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Cho, Mi Suk,Park, Won Sun,Jung, Won-Kyo,Qian, Zhong-ji,Lee, Dae-Sung,Choi, Jung-Sik,Lee, Da-Young,Park, Sae-Gwang,Seo, Su-Kil,Kim, Hak-Ju,Won, Jun Yeon,Yu, Byeng Chul,Choi, Il-Whan Informa Healthcare USA, Inc. 2014 PHARMACEUTICAL BIOLOGY Vol.52 No.7
<P><I>Context</I>: Caffeic acid phenethyl ester (CAPE), an active component of honeybee propolis, is known to have antioxidant, anti-inflammatory, and other beneficial medicinal properties. However, the molecular mechanisms underlying its anti-allergic effects in mast cells are unknown.</P><P><I>Objective</I>: The purpose of the present study was to examine whether CAPE modulates the immunoglobulin E (IgE)-mediated local allergic reaction in animals, as well as to elucidate the effects of CAPE on mast cells <I>in vitro</I>.</P><P><I>Materials and methods</I>: To investigate the bioactive potential of CAPE (10 or 20 µM), HMC-1 cells were stimulated with phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI) for 24 h in the presence or absence of CAPE. To study the pharmacological effects of CAPE, enzyme-linked immunosorbent assays (ELISAs), RT-PCR, Western blot analysis, electrophoretic mobility shift assays (EMSAs), and fluorescence assays were used.</P><P><I>Results</I>: CAPE (10 mg/kg) inhibited local IgE-mediated allergic reactions (0.164 versus 0.065 O.D.) in a mouse model. Additionally, CAPE (20 µM) attenuated PMACI-stimulated histamine release (3146.42 versus 2564.83 pg/ml) and the production of inflammatory cytokines, such as interleukin (IL)-1β (4.775 versus 0.713 pg/ml, IC<SUB>50</SUB> = 6.67 µM), IL-6 (4771.5 versus 449.1 pg/ml, IC<SUB>50</SUB> = 5.25 µM), and IL-8 (5991.7 versus 2213.1 pg/ml, IC<SUB>50</SUB> = 9.95 µM) in HMC-1 cells. In activated HMC-1 cells, pretreatment with CAPE decreased the phosphorylation of c-Jun N-terminal kinase. In addition, CAPE inhibited PMACI-induced nuclear factor (NF)-κB activation by suppressing IκBα phosphorylation and its degradation.</P><P><I>Discussion and conclusion</I>: Our results indicated that CAPE can modulate mast cell-mediated allergic disease.</P>
Candida Parapsilosis Spondylodiscitis after Lumbar Discectomy
Cho, Kyun-Gil,Lee, Sun-Ho,Kim, Eun-Sang,Eoh, Whan The Korean Neurosurgical Society 2010 Journal of Korean neurosurgical society Vol.47 No.4
Candida is a relatively rare cause of spinal infections that commonly affects immunocompromised patients. A 70-year-old woman, who underwent a lumbar discectomy on L5-S1 two months earlier, was admitted to our department complaining of persistent back and leg pain. Magnetic resonance imaging showed irregular enhancing mass lesion in L5-S1 intervertebral space, suggest of pyogenic discitis with epidural abscess. The surgery was performed via retroperitoneal approach and the infected material at L5-S1 intervertebral space was removed. The histological examination of the specimen revealed chronic inflammation involving the bone and soft tissue, and a culture of the excised material was positive for Candida parapsilosis. The patient received intravenous fluconazole for 4 weeks after surgery and oral fluconazole 400 mg/day for 3 months after surgery. The patient made a full recovery with no symptoms 6 months after surgery. We present a rare case of spondylodiscitis after a lumbar discectomy due to Candida parapsilosis and discuss treatment option with a review of the literatures.
