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      • KCI등재후보

        Vessel Wall Magnetic Resonance Imaging Findings of Bilateral Middle Cerebral Artery Stenosis Associated with Nilotinib

        Sungjoon Yoon,Seon Deuk Kim,Juhee Lee,Mu Seong Kim,Yong Woo Shin,Eung-Joon Lee 대한신경초음파학회 2021 대한신경초음파학회지 (JNN) Vol.13 No.2

        Nilotinib is a Bcr-Abl tyrosine kinase inhibitor used to treat chronic myelogenous leukemia. There have been case reports of nilotinib-related vasculopathy. However, most cases present peripheral artery disease, whilst reports of nilotinib-related cerebrovascular disease are quite uncommon. Herein, we report a case of nilotinib- induced intracranial stenosis in a patient with recurrent transient ischemic attacks and discuss the results of serial vessel wall magnetic resonance imaging.

      • KCI등재

        A Study on Factors Affecting the Customer-centric Value Co-Production

        Yoon, Sungjoon 한국문화산업학회 2017 문화산업연구 Vol.17 No.2

        In view of increased social awareness of today’s consumers, it is very important to understand whether such social awareness causes consumers to behave in a manner consistent with the underpinning social values to fulfill their sense of good citizenship. It is from this research motive that this study proposes and tests three predictors (CSR perception, network trait, and reciprocal norm) of value co-production behavior by current customers of social enterprises. The study’s result showed that the three predictor variables positively contribute to eliciting value co-producing behavior. We also found that corporate trust plays a mediating role between the three predictors and value-co-producing behaviors. In view of increased social awareness of today’s consumers, it is very important to understand whether such social awareness causes consumers to behave in a manner consistent with the underpinning social values to fulfill their sense of good citizenship. It is from this research motive that this study proposes and tests three predictors (CSR perception, network trait, and reciprocal norm) of value co-production behavior by current customers of social enterprises. The study’s result showed that the three predictor variables positively contribute to eliciting value co-producing behavior. We also found that corporate trust plays a mediating role between the three predictors and value-co-producing behaviors.

      • KCI등재

        화장품 제품의 구매동기, 구매체험, 충동구매에 있어서 성별차이와 관여도의 조절효과

        윤성준(Yoon, SungJoon),김영미(Kim, YoungMi),이형주(Lee, HyoungJu) 한국문화산업학회 2012 문화산업연구 Vol.12 No.1

        This paper addresses the customer in-store experiences regarding purchase of cosmetics as they closely relate to shopping motives and resulting purchase decision. Customers with particular purchase motives (ie., hedonic vs. rational) toward cosmetics would manifest them through actual shopping experiences in store and it is plausible that customers with particular in-store shopping experiences may be induced to buy on impulse without pre-purchase plans. This paper examines this facet of attitude-behavior relationships in terms of the antecedent (purchase motives) and consequence (impulse buy) of customer experience. Another key research objective is to determine whether the gender and involvement plays a role with regard to in-store experiences and impulse buying. This paper based its theoretical framework regarding customer experience on Schmitt"s (1999) SEM (Strategic Experiential Modules) which categories experience into five realms (Sense, Feel, Think, Act, Relate). The study found that the hedonic motives had significant effects on purchase experiences more than rational motives. It also found that involvement played a moderator role between sensory in store- experience and impulse buying. Gender difference was found in shopping motives and some purchase experiences. Gender was also found to moderate the relationship between shopping motives and some purchase experiences. The study results are expected to offfer useful implications for formulating gender-based experiential marketing strategy for cosmetics This paper addresses the customer in-store experiences regarding purchase of cosmetics as they closely relate to shopping motives and resulting purchase decision. Customers with particular purchase motives (ie., hedonic vs. rational) toward cosmetics would manifest them through actual shopping experiences in store and it is plausible that customers with particular in-store shopping experiences may be induced to buy on impulse without pre-purchase plans. This paper examines this facet of attitude-behavior relationships in terms of the antecedent (purchase motives) and consequence (impulse buy) of customer experience. Another key research objective is to determine whether the gender and involvement plays a role with regard to in-store experiences and impulse buying. This paper based its theoretical framework regarding customer experience on Schmitt"s (1999) SEM (Strategic Experiential Modules) which categories experience into five realms (Sense, Feel, Think, Act, Relate). The study found that the hedonic motives had significant effects on purchase experiences more than rational motives. It also found that involvement played a moderator role between sensory in store- experience and impulse buying. Gender difference was found in shopping motives and some purchase experiences. Gender was also found to moderate the relationship between shopping motives and some purchase experiences. The study results are expected to offfer useful implications for formulating gender-based experiential marketing strategy for cosmetics

      • [차량운동성능부문] 자동차운동의 실시간 시뮬레이션을 위한 S/W툴 설계

        윤석준(Sungjoon Yoon),김진원(Jin Won Kim) 한국자동차공학회 2000 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-

