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신경병증성 통증 모델쥐 뒤뿌리신경절의 Nitric Oxide Synthase 아형 및 NADPH-diaphorase 발현에 관한 연구
정성균,김수일,양은진,류택근,권오유,박경란,이영호,김원식 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2
Injury to peripheral nerve somtimes lead to neuropathic pain. Nitric oxide(NO) is increased in the dorsal root ganglia (DRG) of neuropathic pain models, and L-NAME, a nitric oxide synthase (NOS) inhibitor, reduces neuropathic pain. However, it is not known that underlying mechanism of NO involvement in development and maintanence of neuropathic pain. It was found that there were three NOS isoforms-nNOS, eNOS, and iNOS. It is also necessary to investigate NOS isoforms in neuropathic pain. The aim of this study is to investigate NOS isoforms and NADPH-diaphorase expressions and underlying mechanism of NO involvement in neuropathic pain. The 5^th lambar (L5) DRG were obtaind after tight ligation of L5 an L6 spinal nerves for 7 days. Toluidine blue stain, immunohistochemistry for nNOS, eNOS, and iNOS, and NADPH-diaphorase histochemistry were performed. All specimens were observed under light microscope. nNOS expression was increased significantly in the cytoplasm of the DRG of ligated side at 7 day post-ligation (7D PL). eNOS expression was also increased in the blood vessel, a few neurons or satellite cells, and cell membrane of Schwann cells in the DRG of ligated side at 7D PL. iNOS expression was increased in a few blood vessels and cytoplasm of small neurons in the DRG of ligated side at 7D PL. NADPH-diaphorase expression was increased significantly in the neurons of the DRG of ligate side at 7D PL, but NADPH-diaphorase expressions were weak or absent in the blood vessel and Schwann cell in the contralateral DRG and the DRG of ligated side at 7D PL. It is suggested that NOS isoforms may be closely related to development and mantanence of neuropathic pain in order of nNOS>eNOS>iNOS.
( Eun Hee Seo ),( Kwan Sik Park ),( Min Kyu Jung ),( Seong Woo Jeon ),( Sung Kook Kim ),( Chang Min Cho ),( Yong Hwan Choi ),( Young Oh Kweon ),( Won Young Tak ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Development in colonoscopic equipment and methods has led to a large number of endoscopic diagnosis and treatment for colorectal neoplasms. Endoscopic mucosal resection (EMR) for early colorectal cancer (ECC) is increasing as an alternative to surgery, but there are little reports about long-term outcomes of EMR. The present study analysed the clinical, histologic endoscopic findings and the follow-up data of patients with ECC who underwent EMR and aimed to assess the efficacy and the long-term outcomes. Methods: From Match 2000 to August 2007, EMR was performed for the treatment of ECCs in 69 patients (43 males, 26 females, mean age 60.4 years) at Kyungpook National University Hospital. We retrospectively reviewed their medical records. Tumor size, shape, location, depth and procedure related complications, and immediate and follow-up outcomes were evaluated. Results: For the EMR treated group of lesions, the median size of ECC was 18.8 mm (range 6-25 mm). En-bloc resection was performed in 58 of 70 ECCs (79.5%). The complete resection was achieved in 48 of 70 EGCs (68.6%). Submucosal invasion was found in 13 cases (18.6%), 10 patients of those were oprated, 1 patient underwent an additional EMR, 2 patients were followed up without recurrence. Seventeen cases involved submucosal invasion or resection margin, who received surgery, while 11 surgical specimens discovered no residual tumor. Two perforations occurred following EMR and were treated conservatively with clipping. For 35 patients, information from a mean follow-up of 19.5 months of (range 3-67) months was available and recurrence was observed in six cases (17.1%), in which were hisologically proven tubular adenomas and treated successfully endoscopically. Out of 7 incompletely resected cases without surgery. 3 cases developed benign tumor recurrence without histologic malignancy. Conclusions: Endoscopic mucosal resection is a safe and efficient treatment for early colorectal cancers.
철도관광산업의 벤치마킹을 통한 서해안의 철도사업 개발에 대한 기초 연구
박은수(Eun Soo Park),탁준우(Jun Woo Tak),장병철(Byung Chul Chang),이태식(Tai Sik Lee) 한국철도학회 2009 한국철도학회 학술발표대회논문집 Vol.2009 No.11월
The Northeast Asia economic bloc by recently Chinese economic growth form. Therefore, speech China and Northeast Asia to economy center which face each other the importance of west-coast area recognize. We need wide area network formation of west-coast ambit, and construction of social overhead capital equipment such as west-coast railroad to achieve these role effectively. We must utilize west-coast area latent tourism resource, and develop goods connected with west-coast railway business. Through this, we must ready draft for activation of west-coast bloc economy and development of railway industry. This research utilizes tourism resource that was latented in existing and enforced inside and outside of the country benchmarking about railway tourism business. And executed basis research for railway tourism business development of west-coast.
