Clinicopathological study on metastatic skin cancer

( Chang Il Kwon ),( Seo Mi Gon Jeong ),( Young Bin Shin ),( Yun Sun Moon ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Various primary tumors can cause metastatic skin cancer. Metastatic skin lesion should be distinguished from other skin lesion. Objectives: We studied patients with metastatic skin cancer to find out average age, gender distribution, frequency of primary tumor, time interval between manifestation and primary cancer, and their clinical appearance, location and other metastatic sites. Methods: We reviewed the medical records, clinical photographs and histopathologic records of patients who had been diagnosed with metastatic skin cancer. Results: In the comparison according to clinical records, the mean age at the time of diagnosis was 60.6 years. The ratio of men to women was 1.05:1. The most frequent primary tumors were breast cancer (22.0%), lung cancer (17.0%), head and neck cancer (17%), melanoma (17.0%), gastrointestinal cancer (11%), urologic cancer (11%), and gynecologic cancer (6%). Metastatic skin cancers usually presented as discrete, painless, hard nodules, with sudden onset (88%). Conclusion: Based on the results of this study, it is believed that it is important to recognize the metastatic lesion between various skin lesion such as infections and granulomatous changes of other cause due to drugs and reactive changes.

A case of HPV-16 positive squamous cell carcinoma arose in vulva

( Chang Il Kwon ),( Young Bin Shin ),( Jeong Won Jo ),( Yun Sun Moon ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer. In SCC, ultraviolet radiation is known as typical risk factor and it is mainly found on sun-exposed areas such as face, neck, and arm. SCC that occurs in a female vulva is a rare cancer. It represents 3-5% of gynecological cancers with an incidence of 2 per 100,000 women/year. It can occur at any age, mainly in women of the 6th decade. Clinically, it is represented as an erythematous to whitish colored patch and it may also be nodular or ulcerative appearance. A 76-year-old woman visited our hospital with multiple erythematous erosive patch on labia minora 6 months ago. We performed biopsy and we can confirm the diagnosis as SCC with no other metastasis. In addition, there was HPV-16 positive in HPV genotyping. The prognostic significance of HPV in vulva SCC is not established firmly. Some studies of vulva SCC have shown that HPV-associated SCC have a better prognosis where as others have not. HPV-associated SCC occur typically in younger women and HPV-independent SCC occur more frequently in older women. Herein, we report a case of 76-year-old woman with HPV-associated SCC.

보조호르몬요법을 받는 여성 유방암 환자의 모발 변화와 치료 실태에 대한 기초 연구

이재경 ( Jae Kyung Lee ),김창현 ( Chang-hyun Kim ),홍동균 ( Dongkyun Hong ),정경은 ( Kyung Eun Jung ),서영준 ( Young-joon Seo ),김창덕 ( Chang-deok Kim ),이진선 ( Jin Sun Lee ),권인선 ( In Sun Kwon ),박상현 ( Sanghyun Park ),이영 대한피부과학회 2021 대한피부과학회지 Vol.59 No.7

Background: Hormone therapy, which includes tamoxifen and aromatase inhibitors, is the most common adjuvant therapy used for breast cancer. However, only a few studies have reported endocrine therapy induced alopecia. Objective: We investigated the effects of long-term adjuvant hormone therapy on hair in patients with breast cancer, in addition to patients’ concerns and current treatment for hair loss. Methods: Patients completed a questionnaire that included information on self-perceived hair changes after each adjuvant therapy session, distress, and current treatment for hair loss. Using a folliscope, we measured hair density and thickness in each patient and in healthy controls. Results: The study included 93 patients with breast cancer (mean age 51.9±9.8 years). The density and hair thickness were 106.36±21.85 hairs/cm2 and 0.07±0.01 mm in the patient group and 147.86±30.67 hairs/cm2 and 0.07±0.01 mm in the control group (n=98, mean age 52.10±8.40 years), respectively. The mean hair density was significantly lower in the patient group than in the control group; however, no statistically significant intergroup difference was observed in hair thickness. Among 76 patients who perceived hair changes after adjuvant therapy, 71.1% (n=54) were distressed with regard to hair changes. However, only 7.8% of the patients, including two who were treated by dermatologists, currently received treatment for hair changes. Conclusion: Dermatologists should be familiar with hair changes in patients with breast cancer and provide appropriate education to encourage patients to consult dermatologists for hair loss and thinning after breast cancer treatment. (Korean J Dermatol 2021;59(7):521∼526)

