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- 저자 : Tabata, Hidekazu (검색결과 100 건)
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Tabata, Chiharu,Tabata, Rie,Nakano, Takashi Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
Malignant pleural mesothelioma (MPM), an aggressive malignant tumor of mesothelial origin associated with asbestos exposure, shows a limited response to conventional chemotherapy and radiotherapy. Therefore, the overall survival of MPM patients remains very poor. Progress in the development of therapeutic strategies for MPM has been limited. We recently reported that the calpain inhibitor, calpeptin exerted inhibitory effects on pulmonary fibrosis by inhibiting the proliferation of lung fibroblasts. In the present study, we examined the preventive effects of calpeptin on the cell growth of MPM, the origin of which is mesenchymal cells, similar to lung fibroblasts. Calpeptin inhibited the proliferation of MPM cells, but not mesothelial cells. It also prevented 1) the expression of angiopoietin (Ang)-1 and Tie-2 mRNA in MPM cells, but not mesothelial cells and 2) the Ang-1-induced proliferation of MPM cells through an NF-kB dependent pathway, which may be the mechanism underlying the preventive effects of calpeptin on the growth of MPM cells. These results suggest potential clinical use of calpeptin for the treatment of MPM.
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Transient osteoporosis of the hip with a femoral neck fracture during follow-up: a case report
( Yusuke Tabata ),( Shuhei Matsui ),( Masabumi Miyamoto ),( Koichiro Omori ),( Yoichiro Tabata ),( Tokifumi Majima ) 영남대학교 의과대학 2023 Yeungnam University Journal of Medicine Vol.40 No.2
We report a case of transient osteoporosis of the hip with a femoral neck fracture found during follow-up. A 53-year-old man pre sented with left hip pain without trauma. The pain did not improve after 2 weeks and he was brought to our hospital by ambulance. Magnetic resonance imaging (MRI) of the left hip joint showed diffuse edema in the bone marrow, which was identified by low signal intensity on T1-weighted images, high signal intensity on T2-weighted images, and increased signal intensity on short tau inversion recovery. This edema extended from the femoral head and neck to the intertrochanteric area. He was diagnosed with transient osteo porosis of the left hip. Rest gradually improved his pain; however, 3 weeks later, his left hip pain worsened without trauma. X-ray, computed tomography, and MRI results of the hip joint demonstrated a left femoral neck fracture, and osteosynthesis was performed. Differential diagnoses included avascular necrosis of the femoral head, infection, complex regional pain syndrome, rheumatoid arthri tis, leukemia, and other cancers. Transient osteoporosis of the hip generally has a good prognosis with spontaneous remission within a few months to 1 year. However, a sufficient length of follow-up from condition onset to full recovery is necessary to avoid all probable complications such as fractures.
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Extraction of Water-Soluble Porphyrin and Metalloporphyrins into Acetonitrile by Salting-out
Tabata, Masaaki,Kumamoto, Midori 한국분석과학회 1995 분석과학 Vol.8 No.4
A cationic water soluble porphyrin (5,10,15,20-tetrakis (l-methyl-pyridinium-4-yl)porphyrin, $H_2tmpyp^{4+}$) and its metalloporphyrins (MP) were easily extracted into acetonitrile separated by addition of sodium chloride ($4mol\;dm^{-3}$) in the presence of sodium perchlorate, where M denotes $Zn^{2+}$, $Cu^{2+}$, $Co^{3+}$, $Fe^{3+}$, and $Mn^{3+}$ and $P^{2-}$ is porphyrinate ion. The extracted ion-pair complexes were completely dissociated to $[MP(ClO_4)_3]^+$, and $[MP(ClO_4)_2]^{2+}$. The extraction and the dissociation constants were determined by taking into account of the partition constant of sodium perchlorate ($K_D=1.82{\pm}0.01$). The chemical properties of the separated acetonitrile phase as $E_{T(30)}$ and $D_{II,I}$ were determined and compared with other water miscible solvents (acetone, actonitrile, 1,4-dioxane, tetrahydrofuran, 1-propanol and 2-propanol). Furthermore, a sensitive and selective method was proposed for the determination of a subnanogram amount of copper(II) in natural water samples by using the present salting-out method and the porphyrins.
