS gene and PCR analysis confirmed the NP TⅡ gene was integrated. Transformation frequency was about 10.0% and 11.1% of total regenerants from 135Q and 276F, respectively.

중소기업에서의 ERP의 성공적인 도입을 위한 요소와 주요 ERP패키지의 특성에 대한 조사연구

吳根泰,金明洙 水原大學校 1999 論文集 Vol.17 No.-

ERP is the general trend of industrial information system and many companies are introducing strategically to strengthen the competitive power. But it is too expensive for small companion to introduce and there are frequent occasions which are far from satisfactory because of making a bad choice. So this study proposes the critical success factors for the introduction of ERP system to small companies which is extracted from many success and failure cases and shows the characteristics and functions of main ERP packages.

다단계 다계단 재고체계의 CSP 소요량 결정

오근태,김명수 수원대학교 산업기술연구소 1998 산업기술연구소논문집 Vol.13 No.-

This paper considers a problem of determining concurrent spare part requirements for a multi-indentured multi-echelon inventory system where initial spares are necessary to operate and maintain a system of newly-deploying end equipments without any intermediate inventory replenishment during a certain initial period of service. For the problem, mathematical models derived, based on supplier-provided design information such as reliability and maintenance data, to minimize the total procurement cost of all the required initial spares subject to a target operational availability, an integrated measure for the associated system of all the end equipments. In the model analysis, the structural behavior of each component is characterized in terms of its contribution to the whole system operational availability, based on which a solution algorithm is derived to determine the stockage levels for each of the associated spares and their locations.