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Lee, Yun-Gyoo,Lee, Ju Hyun,Kim, Se-Hyun,Kim, Yu Jung,Lee, Heeyoung,Ahn, Soyeon,Jang, Joung-Soon,Lee, Jong-Seok,Kim, Jee Hyun Elsevier 2018 Lung cancer Vol.122 No.-
<P><B>Abstract</B></P> <P><B>Introduction</B></P> <P>To determine whether an upfront combination compared to single-agent therapy is beneficial for elderly patients with advanced non-small cell lung cancer (NSCLC) in the real world, a population-based epidemiologic study was conducted.</P> <P><B>Methods</B></P> <P>Patients ≥70 years with advanced NSCLC from 2007 to 2012 were identified in the National Health Insurance Service Database of Korea. A Cox proportional-hazards regression model and propensity score analysis were used to examine the effect of treatment modality on survival.</P> <P><B>Results</B></P> <P>Among 41,276 patients newly diagnosed with lung cancer, 8274 (20.0%) identified to be treated with upfront palliative chemotherapy were eligible for this study. After excluding 976 patients who received a first-line anti-epidermal growth factor receptor (EGFR) treatment, 7298 (88.2%) who received cytotoxic chemotherapy were included in further analyses: 5636 (77.2%) received doublet chemotherapy and 1662 (22.8%) received monotherapy. The most frequent regimen in combination group was gemcitabine and platinum doublet (44.7%), whereas that in monotherapy group was gemcitabine (46.7%). Multivariate analyses indicated lower use of combination chemotherapy with increasing age (odds ratio [OR] 0.73; 95% CI 0.67–0.79; <I>P</I> < 0.001) and female sex (OR 0.71; 95% CI 0.62–0.80; <I>P</I> < 0.001). Receipt of combination over single-agent chemotherapy was associated with a reduced risk of death (hazard ratio [HR] 0.91; 95% CI 0.86–0.96; <I>P</I> = 0.001) in overall population and (HR 0.89; 95% CI 0.80–0.98; <I>P</I> = 0.019) in the propensity-matched cohort.</P> <P><B>Conclusion</B></P> <P>In elderly patients with advanced NSCLC excluding those receiving frontline anti-EGFR targeted agents, receiving initial combination chemotherapy compared to single-agent was associated with improved survival.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This population-based study included all patients ≥70 years of advanced NSCLC. </LI> <LI> We examined if an upfront combination compared to singlet therapy is beneficial. </LI> <LI> Combination over singlet chemotherapy was associated with a reduced risk of death. </LI> <LI> Our results were consistent between overall and propensity score-matched cohort. </LI> </UL> </P>
이소연(주저자) ( Lee Soyeon(주저자) ),김나영(공동저자) ( Kim Nayeong(공동저자) ),이소연(교신저자) ( Lee Soyeon(교신저자) ) 디자인융복합학회 2018 디자인융복합연구 Vol.17 No.6
여성들의 사회적 역할이 확대되고 지위가 상승하고 있으나 기존의 공간은 아직도 여성들의 주요 활동 공간이 제한된 범위에 머물러 있다는 인식 안에 있다. 본 연구는 여성과 공간에 대한 선행 연구 분석과 토론을 통해 기존의 여성 공간 연구를 검토하고 앞으로의 연구의 방향을 모색하고자 한다. 연구방법으로 선행 문헌을 키워드, 게재연도, 연구대상지, 연구목적, 연구방법, 학회지 분야의 유목별로 분류하여 분석하였다. 아울러, 초점집단면접(focus group interview)을 실시해 기존 공간의 문제점을 제시하고 새로운 연구의 방향을 모색하였다. 키워드의 네트워크 분석 결과, ‘여성전문병원’, ‘CPTED(crime prevention through environmental design’, ‘여성친화도시’, ‘여성성’이 연결 중심성이 높게 나타났다. 아울러 그동안의 여성 공간에 대한 연구는 절대적으로 부족한 실정이나, 최근 연구 공간의 범위가 다양해지고 있으며, ‘도시’적 관점에서 여성 공간에 접근하는 거시적이고 입체적 연구가 활발해지고 있다. 마지막으로 여성 공간에 대한 초점집단면접을 통해, 여성의 니즈에 대한 심층적 연구를 통한 ‘여성성’과 ‘출산·양육’을 고려한 공간 연구와 ‘양성 평등 공간’ 및 ‘안전한 공간’에 대한 연구가 요구되었다. Although women’s status in society have been improving, the existing space for women’s main activities is still perceived as limited in scope. In this respect, this study analyzes the domestic literature on women’s space and discusses the space for women with intent to gain some implications for further studies on space associated with women. Articles on women’s space were sub-classified in light of keywords, years of publication, sites, purposes, methods and journal categories, followed by network and frequency analyses. In addition, focus group interview was conducted to explore a new orientation for further studies. The degree centrality was found high in such keywords as ‘women’s clinics’, ‘CPTED’, ‘women-friendly cities’ and ‘femininity’. In addition, there is a paucity of studies on women’s space. Recent studies have diversified the scope of women’s space. At the same time, macroscopic ‘urban’ approaches to women’s space have lately been emerging. Finally, the focus group interview on women’s space highlighted the needs to further studies about ‘femininity, ‘maternity’, and ‘gender equality’ in space, and ‘safe environment’.
