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      • SCOPUSKCI등재

        Characteristics of Mitochondrial DNA Sequence Polymorphisms and Haplogroups in Korean Population

        Hye Ran Kim,Myung Geun Shin,Mi Ji Kim,Jong Hee Shin,Soon Pal Suh,Dong Wook Ryang 한국유전학회 2008 Genes & Genomics Vol.30 No.2

        We examined sequence variations in the mitochondrial DNA (mtDNA) control region, tRNA leucine1 ( tRNA leu1) and cytochrome b ( CYTB) genes in order to investigate the characteristics of mtDNA polymorphisms and haplogroups in Korean population. Seventy maternally unrelated healthy Korean donors provided blood samples for the present study. The small deletion mutations exist only in the hypervariable region (HV) region. The Korean population exhibited a high level of length heteroplasmy in the 16184-16193 and 303-315 poly-C regions from the mtDNA control region. Some of the most common polymorphisms found in all subjects were 73A > G, 263A > G, 3107delC and 15326A > G from HV2, HV1, tRNA leu1 and CYTB genes, respectively. The most common haplogroup in the Korean population was D4 which was found in 16% of the population, followed by A, B, B4a, D5, G1a and M10 (each of 6%). Several haplogroups appear to be restricted to the Japanese and Korean populations. However, the current study revealed different distribution of some haplogroups in the Korean population in comparison with a previous study. The overall pattern and frequency of haplogroups among Koreans in the current study were closer to those of a Japanese population than to a Han Chinese population.

      • KCI등재

        문화원형콘텐츠의 장기보존에 관한 연구 - 디지털 소리자료를 중심으로 -

        서혜란,Suh, Hye-Ran 한국비블리아학회 2006 한국비블리아학회지 Vol.17 No.2

        The purpose of this study is to present some basic information essential for planning long-term preservation of digital audio files, which have been collected through 'Cultural Archetypes Digitization Project' by the Korea Culture & Content Agency. Needs and limitations of digitization of audio resources for their long-term preservation, digital audio archiving models(OAIS Reference Model and AHDS Model), some technical principles for audio digitization and preservation, preservation metadata and storing media for digital audio files were discussed. Compliance to the requisites listed in Audit Checklist for the Certification of Trusted Digital Repositories of RLG & NARA was suggested. It was also recommended to review the appropriateness of collaborating on digital preservation project with other institutions.

      • KCI등재

        기록유산의 보존과 활용을 위한 도서관과 기록관의 협력

        서혜란,Suh, Hye-Ran 한국비블리아학회 2005 한국비블리아학회지 Vol.16 No.2

        Collaboration between libraries and archives would be an effective and efficient strategy for them to accomplish their mission to make useful information accessible for current users and to preserve valuable documentary heritage for future users. This paper indicated differences in their organizational culture and some technical problems as obstacles to collaboration. Nine cases of collaboration and cooperation between libraries and archives in some foreign countries were introduced. This paper analysed strength and weakness for Korean libraries and archives when they explore ways to go into partnership. Based on the analysis. it suggested to develop the communication channels between libraries and archives; to further the education of competent professionals; to establish necessary standards. to get legal and financial support from the central and local authorities. 도서관과 기록관의 협력은 이용자에게 유용한 정보를 좀 더 많이, 더욱 편리하게 활용할 수 있도록 하고 가치 있는 기록유산을 장기보존하기 위한 효과적이고 효율적인 전략임을 주장하였다. 두 기관 간 협력의 장애요소로서 조직문화의 차이와 기술적 문제를 제시하였다. 외국에서 진행되고 있는 도서관과 기록관 간의 협력사례 아홉 개를 유형별로 나누어 소개하고 시사점을 도출하였다. 우리나라가 기록유산의 활용과 보존을 위해서 도서관과 기록관의 협력을 모색할 경우에 작용할 수 있는 강점과 약점을 분석하였다. 이러한 분석을 바탕으로 우리나라에서 도서관과 기록관의 협력을 촉진할 수 있는 방안을 제시하였다.

      • KCI등재

        웹 아카이빙의 성과와 과제

        서혜란,Suh, Hye-Ran 한국비블리아학회 2004 한국비블리아학회지 Vol.15 No.1

        이 연구의 목적은 도서관들이 웹 아카이빙이라는 새로운 도전에 대응하여 어떻게 해결책을 모색해 왔으며 앞으로 어떤 과제를 해결해 나가야 할 것인지를 정리하는 것이다. 이 논문에서는 웹 정보자원의 특성을 양적 급성장, 심층 웹의 존재, 웹 정보의 신뢰성에 대한 의문과 역동성, 웹 출판의 무정부성으로 규정하고, 도서관 이 왜 웹 아카이빙을 해야 하는가에 대해서 논의하였다. Kurturarw3, PANDORA, Internet Archive를 중심으로 웹 아카이빙 프로젝트의 성과를 검토하였다. 그리고 효과적이고 성공적인 웹 아카이빙을 실현하기 위해서 해결해야 할 정책적 과제와 기술적 과제들을 점검하였다. The purpose of this study is to review what we have done and to identify what we have to do to be successful with Web archiving which is important to preserve our cultural heritage for the next generation. Some characteristics of Web resources as information sources were identified and some difficulties with Web archiving were discussed. The outcome of national and/or international Web archiving projects including Kurturarw3, PANDORA and Internet Archive were reviewed. Policy issues and technological problems of Web archiving we have to solve were listed.

