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김희진(KIM Hee Jin),강민규(KANG Mill Kyu),김진학(KIM Jm Hak),박재한(PARK Jae Han),이상섭(LEE Sang Heon),이상헌(LEE Sang Sup),정인혁(CHUNG In Hyuk2) 대한체질인류학회 1997 대한체질인류학회지 Vol.10 No.2
연구자들은 한국인 어른 남녀 시신의 머리와 목 61 을 대상으로 깊은 층 육안해부를 시행하여 혀동맥의 형태를 조사하였다 혀동맥이 일어나는 유형은 위갑상동맥, 혀동맥, 그리고 얼굴동맥이 바깥목동액에서 따로 가지를 내어 나뉘는 경우가 563% 호 가장 않았으며, 얼굴동맥과 혀동맥이 강은 가지에서 얼어나 나뉘는 경우 (312%), 그리고 위 강상동액과 혀동맥이 같은 가지에서 나뉘는 경우 (12 5%) 등이 있었다. 혀동맥과 혀동맥의 둘째 부분은 덮는 목뿔혀근 과의 영대학적 관계는 각각 혀동맥의 첫째 부분이 목뿔혀근 뒤에서 심하게 휘어져 깊은 층으로 들어가는 유형 (41 2 %), 그리고 혀동맥의 첫째 부분이 목뿔혀근의 뒤쪽 근육모셔리 바로 뒤흘 지나 깊은 층으로 들어가는 경우가 661% 로 가장 많았다 목뿔혀근 깊은층에서 혀동맥의 둘째 부분이 달리는 양상은 급하게 위쪽으로 꺾역 달리다가 다시 앞쪽으로 꺾여 혀의 깊은 곳으로 들어가는 경우와 목뿔빼에서 혀쪽으로 완만한 굽이플 이루며 올라가는 경우가 비슷한 반도로 관찰되었다. 입안바닥에 분포하는 혀밑동맥이 혀동맥 셋째 부분에서 나오는 경우슨 전체의 590% 에서만 관창되었으며 그 외는 대부분 얼굴동맥의 턱끝 및동맥 가지가 턱옥뽕근응 옳고 입안바닥에 분포하였다. 따라서 연구자들은 한국인 업안바 닥에는 혀동액이 전체의 59%에서만 분포하며 그외는 영굴동액의 턱끝밑동맥 가지 , 그리고 기타 다른 동맥의 가지들이 분포한다는 사실을 확인하였다
Optimal design of slotless-type PMLSM considering multiple responses by response surface methodology
Sung-Il Kim,Jung-Pyo Hong,Young-Kyoun Kim,Hyuk Nam,Han-Ik Cho IEEE 2006 IEEE transactions on magnetics Vol.42 No.4
<P>This paper shows the usefulness of response surface methodology (RSM) for optimal design considering multiple responses. Moreover, full factorial design, one of the experimental design methods, is proposed to establish more reasonable and objective design area for applying RSM. The slotless-type permanent-magnet linear synchronous motor is optimized to develop larger average thrust and lower thrust ripple than the prototype, and the optimally designed one is manufactured. In the end, all analysis results are obtained by space harmonic method for fast and efficient design, and the validity of the results is verified by comparison with finite-element analysis and test</P>
( Sung Hye Eun ),( Hyun Jung Joo ),( Hyuk Sun Kwon ),( Han Mi Jung ),( Ji Hae Lee ),( Gyong Moon Kim ),( Jung Min Bae ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Idiopathic guttate hypomelanosis (IGH) is common acquired leukoderma characterized by discrete, tiny, white macules in the elderly. Until now, there was no definite therapeutic modality for IGH. Objectives: To investigate the effectiveness of low-fluence fractional CO<sub>2</sub> laser in the treatment of IGH Methods: A retrospective review was performed, and a total of 87 lesions on 26 body parts in 17 patients with IGH were included from October, 2016 to June, 2017. A CO<sub>2</sub> fractional laser treatment was performed on all lesions with 2 passes of 2-4 mJ, 400 spots/cm2 with no anesthesia at a 1-week interval. All lesions were classified into three body parts including face, chest, and extremities, and were evaluated according to the body parts. Clinical assessments were evaluated using 6-point scales (0, no; 1, mild; 2, moderate; 3, good; 4, excellent; 5, complete response). Results: Overall, 61.5% (21 out of 26 body parts) showed excellent or complete response after a median of 5.5 treatment sessions (range: 2-9). In the subgroup analysis, 80% (8/10) of face lesions showed excellent response, while 40% (4/10) of extremities reached excellent response. Transient erythema and crust after treatment was common, and one patient stopped treatment because of prolonged hyperpigmentation at irradiation site. Conclusion: Low-fluence fractional CO<sub>2</sub> laser therapy could be an effective option for IGH. It is convenient without need for anesthesia.