Sang-Hoon Lee,June-Hyuk Kim,Whan-Seong Cho,Sung-Wook Seo,Sung-Kyu Kim,Joo-Han Oh 한국식품영양과학회 2005 Preventive Nutrition and Food Science Vol.10 No.3
In this double-blind, placebo-controlled trial, we assessed the efficacy and safety of beef tallow extract (BTE) including Cis-9-cetylmyristoleate in patients with arthritis. Between May and December 2003, we selected 80 patients (n=80) who showed/manifested arthritic symptoms and whose radiological findings were suggestive of arthritis, and randomly assigned them to placebo-controlled (n=40) and treatment group (n=40). The placebo (corn starch 350 mg) and BTE (208 mg) were orally administered to placebo-controlled and treatment group three times a day, respectively. We assessed the efficacy and safety based on the visual analogue scale (VAS) and modified knee society knee scores (MKSKS) at baseline and endpoint, respectively. To assess the safety, we monitored the adverse effects noted in liver, kidney, cardiovascular and gastrointestinal system for 3 weeks. Then, we performed not only a questionnaire study but also laboratory tests (e.g., liver function test, kidney function test, urinalysis, electrocardiography [EKG], complete blood cell counts [CBC] and chest X-ray). For statistical analysis, Student t-test and paired t-test were done using SPSS^® Version 11.0. Statistical significance was set at p<0.05. The scores between VAS and MKSKS showed statistical significance (p<0.05) with an improvement of 69.2% (27/39) and 3.8% (21/39) of treatment-group patients, respectively. Abnormal laboratory findings were noted in neither placebo-controlled nor treatment group. In conclusion, our results indicate that the administration of BTE was a safe and effective treatment regimen for patients with arthritis. In addition, the efficacy of BTE was more remarkable in alleviating the symptoms rather than improving the function.
In-hospital mortality in patients with STEMI admitted during off hours
( Sung-Soo Kim ),( Myung Ho Jeong ),( Jeong Gwan Cho ),( Young Keun Ahn ),( Jong Hyun Kim ),( Shung Chull Chae ),( Young Jo Kim ),( Seung Ho Hur ),( In Whan Seong ),( Taek Jong Hong ),( Dong-hoon Choi 대한내과학회 2013 대한내과학회 추계학술발표논문집 Vol.2013 No.1
Conflicting results exist on the outcome of off hours PCI in ST elevation myocardial infarction (STEMI). However, there were only a few studies that have focused on the clinical characteristics and outcomes of off hours PCI in STEMI. So, we studied the clinical characteristics and hospital mortality in STEMI patients treated with primary PCI during regular hours (weekdays 9:00 AM to 6:00 PM) versus off hours Weekdays 6:01 PM to 8:59 AM, weekends, and holidays) in Korea Acute Myocardial Infarction Registry. We analyzed in hospital and one year mortality among 5,665 consecutive ST segment elevation myocardial infarction patients treated with primary PCI between November 2005 to January 2008. Total 2,848 (50.2%) patients were treated during off hours. Baseline finding were similar, although regular hours patients were older. Median symptom to balloon time (304 min, IQR 175 to 750 vs. 270 min, IQR 145 to 551, p=0.001) were longer for regular hours primary PCI. Median door to balloon time (71min, IQR: 48 to 132 vs. 59 min, IQR 39 to 110 min, p=0.001) were longer for off hours pPCI. Also, Cardiac enzyme such as Max CK-MB (212.1±299.3 vs 194.7±303.4, p=0.031) and max TnI (72.6±239.5 vs. 58.9±94.4, p=0.013) were increased in off hours pPCI. However, unadjusted in hospital (6.0% off hours vs. 6.0% regular hours, p=0.946) and one year cardiac mortality (11.3% off hours vs. 11.7% regular hours, p=0.661) were comparable. In multivariate analysis, off hours primary PCI did not predict an adverse outcome. In conclusion, when primary PCI was performed within an appropriate reperfusion strategy, the clinical effectiveness of either off hours or regular hours pPCI is comparable.
Cho Yongwon,Park Soojung,Hwang Sung Ho,Ko Minseok,Lim Do-Sun,Yu Cheol Woong,Park Seong-Mi,Kim Mi-Na,Oh Yu-Whan,Yang Guang 대한의학회 2023 Journal of Korean medical science Vol.38 No.37
Background: To propose a deep learning architecture for automatically detecting the complex structure of the aortic annulus plane using cardiac computed tomography (CT) for transcatheter aortic valve replacement (TAVR). Methods: This study retrospectively reviewed consecutive patients who underwent TAVR between January 2017 and July 2020 at a tertiary medical center. Annulus Detection Permuted AdaIN network (ADPANet) based on a three-dimensional (3D) U-net architecture was developed to detect and localize the aortic annulus plane using cardiac CT. Patients (N = 72) who underwent TAVR between January 2017 and July 2020 at a tertiary medical center were enrolled. Ground truth using a limited dataset was delineated manually by three cardiac radiologists. Training, tuning, and testing sets (70:10:20) were used to build the deep learning model. The performance of ADPANet for detecting the aortic annulus plane was analyzed using the root mean square error (RMSE) and dice similarity coefficient (DSC). Results: In this study, the total dataset consisted of 72 selected scans from patients who underwent TAVR. The RMSE and DSC values for the aortic annulus plane using ADPANet were 55.078 ± 35.794 and 0.496 ± 0.217, respectively. Conclusion: Our deep learning framework was feasible to detect the 3D complex structure of the aortic annulus plane using cardiac CT for TAVR. The performance of our algorithms was higher than other convolutional neural networks.