서해안의 낙조 테마 철도 관광산업 개발에 관한 기초 연구
박은수(Eun Soo Park),탁준우(Jun Woo Tak),조홍준(Hong Jun Cho),이태식(Tai Sik Lee),이동욱(Dong Wook Lee) 한국철도학회 2010 한국철도학회 학술발표대회논문집 Vol.2010 No.7
By Chinese growth, economic development and investment of the West-coast are consisting. Specially, the West-coast area need tourist development and tourism Import for the Incheon and the Pyeongtaekhang of the Gyeonggido Province, China trade through the Chungcheongdo Province area. According to such regional special quality, the railroad tourism industry should be activated. Sunset of tourism infra in the West-coast is high value as representative goods of the West coast. Development of the theme railroad tourism industry that utilize the tide may maximize regional advantage of China and capital region. This research is basis investigation to examine development possibility as sunset theme railroad tourism industry of the West-coast. Scope of this research limited by the sunset theme railroad tourism industry for the Chungchongdo Province area.
목정은(Jung Eun Mok),조준식(Jun Sik Jo),나준희(Jun Hee Na),김종혁(Jong Hyeok Kim),김봉희(Bong Hee Kim),허주령(Joor Rung Huh),김용만(Yong Man Kim),김영탁(Young Tak Kim),남주현(Joo Hyun Nam) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.3
N/A Objective The aim of this study was to evaluate the clinicopathologic findings of eight patients with primary cancer of fallopian tube diagnosed and treated in the department of Obstetrics and Gynecology, University of Ulsan, Asan Medical Center for nine years. Methods Demographic characteristics, symptoms, signs, stage, tumor grade, mode of therapy and survival of patients were reviewed retrospectively. Results The patients with primary cancer of fallopian tube constituted 0.4% of all gynecologic malignancies encountered during this period. The age of patients ranged 42 to 70 years(mean+- S.D.; 53.9+-9.9) and half of patients were postmenopausal and two patients were nulliparous. Patients were treated by simple or radical hysterectomy and bilateral salpingoophorectomy with or without omentectomy and five patients received postoperative chemotherapy. The FIGO surgical stages of the patients were I(4 cases), II(2 cases), III(1 case) and IV(1 case). There were 3 cases of adenocarcinoma, 3 cases of malignant mixed Mullerian tumor, 1 case of undifferentiated carcinoma and 1 case of serous cystic tumor of low malignancy potential. Serum CA 125 values were followed during treatment and decreased during clinical remission and increased at the time of tumor progression. The mean follow-up duration was 24.3(+28.3) months and 7 patients were alive free of disease and one patients with stage Ic died of the disease. Conclusion Primary fallopian tube cancer is an extremely rare malignancy of the female genitalia and preoperative diagnosis of this disease is difficult. Cytoreductive surgery and postoperative combination chemotherapy seem to be effective treatment and CA 125 value could reflect the disease status during the treatment and follow-up of patients.
김영탁,남주현,김용만,김종혁,목정은,나준희,장영우,전대준,공훈식 대한부인종양 콜포스코피학회 1998 Journal of Gynecologic Oncology Vol.9 No.3
Uterine sarcomas are rare, characterized by rapid clinical progression and poor prognosis, and their management has been a challenge. The purpose of this study was to investigate the clinical and pathologic characteristics of patients with uterine sarcoma managed in the department of Obstetric and Gynecology, college of medicine, University of Ulsan, Asan Medical center, Seoul, Korea from June 1989 to August 1998. Data including clinical and histologic findings, treatment and outcome of nineteen patients were evaluated. The age of patients ranged 22 to 71 years (mean ±S.D.; 46.9 ±13.1) and half of patients were postmenopausal and four patients were nulliparous. Palpable pelvic mass or abnormal uterine bleeding were the most common sign or symptom. Twelve patients (63.2%) had stage Ⅰdisease and seven (36.8%) had stage Ⅲdisease. There were 13 cases (68.4%) of leiomyosarcoma, 4 cases (21.1%) of endometrial stromal sarcoma, 2 cases (10.5%) malignant mixed mullerian tumor. All except one received hysterectomy ple or radical) with or without bilateral salpingo-oophorectomy. Some received omentectomy or pelvic lymphadenectomy. Postoperative chemotherapy was administered in ten patients with regimen of VAC, VBP, VIC and etc. The mean follow-up duration was 29.3 (± 24.7) months and 5 patients died of the disease resulting 2-year survival of 68.1%. FIGO stage and mitotic count were considered to have prognostic significance, but without statistical confirmation. In conclusion, uterine sarcomas are aggressive tumors with a poor prognosis. Our data showed excellent outcome in early disease with surgery with or without adjuvant chemotherapy, whereas there was no long-term survivor in advanced disease despite postoperative chemotherapy.