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      • A Nonchlorinated Solvent-Processable Fluorinated Planar Conjugated Polymer for Flexible Field-Effect Transistors

        Lee, Myeongjae,Kim, Min Je,Ro, Suhee,Choi, Shinyoung,Jin, Seon-Mi,Nguyen, Hieu Dinh,Yang, Jeehye,Lee, Kyung-Koo,Lim, Dong Un,Lee, Eunji,Kang, Moon Sung,Choi, Jong-Ho,Cho, Jeong Ho,Kim, BongSoo American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.34

        <P>High carrier mobilities have recently been achieved in polymer field effect transistors (FETs). However, many of these polymer FET devices require the use of chlorinated solvents such as chloroform (CF), chlorobenzene (CB), and odichlorobenzene (DCB) during fabrication. The use of these solvents is highly restricted in industry because of health and environmental issues. Here, we report the synthesis of a low band gap (1.43 eV, 870 nm) semiconducting polymer (PDPP2DT-F2T2) having a planar geometry, which can be readily processable with nonchlorinated solvents such as toluene (TOL), o-xylene (XY), and 1,2,4-trimethylbenzene (TMB). We performed structural characterization of PDPP2DT-F2T2 films prepared from different solvents, and the electrical properties of the films were measured in the context of FETs. The devices exhibited an ambipolar behavior with hole dominant transport. Hole mobilities increased with increasing boiling point (bp) of the nonchloririated solvents: 0.03, 0.05, and 0.10 cm(2) V-1 s' for devices processed using TOL, XY, and TMB, respectively. Thermal annealing further improved the FET performance. TMB-based polymer FETs annealed at 200 degrees C yielded a maximum hole mobility of 1.28 cm(2) s(-1), which is far higher than the 0.43 cm(2) V-1 s(-1) obtained from the CF-based device. This enhancement was attributed to increased interchain interactions as well as improved long-range interconnection between fibrous domains. Moreover, all of the nonchlorinated solutions generated purely edge-on orientations of the polymer chains, which is highly beneficial for carrier transport in FET devices. Furthermore, we fabricated an array of flexible TMBprocessed PDPP2DT-F2T2 FETs on the plastic PEN substrates. These devices demonstrated excellent carrier mobilities and negligible degradation after 300 bending cycles. Overall, we demonstrated that the organized assembly of polymer chains can be achieved by slow drying using high bp nonchlorinated solvents and a post thermal treatment. Furthermore, we showed that polymer FETs processed using high bp nonhalogenated solvents may outperform those processed using halogenated solvents.</P>

      • How much solar panel waste would be generated in South Korea?: application of population balance model (PBM)

        ( Suhee Lee ),( Yong-chul Jang ),( Byeonghwan Kim ),( Youngsun Kwon ),( Hakyun Song ),( Kyunghoon Choi ) 한국폐기물자원순환학회 2022 ISSE 초록집 Vol.2022 No.-

        As the demand of renewable energy keeps growing, the installation of solar panels has been increased in the world. Once life-span of solar panels is reached, end-of-life of solar panels or solar panel waste can be generated for waste management. Environmentally sound management of solar panel waste has become an issue of concern around the world because they contain valuable materials as well as toxic pollutants upon disposal. This study examines the estimation of solar panel waste by using population balance model by 2050 in South Korea. The lifespan distribution analysis of solar panels was based on the literature with the Weibull distribution. Based on the results in this study, we found that solar panel waste in 2040 is estimated to be approximately 76,000 ton in South Korea, consisting of 57,000 ton of glass, 7,600 ton of polymers, 6,000 ton of aluminium, 3,800 ton of silicon, and other metals (silver, tin, and lead) for disposal. By 2050, approximately 1.7 million ton of solar panel waste would be accumulatively generated with continued annual increase. Material recycling and recovery from the waste should be implemented for resource conservation towards a circular economy. Refined estimation of the solar panel waste is still needed by conducting sensitive analysis with more reliable data such as its life spans, demands for solar panels, and mass of panel types.

      • KCI등재

        알츠하이머 질병 진단을 위한 혈액 바이오마커 검출용 바이오칩 센서 개발

        김수희 ( Suhee Kim ),이상혁 ( Sang Hyuk Lee ),이혜진 ( Hye Jin Lee ) 한국공업화학회 2017 공업화학 Vol.28 No.4