Responses of blood electrolyte in royale and king course triathlons competition
Cho, Hyun Chul,Kim, Hag Lyeol,Hwang, Moon Sook,Hwang, Kyu Ja,Kang, Sung Chul,Hong, Whan Pyo 龍仁大學校 體育科學硏究所 1996 體育科學硏究論叢 Vol.6 No.2
수영, 싸이클 및 런닝을 동시적으로 트레이닝을 수행하는 트라이애슬론은 최근 일반인들 뿐만 아니라 운동선수들 사이에서 급속하게 흥미를 불러 일으키고 있다. 이 연구에 대한 목적은 철인3종경기선수들을 대상으로 Royale(수영 1.5km, 싸이클 40km, 런닝 10km)과 King(수영 3km, 싸이클 180km, 런닝 42.195km)Course 시합 전.후에 따른 혈중 전해질 농도의 반응을 평가하는 것이다. Royale Course에 참여한 모든 선수들은 안정시에 비해 시합직후에서 나트륨(Na, p〈0.001), 칼륨(K, p〈0.001), 총 단백질 (TP, p〈0.001), 칼슘(Ca, p〈0.001), 및 마그네슘(Mg, p〈0.001)농도에서 유의한 증가를 나타내었다. 그러나 글루코스(Glu) 및 중성지방질 (Triglyceride)농도에 유의한 차이는 관찰되지 않았다. 유사하게, King Course의 경우에 있어서도칼륨(K, p〈0.001), 총단백질(TP, p〈0.001), 칼슘(Ca, p〈0.001), 및 마그네슘(Mg, p〈0.001)농도에서 유의한 증가를 나타내었으나, 글루코스, 나투륨 및 트리글리세라이드 농도에서 통계적 유의차는 관찰되지 않았다. 현재연구에 대한 결과로서 5가지의 혈중 전해질(Na, K, TP, Ca and Mg)농도는 Royale 과 King Course 레이스의 시합전에 비해 시합후에서 통계적으로 유의한 증가가 입증되었다. 현재연구에서 혈중 전해질 농도의 유의한 증가는 트라이애슬론 레이스시 피로를 유발시켜 신체적 운동능력을 제한시키는 중추적인 요인이 된다는 것을 시사하는 것이다.
Cho, K.W.,Kim, N.K.,Oh, S.H.,Choi, E.S.,Sun, H.J.,Yeom, S.J.,Lee, K.N.,Lee, Seoung Soo,Hong, Suk Kyoung,Choi, S.K.,Hong, Tae Whan,Kim, Il Ho,Lee, J.I.,Ur, Soon Chul,Lee, Young Geun,Ryu, Sung Lim,Kweon Trans Tech Publications, Ltd. 2005 Materials science forum Vol.486 No.-
<P>Ferroelectric properties of Pb-free (Bi,La)4Ti3O12 (BLT) films were optimized on a newly developed MTP cell structure. BLT films were coated on Pt/IrOx/Ir bottom electrode using sol-gel solutions. The composition of the optimized BLT film was about Bi3.25La0.75Ti3.0O12, which was analyzed by ICP-MS method. The switchable polarization obtained in a 100nm-thick BLT film was about 20 uC/cm2 at the 3 V applied voltage, and the optimized BLT film showed little fatigue loss about 10% up to 1×1011 cycles. The imprint properties of the BLT film were also characterized at 25 °C and 90 °C operating temperature after 125 °C data storage. Regardless of operating temperature, switchable polarization of BLT had a sufficiently large margin for device operation up to 10 years.</P>