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日本語學,日本語敎育學 篇 : ことわざの比喩に關する一考察 -「江戶いろは」と「上方いろは」を中心に-
다바타미쓰코 ( Tabata Mitsuko ) 한국일어일문학회 2011 日語日文學硏究 Vol.78 No.1
本硏究では「江戶·上方いろは」を對象に認知言語學的な立場よりことわざに內在する思考のプロセスを考察をしつつ比喩の類型分析を試みた。その分析の基準として從來の隱喩、換喩、提喩の3つの型に「隱喩+換喩」型「換喩+提喩」型「隱喩+提喩」型の3種類を加えた6つの類型がそれぞれ見られ、圖式化することができた。その結果は次の通りである。①隱喩型は、性質の類似性(S)に着目してYをXで言い換える「YはXだ」型と「YはXだ」の型をとらない擬人法に分類できた。YをXで言い換える轉義は主に「人間を動物で言い換えるもの」と「抽象を具象で言い換えるもの」の二通りのパタ―ンが見られ、擬人法は、ことわざにおいても人に見立てる對象を生物(動植物)に限らず、一般の抽象物まで擴大したものが見られた。②換喩型は、容器(場所)と中身、道具と機能、全體と部分、實體と屬性、省略形、數字などの項目に分類できた。③提喩型は、種で類を表わすものと類で種を表わすものに分類でき、上位槪念と下位槪念の包攝關係を具體的に提示することができた。類で種を表わす提喩型は、句全體のものと句の一部のものに分類できた。④「隱喩+換喩」型は、「臭いものに蠅がたかる」と「臭いものに蓋」2句のみであった。⑤「換喩+提喩」型は、「泣き面に蜂」と「寺から里へ」2句のみで見られた。この時の提喩は、種で類を表わすものであることがわかる。⑥「隱喩+提喩」型は、「YはXだ」型で表した「X」は、ことわざ全體に現われ「Y」はことわざの表象には現われない。Yの下にいくつもの下位槪念を持つものである。この時の提喩は、「換喩+提喩」型のそれとは違い、類で種を表わすものであることがわかる。比喩の類型の中で最も多く、一覽表に示したように45句で見られ、江戶·上方いろは全句の半數近い約47.4%を占めた。
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일본어 학습자의 커뮤니케이션 능력과 전략, strategy 고찰
다바타미쓰코 ( Tabata Mitsuko ) 한국일어일문학회 2014 日語日文學硏究 Vol.89 No.1
비모어화자는 다양한 방법을 사용하여 커뮤니케이션을 하는데 그 오류라고 할 수 있는 비모어화자 표현은 그 나름의 고심한 산물이라고 할 수 있다. 그러므 로 커뮤니케이션교육에 있어서는 비모어화자에게서 나타나는 자료에서 그들의 고민과 일본어 운용 실태를 명확하게 하는 연구가 필수적이다. 본고에서는 한국어를 모어로 가진 일본어 학습자의 커뮤니케이션 능력과 그 전략에 대하여 연구하였으며, 학습자의 배경과 오용에 초점을 맞추어 고찰하였 다. 분석 결과, ``ね, よ, よね``의 사용, ``웃게 만드는 기술``, ``청자의 이해를 도우는 배려``, ``共話(두 명 이상이 하나의 발화를 같이 이해한다는 전제 하에 말을 완성 해 나가는 이야기방식)``, ``の/んだから``, ``포말, 인포말 표현의 혼용``, ``なんか, やっぱり``등의 필러(filler)에서 학습자의 사회적 및 비사회적 전략을 찾아볼 수 있었다. 이것이 그들의 개성이며 그들의 고유한 전략이 반영된 것으로 본다. The nonnative language speakers are using various sort of method doing for their communication, but it is misused doing for their communication, but it is misused, their peculiar expressions are their devised production. Therefore, the educational communication for them is, from the data of nonnative language using, we have to find their type of study and real condition of practical use, so we think such kind of research to clear should be very important. This manuscript is considerate of the communication ability and its strategy for the Japanese language learner who is using Korean mother-language. As a result I found the two big aspects. The first one is can observe progressive posture of strategy, using of last postpositional particle ``NE, YO, YONE``, think hard for take the laughing consideration to help listener`s understand, and ``KYOWA`` - more than two speaker talk about one thing and helping each other to understand, making the way to talk also. The another one is, to the listener making displease and feeling of fear by strategy using ``NO-NDAKARA``, mixing to use expression of formal and informal, and ``NANKA``, ``YAPPARI`` of etc, to use kind of fillers. For that result, on the learner`s communication of strategy, we have known, there was bigly influenced by the way of study, learning object, and personal ideas, than learner`s learning experiences. These are personality of them and their original strategy was very clearly and reflected.
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