      • KCI등재

        공공도서관의 재원확보에 관한 연구

        서혜란,Suh Hye-ran 한국문헌정보학회 1992 한국문헌정보학회지 Vol.23 No.-

        In recent years, Korean public libraries, placed under changing circumstances, require that some new and positive financial policies be formulated for the improvement of their services. T he purpose of this study is to propose a scheme to ensure the revenues of Korean public libraries. The main contents of this study are as follows : (1) Public finance theory is applied to the question of why the public library is publicly supported. The public library does not contribute to stabilization, but it does playa role in each of the other public sector functions : allocation of resources and redistribution of income. In public finance terms there is justification for at least partial subsidy of public library services, which have the attributes of public goods, merit goods and externalities. (2) Public libraries in Korea find themselves suffering from limited budgets. They are neglected in national and local budgets. The lack of adequate funding for library collections prevents libraries from rendering efficient services. (3) In order to put the finances of the Korean public library system on a firm basis, the following proposals are made: 1) It is proposed that the parallel administration under which public libraries are organized be unified to be directly under the local governments. 2) It is proposed that the legislative and administrative system for public library finance be strengthened. (1) Library expenses should be itemized independently in the calculation of general grants-in-aid to local governments. (2) A fixed portion of the total municipal revenue should be appropriated for public library services. It can be executed by making provisions expressly in the annual guidelines for budgeting, municipal ordinances, or in the Library Promotion Law. The rate of allocation should be specified as a part of the national public library development plan. (3) Library tax as a local tax can be imposed. An indirect tax is preferable in order to avoid public misunderstanding and antagonism. 3) The augmentation of the specific grants-in-aid for the public library is proposed. The Library Promotion Law and the Law on Budget and Administration of Grants should be amended to oblige the central government to give financial assistance to local public libraries. 4) It is proposed that strategies to encourage private endowments be worked out. Revision of the Law on Tax Reduction and Exemption and the activation of an advisory library committee at each public library are recommended. 5) Funding and utilization of the envisioned Library Promotion Foundation is proposed. Government contributions, contributions from the Culture and Arts Foundation, and donations from individuals, corporations, and enterprises can be considered as the financial resources of the Foundation. 6) It is proposed that the structure of the Korean Library Association be consolidated to exercise greater influence over the formation of national policy on the public library system. 7) It is proposed as an ultimate guarantee of the health of the public libraries that the citizenry be educated to strongly support library services in responce to the active services provided by the public libraries.

      • KCI등재

        미국의 대학평가인정기준에 나타나는 대학도서관 평가기준의 최근 경향

        서혜란,Suh, Hye-Ran 한국비블리아학회 2004 한국비블리아학회지 Vol.15 No.2

        American Academic Accreditation System was reviewed. Current accreditation standards of the six regional accreditation associations were analysed with reference to the evaluation of academic libraries. That analysis was led to the recognition of some trends; mission and goal based assessment, qualitative evaluation, emphasis on the student learning outcomes, emphasis on the teaching role of academic librarians, distance education, and less prescriptive text. Some suggestions were made for revision of the Korean academic accreditation standards related to libraries. 미국의 대학평가인정제를 개관하였다. 그리고 2000년을 전후하여 대폭적으로 개정된 여섯 개 지역별 대학평가 인정기준을 대학도서관에 대한 평가기준을 중심으로 분석하였다. 그 결과 여섯 가지 특징적 변화 경향을 파악 하였다. 즉 목적 기반의 평가, 성과 중심의 정성적 평가, 학생의 학습성과 강조, 도서관의 가르치는 역할 강조, 원격교육 서비스 강화, 그리고 규범성과 구체성의 후퇴가 그것이다. 연구자는 이러한 최신 경향에 대한 이해를 바탕으로 우리나라의 대학평가기준 중 도서관 관련 평가항목이 지향해야 할 방향을 제안하였다.

      • KCI등재

        Mitochondrial DNA Aberrations of Bone Marrow Cells from Patients with Aplastic Anemia

        Kim, Hye Ran,Shin, Myung Geun,Kim, Mi Ji,Kim, Hyeoung Joon,Shin, Jong Hee,Suh, Soon Pal,Ryang, Dong Wook Korean Academy of Medical Sciences 2008 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.23 No.6

        This study was undertaken primarily to test the hypothesis that mitochondrial DNA (mtDNA) mutations may be associated with aplastic anemia. Complete mtDNA nucleotide sequence was analyzed in nine and eight bone marrow specimens from Korean patients with aplastic anemia and healthy individuals, respectively. We found a large number of polymorphisms as well as apparent new mutations in both patients and controls throughout the entire mtDNA genome; 12 mutations harbored amino acid changes in patients and none of the mutations in controls produced amino acid changes. There were heteroplasmic mutations and more nonsynonymous mtDNA changes observed in patients, so the mean number of mtDNA aberrations of bone marrow cells showed statistically significant difference overall between patients (mean=25.6) and controls (mean=12.8) (p=0.019). Our data may support an association of mtDNA aberrations with aplastic anemia.

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