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Associations of night shift status during pregnancy with birth outcomes
Se Jin Lee(Se Jin Lee),Chorong Kim(Chorong Kim),Eun Ju Lee(Eun Ju Lee),Myoung-Nam Lim(Myoung-Nam Lim),Jeeyoung Kim(Jeeyoung Kim),Sunghun Na(Sunghun Na),Woo Jin Kim(Woo Jin Kim),Ko-CHENS study group(Ko 한국환경보건학회 2022 한국환경보건학회 학술대회 자료집 Vol.2022 No.5
Kim Hyeok,Park Soon-Jung,Park Jae-Hyun,Lee Sunghun,Park Bong Woo,Lee Soon Min,Hwang Ji-Won,Kim Jin-Ju,Kang Byeongmin,Sim Woo-Sup,Kim Hyo-Jin,Jeon Seung Hwan,Kim Dong-Bin,Jang Jinah,Cho Dong-Woo,Moon S 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Since an impaired coronary blood supply following myocardial infarction (MI) negatively affects heart function, therapeutic neovascularization is considered one of the major therapeutic strategies for cell-based cardiac repair. Here, to more effectively achieve therapeutic neovascularization in ischemic hearts, we developed a dual stem cell approach for effective vascular regeneration by utilizing two distinct types of stem cells, CD31+-endothelial cells derived from human induced pluripotent stem cells (hiPSC-ECs) and engineered human mesenchymal stem cells that continuously secrete stromal derived factor-1α (SDF-eMSCs), to simultaneously promote natal vasculogenesis and angiogenesis, two core mechanisms of neovascularization. To induce more comprehensive vascular regeneration, we intramyocardially injected hiPSC-ECs to produce de novo vessels, possibly via vasculogenesis, and a 3D cardiac patch encapsulating SDF-eMSCs (SDF-eMSC-PA) to enhance angiogenesis through prolonged secretion of paracrine factors, including SDF-1α, was implanted into the epicardium of ischemic hearts. We verified that hiPSC-ECs directly contribute to de novo vessel formation in ischemic hearts, resulting in enhanced cardiac function. In addition, the concomitant implantation of SDF1α-eMSC-PAs substantially improved the survival, retention, and vasculogenic potential of hiPSC-ECs, ultimately achieving more comprehensive neovascularization in the MI hearts. Of note, the newly formed vessels through the dual stem cell approach were significantly larger and more functional than those formed by hiPSC-ECs alone. In conclusion, these results provide compelling evidence that our strategy for effective vascular regeneration can be an effective means to treat ischemic heart disease.
김재욱(Jaeuk Kim),김성훈(Sunghun Kim),이유정(Yujung Lee),전영주(Youngju Jeon),김근호(Keunho Kim),김종열(Jongyoel Kim) 한국한의학연구원 2009 한국한의학연구원논문집 Vol.15 No.2
Recently, there have been emerging research activities in classifying the Sasang constitution objectively by machine-based methods. The concordance rate of the classification by the pulse wave features was, however, only around 50% up to now. In this paper, we introduce a novel classification algorithm that can promote the accuracy substantially at the expense of the non-classifiable subgroup as a byproduct. For instance, with the pulse wave features alone, we show that female/male subject group in their 20s can be classified into the Sasang constitution group with the concordance rate of 68.4%/65.5% for a subgroup of 57/29(31%/15%) subjects out of 184/195, by leaving the other subjects as the non-classifiable group. Next, we show that the pulse diagnosis has been used only as a supportive tool in determining one's constitution, and consequently the accuracy of the concordance ratio by the pulse wave features alone cannot exceed a finite value, which we estimate to be about 60%.