東樞鍼에 의한 비침습적 少府穴 자극이 심박변이도에 미치는 영향

정대선(Dae-Sun Jung),한창현(Chang-Hyun Han),박수진(Soo-Jin Park),권영규(Young-Kyu Kwon) 한국한의학연구원 2007 한국한의학연구원논문집 Vol.13 No.1

Background : Recently a discussion about Qi including a study about the effect or the theory of acupuncture is getting prevailing in various angles. In most of studies about acupuncture stimulus, 'Filiform acupuncture'(毫鍼) is used. A study about Nine kinds of acupuncture(九鍼), except 'Filiform acupuncture'(毫鍼) has not been reported yet, and there is no study about using a special acupuncture made for controling Qi either. Objectives : 'DONG CHU CHIM' can be used for patients who are scared of a pain because it is a medical Qikong tool and non-invasive stimulus one. To assess a effect of Qikong operation using 'DONG CHU CHIM' objectively, we stimulated non-invasive to Sobu point of 30 normal adults using 'DONG CHU CHIM' and examined the result in the basis of high confirmed and repetitive HRV which is a functional assessment method of the autonomic nervous system. Method : This study has been proceeded in three periods. Total was 35min : 10min for the former and latter period of acupuncture stimulus, 15min for the acupuncture stimulus period. For each period, we measured 5 min of 3 times(Stage Ⅰ, Ⅱ, Ⅲ). Result : Comparing the changes of HRV during pre-stimulation and post-stimulation, HRT was significantly reduced, LOGTP, LOGVLF, LOGLF, LF/HF were significantly increased and SDNN, LOGHF were generally increased but did not show any significant changes. So we think that the stimulus of 'DONG CHU CHIM' affects on the sympathetic system and parasympathetic system, it activates the autonomic nervous system, and it makes the inequality of the sympathetic and parasympathetic nerve to be equal status. Conclusions : We can conclude that the non-invasive stimulus of 'DONG CHU CHIM' can affect significantly to the autonomic nervous system. So it can be used in clinic as a tool of Qikong operation, and it can be also used to weak patients or children because it doesn't give a lot of pain like 'Filiform acupuncture'(毫鍼) compared to invasive stimulus. By the basis of this study, more studies about the effect of 'DONG CHE CHIM' should be done in the future.

A survey of counseling and behavior regarding skin cancer

( Young Bin Shin ),( Chang Il Kwon ),( Jeong Won Jo ),( Yun Sun Moon ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: As the incidence of skin cancer increases, more information and education on skin cancer are needed. Although skin cancer is not rare, most patients are little known about general awareness of skin cancer. Objectives: The purpose of this study is to investigate the post-education effects on skin cancer in our hospital outpaitents and carers. Methods: We reviewed a written questionnaire and patients’ self-checked records including patients’ basic medical information and knowledge of skin cancer protective modalities. Results: In total 340 cases, 215 (63.2%) patients were female and 125 (36.8%) patients were male. 6 people in their teens, 56 people in their 20s and 30s, 156 people in their 40s and 50s, 122 people in their 60s or older. Before education, 142 people said sunlight can cause a skin cancer and 178 did not. After education, 246 people said Yes and 94 people did not. When asked how you wanted to get more information on skin cancer, 104 (30.6%) people said that they were printed handout, 142 (41.8%) were visit to dermatologists, 52 (15.3%) were photos of skin symptoms, and 42 (12.3%) were phone calls. Conclusion: This result showed that people are little known about risk factor of skin cancer such as sunlight and artificial tanning. However, we found that through education, people's perceptions could change. The education on behavior for skin cancer prevention should be continued so that the awareness of the risk of skin cancer can be changed.