A population-based observational study of patients with pulmonary disorders in intensive care unit
Hyun Woo Lee,Eunjeong Ji,Soyeon Ahn,Hye-Joo Yang,Seo-Young Yoon,Tae Yeon Park,Yeon Joo Lee,Jinwoo Lee,Sang Min Lee,Seung-Hye Choi,Young-Jae Cho 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.6
Background/Aims: Only a few epidemiologic studies on the patients with pulmonary disorders admitted to intensive care unit exist. We investigated the characteristics and clinical outcomes of the patients with severe pulmonary disorders. Methods: The sample cohort database of National Health Insurance Sharing Service from 2006 to 2015 was used. Operational definition of critically ill patients was adults who were either admitted to intensive care unit for at least 3 days or expired within first 2 days in the unit. The pulmonary disorder group comprised of critically ill patients with respiratory disease as the main diagnosis. Results: Among the 997,173 patients, 12,983 (1.3%) in 383 intensive care units were categorized as critically ill. Patients in the pulmonary disorder group tended to have more comorbidities or disabilities. The length of hospital stay and duration of mechanical ventilation were longer in the pulmonary disorder group. Overall mortality and re-admission were higher in the pulmonary disorder group, with adjusted incidence rate ratios of 1.22 (95% confidence interval, 1.18 to 1.27) and 1.26 (95% confidence interval, 1.17 to 1.36), respectively. After adjustment by Cox regression, the pulmonary disorder group was an independent risk factor for in-hospital mortality. Conclusions: In critically ill patients with pulmonary disorder, the use of healthcare resources was higher, and their clinical outcomes were significantly worse than the non-pulmonary disorder group.
선천성 담관 낭종 수술 후 잔류 낭종에서 15년 만에 발생한 담관암
이형경 ( Hyeung Kyeung Lee ),이경민 ( Kyoung Min Lee ),김진영 ( Jinyoung Kim ),이정선 ( Jungsun Lee ),안소연 ( Soyeon An ),홍승모 ( Seung-mo Hong ),이현우 ( Hyun Woo Lee ),김명환 ( Myung-hwan Kim ) 대한췌담도학회 2017 대한췌담도학회지 Vol.22 No.3
담관 낭종은 담관에 발생하는 선천성 담관 확장증을 의미하며, 담도계에 발생하는 비교적 드문 질환이다. 담관 낭종과 관련된 합병증으로는 담석 형성, 담관염, 췌장염이 있으며, 무엇보다도 담관암이 발생할 수 있어서 낭종 절제술 같은 외과적 절제가 치료 원칙이다. 담관 낭종을 수술한 후에도 담관 낭종의 불완전 절제로 인해 남아있는 낭종에서 담도계 암이 발생하는 경우가 종종 있다. 저자들은 담관 낭종으로 수술받은 후일부 남아있는 췌장내 총담관 부위 낭종에서 수술 15년 후 담관암이 발생한 1예를 경험하여 보고하고자 한다. 이 증례는 담관 낭종의 치료로써 완전 절제의 중요성과 정기적인 추적 검사의 필요성을 일깨워준다고 볼 수 있다. Among complications of choledochal cysts, malignant transformation is most concerning and management of choledochal cyst now includes complete cyst excision, whenever possible. In cases of choledochal cyst associated with pancreaticobiliary maljunction like our case, cholecystectomy along with the resection of dilatated bile duct and the biliary diversion are generally performed. However, incomplete cyst excision can result in malignant transformation within the remnant cyst. We present the case of cholangiocarcinoma arising from remnant intrapancreatic cyst 15 years after choledochal cyst excision in a patient with Todani type 1 choledochal cyst associated with pancreaticobiliary maljunction. We learn from the case that a careful long-term follow-up is needed in patients with choledochal cysts if residual cyst is remained after excision.
Lee, Soyeon,Park, Jin-Woo Elsevier Sequoia 2019 Sensors and actuators. B Chemical Vol.298 No.-
<P><B>Abstract</B></P> <P>We analyze and explain the reversible humidity-responsive behavior of porous structured luminescent oxygen (O<SUB>2</SUB>) sensing films in terms of O<SUB>2</SUB> permeability and optical light scattering. The luminescent O<SUB>2</SUB> sensing films are composed of an O<SUB>2</SUB>-sensitive dye within porous polymer matrices, where the porous structure is formed via phase separation between immiscible polystyrene (PS) and polyethylene glycol (PEG). A comparison of the sensing film with a porous polymeric film without an O<SUB>2</SUB>-sensitive dye by in situ measurement of both the photocurrent signal and diffused reflectance under different relative humidity (RH) levels reveals the origin of the optical variations in the luminescent O<SUB>2</SUB> sensing film as a function of RH. Here, the hygroscopic PEG surrounded by the PS matrix swells and fills up the pores as the RH increases, which mainly tunes the optical scattering property of the porous polymeric films, and the variation in light scattering of the porous polymeric films is explained by Mie scattering theory. By considering and analyzing the humidity response in luminescent O<SUB>2</SUB> sensing films in the aspects of fabrication processes and experimental systems as well as the hydration property of the materials, this study can provide fundamental insights into the cross-sensitivity of optical O<SUB>2</SUB> sensors to humidity. Moreover, the fully reversible humidity-driven tuning of the light scattering properties in porous polymeric films allows various applications, such as dual monitoring of O<SUB>2</SUB> and RH in wearable sensors, responsive coating or smart windows, that require optical tuning without extra energy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Humidity-driven optical changes in a luminescent O<SUB>2</SUB> sensing film are examined. </LI> <LI> The optical changes are originated from light scattering in the porous polymer matrix. </LI> <LI> Hygroscopic PEG fills up the pores under humid conditions, changing the light refraction. </LI> <LI> The variation in light scattering of the porous polymeric films is explained by Mie scattering theory. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>