Extremely Flexible Transparent Conducting Electrodes for Organic Devices
Jung, Sunghoon,Lee, Sunghun,Song, Myungkwan,Kim, Do-Geun,You, Dae Sung,Kim, Jong-Kuk,Kim, Chang Su,Kim, Tae-Min,Kim, Kwon-Hyeon,Kim, Jang-Joo,Kang, Jae-Wook Wiley Blackwell (John Wiley Sons) 2014 Advanced Energy Materials Vol.4 No.1
<P>Extremely flexible transparent conducting electrodes are developed using a combination of metal-embedding architecture into plastic substrate and ultrathin transparent electrodes, which leads to highly transparent (optical transmittance approximate to 93% at a wavelength of 550 nm), highly conducting (sheet resistance approximate to 13 Omega square(-1)), and extremely flexible (bending radius approximate to 200 mu m) electrodes. The electrodes are used to fabricate flexible organic solar cells and organic light-emitting diodes that exhibit performance similar or superior to that of devices fabricated on glass substrates. Moreover, the flexible devices do not show degradation in their performance even after being folded with a radius of approximate to 200 mu m.</P>
Studying the reduction of graphene oxide with magnetic measurements
Kim, Soo-Whan,Kim, Hyun-Kyung,Lee, Kyujoon,Roh, Kwang Chul,Han, Joong Tark,Kim, Kwang-Bum,Lee, Sunghun,Jung, Myung-Hwa Elsevier 2019 Carbon Vol.142 No.-
<P><B>Abstract</B></P> <P>The reduction of graphene oxide is one of the most facile methods to fabricate a large amount of graphene. The reduction rate is generally examined by various spectroscopic techniques, but each technique is applied for different purposes. Herein, we demonstrate the correlation between spectroscopic results and magnetic data, which plays an important role in determining the quality of reduced graphene oxides. The magnetic signals are related with the carbon-oxygen functional groups analyzed by spectroscopic tools. Especially, highly reduced sample exhibits the diamagnetic property similar to graphene-like materials. This report can provide an insight to determine the reduction rate of graphene oxides by using simple magnetic measurements.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Fabrication of Various Conducting Polymers Using Graphene Oxide as a Chemical Oxidant
Kim, Minkyu,Lee, Choonghyeon,Seo, Young Deok,Cho, Sunghun,Kim, Jihoo,Lee, Gyeongseop,Kim, Yun Ki,Jang, Jyongsik American Chemical Society 2015 Chemistry of materials Vol.27 No.18
<P>Recently, using graphene oxide (GO) for “carbocatalysis” has been very attractive as a novel application of graphene-based nanomaterials and is expected to open a host of possibilities for chemical synthesis because of the abundance of natural carbon sources, as well as the low density, extensive chemical functionalization, hydrophilicity, low cost, and ease of preparation. Here, we demonstrate that the GO can play a role as a chemical oxidant for various CPs (polythiophene, polyaniline, and polypyrrole), and diverse graphene–CP composites (graphene–polythiophene, graphene–polyaniline, and graphene–polypyrrole) can simply and rapidly be synthesized by using the GO as both graphene precursor and chemical oxidant. The UV–vis analysis confirms that the GO has successfully polymerized the CPs and been transformed to reduced graphene oxide (RGO). The SEM and TEM analyses show that the CPs have successfully been coated on the few-layered graphene sheets. Raman analysis and series of FT-IR analyses have been conducted to survey what functional group in the GO polymerized the monomers, and they reveal that hydroxyl and epoxy groups in the GO polymerized the monomers. Finally, plausible polymerization mechanisms have specifically and deeply proposed based on the IR result, classical radical polymerization mechanisms of the CPs, and widely adopted thermal reduction mechanism of the GO.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cmatex/2015/cmatex.2015.27.issue-18/acs.chemmater.5b01408/production/images/medium/cm-2015-01408r_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cm5b01408'>ACS Electronic Supporting Info</A></P>
Kim, Hye Jin,Choi, Sunghun,Lee, Seung Jong,Seo, Myung Won,Lee, Jae Goo,Deniz, Erhan,Lee, Yong Ju,Kim, Eun Kyung,Choi, Jang Wook American Chemical Society 2016 Nano letters Vol.16 No.1
<P>Despite the recent considerable progress, the reversibility and cycle life of silicon anodes in lithium-ion batteries are yet to be improved further to meet the commercial standards. The current major industry, instead, adopts silicon monoxide (SiOx, x approximate to 11), as this phase can accommodate the volume change of embedded Si nanodomains via the silicon oxide matrix. However, the poor Coulombic efficiencies (CEs) in the early period of cycling limit the content of SiOx, usually below 10 wt % in a composite electrode with graphite. Here, we introduce a scalable but delicate prelithiation scheme based on electrical shorting with lithium metal foil. The accurate shorting time and voltage monitoring allow a fine-tuning on the degree of prelithiation without lithium plating, to a level that the CEs in the first three cycles reach 94.9%, 95.7%, and 97.2%. The excellent reversibility enables robust full-cell operations in pairing with an emerging nickel-rich layered cathode, Li[Ni0.8Co0.15Al0.05] O-2, even at a commercial level of initial areal capacity of 2.4 mAh cm(-2), leading to a full cell energy density 1.5-times as high as that of graphite-LiCoO2 counterpart in terms of the active material weight.</P>