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Cho, Jae-Heung,Lee, Jong Hyun,Lee, Eun-Jung,Nam, Dongwoo,Shim, Bum Sang,Song, Mi-Yeon,Kim, Sung-Soo,Kim, Sung-Hoon,Jung, Sang Hoon,Chung, Won-Seok,Ahn, Kwang Seok Informa Healthcare USA, Inc. 2013 IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY Vol.35 No.5
<P>The flying squirrel’s droppings (<I>Pteropus pselaphon</I>) have been used for improving the blood circulation, arresting bleeding to treat hematological disorders, and reducing pain. Here, 8β-hydroxy-3-oxopimar-15-ene (OXO), one of main constituents of <I>P. pselaphon</I>, was examined for its anti-inflammatory activity in murine macrophages. We found that OXO significantly suppressed LPS-induced nitric oxide (NO) without exerting cytotoxic effects on RAW 264.7 cells. OXO inhibited the expression of LPS-induced iNOS and COX-2 protein and their mRNA in a dose-dependent manner. Also, TNF-α, IL-6, and PGE2 secretion was decreased by OXO in LPS-stimulated macrophages. These inflammatory biomarkers were attributed to the suppression of LPS-induced activation of p38 MAPK and subsequent activation of two components of AP-1 (c-Jun and c-Fos), but not of ERK, JNK, NF-κB. Moreover, OXO inhibited LPS-induced intracellular reactive oxygen species (ROS) production and co-incubation of OXO and hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>) suppressed the phosphorylation of p38 in a concentration-dependent manner. In addition, OXO completely disrupted the formation of TRAF6-ASK complex in the cells. Therefore, we demonstrate here that OXO can potentially inhibit several biomarkers related to inflammation through inhibition of ROS-mediated activation of TRAF6-ASK1-p38 pathway.</P>
Cho, Sung-Hwoan,Jo, Jae-Yoon,Hur, Sung-Bum,Kim, You-Hee,Shin, Chang-Hoon The Korean Society of Fisheries and Aquatic Scienc 2000 韓國養殖學會誌 Vol.13 No.1
The effect of various dietary protein levels on growth and body composition of young common carp raised from 56 g to 170 g in recirculating system was investigated for 15 weeks when they were fed to visual satiety three times daily. Five experiemtal diets were formulated to contain 40, 35, 30, 25 and 21% protein levels and 3.56, 3.59. 3.63, 3.66 and 3.69 kcal/g diet GE levels respectively. Mean survival rates of the fish fed the 40, 35, 30 and 25% protein diets were not different but sig-nificantly higher than that of the fish fed the 40, 35, 30 and 25% protein diets were not different but sig-nificantly higher than that of o the fish fed the 21% protein diet(P<0.05) Weight gain (g/tank) of common carp fed the 30% protein diet was the best. However weight gain of the fish fed the 25, 30, 35 and 40% protein diets were not different but significantly better than that of the fish fed the 21% protein diet. Feed efficiency ratio of the 21% protein diet was significantly lower (P<0.05) than for other groups of diets which were not different among them. Protein efficiency ratio for the 21% protein diet was significantly lower (P<0.05) than for other groups of diets which were not different among them(P>0.05) Dietary protein level had no effect on hemoglobin content in the fish(P>0.05) Crude protein contents of whole body of the fish fed the 35 and 40% protein diets were significantly higher than that of the fish fed the 21$$\mid$% or 25% protein diet(P<0.05) Body crude lipid contents of the fish fed the 21 and 25% protein diets were significantly higher than that of the fish fed the 30% or 35% protein diet. Crude ash contents of the fish fed the 35 and 40% protein diets were significantly higher than that of the fish fed the 21% or 25% protein diet(P<0.05) Moisture content of the fish fed the 35% protein diet was significantly higher than that of the fish fed the 21% protein diet(P<0.05) In considering growth performance of common carp and efficiency of diet dietary protein level could be lowered up to 25% without the reduction of young common carp production in recirculating system.
