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할로아세틸시코닌 유도체의 합성 및 항암성 평가 : Synthesis and Evaluation of Antitumor Activity
鄭相國,金光洙,송규용,조훈,안병준 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-
The secondary hydroxy group at side chain of shikonin structure was selectively acylated with various haloacetic acids in presence of dicyclohexylcarbodiimide and 4-dimethylaminopyridine to produce haloacetylshikonin derivatives. The cytotoxicity of monohaloacetylshikonin derivatives against L1210 cells increased in the following order: monochloroacetylshikonin (ED_50, 0.142 ㎍/㎖) nonobromoacetylshikonin (ED_50, 0.158㎍/㎖)>monoiodoacetylshikonin (ED_50, 0.173 ㎍/㎖). Introduction of larger halogen atoms decreased the cytotoxic activity, presumably due to steric hinderance. The cytotoxicity of chloroacetylshikonin derivatives was dependent on the number of chlorine atom, thus increasing in the following order : trichloroacetylshikonin (0.032 ㎍/㎖)>dichloroacetylshikonin (0.059 ㎍/㎖)> monochloroacetylshikonin (ED_50, 0.142 ㎍/㎖). Thus, the electron-withdrawing effect seems to be important for the cytotoxicity of chloracetylshikonin derivatives. Consistent with the above, dichloracetylshikonin (T/C, 182%) and trifluoroacetylshikonin (195%) showed higher T/C values than monochloroacetyl-(T/C, 122%), monobromoacetyl-(T/C, 154%) and monoiodoacetylshikonin (T/C, 117%) derivatives. Haloacetylshikonin derivatives showing lower cytotoxic activities against L1210 cells exhibited lower T/C values. It seems that there is a relationship between the cytotoxicity of haloacetylshikonin and their antitumor activity.
Song Xiang,Ying-tao Chen 국제구조공학회 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.51 No.6
Meshless local collocation method produces much better conditioned matrices than meshless global collocation methods. In this paper, the meshless local collocation method based on thin plate spline radial basis function and first-order shear deformation theory are used to calculate the natural frequencies and mode shapes of laminated composite shells. Through numerical experiments, the accuracy and efficiency of present method are demonstrated.
Xiang, Xiao-song,Su, Yu,Li, Guo-li,Ma, Long,Zhou, Chang-sheng,Ma, Ru-feng The Korean Gastric Cancer Association 2020 Journal of gastric cancer Vol.20 No.4
Purpose: A phase II study was conducted to evaluate the safety and efficacy of preoperative, intra-arterial perfusion of epirubicin, etoposide, and oxaliplatin combined with oral chemotherapy S-1 (SEEOX) for the treatment of type 4 gastric cancer. Materials and Methods: A single-center, single-arm phase II trial was conducted on 36 patients with histologically proven type 4 gastric cancer without distant peritoneal or organ metastasis. Patients received 3, 21-day courses of SEEOX preoperative chemotherapy. The primary endpoint was overall survival (OS) and the secondary outcomes assessed were chemotherapeutic response, radical resection rate, pathological regression, toxicities, postoperative morbidity, and mortality. Results: All patients were at an advanced stage of cancer (stage III or IV) and completed the entire course of treatment. Based on changes in tumor volume and peritoneal metastasis, the objective response rate was 55.6% (20/36; 95% confidence interval [CI], 38.5%-72.6%) and the disease control rate was 69.4% (25/36; 95% CI, 53.6%-85.3%). The radical resection rate was 75% (27/36; 95% CI, 60.1%-89.9%) and the proportion of R0 resections was 66.7% (21/36; 95% CI, 50.5%-82.8%). The pathological response rate was 33.3%, of which 13.9% showed complete pathological regression. The median survival was 27.1 months (95% CI, 22.24-31.97 months), and the 2-year OS was 48.5% (95% CI, 30.86%-66.1%). Conclusions: Preoperative SEEOX is a safe and effective treatment for type 4 gastric cancer. Based on these preliminary data, a phase III study will be conducted to confirm the superiority of this regimen over standard treatment.
Song Jian,Song Wen-Xiang,Liu Zhan-Jun,Ma Shao-Cai 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.2
Aiming at the unstable phenomena such as high DC-link voltage ripple that occur in the interior permanent magnet synchronous motor drive system of the small DC-link capacitor when the rotor speed is high or the load power is large, this paper proposes an active damping control method based on voltage compensation. The method starts from the mathematical model of the driving system, based on the characteristic equation of the driving system, and according to the Rouse stability criterion, the driving system is stabilized by applying a virtual resistance to change the coefficient of the characteristic equation. The proposed method only needs a bandpass filter to extract the DC-link voltage ripple, which is then compensated to the motor stator voltage axis by the damping coefficient. In order to obtain high damping performance, considering the time constant and the delay of the control loop, the theoretical design basis for a reasonable value of the damping coefficient is given, and the influence of the proposed method on the performance of the drive system is evaluated. Simulation and experimental results verify the effectiveness of the proposed method.