Han, Kap-Soo,Lee, Sang Hyuk,Ryu, Han Uk,Park, Se-Hyoung,Chung, Gyung-Ho,Cho, Young I.,Jeong, Seul-Ki Hindawi 2017 BioMed research international Vol.2017 No.-
<P>The aim of the study was to calculate the arterial wall signal intensity gradient (SIG) from time-of-flight MR angiography (TOF-MRA) and represent arterial wall shear stress. We developed a new algorithm that uses signal intensity (SI) of a TOF-MRA to directly calculate the signal intensity gradient (SIG). The results from our phantom study showed that the TOF-MRA SIG could be used to distinguish the magnitude of blood flow rate as high (mean SIG ± SD, 2.2 ± 0.4 SI/mm for 12.5 ± 2.3 L/min) and low (0.9 ± 0.3 SI/mm for 8.5 ± 2.6 L/min) in vessels (<I>p</I> < 0.001). Additionally, we found that the TOF-MRA SIG values were highly correlated with various flow rates (<I>β</I> = 0.96, <I>p</I> < 0.001). Remarkably, the correlation coefficient between the WSS obtained from the computational fluid dynamics (CFD) analysis and the TOF-MRA SIG was greater than 0.8 in each section at the carotid artery (<I>p</I> < 0.001 for all <I>β</I> values). This new technique using TOF-MRA could enable the rapid calculation of the TOF-MRA SIG and thereby the WSS. Thus, the TOF-MRA SIG can provide clinicians with an accurate and efficient screening method for making rapid decisions on the risk of vascular disease for a patient in clinical practice.</P>
Kinase Suppressor of Ras 1 Promotes YAP/TAZ-Mediated Tumorigenesis in the Liver
( Hyuk Moon ),( Kyungjoo Cho ),( Soonyoung Shin ),( Simon W. Ro ),( Beom Kyung Kim ),( Seung Up Kim ),( Jun Yong Park ),( Sang Hoon Ahn ),( Do Young Kim ),( Kwang-hyub Han ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Liver cancer is the second most common cause of cancer-related deaths worldwide. The Hippo signaling pathway is tumor suppressive, as its inactivation leads to tissue overgrowth and tumor formation via YAP- or TAZ-mediated transcriptional activation. YAP is overexpressed in 62% of patients with hepatocellular carcinoma (HCC) and in almost 90% of human cholangiocarcinoma (CCC). Kinase Suppressor of Ras 1 (KSR1) is a scaffold protein for the Ras/Raf/MEK/ERK signaling pathway, promoting activation of MEK and ERK. Pro-tumorigenic roles of KSR1 in Ras-activated cancers have been verified in murine models for lung, skin, and pancreatic cancers. In this study, we have investigated the role of KSR1 in YAP/TAZ-mediated hepatocarcinogenesis. Methods: Transposons were constructed encoding KSR1 and an activated from of TAZ (TAZ<sup>S89A</sup>). Transposons were hydrodynamically delivered to livers of 6-week-old C57BL/6 mice. Mice were monitored at least twice per week and sacrificed when moribund. Tumor-bearing livers were formalin fixed for hematoxylin-eosin staining and immunohistochemistry. Results: Analysis of gene expression levels in human HCC and CCC samples deposited in The Cancer Genome Atlas (TCGA) revealed that KSR1 was significantly upregulated both in human HCC and CCC, compared with non-tumoral surrounding livers (P<0.0001 in HCC and P=0.0063 in CCC). Co-expression of KSR1 and an activated form of TAZ (TAZ<sup>S89A</sup>) led to the development of both HCC and CCC in the murine livers, while expression of TAZ<sup>S89A</sup> alone failed to induce hepatic tumors. Conclusions: KSR1 promotes hepatocarcinogenesis, both in HCC and CCC. Suppression of KSR1 might be an attractive therapeutic option for both types of hepatic malignancies.
Sung-Kyu Kwon,Hyuk-Min Kwon,Ho-Young Kwak,Jae-Hyung Jang,Jong-Kwan Shin,Seon-Man Hwang,Seung-Yong Sung,Ga-Won Lee,Song-Jae Lee,In-Shik Han,Yi-Sun Chung,Jung-Hwan Lee,Hi-Deok Lee 대한전자공학회 2013 Journal of semiconductor technology and science Vol.13 No.6
In this paper, the 1/f noise characteristics of n-channel MOSFET (NMOSFET) and p-channel MOSFET (PMOSFET) are analyzed in depth as a function of body bias. The normalized drain current noise, SID/ID <SUP>2</SUP> showed strong dependence on the body bias in the sub-threshold region for both NMOSFET and PMOSFET, and NMOSFET showed stronger dependence than PMOSFET on the body bias. On the contrary, both of NMOSFET and PMOSFET do not exhibit the dependence of SID/ID <SUP>2</SUP> on body bias in strong inversion region, although the noise mechanisms of two MOSFETs are different from each other.