최근 30년간 스포로트리쿰증 임상 병형의 추세에 대한 관찰

임채성,권경술,장호선,정태안,오창근 대한의진균학회 1997 대한의진균학회지 Vol.2 No.1

Background: The clinical types of sporotrichosis are generally classified into four group: lymphocutaneous, fixed cutaneous, and cutaneous disseminated, and hematogenous. Of these, the lymphocutaneous variety is the most frequently encountered pattern, constituting 80% of sporotrichosis patients and the fixed cutaneous sporotrichosis is the next. Potassium iodide (KI) was the most commonly used drug for the treatment of sporotrichosis. Many studies about these clinical findings of sporotrichosis have been reported, but comparative study on the changes in clinical findings has not been reported. Objective: The purpose of this study is to clarify the changes of the clinical findings in sporotrichosis in Korea. Methods: A total of 58 patients with sporotrichosis who had visited the Department of Dermatology, Pusan National University were divided into 2 groups according to the period and then the clinical findings of sporotrichosis were compared. Results: The results of study are summarized as follows: 1. During this period, there were 58 cases of sporotrichosis. In the past period (1967~1979) there were 35 cases of sporotrichosis, and there were 23 cases in the recent period (1980~1997) 2. In the past period, most cases (71.4%) were lymphocutaneous type, however in the recent period, most cases (69.2%) were fixed cutaneous type. 3. The most commonly affected site was right upper extremity in the past period, but face fright upper extremity were the most commonly affected sites in the recent period. 4. In the past period, 2nd and 3rd decades were prevalent age group, but 5th to 7th decades were prevalent age group in the recent period. 5. In the treatment of sporotrichosis, potassium iodide (KI) was the choice of treatment in the past period, however itraconazole is gradually used in the recent period. Conclusion: According to this study, many changes in clinical findings of sporotrichosis were noted, especially in the clinical type. We found that clnical type of sporotrichosis changed from lymphocutaneous type to the fixed cutaneous type with time. And we suggest that further observation would be necessary to define the meaning of these changes.

Treatment of alopecia areata with tofacitinib

( Ji Su Lee ),( Min-woo Kim ),( Hyun-sun Park ),( Jung Yoon Ohn ),( Hyun-sun Yoon ),( Chang-hun Huh ),( Ohsang Kwon ),( Soyun Cho ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Treatment of alopecia areata (AA) is often empiric and not yet satisfactory. Recently, Janus kinase inhibitor showed promising results in Caucasians. Objectives: To investigate efficacy, tolerability, and hair growth trajey of oral tofacitinib monotherapy for Korean AA patients over extended period. Methods: This is a retrospective study of adult AA patients treated with tofacitinib monotherapy for least 4 months. Results: Thirty-six Korean patients with median initial SALT score of 98.9 were included; 91.7% had refractory AA. Twenty-nine (80.6%) patients demonstrated more than 5% SALT change. Twenty patients (55.6%) achieved 50% SALT change at median 7.5 months with 5 mg twice dosage. There were significant differences between SALT 50 achievers and non-achievers: duration of current episode (ρ = 0.009), duration of disease since first onset (ρ = 0.026) and age at onset of first episode (ρ = 0.011). Tofacitinib was well tolerated and there was no any serious adverse effect such as malignancy or tuberculosis reactivation. Conclusion: Oral tofacitinib monotherapy may be effective and tolerable in patients with AA. SALT 50 achievement was associated with followings: duration of current episode, duration of disease since first onset, and age at onset of first episode.

인삼 투여가 정신지체아의 GPX와 MDA에 미치는 영향

이소영,장석암,김창환,권광선 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

The purpose of this study is to investigate the change of antioxidant enzyme(GPX) and lipid peroxide (MDA) by ginseng supplementation for nine weeks. Choosing as objects of test women mental retardation, this study analyzed the blood obtained from the objects who were in a rest, immediately and 30 minutes after maximal exercise. The comclusions obtained from this study were as follow. 1. In the tendency of whole activation of GPX, ginseng supplemintation group showed more GPX activation than placebo group. 2. In the change of GPX activation according to the passage of exercise time, there was no difference between each group before and after supplementation for nine weeks. 3. In the change of GPX activation according to (before and after) supplementation, there was no significant difference between each group at a rest, immediately and 30 minutes after maximal exercise. 4. In the change of MDA concentration according to the passage of exercise time, there was no difference between each group before and after supplemintation for nine weeks. 5. In the change of MDA concentration according to (before and after) supplementation there was o significant difference between each group at a rest, immediately and 30 minutes after maximal exercise.

난소의 장액성 종양에서의 p27^kip1과 Cyclin D1 발현에 대한 조사

권선영,장은숙,권건영,박관규,김수경 대한병리학회 2001 Journal of Pathology and Translational Medicine Vol.35 No.3

흰쥐에서 분리 배양한 척수앞뿔신경세포의 형태 분화 및 축삭 형성

엄창섭,엄창섭,박창현,권계숙,유임주,박선화,전용혁 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.2