Microstructure and Bonding Strength of Tungsten Coating Deposited on Copper by Plasma Spraying
Song Shu-Xiang,Zhou Zhang-Jian,Du Juan,Zhong Zhi-Hong,Ge Chang-Chun 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
Tungsten coatings with different interlayers onto the oxygen-free copper substrates were fabricated by atmosphere plasma spraying. The effects of different interlayers of NiCrAl, NiAl and W/Cu on bonding strength were studied. SEM, EDS and XRD were used to investigate the photographs and compositions of these coatings. The tungsten coatings with different initial particle sizes resulted in different microstructures. Oxidation was not detected in the tungsten coating, but in the interlayer, it was found by both XRD and EDS. The tungsten coating deposited directly onto the copper substrate presented higher bonding strength than those with different interlayers.
Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus
Song, Fu-Qiang,Liu, Ying,Kong, Xiang-Shi,Chang, Wei,Song, Ge Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
Cancer is a leading cause of death worldwide. Recently, the demand for more effective and safer therapeutic agents for the chemoprevention of human cancer has increased. As a white rot fungus, Inonotus obliquus is valued as an edible and medicinal resource. Chemical investigations have shown that I. obliquus produces a diverse range of secondary metabolites, including phenolic compounds, melanins, and lanostane-type triterpenoids. Among these are active components for antioxidant, antitumoral, and antiviral activities and for improving human immunity against infection of pathogenic microbes. Importantly, their anticancer activities have become a hot recently, but with relatively little knowledge of their modes of action. Some compounds extracted from I. obliquus arrest cancer cells in the G0/G1 phase and then induce cell apoptosis or differentiation, whereas some examples directly participate in the cell apoptosis pathway. In other cases, polysaccharides from I. obliquus can indirectly be involved in anticancer processes mainly via stimulating the immune system. Furthermore, the antioxidative ability of I. obliquus extracts can prevent generation of cancer cells. In this review, we highlight recent findings regarding mechanisms underlying the anticancer influence of I. obliquus, to provide a comprehensive landscape view of the actions of this mushroom in preventing cancer.
Xiang, Song,Chen, Ying-Tao Techno-Press 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.51 No.6
Meshless local collocation method produces much better conditioned matrices than meshless global collocation methods. In this paper, the meshless local collocation method based on thin plate spline radial basis function and first-order shear deformation theory are used to calculate the natural frequencies and mode shapes of laminated composite shells. Through numerical experiments, the accuracy and efficiency of present method are demonstrated.
Yu-Xiang Song,Dong Ye,Shi Han,Bo-Ning Xu,Yan-Qing Zhang,Yong Liu 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.8
In order to study the influence of various design parameters on the ultimate load of the biascomponent of the pipe-roof pre-construction (PP) structure, a variable section steel-concretesteel(VSSCS) bias component, incorporating studs, was designed, and a bias loading testconducted. The impact of component parameters on bearing capacity underwent furtheranalysis using a finite element model, leading to the optimization of the PP structure and arevision of its bearing capacity calculation model. The following conclusions are obtained: 1)The failure mode of VSSCS bias components is mainly characterized by large eccentric tensilefailure. 2) For each 1mm increase in steel plate thickness and each 5 Mpa enhancement inconcrete strength, the maximum bearing capacity of the component correspondingly rises by1.6% − 10.9% and 6.4% − 15.7%, respectively. 3) The strength and stiffness of the components areincreased by 9.2% − 13.1% and 18.1% − 64.9% by adding stud connectors, respectively.
충적과정중 미국인삼 종자의 생리 및 생화하적 지표에 관한 동태학적 연구 III
Huang, Yao-Ge,Li, Xiang-Gao,Kuang, Ya-Lan,Yan, Jie-Kun,Cui, Shu-Yu,Yu, Wen-Bo,Yang, Ji-Xiang,Liu, Ren-Song,Kim, Hack-Seang 고려인삼학회 1997 Journal of Ginseng Research Vol.21 No.1
Dynamic parameters of biochemistry including the POD (peroxidase) activity, contents of DNA and RNA, isozymes of POD and ES (esterase) in American send (Panax quinquefolium L.) seed are reported in the present paper. The dynamic changes of POD activity proved that the PAS (physiological afterripening stage) is a stage in which some substances are prepared for seed germination. The POD activity correlated with ER (embryo ratio) significantly DNA content changed little only within 0.0036∼0.013 mg/ml, which did not correlate with ER. RNA content changed from 0.1539 to 1.0313 mg/ml and correlated significantly with RE during all of the embryo afterripening. None of the POD isozyme band was obtained in ESGS (embryo slowly growth stage), but five bands in ERGS (embryo rapidly growth stage) and six bands in PAS. Four bands of ES isozymes were obtained in ESGS, but six bands in ERGS, particularly, the content of ES isozymes increased in PAS. All of these may provide some information for understanding the dormancy mechanisms of American song seed.