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서울시내 고등학교 위탁급식의 급식비와 투자비의 실태 및 위탁업체의 기대수준 비교 분석
양일선,배환미,김현아,신서영,조미나,박수연,차진아,이보숙 한국식생활문화학회 2002 韓國食生活文化學會誌 Vol.17 No.5
The purposes of this study were to a) find out the operational characteristics of the contract-managed highschool foodservice in Seoul, b) investigate the expected level of meal-price and facilities investment cost perceived by contract-managed highschool foodservice managers c) compare the present level and expected level of meal-price and facilities investment cost. From October 12 to November 13 in 2001, the questionnaires were mailed to 249 high schools which was managed by contract foodservice company with respondent rate 40.2%. Data were analyzed using SPSS Win(10.0) for descriptive analysis and one group paired t-test. The results of this study were as follows ; 1. The student enrollment of highschools run by contract-managed foodservice was 1,243 with 72.6% participation rate of school lunch program. The average meal-price was 2,138 won. The average annual period of school foodservice operation was 156.78 days per year. The average contracting period was about 3 years. 2. The average cost concerned in the facilities investment amounts 169,578,180 won at the initial investment and 25,204,092 won at the repairs and maintenance cost in the course of operation. 3. The present level of meal-price and facilities investment cost were respectively 2,136won/meal and 171,157,336.72 won. And expected level.of meal-price and amount of facilities investment cost were 2,418.75 won and 121,353,215.19 won. Comparing the present level with expected level of the meal-price and facilities investment cost, expected level of meal-price was significantly higher than the present level of meal-price(p<.001) and expected level of facilities investment cost was significantly lower than present level of facilities investment cost(p<.001).
A novel adenoviral vector-mediated mouse model of Charcot-Marie-Tooth type 2D (CMT2D)
Seo, Ah Jung,Shin, Youn Ho,Lee, Seo Jin,Kim, Doyeun,Park, Byung Sun,Kim, Sunghoon,Choi, Kyu Ha,Jeong, Na Young,Park, Chan,Jang, Ji-Yeon,Huh, Youngbuhm,Jung, Junyang Springer-Verlag 2014 Journal of molecular histology Vol.45 No.2
Seo Jung-Ah,Cho Sun-A,Park Chang Eon,Seo Dong Hyuk,Choi Myungsuk,An Susun,Kim Bae-Hwan 한국독성학회 2022 Toxicological Research Vol.38 No.4
Skin sensitization is induced when certain chemicals bind to skin proteins. Direct peptide reactivity assay (DPRA) has been adopted by the OECD as an alternative method to evaluate skin sensitization by assessing a substance's reaction to two model peptides. A modified spectrophotometric method, Spectro-DPRA, can evaluate skin sensitization, in a high throughput fashion, to obviate some limitations of DPRA. Pre-validation studies for Spectro-DPRA were conducted to determine transferability and proficiency, within- and between-laboratory reproducibility, and predictive ability based on GLP principles at three laboratories (AP, KTR, and KCL). All laboratories confirmed high (> 90%) concordance for evaluating the sensitivity induced by ten chemical substances. The concordance among the three tests performed by each laboratory was 90% for AP, 100% for KTR, and 100% for KCL. The mean accuracy of the laboratories was 93.3% [compared to the standard operating procedure (SOP)]. The reproducibility among the three laboratories was as high as 86.7%; the accuracy was 86.7% for AP, 100% for KTR, and 86.7% for KCL (compared to the SOP). An additional 54 substances were assessed in 3 separate labs to verify the prediction rate. Based on the result, 29 out of 33 substances were classified as sensitizers, and 19 out of 21 identified as non-sensitizers; the corresponding sensitivity, specificity, and accuracy values were 87.9%, 90.5%, and 88.9%, respectively. These findings indicate that the Spectro-DPRA can address the molecular initiating event with improved predictability and reproducibility, while saving time and cost compared to DPRA or ADRA.
Comparison of susceptible and resistant SARS-CoV-2 mouse models on FVB background
Sun-Min Seo,Jae-Hyung Son,Ji-Hun Lee,Na-Won Kim,Eun-Seon Yoo,Ah-Reum Kang,Ji-Yun Jang,Da In On,Hyun Ah Noh,Jun-Won Yun,Jun Won Park,Ho Young Lee,Jeon-Soo Shin,Jun-Young Seo,Ki Taek Nam,Ho Lee,Je Kyung 한국실험동물학회 2022 한국실험동물학회 학술발표대회 논문집 Vol.2022 No.1
Effect of genetic background differences between FVB and C57BL/6 mice in SARS-CoV-2 infection
Ah-Reum Kang,Hyun Ah Noh,Jae Hyung Son,Sun-Min Seo,Ji-Hun Lee,Na-Won Kim,Eun-Seon Yoo,Han-Bi Jeong,Da In On,Ji Yun Jang,Jun-Won Yun,Jun Won Park,Kang-Seuk Choi,Ho-Young Lee,Jun-Young Seo,Ki Taek Nam,J 한국실험동물학회 2022 한국실험동물학회 학술발표대회 논문집 Vol.2022 No.7
Jeon, Sun-Ah,Choo, Hyun-Ah,Park, Woo-Kyu,Rhim, Hye-Whon,Ko, Soo-Y.,Cho, Yong-Seo,Koh, Hun-Yeong,Pae, Ae-Nim Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.2
The 5-HT6 antagonists are mainly related to the treatment of cognitive dysfunction or impairment associated with Alzheimer's disease and schizophrenia. There have been lots of efforts to develop 5-HT6 antagonists. As in our efforts, arylsulfonylpiperazine derivatives 1-3 were designed, synthesized and biologically evaluated against the human recombinant 5-HT6 serotonin receptor. Total 36 compounds were synthesized and the most active compound among the synthesized compounds is compound 2h with an IC50 value of 1.5 μM. The compound 2h is novel as 5-HT6 receptor ligand and could act as lead for the novel 5-HT6 receptor ligands.