        In order to perform the development of Automotive parts and system, MATLAB and Simulink based Real Time Simulation tool is designed for the analysis of Automotive Dynamics. With Visual Basic GUI environment, developers are able to access the object oriented Automotive Parts Model for the model and parameter change. Again, economical research is possible when using PCs as platforms. Automotive Dynamic Modeling, which is based on the USA ADI(Applied Dynamics International)'s 17 D.O.F. one, is beefed up for the 3D geometric road condition along with various ABS method. In order to extract geometric polygon or related parameters Searching Window, Level of Detail, Delaunay Triangulation, and etc data searching methods are introduced to increase simulation speed. Besides 17 degree of freedom model, 7 D.O.F. & 17 D.O.F. ones are being studied to prove their modeling effectiveness by comparison. Research tool for the Automotive Dynamics is under development as a part of the integrated simulation tool of the Aircrtft, Train, and Tank dynamic analysis, which will be extended to HILS(Hardware-in-the-loop Simulation).

      • KCI등재

        Machine Learning-Based Proteomics Reveals Ferroptosis in COPD Patient-Derived Airway Epithelial Cells Upon Smoking Exposure

        Yoon Jung-Ki,Park Sungjoon,Lee Kyoung-Hee,Jeong Dabin,Woo Jisu,Park Jieun,Yi Seung-Muk,Han Dohyun,Yoo Chul-Gyu,Kim Sun,Lee Chang-Hoon 대한의학회 2023 Journal of Korean medical science Vol.38 No.29

        Background: Proteomics and genomics studies have contributed to understanding the pathogenesis of chronic obstructive pulmonary disease (COPD), but previous studies have limitations. Here, using a machine learning (ML) algorithm, we attempted to identify pathways in cultured bronchial epithelial cells of COPD patients that were significantly affected when the cells were exposed to a cigarette smoke extract (CSE). Methods: Small airway epithelial cells were collected from patients with COPD and those without COPD who underwent bronchoscopy. After expansion through primary cell culture, the cells were treated with or without CSEs, and the proteomics of the cells were analyzed by mass spectrometry. ML-based feature selection was used to determine the most distinctive patterns in the proteomes of COPD and non-COPD cells after exposure to smoke extract. Publicly available single-cell RNA sequencing data from patients with COPD (GSE136831) were used to analyze and validate our findings. Results: Five patients with COPD and five without COPD were enrolled, and 7,953 proteins were detected. Ferroptosis was enriched in both COPD and non-COPD epithelial cells after their exposure to smoke extract. However, the ML-based analysis identified ferroptosis as the most dramatically different response between COPD and non-COPD epithelial cells, adjusted P value = 4.172 × 10−6, showing that epithelial cells from COPD patients are particularly vulnerable to the effects of smoke. Single-cell RNA sequencing data showed that in cells from COPD patients, ferroptosis is enriched in basal, goblet, and club cells in COPD but not in other cell types. Conclusion: Our ML-based feature selection from proteomic data reveals ferroptosis to be the most distinctive feature of cultured COPD epithelial cells compared to non-COPD epithelial cells upon exposure to smoke extract.

      • KCI등재

        Surge Capacity and Mass Casualty Incidents Preparedness of Emergency Departments in a Metropolitan City: a Regional Survey Study

        Park SungJoon,Jeong Joo,Song Kyoung Jun,Yoon Young-Hoon,Oh Jaehoon,Lee Eui Jung,Hong Ki Jeong,Lee Jae Hee 대한의학회 2021 Journal of Korean medical science Vol.36 No.33

        Background: Emergency departments (EDs) generally receive many casualties in disaster or mass casualty incidents (MCI). Some studies have conceptually suggested the surge capacity that ED should have; however, only few studies have investigated measurable numbers in one community. This study investigated the surge capacity of the specific number of accommodatable patients and overall preparedness at EDs in a metropolitan city. Methods: This cross-sectional study officially surveyed surge capacity and disaster preparedness for all regional and local emergency medical centers (EMC) in Seoul with the Seoul Metropolitan Government's public health division. This study developed survey items on space, staff, stuff, and systems, which are essential elements of surge capacity. The number of patients acceptable for each ED was investigated by triage level in ordinary and crisis situations. Multivariate linear regression analysis was performed on hospital resource variables related to surge capacity. Results: In the second half of 2018, a survey was conducted targeting 31 EMC directors in Seoul. It was found that all regional and local EMCs in Seoul can accommodate 848 emergency patients and 537 non-emergency patients in crisis conditions. In ordinary situations, one EMC could accommodate an average of 1.3 patients with Korean Triage and Acuity Scale (KTAS) level 1, 3.1 patients with KTAS level 2, and 5.7 patients with KTAS level 3. In situations of crisis, this number increased to 3.4, 7.8, and 16.2, respectively. There are significant differences in surge capacity between ordinary and crisis conditions. The difference in surge capacity between regional and local EMC was not significant. In both ordinary and crisis conditions, only the total number of hospital beds were significantly associated with surge capacity. Conclusion: If the hospital's emergency transport system is ideally accomplished, patients arising from average MCI can be accommodated in Seoul. However, in a huge disaster, it may be challenging to handle the current surge capacity. More detailed follow-up studies are needed to prepare a surge capacity protocol in the community.

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