        해마다 증가하는 알츠하이머 질병에 걸린 환자 수는 전체 노인 인구의 15%에 다다르고 있다. 인지장애를 유발하는 심각한 알츠하이머 질병을 조기에 진단하는 것은 중요한 일이지만 MRI, PET, 척수액 진단법과 같은 기존 진단법은 고비용뿐만 아니라 장시간의 진단으로 환자에게 부담을 줄 수 있다. 이러한 기존 알츠하이머 질병 진단법의 단점을 극복하기 위하여 소량의 환자 시료(예 : 혈액)만으로 신속하게 알츠하이머 질병을 조기에 진단할 수 있는 다양한 바이오센싱 기술을 개발하는 연구가 지속되고 있다. 본 미니총설에서는 알츠하이머 질병 진단에 유용하게 활용될 수 있는 혈액 바이오마커를 정성 및 정량적으로 검출할 수 있는 바이오칩 기반의 센서 기술과 이를 통한 조기진단 기술에 대해 간략하게 서술하고, 이와 관련한 최신 연구현황과 발전방향에 대해 논의하고자 한다. The number of patients suffering from Alzheimer`s disease is increasing year after year and almost approaching 15% of the total elderly population. Although it is critical to detect the early stage of Alzheimer`s disease, which is a serious illness causing cognitive deficits, various existing diagnosis methods such as MRI, PET and CSF analysis could be the burdens for patients due to their high costs and long time to diagnosis. In order to tackle some of challenging issues for such existing diagnosis methods, extensive efforts have been made on developing fast and convenient biochip sensing methodologies for the diagnosis of Alzheimer`s disease with a droplet of patient biofluids (e.g., blood). In this mini-review, we highlight some of the latest biochip sensing technologies that could qualitatively and quantitatively analyze blood biomarkers used for Alzheimer`s disease diagnostics and discuss briefly related research trends and future aspects.

      • SCISCIESCOPUS

        An aptamer-aptamer sandwich assay with nanorod-enhanced surface plasmon resonance for attomolar concentration of norovirus capsid protein

        Kim, Suhee,Lee, Sanghyuk,Lee, Hye Jin Elsevier 2018 Sensors and actuators. B Chemical Vol.273 No.-

        <P><B>Abstract</B></P> <P>A Gold nanorod (NR) enhanced surface sandwich assay utilizing a novel pair of aptamers for the attomolar concentration of norovirus (NoV) capsid protein was developed in conjunction with surface plasmon resonance (SPR). A total of four different DNA aptamer sequences (aptamer I-IV) known to be specific for the NoV protein were examined using SPR for individual binding strength with the NoV protein and for the formation of surface sandwich with the NoV protein, meaning that the chosen aptamer pair possesses different binding epitope towards the NoV protein. One of the aptamer (aptamer II) sequences with the strongest binding constant was covalently tethered onto a chemically modified thin gold chip surface, while the other aptamer I was used for tethering onto the Au NR surface. The surface sandwich complex was formed via the sequential adsorption of NoV capsid protein and Au NR coated aptamer I onto the aptamer II surface. As low as a 70 aM concentration of the NoV protein in buffer solution could be detected, which is 10<SUP>5</SUP> times better than that of using the aptamer-aptamer sandwich platform without any gold NR particles. As a demonstration, the aptamer-NR coated aptamer sandwich assay was applied to analyze NoV capsid protein concentrations spiked in human serum solutions.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Highly sensitive and selective surface sandwich bioassays for norovirus (NoV) capsid protein. </LI> <LI> A pair of DNA aptamer bioreceptors for enhancing the selectivity of NoV capsid protein sensing. </LI> <LI> Gold nanorod-DNA aptamer conjugates to improve the sensitivity for NoV capsid protein sensing. </LI> <LI> Direct analysis of NoV capsid protein concentrations in undiluted human serum samples. </LI> <LI> A lowest detectable concentration of 50 aM NoV capsid protein. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

      • KCI등재

        유아교사의 직무 스트레스, 학부모와의 관계, 사회적 지지가 소진에 미치는 영향

        이수희(Suhee Lee),차정주(Jungju Cha) 한국어린이미디어학회 2022 어린이미디어연구 Vol.21 No.1

        본 연구는 유아교사의 직무 스트레스와 학부모와의 관계, 사회적 지지가 그들의 소진에 미치는 영향을 알아보기 위한 목적으로 이루어졌다. 이를 위하여 대구, 경북 지역 유아교사 205명을 대상으로 약 3주간 비대면 설문을 실시하고, 설문 자료를 토대로, 기술통계 분석, 상관관계 분석, 중다회귀분석을 실시하였다. 분석을 통해 도출된 결과를 제시하면 다음과 같다. 첫째, 유아교사의 직무 스트레스, 학부모와의 관계, 사회적 지지, 소진 사이의 상관관계를 분석한 결과 유아교사의 직무 스트레스는 그들의 학부모와의 관계, 사회적 지지와 유의미한 부적 상관을 가지고, 소진과는 유의미한 정적 상관을 가지고 있었다. 둘째, 유아교사의 직무 스트레스, 학부모와의 관계, 사회적 지지가 소진에 미치는 영향을 탐색하기 위해 중다회귀분석을 실시한 결과, 직무 스트레스, 학부모와의 관계, 사회적 지지 모두 그들의 소진에 유의한 영향을 미치는 것으로 나타났다. 본 논문은 유아교사의 소진을 예방하기 위해 그들의 직무 스트레스를 최소화하고, 학부모와의 관계에서 발생하는 부정적 감정 소모를 감소시키기 위한 정책적 지원과 더불어 주변 및 조직의 지지 형성을 위한 사회적인 지원도 필요함을 시사한다. This research examines the relationships among job stress, human relation with parent, social support, and burnout of early childhood teachers. An untact survey mehtod is employed to collect data from 205 early childhood teachers who have worked in Daegu and Gyeongbuk. Based on multiple regression analysis, the result indicates that the four variales used in this research are significantly correlated. Job stress, human relation with parent, and social support have statistically significant impacts on their burnout. In other words, it turns out that job stress, human relation with parent, and social support are critical variables in explaining the burnout of early childhood teachers. Based on the research findings, this research suggests that the job stress of early childhood teachers should be reduced and human relation with parent and social support should be encouraged for preventing their burnout. Additionally, they need to learn how to redece their job stress, how to manage relation with parents, and how to attain social support if they are to avoid burnout.