0.7 inch FED Panel system build - up by using proper sealing process
Sang Jik Kwon,Kun Jo Hong,Tae Hee Cho,Jong Duk Lee,Chang Woo Oh,Yong Bum Kwon 한국진공학회(ASCT) 1999 Journal of Korean Vacuum Science & Technology Vol.3 No.1
FED panel was successfully fabricated through the integration of a 0.7″ diagonal Si-based Mo-tip FEA with 25×25 pixels, Y₂O₃:Eu or ZnO:Zn phosphor screen, and vacuum sealing through an exhausting glass tube, including a getter. The panel system was driven by an external driver circuit having pulse width modulation(PWM) driving scheme. Before character imaging, it was stabilized through tip aging by slowly increasing a pulse-mode emission current and phosphor aging by a coulombic charging process. After aging, luminescent characteristics such as emission uniformity, charging and arcing phenomena were shown to be improved significantly.
( Sung Min Park ),( Gun Wook Kim ),( Hyun Ho Cho ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ),( Hyun Chang Ko ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Dermatologic diseases are generally managed on outpatient clinic and most of them show very low mortality. However, some severe dermatologic diseases are life- threatening. Objectives: To investigate the dermatological diseases leading to death and related factors. Methods: A retrospective study was conducted by reviewing medical records of patients who died in the dermatology ward, Pusan National University Hospital from 1998 to 2014. Patients`` demographics, their dermatologic diseases, immediate causes of death, comorbidities, and factors related death were investigated. Results: The total number of inpatients on dermatology during the study period was 3,142. Fourteen patients (6 males, and 8 females) expired while in hospital. The median age was 63.8 years (ranged 18 to 86), and the maximum number of death occurred in the age group more than 70 years old. Drug reaction was the most common underlying dermatologic disease, followed by bullous disease, generalized pustular psoriasis, dermatomyositis. Sepsis due to infection was the most common immediate cause of death. All patients had at least one comorbidities including hypertension, diabetes mellitus, kidney disease, and angina. Conclusion: Old age, comorbidities and septicemia were important factors which contributed to the mortality. Theintensive care is required during hospitalization in patients with severe dermatologic disease accompanying above risk factors.
( Sung Bum Cho ),( Jong Sun Rew ),( Sung Young Park ),( Hyeng Chen Park ),( Kyeong Won Yoon ),( Seok Cho ),( Wan Sik Lee ),( Chang Hwan Park ),( Hyen Soo Kim ),( Sung Kyu Choi ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background Aims: Rectal carcinoid has been increasingly detected due to the recent wide use of colonoscopy for routine health examination. Although endoscopic resection should be considered as the treatment for rectal carcinoid, the scar formation after colonoscopic biopsy can lead to unpredicted difficulty in this procedure. This study evaluates the per-procedure findings and treatment results in an attempt to elucidate the effect of scar formation after colonoscopic biopsy in endoscopic resection for rectal carcinoid. Methods: Twelve cases of rectal careinoid with scar formation were compared with 18 non-scar cases, which were treated using the endoscopic resection from January 2002 to August 2007, in terms of the endoscopic findings, resection methods and treatment results. Results: The differences in the clinical findings and tumor size between the scar group and the non-scar group were nonspecific. The average waiting-time between biopsy and resection was shorter (13±16 vs 42±26 ds; p=0.11) in the scar group. During endoscopic resection, small active ulcer was found in 4 scar cases with lesser than 7 days of waiting-time. The risk of limited elevation after submucosal injection was higher (83% vs 44%, p=0.03) in the scar group. In resection methods, ESD was frequently adopted in the scar group (4 cases vs 1 case). The difference in the result of pathologic complete resection between two group were nonspecific. Four patients in the scar group should be admitted (vs 1 case in the non-scar group). Conclusions: ESD technique should be considered in selected cases, because of the postbiopsic scar can block the submucosal elevation in endoscopic resection for rectal carcinoid.