      • SCOPUSKCI등재SCIE

        Promising Therapeutic Effects of Embryonic Stem Cells-Origin Mesenchymal Stem Cells in Experimental Pulmonary Fibrosis Models: Immunomodulatory and Anti-Apoptotic Mechanisms

        Hanna Lee,Ok-Yi Jeong,Hee Jin Park,Sung-Lim Lee,Eun-yeong Bok,Mingyo Kim,Young Sun Suh,Yun-Hong Cheon,Hyun-Ok Kim,Suhee Kim,Sung Hak Chun,Jung Min Park,Young Jin Lee,Sang-Il Lee 대한면역학회 2023 Immune Network Vol.23 No.6

        Interstitial lung disease (ILD) involves persistent inflammation and fibrosis, leading to respiratory failure and even death. Adult tissue-derived mesenchymal stem cells (MSCs) show potential in ILD therapeutics but obtaining an adequate quantity of cells for drug application is difficult. Daewoong Pharmaceutical’s MSCs (DW-MSCs) derived from embryonic stem cells sustain a high proliferative capacity following long-term culture and expansion. The aim of this study was to investigate the therapeutic potential of DW-MSCs in experimental mouse models of ILD. DW-MSCs were expanded up to 12 passages for in vivo application in bleomycin-induced pulmonary fibrosis and collagen-induced connective tissue disease- ILD mouse models. We assessed lung inflammation and fibrosis, lung tissue immune cells, fibrosis-related gene/protein expression, apoptosis and mitochondrial function of alveolar epithelial cells, and mitochondrial transfer ability. Intravenous administration of DWMSCs consistently improved lung fibrosis and reduced inflammatory and fibrotic markers expression in both models across various disease stages. The therapeutic effect of DW-MSCs was comparable to that following daily oral administration of nintedanib or pirfenidone. Mechanistically, DW-MSCs exhibited immunomodulatory effects by reducing the number of B cells during the early phase and increasing the ratio of Tregs to Th17 cells during the late phase of bleomycin-induced pulmonary fibrosis. Furthermore, DW-MSCs exhibited antiapoptotic effects, increased cell viability, and improved mitochondrial respiration in alveolar epithelial cells by transferring their mitochondria to alveolar epithelial cells. Our findings indicate the strong potential of DW-MSCs in the treatment of ILD owing to their high efficacy and immunomodulatory and anti-apoptotic effects.

      • KCI등재

        국내 송아지 분변 내 설사병 병원체 검출과 설사 발병율 조사

        김수희 ( Suhee Kim ),강진희 ( Jin-hee Kang ),이창준 ( Chang-joon Lee ),이영성 ( Young-sung Lee ),채정병 ( Jeong-byoung Chae ),강성우 ( Sung-woo Kang ),정숙한 ( Suck-han Jeong ),유도현 ( Do-hyeon Yu ),조아라 ( Ara Jo ),류재규 ( Jae 한국동물위생학회 2016 한국동물위생학회지 (KOJVS) Vol.39 No.3

        Diarrhea is reported as one of the most common diseases in calves. It is thought to be a major cause of productivity and economic loss to cattle producers. The aim of this study is to provide a better under-standing of well-known diarrheagenic pathogens and incidence of diarrhea in Korean calves. In this study, the relationship of calf diarrhea and pathogens were investigated from calves under 60 days of age in five areas of Korea from April to July, 2016. Of examined fecal samples, 38.3% was positive for any pathogens, and Giardia was the most common pathogen (25.5%). The incidence of diarrhea was 31% from pathogen-negative fecal samples whereas 61.1% from pathogen-positive fecal samples, sug-gesting high correlation between pathogenic factor and diarrhea. In addition, 80% of E. coli (K99) pos-itive calves showed diarrhea, suggesting E. coli (K99) could be highly pathogenic. The incidence of diarrhea and infection rate increased with age. Rotavirus was revealed as a major pathogen in calves under 20 days of age, and the infection rate of Giardia increased rapidly in calves 20 to 39 days of age. The information on interconnections between clinical diarrhea and pathogens would contribute to developing strategies for treatment of calf diarrhea.

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